Correlation between quantitative in vivo and in vitro responses in nickel-allergic patients.

Abstract:

:Forty-three nickel-allergic patients (40 females and 3 males) participated in this study which was designed to elucidate the correlation between quantitative in vivo and in vitro responses. All were patch-tested with various concentrations of nickel-sulphate serial-diluted in water. The lowest concentration eliciting a cutaneous reaction (indicating the severity of the allergy) was recorded for each individual and compared with the in vitro lymphocyte response, using the lymphocyte transformation test. The best correlation coefficients obtained were 0.42 and 0.46, tested for linear and logarithmic correlation respectively. However, there were individuals who showed a weak cutaneous response and high lymphocyte reactivity. The converse situation was also found, however, indicating that other mechanisms than those mediated via lymphocytes may be of significance in the patch test response.

journal_name

Acta Derm Venereol

authors

Al-Tawil NG,Berggren G,Emtestam L,Fransson J,Jernselius R,Marcusson JA

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

385-9

issue

5

eissn

0001-5555

issn

1651-2057

journal_volume

65

pub_type

杂志文章
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