当前位置： SCI文献检索 > JOURNAL OF MOLECULAR BIOLOGY期刊下所有文献 > Cation transport: an example of structural based selectivity.

Cation transport: an example of structural based selectivity.

Abstract：

:Through the high-resolution structure of the gramicidin A channel in lamellar phase lipids and the characterization of specific ion peptide interactions, fundamental principles for ion channel selectivity and conductance efficiency are illustrated with atomic resolution detail. Delocalized cation binding in the first turn of the helix reduces the unfavorable entropy contribution upon binding. Stepwise dehydration minimizes the energy barrier for cation entry and provides valence selectivity in this channel. Three or more water molecules in the monovalent cation binding site result in flexibility in the cation solvation environment causing weak cation size selectivity. Lack of cation induced structural modification avoids the formation of a significant energy barrier, thus permitting efficient cation transport.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Tian F,Cross TA

doi

10.1006/jmbi.1998.2434

subject

Has Abstract

pub_date

1999-02-05 00:00:00

pages

1993-2003

issue

5

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(98)92434-2

journal_volume

285

pub_type

杂志文章

相关文献

JOURNAL OF MOLECULAR BIOLOGY文献大全
  • Effect of pseudorepeat rearrangement on alpha-synuclein misfolding, vesicle binding, and micelle binding.

    abstract：:The pathological and physiological hallmarks of the protein alpha-synuclein (aS) are its misfolding into cytotoxic aggregates and its binding to synaptic vesicles, respectively. Both events are mediated by seven 11-residue amphiphilic pseudorepeats and, most generally, involve a transition from intrinsically unstructu...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2009.05.058

    authors： Rao JN,Kim YE,Park LS,Ulmer TS

    更新日期：2009-07-17 00:00:00

  • Active-site properties of the oxidized and reduced C-terminal domain of DsbD obtained by NMR spectroscopy.

    abstract：:The periplasmic C-terminal domain of the Escherichia coli DsbD protein (cDsbD) has a thioredoxin fold. The two cysteine residues in the CXXC motif serve as the reductant for the disulfide bond of the N-terminal domain which can in turn act as a reductant for various periplasmic partners. The resulting disulfide bond i...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2007.04.038

    authors： Mavridou DA,Stevens JM,Ferguson SJ,Redfield C

    更新日期：2007-07-20 00:00:00

  • Complex of lac repressor headpiece with a 14 base-pair lac operator fragment studied by two-dimensional nuclear magnetic resonance.

    abstract：:Two-dimensional nuclear Overhauser enhancement spectra are presented of the complex of lac repressor headpiece with a 14 base-pair lac operator fragment. Analysis of nuclear Overhauser enhancements observed between protein and DNA shows that the second helix of the headpiece ("the recognition helix") binds in the majo...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/0022-2836(87)90638-3

    authors： Boelens R,Scheek RM,van Boom JH,Kaptein R

    更新日期：1987-01-05 00:00:00

  • Long-range identification of hepatocyte nuclear factor-3 (FoxA) high and low-affinity binding sites with a chimeric nuclease.

    abstract：:Identifying the complete set of transcription factors that bind the promoter and other regulatory regions of a gene of interest is an essential step in functional genomics. We have developed an original assay for the systematic detection of hepatocyte nuclear factor-3 (HNF-3) binding sites within cloned promoters. Thi...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.2001.4788

    authors： Ruminy P,Derambure C,Chandrasegaran S,Salier JP

    更新日期：2001-07-13 00:00:00

  • Symmetry and chirality in topoisomerase II-DNA crossover recognition.

    abstract：:Several experimental data support the notion that the recognition of DNA crossovers play an important role in the multiple functions of topoisomerase II. Here, a theoretical analysis of the possible modes of assembly of yeast topoisomerase II with right and left-handed tight DNA crossovers is performed, using the crys...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章,meta分析

    doi：10.1006/jmbi.1998.2281

    authors： Timsit Y,Duplantier B,Jannink G,Sikorav JL

    更新日期：1998-12-18 00:00:00

  • Differential expression of two clusters of mouse histone genes.

    abstract：:The mouse histone mRNAs coded for by three different cloned DNA fragments have been characterized. Two of these cloned DNA fragments, MM221 and MM291, located on chromosome 13, code for H3, H2b and H2a histone mRNAs, which are expressed at low levels in cultured mouse cells and fetal mice. The other DNA fragment, MM61...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/0022-2836(85)90211-6

    authors： Graves RA,Wellman SE,Chiu IM,Marzluff WF

    更新日期：1985-05-25 00:00:00

  • Two distinct binding modes of a protein cofactor with its target RNA.

