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The effect of extracts from human dental plaque, oral streptococci and actinomyces bacteria on HELA cell growth, [3H]-thymidine uptake and 51Cr release.

Abstract：

:Dialysed extracts from dental plaque and a number of species of oral streptococci and actinomycetes have been investigated for their effects on cell growth, [3H]-thymidine uptake and 51Cr release from HeLa cell cultures. Eight of the 15 extracts inhibited cell growth and all but one inhibited [3H]-thymidine incorporation. None of the extracts stimulated 51Cr release from prelabelled cells. These results suggest that many of the species of streptococci and actinomyces found in the mouth and in dental plaque are capable of producing high mol. wt substances that interfere with HeLa cell cultures by inhibiting [3H]-thymidine uptake and DNA synthesis but do not affect the degree of intactness of the external cell membrane.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Duguid R,Lyons IR

doi

10.1016/0003-9969(82)90178-9

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

65-8

issue

1

eissn

0003-9969

issn

1879-1506

journal_volume

27

pub_type

杂志文章

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