Abstract:
:Although recently developed drugs have brought significant improvement, the treatment of psychotic disorders still presents serious drawbacks. Since inherent complexity and lack of satisfactory understanding of the underlying pathophysiology impose limits for rational drug design, resourceful approaches in the search for antipsychotics are pertinent. This paper reports pharmacological properties of alstonine, a heteroyohimbine type alkaloid, which exhibited an antipsychotic-like profile, inhibiting amphetamine-induced lethality, apomorphine-induced stereotypy and potentiating barbiturate-induced sleeping time. Atypical features of alstonine were the prevention of haloperidol-induced catalepsy and lack of direct interaction with D1, D2 and 5-HT2A receptors, classically linked to antipsychotic mechanism of action.
journal_name
An Acad Bras Ciencjournal_title
Anais da Academia Brasileira de Cienciasauthors
Costa-Campos L,Elisabetsky E,Lara DR,Carlson TJ,King SR,Ubillas R,Nunes DS,Iwu MM,Nkemjika CO,Ozioko A,Agwu COsubject
Has Abstractpub_date
1999-01-01 00:00:00pages
189-201issue
2eissn
0001-3765issn
1678-2690journal_volume
71pub_type
杂志文章abstract::This paper reports on total Hg concentrations in muscle tissue from 12 fish species collected in the Itacaiúnas and Parauapebas Rivers in the Carajás region, South Pará. It is found that carnivorous species present Hg concentrations higher than herbivorous and omnivorous species. Also, large carnivorous species presen...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The adsorption of Violet Remazol 5R (VR 5) on wood sawdust modified with succinic anhydride (SSA) as a function of contact time, pH, and initial dye concentrations was investigated using a batch technique under ambient conditions. The SSA obtained was confirmed by IR spectroscopy, thermogravimetry and 13C NMR, and deg...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765201620140656
更新日期:2016-09-01 00:00:00
abstract::Despite the indisputable significance of identification of modern analogs for Paleoecology research, relatively few studies attempted to integrate modern and fossil samples on paleoenvironmental reconstructions. In Palynology, this general pattern is not different from other fields of Paleoecology. This study demonstr...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/s0001-37652009000400013
更新日期:2009-12-01 00:00:00
abstract::Leaves of Psidium guajava L. (guava) have been widely used in the popular way for prevention and treatment of various diseases. Thus, the objective of this study was to evaluate the inhibitory potential of leaves aqueous extract from three cultivars of P. guajava (Pedro Sato, Paluma and Século XXI) on α-amylase, α-gly...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765201720160067
更新日期:2017-01-01 00:00:00
abstract::Several parasitoids attacking the same host may lead to competition. Adult parasitoids' abilities to find, parasitize and defend hosts determine resource's retention potential. In soybean, two egg parasitoid species, Telenomus podisi and Trissolcus urichi (Hymenoptera: Platygastridae), compete on the egg masses of Pie...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765201920180597
更新日期:2019-10-14 00:00:00
abstract::Life history traits are considered key indicators of plant invasibility. Among them, the germination behavior of seeds is of major relevance because it is influenced by environmental factors of invaded ecosystem. Here, we investigated how seed traits and seed tolerance to environmental factors on seed germination of C...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/S0001-37652013000300013
更新日期:2013-09-01 00:00:00
abstract::With the advance and popularization of molecular techniques, the identification of genetic mutations that cause diseases has increased dramatically. Thus, the number of laboratories available to investigate a given disorder and the number of subsequent diagnosis have increased over time. Although it is necessary to id...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章,评审
doi:10.1590/0001-3765201520140711
更新日期:2015-08-01 00:00:00
abstract::Current two-dimensional (2D) ultrasonic marker measurements are inherent with intra- and inter-observer variability limitations. The objective of this paper is to investigate the performance of conventional 2D ultrasonic marker measurements and proposed programmable interactive three-dimensional (3D) marker evaluation...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/s0001-37652012000400030
更新日期:2012-12-01 00:00:00
abstract::A simple and reliable method for the measurement of sodium and potassium in blood serum without any sample dilution by using flow injection and atomic absorption spectrophotometry is described. A sample throughout of 100 measurements per hour is possible. Matrix problems have not been encountered. The coefficient of v...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:
更新日期:1983-06-01 00:00:00
abstract::Antagonistic interactions among predators have the potential to dampen top-down impacts on a shared pest. Strong cannibalism by adults and larvae on eggs along with a stronger intraguild predation by Eriopis connexa on Cycloneda sanguinea (Coccinellidae) than vice versa had been documented. The intensity and direction...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765202020181163
更新日期:2020-07-31 00:00:00
abstract::Environmental stimuli exert important effects on the expression of the endogenous rhythms. Daily movements of groups of parrots in response to the light/dark cycle have been studied by several researchers. However, the factors modifying the intrinsic rhythmicity of this behaviour remain little known. This study descri...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/s0001-37652012005000029
更新日期:2012-06-01 00:00:00
abstract::We present a review on two new tools to study biophysical properties of single molecules and single cells. A laser incident through a high numerical aperture microscope objective can trap small dielectric particles near the focus. This arrangement is named optical tweezers. This technique has the advantage to permit m...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/s0001-37652007000100003
更新日期:2007-03-01 00:00:00
abstract::Ecological capability evaluation is referred to as evaluation of potential capability of land and determination of its natural land use. In this paper, ecological capability of Lille Basin in Lahijan was evaluated for afforestation and forest expansion using Geographical Information Systems (GIS). For this purpose, in...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765201820170805
更新日期:2018-10-01 00:00:00
