Abstract：
:Different scoring systems have been developed to determine the severity of atopic dermatitis. The SCORAD (SCORing Atopic Dermatitis), one of the best validated systems, is suited for clinical trials, but is too complicated and time consuming for routine clinical use. The TIS score (Three Item Severity score), a simplified system, is based on the evaluation of erythema, oedema/papulation and excoriation on a scale from 0 to 3. In order to determine the value of the TIS score we conducted a prospective study in 126 children with mild to severe atopic dermatitis. Both the TIS score and the SCORAD were assessed by trained investigators. Interobserver agreement was investigated in 20 children by comparing the independently performed scores of three investigators. A positive correlation was found between the TIS score and the SCORAD (Rank Spearman r(s)=0.86; p<0.0005). The item which correlated best with the SCORAD was excoriation (r(s)=0.72; p<0.0005) followed by oedema/papulations (r(s)=0.66; p<0.0005). Interobserver agreement which was calculated by Cohen's kappa (kappa) was "excellent" for SCORAD (kappa=0.82; p<0.001) and "fair" for TIS score (kappa=0.58; p<0.01). We conclude that the TIS score is a rough, though reliable and simple system for scoring atopic dermatitis. It is particularly suitable in general practice, for routine clinical use and for screening purposes in clinical trials. For research purposes, the objective SCORAD offers a more detailed and comprehensive assessment.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Wolkerstorfer A,de Waard van der Spek FB,Glazenburg EJ,Mulder PG,Oranje APdoi
10.1080/000155599750010256subject
Has Abstractpub_date
1999-09-01 00:00:00pages
356-9issue
5eissn
0001-5555issn
1651-2057journal_volume
79pub_type
杂志文章abstract：:Recent findings indicate that patients with systemic sclerosis have an increased risk of cardiovascular disease. To determine whether patients with systemic sclerosis or localized scleroderma are at increased risk of cardiovascular disease, a cohort study of the entire Danish population aged ≥ 18 and ≤ 100 years was c...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-2842
更新日期：2018-03-13 00:00:00
abstract：:The nickel content of food items consumed in Denmark was estimated on the basis of analysis by atomic absorption spectrophotometry. The highest concentrations (1-10 mg nickel/kg fresh weight) were found in cocoa, licorice, lucerne seeds, dried beans, peanuts, hazel nuts, sunflower seeds, oat meal and wheat bran. A die...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Retinoid transfer into breast milk was studied in a psoriatric woman receiving oral acitretin at a dosage of 40 mg once daily. Concentrations of the parent compound and its main metabolite, 13-cis acitretin, were measured in serum and mature milk during the initial nine days of therapy, using reverse-phase high perfor...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：102340/0001555570487490
更新日期：1990-01-01 00:00:00
abstract：:Human leukocytes and fibroblasts were cultured in medium containing 3H-8-methoxypsoralen (10(-6) M and 3.3 X 10(-6) M). At different stages during the culturing period the cells were exposed to ultraviolet light (1, 2, and 10 J/cm2). After the culture period the slides for chromosome analysis and smears of the cells w...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Previously we observed that systemic CyA induces hair growth in an experimental model of human scalp skin graft transplanted onto nude mice. In the present study we investigated the role of topical CyA in the murine transplantation model, using human split-thickness skin grafts (HSTSG). Ten mice grafted with 1-mm-thic...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The expression of blood-group antigens was studied on human epidermal cultures used as allografts in 13 non-immunosuppressed patients treated for leg ulcers. The study was carried out using monoclonal antibodies to A and B antigens by an indirect immunofluorescence technique. Blood-group antigens are weakly expressed ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Twenty-six patients with chronic dermatophytosis (CD) by Trichophyton rubrum (TR) through one year were included in a double-blind clinical trial with Levamisole/Placebo. All patients were treated with griseofulvin concomitantly. Before, during and after the trial, studies of the cellular and humoral immune response w...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Eighty-two cases of nodular panniculitis of the legs were examined clinically, histologically and immunohistologically. Clinically the cases could be divided into four groups: typical erythema nodosum (ENty) (35 cases), erythema nodosum migrans (ENmi) (11 cases), erythema induratum (EI) (11 cases) and the remaining 25...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:A 10-year follow-up of patients with juvenile plantar dermatosis and gluteo-femoral eczema disclosed a worse prognosis than previously assumed, with a course in some cases protracted into adult age. The presence of atopy was established with a clinical point score system. It was found that 52% of the patients with juv...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:A case of simultaneous occurrence of lichen planus (LP) and hepatitis C in the same patient is presented. The patient had received treatment with interferon alpha for her chronic liver disease, and the association between LP, hepatitis C and interferon alpha treatment is discussed. ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：101080/000155572380
更新日期：1992-09-01 00:00:00
abstract：:Human epidermal keratinocytes sense the presence of human skin microbiota through pathogen recognition receptors, such as toll-like receptors, and induce innate immune and inflammatory events. In healthy epidermis there is an absence of inflammation despite the continuous presence of cutaneous microbes, which is evide...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3707
更新日期：2021-01-13 00:00:00
abstract：:We have analyzed 8 patients (6 men and 2 women, aged 52 to 70 years) with psoriasis associated with hepatitis C virus (HCV) infection among 79 psoriatic patients. Psoriasis preceded in 6 cases. One patient had generalized pustular psoriasis (GPP), and the others had psoriasis vulgaris (PV). The psoriasis area and seve...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555575482483
更新日期：1995-11-01 00:00:00
