Antipsychotic profile of alstonine: ethnopharmacology of a traditional Nigerian botanical remedy.

Abstract:

:Although recently developed drugs have brought significant improvement, the treatment of psychotic disorders still presents serious drawbacks. Since inherent complexity and lack of satisfactory understanding of the underlying pathophysiology impose limits for rational drug design, resourceful approaches in the search for antipsychotics are pertinent. This paper reports pharmacological properties of alstonine, a heteroyohimbine type alkaloid, which exhibited an antipsychotic-like profile, inhibiting amphetamine-induced lethality, apomorphine-induced stereotypy and potentiating barbiturate-induced sleeping time. Atypical features of alstonine were the prevention of haloperidol-induced catalepsy and lack of direct interaction with D1, D2 and 5-HT2A receptors, classically linked to antipsychotic mechanism of action.

journal_name

An Acad Bras Cienc

authors

Costa-Campos L,Elisabetsky E,Lara DR,Carlson TJ,King SR,Ubillas R,Nunes DS,Iwu MM,Nkemjika CO,Ozioko A,Agwu CO

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

189-201

issue

2

eissn

0001-3765

issn

1678-2690

journal_volume

71

pub_type

杂志文章
  • Mercury concentrations in fish from the Itacaiúnas-Parauapebas River system, Carajás region, Amazon.

    abstract::This paper reports on total Hg concentrations in muscle tissue from 12 fish species collected in the Itacaiúnas and Parauapebas Rivers in the Carajás region, South Pará. It is found that carnivorous species present Hg concentrations higher than herbivorous and omnivorous species. Also, large carnivorous species presen...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Lacerda LD,Bidone ED,Guimarães AF,Pfeiffer WC

    更新日期:1994-01-01 00:00:00

  • Sawdust Derivative for Environmental Application: Chemistry, Functionalization and Removal of textile dye from aqueous solution.

    abstract::The adsorption of Violet Remazol 5R (VR 5) on wood sawdust modified with succinic anhydride (SSA) as a function of contact time, pH, and initial dye concentrations was investigated using a batch technique under ambient conditions. The SSA obtained was confirmed by IR spectroscopy, thermogravimetry and 13C NMR, and deg...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620140656

    authors: Pinto TF,Bezerra CW,Silva DS,Silva EC Filho,Vieira AP,Airoldi C,Melo JC,Silva HA,Santana SA

    更新日期:2016-09-01 00:00:00

  • Testing multivariate analysis in paleoenvironmental reconstructions using pollen records from Lagoa Salgada, NE Rio de Janeiro State, Brazil.

    abstract::Despite the indisputable significance of identification of modern analogs for Paleoecology research, relatively few studies attempted to integrate modern and fossil samples on paleoenvironmental reconstructions. In Palynology, this general pattern is not different from other fields of Paleoecology. This study demonstr...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652009000400013

    authors: Toledo MB,Barth OM,Silva CG,Barros MA

    更新日期:2009-12-01 00:00:00

  • Aqueous extract of Psidium guajava leaves: phenolic compounds and inhibitory potential on digestive enzymes.

    abstract::Leaves of Psidium guajava L. (guava) have been widely used in the popular way for prevention and treatment of various diseases. Thus, the objective of this study was to evaluate the inhibitory potential of leaves aqueous extract from three cultivars of P. guajava (Pedro Sato, Paluma and Século XXI) on α-amylase, α-gly...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201720160067

    authors: Simão AA,Marques TR,Marcussi S,Corrêa AD

    更新日期:2017-01-01 00:00:00

  • Foraging behavior of two egg parasitoids exploiting chemical cues from the stink bug Piezodorus guildinii (Hemiptera: Pentatomidae).

    abstract::Several parasitoids attacking the same host may lead to competition. Adult parasitoids' abilities to find, parasitize and defend hosts determine resource's retention potential. In soybean, two egg parasitoid species, Telenomus podisi and Trissolcus urichi (Hymenoptera: Platygastridae), compete on the egg masses of Pie...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920180597

    authors: Cingolani MF,Barakat MC,Liljesthröm GG,Colazza S

    更新日期:2019-10-14 00:00:00

  • Germination responses of the invasive Calotropis procera (Ait.) R. Br. (Apocynaceae): comparisons with seeds from two ecosystems in Northeastern Brazil.

