Effect of orally administered alpha-tocopheryl acetate on human myocardial alpha-tocopherol levels.

abstract：INTRODUCTION:Most circulating fatty acids are contained in lipoprotein triglycerides. For the heart to acquire these lipids, they must be broken down into free fatty acids via the enzyme lipoprotein lipase (LpL). Although it has long been known that hearts primarily use esterified fatty acids as fuel, different sources...

journal_title：Cardiovascular drugs and therapy

authors： Noh HL,Yamashita H,Goldberg IJ

更新日期：2006-12-01 00:00:00

abstract：:Though the exact physiology and pathology of lipoprotein(a) [Lp(a)] remains unknown, it has been demonstrated that increased serum Lp(a) levels are correlated with an increased risk of atherosclerotic vascular disease. The effects of lipid-lowering drugs on Lp(a) levels is unclear because of inconsistencies between st...

journal_title：Cardiovascular drugs and therapy

authors： Dobs AS,Prasad M,Goldberg A,Guccione M,Hoover DR

更新日期：1995-10-01 00:00:00

abstract：:The place of digoxin in the pediatric cardiologist's armamentarium remains uncertain. As an antiarrhythmic, its use in the Wolff-Parkinson-White syndrome is obsolete, but it remains useful in the treatment of the chronic atrial fibrillation seen in some patients postoperatively and in children with dilated cardiomyopa...

journal_title：Cardiovascular drugs and therapy

authors： Redington AN,Carvalho JS,Shinebourne EA

更新日期：1989-03-01 00:00:00

abstract：:Despite the impressive relation between an increased blood cholesterol and increased mortality from coronary artery disease and despite the persuasive results of cholesterol-lowering trials in secondary prevention, there are increasing reservations about the wisdom of lowering moderately raised blood cholesterol level...

journal_title：Cardiovascular drugs and therapy

authors： Opie LH

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:To assess the effects of electro-acupuncture (EA) on glycemic control, myocardial inflammation, and the progression of diabetic cardiomyopathy in mice with type 2 diabetes. METHODS:Db/Db mice received EA at PC6+ST36 (DM-Acu), non-acupoint simulation (DM-Sham), or no treatment (DM). EA was applied for 30 min pe...

journal_title：Cardiovascular drugs and therapy

authors： Ye Y,Birnbaum Y,Widen SG,Zhang Z,Zhu S,Bajaj M,Chen H

更新日期：2020-12-01 00:00:00

abstract：:The use of calcium antagonists and diuretics in combination for treatment of hypertension is controversial. In a single-blind study 16 patients (8 men, 8 women, age range 39 to 62 years) with primary hypertension of mild to moderate degree were given slow-release nifedipine 20 mg twice daily for 6 weeks, thereafter ei...

journal_title：Cardiovascular drugs and therapy

authors： Ferrara LA,Marotta T,Pasanisi F,Mastranzo P,Mancini M

更新日期：1988-03-01 00:00:00

abstract：:There is considerable evidence implicating a key role for p38 mitogen-activated protein kinase (MAPK) in ischemic and pharmacological preconditioning against myocardial infarction. However, there have been few, if any, studies examining the role of p38 MAPK in the protection of stunned myocardium. The purpose of this ...

journal_title：Cardiovascular drugs and therapy

authors： Yoshimura Y,Kristo G,Keith BJ,Jahania SA,Mentzer RM Jr,Lasley RD

更新日期：2004-11-01 00:00:00

abstract：:Mitochondrial health is critically dependent on the ability of mitochondria to undergo changes in mitochondrial morphology, a process which is regulated by mitochondrial shaping proteins. Mitochondria undergo fission to generate fragmented discrete organelles, a process which is mediated by the mitochondrial fission p...

journal_title：Cardiovascular drugs and therapy

authors： Ong SB,Kalkhoran SB,Hernández-Reséndiz S,Samangouei P,Ong SG,Hausenloy DJ

更新日期：2017-02-01 00:00:00

abstract：:Despite the fact that beta blockers were introduced into clinical practice 25 years ago, new beta blockers with differing kinetic and dynamic profiles continue to be developed and marketed. This overview assesses some of the more extensively studied agents from the point of view of proof of utility and the validity of...

journal_title：Cardiovascular drugs and therapy

authors： Fitzgerald JD

更新日期：1991-06-01 00:00:00

abstract：:People who consume a diet rich in fruit and vegetables have lower risks of cancer, cardiovascular disease and all-cause mortality. Many prospective cohort studies have reported inverse associations between dietary intake or blood levels of beta-carotene and risks of cancer. Several large-scale trials were set up to as...

