When is discontinuation of antihypertensive therapy indicated?

abstract：PURPOSE:The glucose-lowering drug metformin has recently been shown to reduce myocardial oxygen consumption and increase myocardial efficiency in chronic heart failure (HF) patients without diabetes. However, it remains to be established whether these beneficial myocardial effects are associated with metformin-induced ...

journal_title：Cardiovascular drugs and therapy

authors： Larsen AH,Wiggers H,Dollerup OL,Jespersen NR,Hansson NH,Frøkiær J,Brøsen K,Nørrelund H,Bøtker HE,Møller N,Jessen N

更新日期：2020-08-08 00:00:00

abstract：PURPOSE:Hypothyroidism (HT) is associated with accelerated atherosclerosis (AS). The efficacy of traditional strategies of hypothyroid AS remains controversial. Here, we aimed to deepen the understanding of the HT-induced acceleration of AS, to decrease the residual risk of coronary artery disease (CAD) and to find a n...

journal_title：Cardiovascular drugs and therapy

authors： Yang Y,Jia Y,Ning Y,Wen W,Qin Y,Zhang H,Du Y,Li L,Jiao X,Yang Y,Liu G,Huang M,Zhang M

更新日期：2020-06-03 00:00:00

abstract：:ATP generates nitric oxide (NO) via activation of P2y receptors, and is degraded to adenosine. This study was undertaken to examine whether ATP causes coronary hyperemic flow via purinoceptors-, NO- and adenosine-dependent mechanisms, and attenuates the severity of contractile and metabolic dysfunction in the ischemic...

journal_title：Cardiovascular drugs and therapy

authors： Kitakaze M,Node K,Komamura K,Minamino T,Kosaka H,Kuzuya T,Hori M

更新日期：1999-09-01 00:00:00

abstract：:Annual mortality from congestive heart failure ranges from 15% to 60%, depending on the severity of the left ventricular damage and underlying disease. Most controlled trials have been too small to detect any beneficial effect on survival from the newer vasodilator and inotropic drugs. However, the results of two rece...

journal_title：Cardiovascular drugs and therapy

authors： Meinertz T,Drexler H,Just H

更新日期：1988-11-01 00:00:00

abstract：PURPOSE:The ischemic/bleeding trade-off of continuing dual antiplatelet therapy (DAPT) beyond 1 year after PCI for patients with high thrombotic risk (HTR) as endorsed by 2018 ESC/EACTS myocardial revascularization guidelines remain unknown. METHODS:Patients undergoing coronary stenting between January 2013 and Decemb...

journal_title：Cardiovascular drugs and therapy

authors： Wang HY,Dou KF,Wang Y,Yin D,Xu B,Gao RL

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:A multicentre, randomized, double-blind, placebo-controlled, parallel-group study aimed to define the potential positive effect of dipeptidyl peptidase-4 inhibition on left ventricular systolic function (LVSF) beyond glycemic control in type 2 diabetes mellitus (T2DM) (DYDA 2™ trial). METHODS:Individuals with ...

journal_title：Cardiovascular drugs and therapy

authors： Giorda CB,Cioffi G,Lucci D,Nada E,Ognibeni F,Mancusi C,Latini R,Maggioni AP,DYDA 2 Investigators.

更新日期：2019-10-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of death in men and women in the USA. Once a patient experiences an acute coronary syndrome (ACS), they are at increased risk for hospital readmission within 30 days and 6 months after discharge and more importantly, they have worse survival. Hospital readmissions lead to po...

journal_title：Cardiovascular drugs and therapy

authors： Paruchuri V,Gaztanaga J,Rambhujun V,Smith R,Farkouh ME

更新日期：2018-12-01 00:00:00

abstract：INTRODUCTION:Irisin is a newly identified 112 amino acid hormone, derived as a product of fibronectin type III domain containing 5 (FNDC5), which is highly related to metabolic activity in skeletal muscle and brown fat. The effects of irisin on cardiovascular functions are unknown. PURPOSE:To explore the effects of ce...

journal_title：Cardiovascular drugs and therapy

authors： Zhang W,Chang L,Zhang C,Zhang R,Li Z,Chai B,Li J,Chen E,Mulholland M

更新日期：2015-04-01 00:00:00

abstract：:Reducing elevated levels of low-density-lipoprotein cholesterol (LDL-C) significantly reduces the incidence of coronary heart disease (CHD) events and mortality in hypercholesterolemic patients. CHD risk reduction is proportional to LDL-C reduction. Despite this knowledge, many physicians are not applying existing tre...

journal_title：Cardiovascular drugs and therapy

authors： McKenney JM

更新日期：2001-09-01 00:00:00

abstract：:To assess the effect of antihypertensive drugs on aortic distensibility, we evaluated the aortic distensibility of 33 hypertensive patients before and after antihypertensive treatment by using cine magnetic resonance imaging. Thirty three hypertensive patients were divided into three groups and treated for 12 weeks wi...