    abstract::Life history traits are considered key indicators of plant invasibility. Among them, the germination behavior of seeds is of major relevance because it is influenced by environmental factors of invaded ecosystem. Here, we investigated how seed traits and seed tolerance to environmental factors on seed germination of C...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/S0001-37652013000300013

    authors: Leal LC,Meiado MV,Lopes AV,Leal IR

    更新日期:2013-09-01 00:00:00

  • New approaches to the treatment of orphan genetic disorders: Mitigating molecular pathologies using chemicals.

    abstract::With the advance and popularization of molecular techniques, the identification of genetic mutations that cause diseases has increased dramatically. Thus, the number of laboratories available to investigate a given disorder and the number of subsequent diagnosis have increased over time. Although it is necessary to id...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/0001-3765201520140711

    authors: Velho RV,Sperb-Ludwig F,Schwartz IV

    更新日期:2015-08-01 00:00:00

  • Comparative studies of two dimensional and three dimensional ultrasonic nuchal translucency in trisomy assessments.

    abstract::Current two-dimensional (2D) ultrasonic marker measurements are inherent with intra- and inter-observer variability limitations. The objective of this paper is to investigate the performance of conventional 2D ultrasonic marker measurements and proposed programmable interactive three-dimensional (3D) marker evaluation...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012000400030

    authors: Wee LK,Chai HY,Samsury SR,Mujamil NF,Supriyanto E

    更新日期:2012-12-01 00:00:00

  • Direct determination of sodium and potassium in blood serum by flow injection and atomic absorption spectrophotometry.

    abstract::A simple and reliable method for the measurement of sodium and potassium in blood serum without any sample dilution by using flow injection and atomic absorption spectrophotometry is described. A sample throughout of 100 measurements per hour is possible. Matrix problems have not been encountered. The coefficient of v...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Burguera JL,Burguera M,Gallignani M

    更新日期:1983-06-01 00:00:00

  • Larval interactions between two aphidophagous coccinellids in sweet pepper.

    abstract::Antagonistic interactions among predators have the potential to dampen top-down impacts on a shared pest. Strong cannibalism by adults and larvae on eggs along with a stronger intraguild predation by Eriopis connexa on Cycloneda sanguinea (Coccinellidae) than vice versa had been documented. The intensity and direction...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020181163

    authors: Rocca M,Rizzo E,Greco NM

    更新日期:2020-07-31 00:00:00

  • Influence of the nycthemeral cycle on the roosting behaviour of the Orange-winged Amazon.

    abstract::Environmental stimuli exert important effects on the expression of the endogenous rhythms. Daily movements of groups of parrots in response to the light/dark cycle have been studied by several researchers. However, the factors modifying the intrinsic rhythmicity of this behaviour remain little known. This study descri...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012005000029

    authors: Moura LN,Silva ML,Vielliard JM

    更新日期:2012-06-01 00:00:00

  • New tools to study biophysical properties of single molecules and single cells.

    abstract::We present a review on two new tools to study biophysical properties of single molecules and single cells. A laser incident through a high numerical aperture microscope objective can trap small dielectric particles near the focus. This arrangement is named optical tweezers. This technique has the advantage to permit m...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652007000100003

    authors: Rocha MS,Mesquita ON

    更新日期:2007-03-01 00:00:00

  • Ecological capability evaluation for afforestation and forest expansion using Geographic Information System (GIS) in management area of Caspian Sea.

    abstract::Ecological capability evaluation is referred to as evaluation of potential capability of land and determination of its natural land use. In this paper, ecological capability of Lille Basin in Lahijan was evaluated for afforestation and forest expansion using Geographical Information Systems (GIS). For this purpose, in...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170805

    authors: Hashemi SA

    更新日期:2018-10-01 00:00:00

  • L(+) lactate dehydrogenase activity from the electric organ of Electrophorus electricus (L.).

    abstract::Properties of L(+) lactate dehydrogenase (LDH) of Electrophorus electricus (L.) electric organ were studied, comparing the substrates pyruvate and lactate. Electric organ LDH is a soluble enzyme with a pH optimum of 7.4 for pyruvate and 9.0 for lactate. The apparent Km was lower for pyruvate (Km = 2.5 X 10(-4) M) than...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Torres-da Matta J,Nery da Matta A,Hassón-Voloch A

    更新日期:1976-01-01 00:00:00

  • Climatological aspects and changes in temperature and precipitation extremes in Viçosa-Minas Gerais.

    abstract::Extreme climatic events and their hazards have strong impact on society. Urban areas in Brazil are especially vulnerable to the impact of such events due to their rapid growth and inappropriate infrastructure. Viçosa is a mid-sized city in Southeastern Brazil that has been experiencing issues associated with urban exp...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020190388

    authors: Avila-Diaz A,Justino F,Lindemann DS,Rodrigues JM,Ferreira GR

    更新日期:2020-01-01 00:00:00

  • D-Pinitol Increases Insulin Secretion and Regulates Hepatic Lipid Metabolism in Msg-Obese Mice.