journal_title：Cardiovascular drugs and therapy

authors： Clarke R,Armitage J

更新日期：2002-09-01 00:00:00

abstract：:Cardiac reperfusion injury after heart transplantation or cardiopulmonary bypass has been difficult to control due to the variable degree of myocardial damage with respect to the length of ischemia and the complexity of the surgical procedure. Here, we evaluated the myocardial metabolic and functional recovery of hear...

journal_title：Cardiovascular drugs and therapy

authors： Orita H,Shimanuki T,Fukasawa M,Abe H,Kuraoka S,Hirooka S,Washio M

更新日期：1991-08-01 00:00:00

abstract：:Quality of life in heart failure patients is receiving increased attention as a reflection of a treatment's potential secondary benefit of general well-being and daily functioning. The Metoprolol in Dilated Cardiomyopathy (MDC) trial was conducted as a large, multicenter trial to establish the effects of metoprolol on...

journal_title：Cardiovascular drugs and therapy

authors： Wiklund I,Waagstein F,Swedberg K,Hjalmarsson A

更新日期：1996-07-01 00:00:00

abstract：:Reducing elevated levels of low-density-lipoprotein cholesterol (LDL-C) significantly reduces the incidence of coronary heart disease (CHD) events and mortality in hypercholesterolemic patients. CHD risk reduction is proportional to LDL-C reduction. Despite this knowledge, many physicians are not applying existing tre...

journal_title：Cardiovascular drugs and therapy

authors： McKenney JM

更新日期：2001-09-01 00:00:00

abstract：:The clinical efficacy and safety of ibopamine and diuretic therapy were compared in a multicenter, multinational, parallel, positive-controlled, randomized, double-blind, 12-week study, involving 103 patients with mild CHF (NYHA Class II). Body weight, NYHA functional class, symptom assessment scores, laboratory blood...

journal_title：Cardiovascular drugs and therapy

authors：

更新日期：1989-12-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) inhibitor therapy has been associated with a substantial (> or = 20%) reduction in the risk of major ischemic events in two recent clinical trials with long-term follow-up: Studies of Left Ventricular Dysfunction (SOLVD) and the Survival and Ventricular Enlargement (SAVE) study. Par...

journal_title：Cardiovascular drugs and therapy

authors： Young JB

更新日期：1995-02-01 00:00:00

abstract：:The purpose of this study was to evaluate the effect of trimetazidine on late potentials in patients with acute myocardial infarction. A total of 60 patients (52 males, mean age 55 +/- 2 years, and 8 females, mean age 54 +/- 1.8 years) with the diagnosis of acute myocardial infarction were included in this study. The ...

journal_title：Cardiovascular drugs and therapy

authors： Ozdemir R,Tuncer C,Aladag M,Güven A,Sezgin AT,Pekdemir H,Korkmaz ME,Müderrisoglu H

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:The melatonin receptor (MT) agonist ramelteon has a higher affinity to MT1 than for MT2 receptors and induces cardioprotection by involvement of mitochondrial potassium channels. Activation of mitochondrial potassium channels leads to release of free radicals. We investigated whether (1) ramelteon-induced cardi...

journal_title：Cardiovascular drugs and therapy

authors： Stroethoff M,Goetze L,Torregroza C,Bunte S,Raupach A,Heinen A,Mathes A,Hollmann MW,Huhn R

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Although Takotsubo syndrome (TS) was once considered to be rare and largely benign, it is now recognized to represent a major cause of cardiac morbidity and mortality, especially in ageing women. The biochemical precipitant of attacks of TS is an increase in catecholamine concentrations within the myocardium...

journal_title：Cardiovascular drugs and therapy

authors： Ong GJ,Nguyen TH,Stansborough J,Surikow SY,Horowitz JD

更新日期：2020-02-01 00:00:00

abstract：:Specific antiarrhythmic therapy with class I and III drugs for atrial fibrillation (AF) conversion and prevention of its recurrence is frequently utilized in clinical practice. Besides being only moderate effective, the utilization of antiarrhythmic drugs may be associated with serious side effects. In the clinical se...

journal_title：Cardiovascular drugs and therapy

authors： Husser D,Stridh M,Sornmo L,Platonov P,Olsson SB,Bollmann A

更新日期：2004-09-01 00:00:00

abstract：:Milrinone is shown in 10 patients to be a valuable pharmacological bridge to heart transplantation; it can stabilize and improve decompensated chronic heart failure (CHF) in cases where the response to beta-agonists is inadequate. One patient who had suffered an acute myocardial infarction with heart failure resistant...