journal_title：Cardiovascular drugs and therapy

authors： Honda T,Hamada M,Shigematsu Y,Matsumoto Y,Matsuoka H,Hiwada K

更新日期：1999-07-01 00:00:00

abstract：:Nicorandil (N) and isosorbide dinitrate (ISDN) are vasodilator drugs used in patients with angina. In 24 healthy male volunteers (18-32 years), the acute effect of a single oral dose (20 mg) of N and ISDN on arterial diameter (D), distensibility, and compliance of the elastic common carotid artery (CCA) and the muscul...

journal_title：Cardiovascular drugs and therapy

authors： Kool MJ,Spek JJ,Struyker Boudier HA,Hoeks AP,Reneman RS,van Herwaarden RH,Van Bortel LM

更新日期：1995-04-01 00:00:00

abstract：:The purpose of this study was to define the role of beta-adrenergic blockade and direct membrane effects in the ability of dl-propranolol to alter ventricular repolarization and refractoriness in the intact heart. The effective refractory period (ERP) and the local Q-T interval were measured at an epicardial site in t...

journal_title：Cardiovascular drugs and therapy

authors： Euler DE,Scanlon PJ

更新日期：1988-03-01 00:00:00

abstract：AIMS:Rapid restoration of sinus rhythm using pharmacological cardioversion is commonly indicated in patients with symptomatic recent-onset atrial fibrillation (AF). The objectives of this large, international, multicenter observational study were to determine the safety and effectiveness of intravenous (IV) vernakalant...

journal_title：Cardiovascular drugs and therapy

authors： Lévy S,Hartikainen J,Ritz B,Juhlin T,Carbajosa-Dalmau J,Domanovits H

更新日期：2020-11-18 00:00:00

abstract：:True positive inotropy of enoximone is hard to prove clinically. It could increase the risk of myocardial ischemia when used in coronary artery disease (CAD). The analysis of the end-systolic pressure-volume relationship (ESPVR) as a load-independent parameter of the contractile left ventricular function (LVF) allows ...

journal_title：Cardiovascular drugs and therapy

authors： Thormann J,Hueting J,Kremer P,Wissemann J,Mitrovic V,Dieterich HA,Schlepper M

更新日期：1990-10-01 00:00:00

abstract：:Quality of life in heart failure patients is receiving increased attention as a reflection of a treatment's potential secondary benefit of general well-being and daily functioning. The Metoprolol in Dilated Cardiomyopathy (MDC) trial was conducted as a large, multicenter trial to establish the effects of metoprolol on...

journal_title：Cardiovascular drugs and therapy

authors： Wiklund I,Waagstein F,Swedberg K,Hjalmarsson A

更新日期：1996-07-01 00:00:00

abstract：:Insertion (I)/deletion (D) polymorphism of the ACE gene has been reported to be involved in various cardiovascular diseases. We investigated prospectively whether the response to the ACE inhibitor fosinopril varied according to the ACE genotype in previously untreated Greek hypertensive patients. After a 4-week observ...

journal_title：Cardiovascular drugs and therapy

authors： Stavroulakis GA,Makris TK,Krespi PG,Hatzizacharias AN,Gialeraki AE,Anastasiadis G,Triposkiadis P,Kyriakidis M

更新日期：2000-08-01 00:00:00

abstract：:The purpose of this study was to examine the effects of the angiotensin-converting enzyme (ACE) inhibitor cilazapril on the elastic properties of the aorta. A standard diuretic antihypertensive drug, hydrochlorothiazide, served for comparisons. Increased aortic stiffness leads to a reduction of the buffering windkesse...

journal_title：Cardiovascular drugs and therapy

authors： Breithaupt-Grögler K,Leschinger M,Belz GG,Butzer R,Erb K,de May C,Sinn W

更新日期：1996-03-01 00:00:00

abstract：:A succession of theories arising from last century has attempted to explain why patients with damaged hearts develop peripheral edema. Opposed to the original simple concepts of backward failure, a number of theories of forward failure have been proposed, the cardiac output being considered inadequate for capillary pe...

journal_title：Cardiovascular drugs and therapy

authors： Harris P

更新日期：1994-06-01 00:00:00

abstract：:Milrinone is shown in 10 patients to be a valuable pharmacological bridge to heart transplantation; it can stabilize and improve decompensated chronic heart failure (CHF) in cases where the response to beta-agonists is inadequate. One patient who had suffered an acute myocardial infarction with heart failure resistant...

journal_title：Cardiovascular drugs and therapy

authors： Sherry KM,Locke TJ

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Acute ST-elevation myocardial infarction (STEMI) is associated with a high incidence of complications as well as a considerable hospitalization rate and economic burden. Preliminary evidence suggests that remote ischemic conditioning (RIC) is a promising non-invasive intervention that may effectively and saf...

journal_title：Cardiovascular drugs and therapy

authors： Zheng Y,Reinhardt JD,Li J,Hu D,Lin S,Wang L,Dai R,Fan Z,Ding R,Chen L,Yuan L,Xu Z,Cheng Y,Yan C,Zhang X,Wang L,Zhang X,Teng M,Yu Q,Yin A,Lu X,i-RIC Trial Collaboration Group.