abstract::Properties of L(+) lactate dehydrogenase (LDH) of Electrophorus electricus (L.) electric organ were studied, comparing the substrates pyruvate and lactate. Electric organ LDH is a soluble enzyme with a pH optimum of 7.4 for pyruvate and 9.0 for lactate. The apparent Km was lower for pyruvate (Km = 2.5 X 10(-4) M) than...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Extreme climatic events and their hazards have strong impact on society. Urban areas in Brazil are especially vulnerable to the impact of such events due to their rapid growth and inappropriate infrastructure. Viçosa is a mid-sized city in Southeastern Brazil that has been experiencing issues associated with urban exp...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765202020190388
更新日期:2020-01-01 00:00:00
abstract::D-pinitol is one of the major inositol found in plants and studies suggest its potential hypoglycemic and hypolipidemic actions in diabetic rodents. Here, we investigated the actions of D-pinitol on adiposity, and in lipid and glycemic homeostasis in monosodium glutamate (MSG)-obese mice. Swiss mice received daily sub...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765202020201382
更新日期:2020-11-20 00:00:00
abstract::The structural complexity of galls depends on species-specific interaction driven by the galling taxa. However, the host plant and environment stressors can impose limits on gall developmental patterns and impact the establishment of gall morphology. Herein, we employed qualitative and quantitative approaches in order...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765202020181002
更新日期:2020-10-19 00:00:00
abstract::In order to produce transgenic goats with hG-CSF, a total of 24 adult Saanen and 48 adult undefined breed goats were used as donors and recipients, respectively. Donors were estrus-synchronized with vaginal sponges and superovulated by a treatment with 200 mg FSH given twice daily in decreasing doses over 3 days start...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/s0001-37652007000400003
更新日期:2007-12-01 00:00:00
abstract::A new discrete distribution is introduced. The distribution involves the negative binomial and size biased negative binomial distributions as sub-models among others and it is a weighted version of the two parameter discrete Lindley distribution. The distribution has various interesting properties, such as bathtub sha...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765201820170733
更新日期:2018-07-01 00:00:00
abstract::Aged skin, featured with dryness and wrinkles, has received mounting attention due to its adverse influences on beauty. β-Sitosterol and vermicularin are two common active ingredients of Thamnolia vermicularis (Sw.) Ach., a traditional Chinese medicine, of which the anti-aging effect has been discovered. Their protect...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765201920181088
更新日期:2019-12-02 00:00:00
abstract::Coronary artery calcification is an early marker of subclinical atherosclerosis, but little research has been done in asymptomatic individuals under 45 years. In this cohort study with 17 years of follow-up, 155 participants were assessed in 2016 with a coronary calcium score for the association with cardiovascular ri...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765201820180052
更新日期:2018-09-01 00:00:00
abstract::Membrane protein patterns in SDS-PAGE clearly characterized Azospirillum amazonense, A. brasilense, A. lipoferum, and Herbaspirillum seropedicae. Each species showed also a typical major band with approximate molecular weights (AMWs) of 44, 39.5, 35.5, and 37.5 Kdaltons for the four species respectively. Characteristi...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract::Tissue engineering holds as a prominent technique to repair or replace the damaged human parts to recreate its native function. In this research, a novel scaffold based on polyurethane (PU) comprising megni oil was electrospun for tissue engineering applications. The obtained polyurethane blended with megni oil nanofi...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765201920190018
更新日期:2019-06-19 00:00:00
abstract::Upwelling systems contain a high diversity of pelagic microorganisms and their composition and activity are defined by factors like temperature and nutrient concentration. Denaturing gradient gel electrophoresis (DGGE) technique was used to verify the spatial and temporal genetic variability of Bacteria and Archaea in...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765201520140098
更新日期:2015-09-01 00:00:00
abstract::Goniopsis cruentata is a common semi-terrestrial crab in Brazilian mangroves and an important fishery resource for traditional communities in the northeastern Brazilian coast. Aiming to contribute to the knowledge about the species, this study evaluated the carapace width and weight growth curves, the relative growth ...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765201520130387
更新日期:2015-04-01 00:00:00
abstract::Long-term potentiation (LTP) is the enhancement of postsynaptic responses for hours, days or weeks following the brief repetitive afferent stimulation of presynaptic afferents. It has been proposed many times over the last 30 years to be the basis of long-term memory. Several recent findings finally supported this hyp...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/s0001-37652008000100007
更新日期:2008-03-01 00:00:00
abstract::The bee Melipona scutellaris is considered the reared meliponine species with the largest distribution in the North and Northeast regions of Brazil, with records from the state of Rio Grande do Norte down to the state of Bahia. Considering the importance of this species in the generation of income for family agricultu...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/s0001-37652012000300010
更新日期:2012-09-01 00:00:00
abstract::The genus Leuconostoc belongs to a group of lactic acid bacteria usually isolated from fermented vegetables, which includes species involved in the production of exopolysaccharides (EPS). These biopolymers possess considerable commercial potential. Because of the wide variety of industrial applications of EPS, this st...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/s0001-37652012000200018
更新日期:2012-06-01 00:00:00
abstract::Establishment of infection by Trypanosoma cruzi, the agent of Chagas' disease, depends on a series of events involving interactions of diverse parasite molecules with host components. Here we focus on the mechanisms of target cell invasion by metacyclic trypomastigotes (MT) and mammalian tissue culture trypomastigotes...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章,评审
doi:10.1590/s0001-37652006000100010
更新日期:2006-03-01 00:00:00
abstract::This study investigates the relationships between yield and evaporation as a function of lake morphology in semi-arid Brazil. First, a new methodology was proposed to classify the morphology of 40 reservoirs in the Ceará State, with storage capacities ranging from approximately 5 to 4500 hm3. Then, Monte Carlo simulat...
journal_title:Anais da Academia Brasileira de Ciencias
pub_type: 杂志文章
doi:10.1590/0001-3765201620150124
更新日期:2016-05-31 00:00:00