journal_title：Cardiovascular drugs and therapy

authors： Sherry KM,Locke TJ

更新日期：1993-08-01 00:00:00

abstract：:Annual mortality from congestive heart failure ranges from 15% to 60%, depending on the severity of the left ventricular damage and underlying disease. Most controlled trials have been too small to detect any beneficial effect on survival from the newer vasodilator and inotropic drugs. However, the results of two rece...

journal_title：Cardiovascular drugs and therapy

authors： Meinertz T,Drexler H,Just H

更新日期：1988-11-01 00:00:00

abstract：:Investment in cardiovascular drug development is on the decline as large cardiovascular outcomes trials require considerable investments in time, efforts and financial resources. Pharmacogenomics has the potential to help revive the cardiovascular drug development pipeline by providing new and better drug targets at a...

journal_title：Cardiovascular drugs and therapy

authors： Dubé MP,de Denus S,Tardif JC

更新日期：2016-02-01 00:00:00

abstract：:In two separate, double-blind, multicenter antiarrhythmic studies, sotalol was compared with propranolol or quinidine using placebo for baseline and/or washout periods. The comparison with quinidine was a crossover study. To be enrolled in these studies, patients were required to have a premature ventricular contracti...

journal_title：Cardiovascular drugs and therapy

authors： Hanyok JJ,MacNeil DJ

更新日期：1990-06-01 00:00:00

abstract：AIMS:We evaluated a generic quality of life (QoL) Functional Status Questionnaire (FSQ), in patients with chronic heart failure (CHF). The FSQ assesses the 3 main dimensions of QoL: physical functioning, mental health and social role. It also includes 6 single item questions about: work status, frequency of social inte...

journal_title：Cardiovascular drugs and therapy

authors： Gallanagh S,Castagno D,Wilson B,Erdmann E,Zannad F,Remme WJ,Lopez-Sendon JL,Lechat P,Follath F,Höglund C,Mareev V,Sadowski Z,Seabra-Gomes RJ,Dargie HJ,McMurray JJ

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:Treatment of atherosclerotic rabbits with intravenous methotrexate or etoposide carried in lipid nanoemulsions (LDE) markedly reduced the lesions in the aorta. Here, the combined treatment with LDE-methotrexate and LDE-etoposide was investigated aiming to increase the anti-atherosclerosis effect. METHODS:Thirt...

journal_title：Cardiovascular drugs and therapy

authors： Leite AC Jr,Solano TV,Tavares ER,Maranhão RC

更新日期：2015-02-01 00:00:00

abstract：:There is still uncertainty of whether combined therapy with a beta-blocker and calcium-channel antagonist provides additive or synergistic clinical benefits in most patients with stable angina pectoris. The comparative antianginal effect of atenolol 50 mg and atenolol 50 mg and slow release nifedipine (20 mg) twice a ...

journal_title：Cardiovascular drugs and therapy

authors： Meyer TE,Adnams C,Commerford P

更新日期：1993-12-01 00:00:00

abstract：:Amlodipine increases NO levels in coronary vessels and aorta via bradykinin-dependent mechanisms in vitro. We have previously reported that a long-acting Ca channel blocker, benidipine, increases cardiac NO levels in ischemic canine hearts, suggesting that benidipine may also protect against ischemia and reperfusion i...

journal_title：Cardiovascular drugs and therapy

authors： Asanuma H,Kitakaze M,Node K,Takashima S,Sakata Y,Asakura M,Sanada S,Shinozaki Y,Mori H,Tada M,Kuzuya T,Hori M

更新日期：2001-01-01 00:00:00

abstract：:Cardiovascular diseases are of fundamental importance in the cause of death and morbidity in the elderly as a group. If the successful management of blood pressure can effect a reduction in morbid events as well as death, as has been indicated by recent trials, the elderly have more to gain than any other group within...

journal_title：Cardiovascular drugs and therapy

authors： Dall JL

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:The benefits of statin treatment initiated in advanced age are largely unknown; however, good adherence to treatment is essential for beneficial effects to be achieved also when treating older people. This study characterizes older statin initiators, including their cardiovascular risk profiles and morbidity, a...

journal_title：Cardiovascular drugs and therapy

authors： Upmeier E,Korhonen MJ,Rikala M,Helin-Salmivaara A,Huupponen R

更新日期：2014-06-01 00:00:00

abstract：:Thiazide diuretics are particularly efficacious in the treatment of hypertension in blacks. A number of observations suggest that many hypertensive blacks have features consistent with a status of "corrected" volume expansion. Our studies, as well as those of other investigators, show that the Na,K pump is inhibited i...

journal_title：Cardiovascular drugs and therapy

authors： Quintanilla AP,Wagener OE

更新日期：1990-03-01 00:00:00