Antioxidant vitamins and risk of cardiovascular disease. Review of large-scale randomised trials.

abstract：:The place of digoxin in the pediatric cardiologist's armamentarium remains uncertain. As an antiarrhythmic, its use in the Wolff-Parkinson-White syndrome is obsolete, but it remains useful in the treatment of the chronic atrial fibrillation seen in some patients postoperatively and in children with dilated cardiomyopa...

journal_title：Cardiovascular drugs and therapy

authors： Redington AN,Carvalho JS,Shinebourne EA

更新日期：1989-03-01 00:00:00

abstract：:To characterize the effects of OPC-8212, a quinolone inotropic agent, in patients with heart failure, we utilized invasive hemodynamics, exercise testing, 24-hour ambulatory electrocardiograms, and two patient self-assessment questionnaires, before and after 1 month of treatment with OPC-8212, in 17 patients with mode...

journal_title：Cardiovascular drugs and therapy

authors： Kubo SH,Rector TS,Strobeck JE,Cohn JN

更新日期：1988-12-01 00:00:00

abstract：:Left ventricular dysfunction is in most cases the consequence of myocardial ischemia. It may occur transiently during an attack of angina and usually it is reversible. It may persist over hours or even days in patients after an episode of ischemia followed by reperfusion, leading to the so-called condition of stunning...

journal_title：Cardiovascular drugs and therapy

authors： Ferrari R,La Canna G,Giubbini R,Milan E,Ceconi C,de Giuli F,Berra P,Alfieri O,Visioli O

更新日期：1994-05-01 00:00:00

abstract：:Inhibition of then renin-angiotensin system (RAS) ranks among the best established and most used cardiovascular therapies. By providing protection against hypertension and heart failure, and also the microvascular complications of diabetes, RAS inhibitors have contributed to the longer life-expectancy now found in hig...

journal_title：Cardiovascular drugs and therapy

authors： Opie LH

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Although erythropoietin (EPO) is known to express angiogenic and cardioprotective effects, it also induces hypertension, polycythemia, and platelet activation, which may cause serious adverse effects in patients with cardiovascular diseases. We compared the angiogenic effects of EPO and its nonerythropoietic de...

journal_title：Cardiovascular drugs and therapy

authors： Yanagawa T,Toba K,Kato K,Suzuki T,Minagawa S,Saigawa T,Ozawa T,Oda M,Takayama T,Hanawa H,Higuchi M,Saito H,Aizawa Y

更新日期：2013-04-01 00:00:00

abstract：:The purpose of the study was to determine whether a new KATP channel opener, Y 26763 (Y), can influence the electrophysiological properties in the ischemic myocardium as well as to determine whether the blunting effect of the alpha 1-adrenoceptor antagonist bunazosin (BN) on an ischemia-induced shortening of repolariz...

journal_title：Cardiovascular drugs and therapy

authors： Tanabe T,Aikawa M,Deguchi Y,Yoshioka K,Handa S

更新日期：2000-06-01 00:00:00

abstract：:In the latter half of the 20th century, among participants of the Framingham Heart Study, incidence of heart failure (HF) has declined by about a third in women but not in men and survival after the onset of HF has improved in both sexes; however, HF remains highly lethal with over 50% dying within 5 years after onset...

journal_title：Cardiovascular drugs and therapy

authors： Kenchaiah S,Vasan RS

更新日期：2015-08-01 00:00:00

abstract：:The effects of nifedipine on left ventricular function were evaluated in 17 patients with coronary artery disease with an ambulatory radionuclide detector (VEST). Hemodynamic data were recorded continuously at rest and during upright bicycle ergometer exercise before and 30 minutes after 10 mg of oral nifedipine admin...

journal_title：Cardiovascular drugs and therapy

authors： Kambara H,Mohiuddin IH,Tamaki N,Fudo T,Hayashi M,Nohara R,Konishi J,Kawai C

更新日期：1990-08-01 00:00:00

abstract：:Endothelial dysfunction contributes to the initiation and development of hypertension. We previously found that simvastatin moderately decreases blood pressure in 2-kidney-2-clip (2k2c) renal hypertension, but the precise mechanisms are still unclear. The present study was designed to examine the protective actions of...

journal_title：Cardiovascular drugs and therapy

authors： Zhang Z,Wang M,Xue SJ,Liu DH,Tang YB

更新日期：2012-02-01 00:00:00

abstract：:Levosimendan, a calcium sensitizer and potassium channel-opener, is widely appreciated by many specialist heart failure practitioners for its effects on systemic and pulmonary hemodynamics and for the relief of symptoms of acute heart failure. The drug's impact on mortality in large randomized controlled trials has be...