    abstract::D-pinitol is one of the major inositol found in plants and studies suggest its potential hypoglycemic and hypolipidemic actions in diabetic rodents. Here, we investigated the actions of D-pinitol on adiposity, and in lipid and glycemic homeostasis in monosodium glutamate (MSG)-obese mice. Swiss mice received daily sub...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020201382

    authors: Silva JÚnior JAD,Silva ACVFD,Figueiredo LS,Araujo TR,Freitas IN,Carneiro EM,Ribeiro ES,Ribeiro RA

    更新日期:2020-11-20 00:00:00

  • Pseudophacopteron longicaudatum (Hemiptera) induces intralaminar leaf galls on Aspidosperma tomentosum (Apocynaceae): a qualitative and quantitative structural overview.

    abstract::The structural complexity of galls depends on species-specific interaction driven by the galling taxa. However, the host plant and environment stressors can impose limits on gall developmental patterns and impact the establishment of gall morphology. Herein, we employed qualitative and quantitative approaches in order...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765202020181002

    authors: Oliveira DC,Martini VC,Moreira ASFP,Fuzaro L,GonÇalves LA

    更新日期:2020-10-19 00:00:00

  • Production of transgenic goat (Capra hircus) with human Granulocyte Colony Stimulating Factor (hG-CSF) gene in Brazil.

    abstract::In order to produce transgenic goats with hG-CSF, a total of 24 adult Saanen and 48 adult undefined breed goats were used as donors and recipients, respectively. Donors were estrus-synchronized with vaginal sponges and superovulated by a treatment with 200 mg FSH given twice daily in decreasing doses over 3 days start...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652007000400003

    authors: Freitas VJ,Serova IA,Andreeva LE,Dvoryanchikov GA,Lopes ES Jr,Teixeira DI,Dias LP,Avelar SR,Moura RR,Melo LM,Pereira AF,Cajazeiras JB,Andrade ML,Almeida KC,Sousa FC,Carvalho AC,Serov OL

    更新日期:2007-12-01 00:00:00

  • A weighted negative binomial Lindley distribution with applications to dispersed data.

    abstract::A new discrete distribution is introduced. The distribution involves the negative binomial and size biased negative binomial distributions as sub-models among others and it is a weighted version of the two parameter discrete Lindley distribution. The distribution has various interesting properties, such as bathtub sha...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820170733

    authors: Bakouch HS

    更新日期:2018-07-01 00:00:00

  • The protective effects of β-sitosterol and vermicularin from Thamnolia vermicularis (Sw.) Ach. against skin aging in vitro.

    abstract::Aged skin, featured with dryness and wrinkles, has received mounting attention due to its adverse influences on beauty. β-Sitosterol and vermicularin are two common active ingredients of Thamnolia vermicularis (Sw.) Ach., a traditional Chinese medicine, of which the anti-aging effect has been discovered. Their protect...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920181088

    authors: Haiyuan YU,Shen X,Liu D,Hong M,Lu Y

    更新日期:2019-12-02 00:00:00

  • Cohort study of cardiovascular risk in asymptomatic young adults: subclinical atherosclerosis and coronary calcium score.

    abstract::Coronary artery calcification is an early marker of subclinical atherosclerosis, but little research has been done in asymptomatic individuals under 45 years. In this cohort study with 17 years of follow-up, 155 participants were assessed in 2016 with a coronary calcium score for the association with cardiovascular ri...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201820180052

    authors: Poletto S,Schvartzman PR,Bruscato NM,Moriguchi E

    更新日期:2018-09-01 00:00:00

  • Membrane protein patterns of three Azospirillum species and Herbaspirillum seropedicae.

    abstract::Membrane protein patterns in SDS-PAGE clearly characterized Azospirillum amazonense, A. brasilense, A. lipoferum, and Herbaspirillum seropedicae. Each species showed also a typical major band with approximate molecular weights (AMWs) of 44, 39.5, 35.5, and 37.5 Kdaltons for the four species respectively. Characteristi...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:

    authors: Dianese JC,Döbereiner J,Dos Santos LT

    更新日期:1989-06-01 00:00:00

  • Blood compatibility assessments of electrospun polyurethane nanocomposites blended with megni oil for tissue engineering applications.

