The evidence for hippocampal long-term potentiation as a basis of memory for simple tasks.

Abstract:

:Long-term potentiation (LTP) is the enhancement of postsynaptic responses for hours, days or weeks following the brief repetitive afferent stimulation of presynaptic afferents. It has been proposed many times over the last 30 years to be the basis of long-term memory. Several recent findings finally supported this hypothesis: a) memory formation of one-trial avoidance learning depends on a series of molecular steps in the CA1 region of the hippocampus almost identical to those of LTP in the same region; b)hippocampal LTP in this region accompanies memory formation of that task and of another similar task. However, CA1 LTP and the accompanying memory processes can be dissociated, and in addition plastic events in several other brain regions(amygdala, entorhinal cortex, parietal cortex) are also necessary for memory formation of the one-trial task, and perhaps of many others.

journal_name

An Acad Bras Cienc

authors

Izquierdo I,Cammarota M,Da Silva WC,Bevilaqua LR,Rossato JI,Bonini JS,Mello P,Benetti F,Costa JC,Medina JH

doi

10.1590/s0001-37652008000100007

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

115-27

issue

1

eissn

0001-3765

issn

1678-2690

pii

S0001-37652008000100007

journal_volume

80

pub_type

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