Levosimendan in Acute and Advanced Heart Failure: an Expert Perspective on Posology and Therapeutic Application.

abstract：:Milrinone is shown in 10 patients to be a valuable pharmacological bridge to heart transplantation; it can stabilize and improve decompensated chronic heart failure (CHF) in cases where the response to beta-agonists is inadequate. One patient who had suffered an acute myocardial infarction with heart failure resistant...

journal_title：Cardiovascular drugs and therapy

authors： Sherry KM,Locke TJ

更新日期：1993-08-01 00:00:00

abstract：:The combination of aspirin and clopidogrel is the mainstay antiplatelet therapy for acute coronary syndromes (ACS). However, the dosing of aspirin, the dosing of clopidogrel, the timing of clopidogrel initiation as well as the duration of clopidogrel therapy remain controversial matters. Clopidogrel resistance is an e...

journal_title：Cardiovascular drugs and therapy

authors： Hanna EB,Glancy DL,Saucedo JF

更新日期：2010-02-01 00:00:00

abstract：:Antihypertensive drugs may lower blood pressure through very different mechanisms, initially as well as during chronic use. This article is a review of the immediate hemodynamic changes induced by a beta blocker (visacor), an alpha-receptor blocker (doxazosin), two calcium antagonists (tiapamil and nisoldipine), an an...

journal_title：Cardiovascular drugs and therapy

authors： Omvik P,Lund-Johansen P

更新日期：1990-08-01 00:00:00

abstract：:True positive inotropy of enoximone is hard to prove clinically. It could increase the risk of myocardial ischemia when used in coronary artery disease (CAD). The analysis of the end-systolic pressure-volume relationship (ESPVR) as a load-independent parameter of the contractile left ventricular function (LVF) allows ...

journal_title：Cardiovascular drugs and therapy

authors： Thormann J,Hueting J,Kremer P,Wissemann J,Mitrovic V,Dieterich HA,Schlepper M

更新日期：1990-10-01 00:00:00

abstract：:The following discourse addresses the pharmacologic profile of KT-362, its clinical potential as an anti-arrhythmic agent with associated hypotensive effects, as well as its additional related potential in myocardial ischemia and related sequellae, and the specific cellular actions that may be responsible for these po...

journal_title：Cardiovascular drugs and therapy

authors： Hester RK,Shibata S

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the impact of granulocyte-colony stimulating factor (G-CSF) administration on cardiac function of rats with chronic myocardial infarction through two different protocols: high dose short term and low dose long term protocols. METHODS:Wistar rats were submitted to MI sur...

journal_title：Cardiovascular drugs and therapy

authors： Louzada RA,Oliveira PF,Cavalcanti-de-Albuquerque JP,Cunha-Carvalho L,Baldanza MR,Kasai-Brunswick TH,Goldenberg RC,Campos-de-Carvalho AC,Werneck-de-Castro JP

更新日期：2010-04-01 00:00:00

abstract：:Ranolazine, an inhibitor of the late current of the cardiac action potential (late I(Na)), is a well established clinical treatment for chronic angina. The late INa in cardiac myocytes also plays an important role in the pathophysiology of acute myocardial ischemia and reperfusion, and thus is a potential therapeutic ...

journal_title：Cardiovascular drugs and therapy

authors： Hale SL,Kloner RA

更新日期：2014-10-01 00:00:00

abstract：:The effects of short- and long-term administration of nifedipine on serum lipids, lipoproteins, and apolipoproteins (apo) were studied. Administration of nifedipine capsule for 4 months significantly decreased triglycerides and increased the HDL2 cholesterol and the HDL2/HDL3 cholesterol ratio. No significant changes ...

journal_title：Cardiovascular drugs and therapy

authors： Sasaki J,Arakawa K

更新日期：1990-08-01 00:00:00

abstract：PURPOSE:Hypothyroidism (HT) is associated with accelerated atherosclerosis (AS). The efficacy of traditional strategies of hypothyroid AS remains controversial. Here, we aimed to deepen the understanding of the HT-induced acceleration of AS, to decrease the residual risk of coronary artery disease (CAD) and to find a n...

journal_title：Cardiovascular drugs and therapy

authors： Yang Y,Jia Y,Ning Y,Wen W,Qin Y,Zhang H,Du Y,Li L,Jiao X,Yang Y,Liu G,Huang M,Zhang M

更新日期：2020-06-03 00:00:00

abstract：:The purpose of this study was to evaluate the effect of trimetazidine on late potentials in patients with acute myocardial infarction. A total of 60 patients (52 males, mean age 55 +/- 2 years, and 8 females, mean age 54 +/- 1.8 years) with the diagnosis of acute myocardial infarction were included in this study. The ...

journal_title：Cardiovascular drugs and therapy

authors： Ozdemir R,Tuncer C,Aladag M,Güven A,Sezgin AT,Pekdemir H,Korkmaz ME,Müderrisoglu H

