Membrane stretch and salivary glands - facts and theories.

Abstract:

:Cell shape in salivary glands is affected by mechanical forces. In the acini and ducts cell shape is modified by the contractions of the myoepithelial cells in both the secretory and ductal portions of the glands. At the organ level shape changes are due to muscle contraction during mastication, food intake and speech. All these factors may cause some degree of stretching of salivary cell membranes. Recent studies suggest that physical forces influence signal transduction, gene expression, secretory function, cell differentiation and proliferation. Here we overview membrane stretch-activated cellular events. Evidence from a variety of tissues suggests that mechanical forces may alter the properties of acinar cells leading to cytoskeletal reorganisation, changes in ion fluxes, modulation of secretory activity and subsequent release of transmitters such as ATP. Transmitters released from acinar cells may modulate the secretory activity of salivary tissue, and interact with classical regulatory pathways.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Zelles T,Boros I,Varga G

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

S67-71

eissn

0003-9969

issn

1879-1506

journal_volume

44 Suppl 1

pub_type

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