journal_title：Cardiovascular drugs and therapy

authors： Bouchez S,Fedele F,Giannakoulas G,Gustafsson F,Harjola VP,Karason K,Kivikko M,von Lewinski D,Oliva F,Papp Z,Parissis J,Pollesello P,Pölzl G,Tschöpe C

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVES:To evaluate and compare the functional type and the degree of antagonism of the selective angiotensin II type 1 receptor blockers (ARB) losartan, EXP 3174 (the active metabolite of losartan), valsartan and candesartan in human internal mammary arteries. METHODS:Human internal mammary arteries were obtained ...

journal_title：Cardiovascular drugs and therapy

authors： Wagenaar LJ,Voors AA,Buikema H,van Buiten A,Lübeck RH,Boonstra PW,van Veldhuisen DJ,van Gilst WH

更新日期：2002-07-01 00:00:00

abstract：:Cholesterol plays an essential role in cell membrane synthesis and in cell growth and differentiation. In mammalian cells, cholesterol can be synthesized from acetate precursors or taken up from dietary or exogenous sources. The major catabolic route for disposal of cholesterol involves conversion into excretable bile...

journal_title：Cardiovascular drugs and therapy

authors： Russell DW

更新日期：1992-04-01 00:00:00

abstract：:Forty-one chronically T. cruzi-infected male adult albino rats with normal resting ECG were submitted to the ajmaline test (1 mg/kg body weight injected into the dorsal vein of the penis). Twenty-one similar noninfected animals served as controls. Ajmaline induced the following ECG alterations in control rats: A decre...

journal_title：Cardiovascular drugs and therapy

authors： Bestetti RB,Soares EG,Sales-Neto VN,Oliveira JS

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Although Takotsubo syndrome (TS) was once considered to be rare and largely benign, it is now recognized to represent a major cause of cardiac morbidity and mortality, especially in ageing women. The biochemical precipitant of attacks of TS is an increase in catecholamine concentrations within the myocardium...

journal_title：Cardiovascular drugs and therapy

authors： Ong GJ,Nguyen TH,Stansborough J,Surikow SY,Horowitz JD

更新日期：2020-02-01 00:00:00

abstract：:Cilazapril, an angiotensin-converting enzyme inhibitor, and mibefradil, a selective T-type voltage-operated calcium channel blocker, have been shown to prevent neointima formation after vascular injury. The goal of the present study was to evaluate the mechanism of action of both drugs. For this purpose, the influence...

journal_title：Cardiovascular drugs and therapy

authors： Schmitt R,Clozel JP,Iberg N,Bühler FR

更新日期：1996-05-01 00:00:00

abstract：:To further evaluate the significance of p38 MAPK as trigger or mediator in ischaemic preconditioning, anisomycin and SB 203580 were used to manipulate its activation status. Special attention was given to the concentration of the drugs and protocols used. The isolated perfused rat heart, subjected to either 25 min glo...

journal_title：Cardiovascular drugs and therapy

authors： Lochner A,Genade S,Hattingh S,Marais E,Huisamen B,Moolman JA

更新日期：2003-05-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) inhibitor therapy has been associated with a substantial (> or = 20%) reduction in the risk of major ischemic events in two recent clinical trials with long-term follow-up: Studies of Left Ventricular Dysfunction (SOLVD) and the Survival and Ventricular Enlargement (SAVE) study. Par...

journal_title：Cardiovascular drugs and therapy

authors： Young JB

更新日期：1995-02-01 00:00:00

abstract：:Despite the fact that beta blockers were introduced into clinical practice 25 years ago, new beta blockers with differing kinetic and dynamic profiles continue to be developed and marketed. This overview assesses some of the more extensively studied agents from the point of view of proof of utility and the validity of...

journal_title：Cardiovascular drugs and therapy

authors： Fitzgerald JD

更新日期：1991-06-01 00:00:00

abstract：:Angiotensin converting enzyme inhibitors have greatly improved the treatment of patients with chronic heart failure but they are not effective in all patients, and their use may be limited by side effects. There is, therefore, a need to investigate new drugs and to compare their efficacy with angiotensin converting en...

journal_title：Cardiovascular drugs and therapy

authors： Cowley AJ,Wynne RD,Swami A,Birkhead J,Skene A,Hampton JR

更新日期：1992-10-01 00:00:00

abstract：:With the increased use of long-acting nitroglycerin preparations, there has been greater recognition of the problem of nitrate tolerance. In recent years extensive research has broadened our understanding of the mechanisms of nitroglycerin action and the mechanisms of drug attenuation. This paper reviews the current s...