abstract：:In a prospective study of 63 patients with long-lasting hand eczema, a diagnosis of atopic dermatitis could be established in 49%. Comparison between patients with atopic dermatitis and those without atopic dermatitis showed that the hand eczema pattern differed very little between the groups. Hyperlinearity was signi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Forty-three nickel-allergic patients (40 females and 3 males) participated in this study which was designed to elucidate the correlation between quantitative in vivo and in vitro responses. All were patch-tested with various concentrations of nickel-sulphate serial-diluted in water. The lowest concentration eliciting ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The effect on dermographic wealing of an H1 and H2 receptor antagonist was studied separately and in combination. a double-blind protocol was used and dermographism was measured as the diameter of weal response to a measured force. Both H1 and H2 antagonists had a small but non-significant effect, but the combination ...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1983-01-01 00:00:00
abstract：:Oxidation of 5-S-cysteinyldopa by mushroom tyrosinase was studied by measuring 5-S-cysteinyldopa consumption with HPLC. 5-S-cysteinyldopa was found to be a substrate for tyrosinase, but our results suggests that a self-catalysed oxidation induced by enzymatically formed 5-S-cysteinyl dopaquinone also takes place. Dopa...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:The antimalarial drug chloroquine is also used in the prevention of photodermatoses and in patients with inflammatory connective diseases. The drug binds strongly to melanin. Melanocytic activity can be studied by analysis of the urinary markers of eumelanin (6-hydroxy-5-methoxyindole-2-carboxylic acid, 6H5MI-2-C) and...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555575287289
更新日期：1995-07-01 00:00:00
abstract：:Pigmented basal cell carcinomas can be difficult to distinguish clinically from melanoma. Dermoscopy has proven to be useful in the differential diagnosis of the two tumour types. SIAscopy (Spectrophotometric intracutaneous analysis) is a fairly new technique of imaging pigmented skin lesions that has been presented p...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0234
更新日期：2007-01-01 00:00:00
abstract：:One of the prepolymers used in Ultraviolet (UV) curing ink formulations is acrylated polyester. The prepolymer investigated is a dimethacrylated polyester, thus a saturated polyester terminated with methacrylic groups. In conventional UV-curing coatings the prepolymer commonly used is an unsaturated polyester. Three o...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:A typical clinical and histologic case of Queyrat's erythroplasia of the glans penis is presented. For several years the patient had been treated for balanitis and inflammation of the glans. A few months before the patient died, the correct diagnosis was established. Shortly after, metastases to the inguinal lymph nod...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:This is the first case in the literature describing naevi spili, café-au-lait spots and melanocytic naevi aggregated along-side Blaschko's lines. The pattern of melanocytic lesions in our patient is different from the congenital pigmentary syndromes and the segmental distribution of melanocytic naevi, the quadrant dis...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,评审
doi：10.1080/000155598443114
更新日期：1998-09-01 00:00:00
abstract：:A patient with a Buschke-Loewenstein tumour associated with human papillomavirus type 6/11 is reported. He was intralesionally treated with human recombinant alpha-2b interferon (9 x 10(6) IU/day) three times weekly. The tumour completely disappeared within 5 months of continuous treatment which was well tolerated. Si...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555574457459
更新日期：1994-11-01 00:00:00
abstract：:Autoimmune blistering diseases (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, dermatitis herpetiformis) and certain genodermatoses with acantholysis (Darier-disease, Hailey-Hailey disease) have different aetiological factors, but all result in bulla formation and/or in acantholysis. Cadherins are Ca++-d...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550310006842
更新日期：2004-01-01 00:00:00
abstract：:Facial melanoma is difficult to diagnose and dermatoscopic features are often subtle. Dermatoscopic non-melanoma patterns may have a comparable diagnostic value. In this pilot study, facial lesions were collected retrospectively, resulting in a case set of 339 melanomas and 308 non-melanomas. Lesions were evaluated fo...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-2759
更新日期：2017-11-15 00:00:00
abstract：:Ten out-patients with pustulosis palmaris et plantaris were examined with direct immunofluorescence (IF) technique for deposition of fibrinogen, fibrin or its degradation products (FR-antigen) in affected and unaffected skin, together with heparin-precipitable fraction (HPF), cryoglobulin and total plasma fibrinogen i...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:Serum IgE concentrations were determined by the paper radioimmunosorbent test in 56 patients with psoriasis and 50 normal controls, and by the paper enzyme-immunosorbent test in 32 of these patients and 50 controls. Elevated IgE levels were found in 26 (46%) of 56 patients with psoriasis and in 1 normal control (2%). ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Patients with X-linked recessive ichthyosis (RXLI) were studied as a model of the effect of disturbed epidermal lipid composition on skin barrier function. Thirteen patients with RXLI and 15 age- and sex-matched controls were patch-tested with sodium lauryl sulphate (SLS) 0.5% for 24 h. Basal skin properties and skin ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555575198201
更新日期：1995-05-01 00:00:00
abstract：:Atopic eczema (AE) is one of the most common non-communicable inflammatory skin diseases, and has a huge socioeconomic impact. Studies on the everyday economic impact of AE on patients, however, are limited. To estimate the annual extra out-of-pocket spending due to AE among patients in Europe, a cross-sectional study...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3102
更新日期：2019-03-01 00:00:00
abstract：:EMLA cream, which is used to provide analgesia prior to venepuncture, induces a skin-blanching reaction. This reaction may be caused by both skin hydration and vasoconstriction. Twenty healthy children with veins suitable for venepuncture on the dorsa of the hands or at the antecubital fossae had applied either EMLA c...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1080/000155500459268
更新日期：2000-09-01 00:00:00
abstract：:A report is given of the successful treatment with transfer factor as an additional therapeutic agent of a patient in the tumour stage of mycosis fungoides who had not responded to conventional treatment with nitrogen mustard, methotrexate, or grenz rays alone. Besides twelve injections of transfer factor, the patient...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
