Abstract:
OBJECTIVE:The existence of stem/progenitor cells in dental tissue has been suggested but their characterization in the human tooth germ remains elusive. The purpose of this study was to investigate these cells in human dental follicles and dental papillae at the crown-forming stage and compare their potential for hard tissue formation. DESIGN:We used dental follicle cells (DFCs) and dental papilla cells (DPCs) derived from dental follicles and dental papillae at the crown-forming stage and compared their proliferative capacity, cell surface antigens and ability to form hard tissue in vitro and in vivo. RESULTS:Both DFCs and DPCs had extensive proliferation ability, expressed similar cell surface antigens and were capable of forming hard tissue in vivo as well as in vitro. However, there were two differences between DFCs and DPCs. First, DPCs had a significantly higher calcium accumulation than that in DFCs. Second, DFCs expressed a cementoblast marker, whereas DPCs expressed an odontoblast marker. CONCLUSIONS:We propose that dental follicles and dental papillae at the crown-forming stage contain different types of stem/progenitor cells and may have hard tissue-forming ability in a possibly origin-specific lineage direction.
journal_name
Arch Oral Bioljournal_title
Archives of oral biologyauthors
Yagyuu T,Ikeda E,Ohgushi H,Tadokoro M,Hirose M,Maeda M,Inagake K,Kirita Tdoi
10.1016/j.archoralbio.2009.10.011subject
Has Abstractpub_date
2010-01-01 00:00:00pages
68-76issue
1eissn
0003-9969issn
1879-1506pii
S0003-9969(09)00264-7journal_volume
55pub_type
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journal_title:Archives of oral biology
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journal_title:Archives of oral biology
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journal_title:Archives of oral biology
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journal_title:Archives of oral biology
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journal_title:Archives of oral biology
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2011.03.002
更新日期:2011-10-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2017.05.013
更新日期:2017-09-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章,评审
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更新日期:2015-02-01 00:00:00
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2013.08.012
更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
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journal_title:Archives of oral biology
pub_type: 杂志文章
doi:10.1016/j.archoralbio.2003.09.002
更新日期:2004-05-01 00:00:00
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pub_type: 杂志文章
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abstract::With scanning electron microscopy, globules were seen in inter-cellular spaces between ameloblasts with ruffled borders and papillary cells at early maturation stage. Numerous globules were located on longitudinal folds between parallel ridges on the sides of ameloblasts, but only a few in the papillary layer. In prev...
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pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Archives of oral biology
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更新日期:2004-06-01 00:00:00