journal_title：Cardiovascular drugs and therapy

authors： Katz RJ

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVE:The aim was to study the pharmacodynamic interactions and safety of the co-administration of the calcium sensitizer levosimendan and the calcium antagonist felodipine in patients with coronary heart disease (CHD) and with normal ejection fraction (EF). METHODS:The study was a randomized, double blind, placeb...

journal_title：Cardiovascular drugs and therapy

authors： Põder P,Eha J,Antila S,Heinpalu M,Planken U,Loogna I,Mesikepp A,Akkila J,Lehtonen L

更新日期：2003-09-01 00:00:00

abstract：:Glucose-insulin-therapy for acute myocardial infarction (AMI) has had a long history, going back 37 years to the pioneering concepts of Sodi-Pallares. Although a recent meta-analysis of a number of smaller trials has suggested mortality benefit, it is only the South American trial, published in Circulation in 1998, th...

journal_title：Cardiovascular drugs and therapy

authors： Apstein CS,Opie LH

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the impact of granulocyte-colony stimulating factor (G-CSF) administration on cardiac function of rats with chronic myocardial infarction through two different protocols: high dose short term and low dose long term protocols. METHODS:Wistar rats were submitted to MI sur...

journal_title：Cardiovascular drugs and therapy

authors： Louzada RA,Oliveira PF,Cavalcanti-de-Albuquerque JP,Cunha-Carvalho L,Baldanza MR,Kasai-Brunswick TH,Goldenberg RC,Campos-de-Carvalho AC,Werneck-de-Castro JP

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:Platelets are essential for primary hemostasis; however, platelet activation also plays an important proinflammatory role. Inflammation promotes the development of cardiac fibrosis and heart failure induced by hypertension. In this study, we aimed to determine whether inhibiting platelet activation using clopid...

journal_title：Cardiovascular drugs and therapy

authors： Jia LX,Qi GM,Liu O,Li TT,Yang M,Cui W,Zhang WM,Qi YF,Du J

更新日期：2013-12-01 00:00:00

abstract：:The effects of oral zofenopril pretreatment were investigated in a chronic closed-chest pig model of ischemia and reperfusion. Pigs (25-35 kg) were pretreated orally with zofenopril (15 mg/day) on the 2 days prior to ischemia, which was evoked by the inflation of a catheter balloon in the left anterior descending coro...

journal_title：Cardiovascular drugs and therapy

authors： Tio RA,de Langen CD,de Graeff PA,van Gilst WH,Bel KJ,Wolters KG,Mook PH,van Wijngaarden J,Wesseling H

更新日期：1990-06-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. There was a typo in the second sentence of the paragraph under the section Was the Dose of Drugs Fair?; "320 mg twice a day" should read "160mg twice a day". The corrected paragraph is shown below. ...

journal_title：Cardiovascular drugs and therapy

authors： Ahn R,Prasad V

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:The natural history of pediatric patients with severely symptomatic neurocardiogenic syncope is poorly defined respect to the likelihood of remission or symptomatic recurrence along time. We undertook this study to investigate the likelihood of clinical relapse, and to assess the effect of prophylactic pharma...

journal_title：Cardiovascular drugs and therapy

authors： Biffi M,Boriani G,Bronzetti G,Frabetti L,Picchio FM,Branzi A

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:Permanent polymer drug-eluting stents (DES) are associated with a higher risk of late and very late stent thrombosis (ST); biodegradable polymer drug-eluting stents (BP-DES) were designed to reduce these risks. However, their benefits are not completely clear. METHOD:We undertook a meta-analysis of randomize...

journal_title：Cardiovascular drugs and therapy

authors： Wang Y,Dong P,Li L,Li X,Wang H,Yang X,Wang S,Li Z,Shang X

更新日期：2014-08-01 00:00:00

abstract：:Vascular endothelium gene expression regulates blood-vessel wall interactions, vascular permeability, smooth muscle cell growth and tone. The possibility to introduce exogenous DNA or RNA sequences in endothelial cells represents a novel therapeutic approach of vascular disease. The aim of the work was to investigate ...

journal_title：Cardiovascular drugs and therapy

authors： Colombo MG,Citti L,Basta G,De Caterina R,Biagini A,Rainaldi G

更新日期：2001-01-01 00:00:00

abstract：AIMS:The primary ain of this study was to investigate the effect of carbachol on ventricular repolarisation in an intact animal heart. METHODS:In five sheep, carbachol was administered to the left circumflex coronary artery (LCX) at 1.0 and 2.5 micromol/ml/min respectively for 3 min. Multiple unipolar ECGs were acquir...

journal_title：Cardiovascular drugs and therapy

authors： Wang L

更新日期：2003-07-01 00:00:00