更新日期：1999-04-01 00:00:00

abstract：:To compare the antiischemic effects of intracoronary administration of a beta blocker, atenolol, and of a calcium antagonist, nifedipine, on the clinical and electrocardiographic signs of myocardial ischemia induced by balloon occlusion of the coronary artery, we studied 32 consecutive patients undergoing routine PTCA...

journal_title：Cardiovascular drugs and therapy

authors： Ghio S,De Servi S,Angoli L,Bramucci E,Eleuteri E,Raffaghello S,Specchia G

更新日期：1992-06-01 00:00:00

abstract：:Male Japanese white rabbits were fed a restricted amount (100 g/head/day) of an atherogenic diet containing 0.2% cholesterol and 6% peanut oil during an 8-week experimental period. Atherosclerotic lesions, characterized by intimal thickening with lipid deposition, were produced by de-endothelialization of the rabbit a...

journal_title：Cardiovascular drugs and therapy

authors： Saso Y,Ohtani A,Odawara A,Iwasaki H,Takashima K,Morita T

更新日期：1993-04-01 00:00:00

abstract：:The effects of equipotent concentrations of diltiazem, verapamil, and nifedipine upon the accumulation of extracellular potassium [K+]out and the left ventricular pressure (LVP) were studied during global ischemia in isolated perfused rat hearts. Measurement of [K+]out and LVP were performed in two series of experimen...

journal_title：Cardiovascular drugs and therapy

authors： Heijnis JB,Coronel R,van Zwieten PA

更新日期：1991-12-01 00:00:00

abstract：:We used Folts' model of critical coronary artery stenosis with endothelial damage, which measures platelet-rich thrombus accumulation from cyclic flow reductions (CFRs). This paper reports results applied to trimetazidine, a member of the piperazine group. Trimetazidine at a dose of 1 mg/kg completely abolished CFRs c...

journal_title：Cardiovascular drugs and therapy

authors： Belcher PR,Drake-Holland AJ,Hynd JW,Noble MI

更新日期：1993-02-01 00:00:00

abstract：:Free radical injury may contribute to the delayed postoperative recovery of myocardial metabolism and ventricular function after elective coronary artery revascularization. This clinical study was designed to evaluate, in stable angina patients having aortocoronary bypass surgery, whether orally administered alpha-toc...

journal_title：Cardiovascular drugs and therapy

authors： Mickle DA,Weisel RD,Burton GW,Ingold KU

更新日期：1991-03-01 00:00:00

abstract：:The present study was performed in order to compare the efficacy, safety, and tolerability of lisinopril, a long-acting angiotensin-converting enzyme (ACE) inhibitor, with captopril, the shorter acting ACE inhibitor available, in the treatment of elderly patients (mean age 70 +/- 0.5 years) with congestive heart failu...

journal_title：Cardiovascular drugs and therapy

authors： Morisco C,Condorelli M,Crepaldi G,Rizzon P,Zardini P,Villa G,Argenziano L,Trimarco B

更新日期：1997-03-01 00:00:00

abstract：:The modifying effect on exercise performance and neuroendocrine response of the nonselective beta blocker timolol (10 mg b.i.d. for 5 days) and the beta 1-selective beta blocker metoprolol (100 mg b.i.d. for 5 days) was studied. The hormones studied were growth hormone, prolactin, cortisol, renin, epinephrine, dopamin...

journal_title：Cardiovascular drugs and therapy

authors： Gullestad L,Dolva LO,Kjeldsen SE,Eide I,Kjekshus J

更新日期：1989-03-01 00:00:00

abstract：:Resistance arteries depolarize and constrict to elevations in intravascular pressure. However, many of the molecular aspects of this phenomenon are not known. We present evidence that large conductance calcium-dependent potassium (KCa) channels, which are activated by intracellular calcium and membrane depolarization,...

journal_title：Cardiovascular drugs and therapy

authors： Nelson MT,Brayden JE

更新日期：1993-08-01 00:00:00

abstract：:Twenty-nine patients with severe heart failure (NYHA III) were randomly assigned to receive therapy with an angiotensin converting enzyme inhibitor (ACE inhibitor), either captopril or enalapril. The mean daily dosage of captopril was 56 +/- 5 mg and of enalapril 9.5 +/- 0.4 mg. After a mean of 8 +/- 1 days, the influ...

journal_title：Cardiovascular drugs and therapy

authors： Osterziel KJ,Dietz R,Harder K,Kübler W

更新日期：1992-04-01 00:00:00

abstract：:The novel insights provided by the molecular genetic applied to the study of cardiac arrhythmias have just started to scratch the surface of the complex relationships between the genetic abnormalities of ion channel structure and the susceptibility to life threatening ventricular arrhythmias. These crucial pieces of i...