更新日期：2020-06-30 00:00:00

abstract：:Torsades de pointes (TdP) is a life-threatening ventricular tachycardia that occurs in the setting of a prolonged QT interval and is most frequently related to administration of antiarrhythmic drugs. Patients with organic heart disease, with low serum electrolyte levels, with a previous episode of TdP and with bradyca...

journal_title：Cardiovascular drugs and therapy

authors： Keren A,Tzivoni D

更新日期：1991-04-01 00:00:00

abstract：:Ca2+ channel antagonists are agents that interact with the voltage-dependent Ca2+ channel in a highly specific way. The prototype agents of cardiovascular importance are verapamil, nifedipine, and diltiazem, in historical order of appearance. These agents all have different molecular structures and bind separately wit...

journal_title：Cardiovascular drugs and therapy

authors： Opie LH

更新日期：1987-12-01 00:00:00

abstract：:Despite continuous advances in myocardial revascularization procedures and intracoronary devices, patients with ischemic heart disease (IHD) still experience worse prognosis and poor quality of life (QoL). Indeed, chronic stable angina (CSA) is a common disease with a large burden on healthcare costs. Traditionally, C...

journal_title：Cardiovascular drugs and therapy

authors： Guarini G,Huqi A,Morrone D,Marzilli M

更新日期：2016-08-01 00:00:00

abstract：:Mivazerol, 3-[1(H-imidazol-4-yl)methyl]-2-hydroxybenzamide hydrochloride, is a selective alpha 2-adrenoceptor agonist designed for the prevention of myocardial infarction in perioperative patients. Because unintended hypothermia occurs frequently during surgery, we were interested, in this study, to examine the relati...

journal_title：Cardiovascular drugs and therapy

authors： Kim SY,Raikoff K,Wülfert E,Hanin I

更新日期：1997-12-01 00:00:00

abstract：AIM:To review whether brain natriuretic peptides (BNP) can be used as a surrogate for the traditional methods of assessing functional status in interventional studies of patients with left ventricular systolic dysfunction (LVSD). METHODS AND RESULTS:The traditional methods for assessing functional status including New...

journal_title：Cardiovascular drugs and therapy

authors： Abdulla J,Køber L,Torp-Pedersen C

更新日期：2004-05-01 00:00:00

abstract：:The pathogenetic theories and treatment of Raynaud's phenomenon are reviewed. In primary Raynaud's disease, most evidence supports a local defect at the digital artery level, with vasoconstriction or vasospasm of the digital arteries inducing the color changes. Normal sympathetic activity, low transmural arterial dist...

journal_title：Cardiovascular drugs and therapy

authors： Coffman JD

更新日期：1990-01-01 00:00:00

abstract：:Specific antiarrhythmic therapy with class I and III drugs for atrial fibrillation (AF) conversion and prevention of its recurrence is frequently utilized in clinical practice. Besides being only moderate effective, the utilization of antiarrhythmic drugs may be associated with serious side effects. In the clinical se...

journal_title：Cardiovascular drugs and therapy

authors： Husser D,Stridh M,Sornmo L,Platonov P,Olsson SB,Bollmann A

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Heart failure (HF) is considered to be a prothrombotic condition and it has been suggested that coagulation factors contribute to maladaptive cardiac remodelling via activation of the protease-activated receptor 1 (PAR1). We tested the hypothesis that anticoagulation with the factor Xa (FXa) inhibitor apixab...

journal_title：Cardiovascular drugs and therapy

authors： Yurista SR,Silljé HHW,Nijholt KT,Dokter MM,van Veldhuisen DJ,de Boer RA,Westenbrink BD

更新日期：2020-05-26 00:00:00

abstract：INTRODUCTION:Atrial dilatation is commonly associated with atrial fibrillation (AF), but the electrophysiological mechanisms and the implications for anti-arrhythmic therapy are poorly understood. In a model of acute stretch-related AF in isolated rabbit hearts, we evaluated the electrophysiological effects of three di...

journal_title：Cardiovascular drugs and therapy

authors： Kalifa J,Bernard M,Gout B,Bril A,Cozma D,Laurent P,Chalvidan T,Deharo JC,Djiane P,Cozzone P,Maixent JM

更新日期：2007-02-01 00:00:00

abstract：:Piperanometozine (OPC-8212) is a new, orally effective inotropic agent. To evaluate the efficacy of this agent on systemic hemodynamics and clinical symptoms in patients with congestive heart failure, a multicenter study was performed. Thirty four patients with New York Heart Association (NYHA) functional classes II t...

journal_title：Cardiovascular drugs and therapy

authors： Inoue M,Hori M,Yasuda H,Takishima T,Sugimoto T,Sasayama S,Sakurai T,Nonogi H,Kodama K,Kusukawa R

更新日期：1987-08-01 00:00:00