    abstract::Tissue engineering holds as a prominent technique to repair or replace the damaged human parts to recreate its native function. In this research, a novel scaffold based on polyurethane (PU) comprising megni oil was electrospun for tissue engineering applications. The obtained polyurethane blended with megni oil nanofi...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201920190018

    authors: Jaganathan SK,Mani MP,Supriyanto E

    更新日期:2019-06-19 00:00:00

  • Bacterial and Archaeal Communities Variability Associated with Upwelling and Anthropogenic Pressures in the Protection Area of Arraial do Cabo (Cabo Frio region - RJ).

    abstract::Upwelling systems contain a high diversity of pelagic microorganisms and their composition and activity are defined by factors like temperature and nutrient concentration. Denaturing gradient gel electrophoresis (DGGE) technique was used to verify the spatial and temporal genetic variability of Bacteria and Archaea in...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201520140098

    authors: Coelho-Souza SA,Araújo FV,Cury JC,Jesus HE,Pereira GC,Guimarães JR,Peixoto RS,Dávila AM,Rosado AS

    更新日期:2015-09-01 00:00:00

  • Growth and reproduction of the mangrove crab Goniopsis cruentata (Latreille, 1803) (Crustacea: Decapoda: Grapsidae) in southeastern Brazil.

    abstract::Goniopsis cruentata is a common semi-terrestrial crab in Brazilian mangroves and an important fishery resource for traditional communities in the northeastern Brazilian coast. Aiming to contribute to the knowledge about the species, this study evaluated the carapace width and weight growth curves, the relative growth ...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201520130387

    authors: Reis CR,Taddei FG,Cobo VJ

    更新日期:2015-04-01 00:00:00

  • The evidence for hippocampal long-term potentiation as a basis of memory for simple tasks.

    abstract::Long-term potentiation (LTP) is the enhancement of postsynaptic responses for hours, days or weeks following the brief repetitive afferent stimulation of presynaptic afferents. It has been proposed many times over the last 30 years to be the basis of long-term memory. Several recent findings finally supported this hyp...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652008000100007

    authors: Izquierdo I,Cammarota M,Da Silva WC,Bevilaqua LR,Rossato JI,Bonini JS,Mello P,Benetti F,Costa JC,Medina JH

    更新日期:2008-03-01 00:00:00

  • Areas of natural occurrence of Melipona scutellaris Latreille, 1811 (Hymenoptera: Apidae) in the state of Bahia, Brazil.

    abstract::The bee Melipona scutellaris is considered the reared meliponine species with the largest distribution in the North and Northeast regions of Brazil, with records from the state of Rio Grande do Norte down to the state of Bahia. Considering the importance of this species in the generation of income for family agricultu...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012000300010

    authors: Alves RM,Carvalho CA,Souza BA,Santos WS

    更新日期:2012-09-01 00:00:00

  • Production, extraction and characterization of exopolysaccharides produced by the native Leuconostoc pseudomesenteroides R2 strain.

    abstract::The genus Leuconostoc belongs to a group of lactic acid bacteria usually isolated from fermented vegetables, which includes species involved in the production of exopolysaccharides (EPS). These biopolymers possess considerable commercial potential. Because of the wide variety of industrial applications of EPS, this st...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/s0001-37652012000200018

    authors: Paulo EM,Boffo EF,Branco A,Valente AM,Melo IS,Ferreira AG,Roque MR,Assis SA

    更新日期:2012-06-01 00:00:00

  • Molecular basis of mammalian cell invasion by Trypanosoma cruzi.

    abstract::Establishment of infection by Trypanosoma cruzi, the agent of Chagas' disease, depends on a series of events involving interactions of diverse parasite molecules with host components. Here we focus on the mechanisms of target cell invasion by metacyclic trypomastigotes (MT) and mammalian tissue culture trypomastigotes...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章,评审

    doi:10.1590/s0001-37652006000100010

    authors: Yoshida N

    更新日期:2006-03-01 00:00:00

  • Trade-off between reservoir yield and evaporation losses as a function of lake morphology in semi-arid Brazil.

    abstract::This study investigates the relationships between yield and evaporation as a function of lake morphology in semi-arid Brazil. First, a new methodology was proposed to classify the morphology of 40 reservoirs in the Ceará State, with storage capacities ranging from approximately 5 to 4500 hm3. Then, Monte Carlo simulat...

    journal_title:Anais da Academia Brasileira de Ciencias

    pub_type: 杂志文章

    doi:10.1590/0001-3765201620150124

    authors: Campos JN,Lima IE Neto,Studart TM,Nascimento LS

    更新日期:2016-05-31 00:00:00