journal_title：Cardiovascular drugs and therapy

authors： Priori SG,Napolitano C

更新日期：2002-03-01 00:00:00

abstract：:Heart rate variability is a noninvasive indicator of autonomic nervous system activity. The role of the autonomic nervous system in the genesis of atrial or ventricular arrhythmias is now well established. Little is known about the effects of flecainide on heart rate variability in patients with normal heart structure...

journal_title：Cardiovascular drugs and therapy

authors： Fauchier L,Babuty D,Autret ML,Poret P,Cosnay P,Fauchier JP

更新日期：1998-10-01 00:00:00

abstract：PURPOSE:The PPAR-alpha agonists (fibrates) are commonly used in the treatment of dyslipidemia. It has been hypothesized that the cardio-protective effects of fibrates are partially due to immunomodulatory effects. However, there is a paucity of data regarding the effect of fibrates on neutrophilic chemokines such as ep...

journal_title：Cardiovascular drugs and therapy

authors： Price ET,Welder GJ,Zineh I

更新日期：2012-04-01 00:00:00

abstract：:Thiazide diuretics are particularly efficacious in the treatment of hypertension in blacks. A number of observations suggest that many hypertensive blacks have features consistent with a status of "corrected" volume expansion. Our studies, as well as those of other investigators, show that the Na,K pump is inhibited i...

journal_title：Cardiovascular drugs and therapy

authors： Quintanilla AP,Wagener OE

更新日期：1990-03-01 00:00:00

abstract：PURPOSE:The prevalence and consequences of prediabetic dysglycemia and undiagnosed diabetes is unknown in patients with heart failure (HF) and preserved ejection fraction (HFpEF) and has not been compared to heart failure and reduced ejection fraction (HFrEF). METHODS:We examined the prevalence and outcomes associated...

journal_title：Cardiovascular drugs and therapy

authors： Kristensen SL,Jhund PS,Lee MMY,Køber L,Solomon SD,Granger CB,Yusuf S,Pfeffer MA,Swedberg K,McMurray JJV,CHARM Investigators and Committees.

更新日期：2017-12-01 00:00:00

abstract：:A rational approach to the treatment of chronic myocardial ischemia requires an appreciation of the pathophysiology of coronary artery disease and the treatment options available. Any factor that causes an imbalance between myocardial oxygen supply and demand can provoke ischemia. Myocardial oxygen requirements rise w...

journal_title：Cardiovascular drugs and therapy

authors： Cohn PF

更新日期：1998-10-01 00:00:00

abstract：:Intravenous amiodarone has been found useful in the emergent management of life-threatening arrhythmias. Experimental studies have shown that its electrophysiologic effects are proportional to its myocardial concentration. However, early after its intravenous administration, the extent of the concentration of amiodaro...

journal_title：Cardiovascular drugs and therapy

authors： Anastasiou-Nana MI,Nanas JN,Alexopoulos G,Karli JN,Margari ZJ,Agapitos E,Patsi EN,Stamatelopoulos SF

更新日期：1999-05-01 00:00:00

abstract：:In order to compare and clarify the effects of various antiarrhythmic drugs when given as monotherapy, we reevaluated our previous data on antiarrhythmic drugs and recalculated antiarrhythmic plasma concentrations of drugs for several canine arrhythmia models. We used three spontaneously occurring arrhythmias: a) digi...

journal_title：Cardiovascular drugs and therapy

authors： Hashimoto K,Haruno A,Matsuzaki T,Sugiyama A,Akiyama K

更新日期：1991-08-01 00:00:00

abstract：PURPOSE:Mechanical stretch is an arrhythmogenic factor found in situations of cardiac overload or dyssynchronic contraction. Ranolazine is an antianginal agent that inhibits the late Na (+) current and has been shown to exert a protective effect against arrhythmias. The present study aims to determine whether ranolazin...

journal_title：Cardiovascular drugs and therapy

authors： Chorro FJ,del Canto I,Brines L,Such-Miquel L,Calvo C,Soler C,Parra G,Zarzoso M,Trapero I,Tormos Á,Alberola A,Such L

更新日期：2015-06-01 00:00:00

abstract：:The vasorelaxant activity of the omega-3 fatty acids--docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids--in comparison with other known vasodilators--sodium nitroprusside, nitroglycerin, papaverine, and D600--were studied in the isolated rat aorta. The relaxant responses of these vasodilators and fatty acids at c...

journal_title：Cardiovascular drugs and therapy

authors： Engler MB

更新日期：1992-12-01 00:00:00

abstract：:Patients with mild to moderate hypertension (diastolic blood pressure > or = 95 and < or = 115 mmHg) and renal dysfunction entered one of two studies to assess the safety of efficacious daily doses of quinapril on renal function and blood pressure. Twenty-four patients with moderate renal impairment (MRI) (creatinine ...

journal_title：Cardiovascular drugs and therapy

authors： Miller MA,Texter M,Gmerek A,Robbins J,Shurzinske L,Canter D

更新日期：1994-04-01 00:00:00