    abstract：:Like most cellular RNA enzymes, the bI5 group I intron requires binding by a protein cofactor to fold correctly. Here, we use single-molecule approaches to monitor the structural dynamics of the bI5 RNA in real time as it assembles with its CBP2 protein cofactor. These experiments show that CBP2 binds to the target RN...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2006.06.048

    authors： Bokinsky G,Nivón LG,Liu S,Chai G,Hong M,Weeks KM,Zhuang X

    更新日期：2006-08-25 00:00:00

  • Deletion analysis of the che operon in the archaeon Halobacterium salinarium.

    abstract：:Halobacterium salinarium is a chemo- and phototactic archaeon whose signal transduction pathway includes the classical two-component system made up of CheA and CheY. Deletion analysis of the che operon in H. salinarium has been undertaken. Following the removal of the entire operon, the importance of each of the four ...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.1996.0267

    authors： Rudolph J,Oesterhelt D

    更新日期：1996-05-17 00:00:00

  • Apoprotein structure in the LH2 complex from Rhodopseudomonas acidophila strain 10050: modular assembly and protein pigment interactions.

    abstract：:The refined structure of the peripheral light-harvesting complex from Rhodopseudomonas acidophila strain 10050 reveals a membrane protein with protein-protein interactions in the trans-membrane region exclusively of a van der Waals nature. The dominant factors in the formation of the complex appear to be extramembrano...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.1997.0966

    authors： Prince SM,Papiz MZ,Freer AA,McDermott G,Hawthornthwaite-Lawless AM,Cogdell RJ,Isaacs NW

    更新日期：1997-05-02 00:00:00

  • Structural comparison of cuticle and interstitial collagens from annelids living in shallow sea-water and at deep-sea hydrothermal vents.

    abstract：:Two types of annelid collagens of different sizes were purified, one from acetic acid extracts of the cuticle (length 2.5 microns) and the other, after pepsin digestion, from interstitial spaces of the body wall (0.3 micron). They were obtained from Alvinella pompejana, Alvinella caudata and Paralvinella grasslei coll...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.1994.0084

    authors： Gaill F,Mann K,Wiedemann H,Engel J,Timpl R

    更新日期：1995-02-17 00:00:00

  • Capsid targeting sequence targets foreign proteins into bacteriophage T4 and permits proteolytic processing.

    abstract：:A membrane-independent morphogenetic viral signal peptide is identified within bacteriophage T4 internal protein III (IPIII). Utilizing a phagederived expression-packaging-processing system, which packages foreign proteins fused with IPIII into the phage capsid, a synthetic cleavage site introduced at the C terminus o...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.1996.0470

    authors： Mullaney JM,Black LW

    更新日期：1996-08-23 00:00:00

  • Functional and structural role of amino acid residues in the odd-numbered transmembrane alpha-helices of the bovine mitochondrial oxoglutarate carrier.

    abstract：:The mitochondrial oxoglutarate carrier (OGC) plays an important role in the malate-aspartate shuttle, the oxoglutarate-isocitrate shuttle and gluconeogenesis. To establish amino acid residues that are important for function, each residue in the transmembrane alpha-helices H1, H3 and H5 was replaced systematically by a...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2007.03.048

    authors： Cappello AR,Miniero DV,Curcio R,Ludovico A,Daddabbo L,Stipani I,Robinson AJ,Kunji ER,Palmieri F

    更新日期：2007-06-01 00:00:00

  • Evaluation of the sequence template method for protein structure prediction. Discrimination of the (beta/alpha)8-barrel fold.

    abstract：:A multiple alignment of five (beta/alpha)8-barrel enzymes has been derived from their structure. The eight beta-strands and eight alpha-helices of the (beta/alpha)8-barrel are correctly aligned and the equivalenced residues in these regions fulfil similar structural roles. Each beta-strand has a central core of usuall...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/0022-2836(92)90499-a

    authors： Pickett SD,Saqi MA,Sternberg MJ

    更新日期：1992-11-05 00:00:00

  • Structural analysis of CYP2R1 in complex with vitamin D3.

    abstract：:The activation of vitamin D to its hormonal form is mediated by cytochrome P450 enzymes. CYP2R1 catalyzes the initial step converting vitamin D into 25-hydroxyvitamin D. A CYP2R1 gene mutation causes an inherited form of rickets due to 25-hydroxylase deficiency. To understand the narrow substrate specificity of CYP2R1...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2008.03.065

    authors： Strushkevich N,Usanov SA,Plotnikov AN,Jones G,Park HW

    更新日期：2008-06-27 00:00:00

  • Positions of proteins S14, S18 and S20 in the 30 S ribosomal subunit of Escherichia coli.

    abstract：:A map of the 30 S ribosomal subunit is presented giving the positions of 15 of its 21 proteins. The components located in the map are S1, S3, S4, S5, S6, S7, S8, S9, S10, S11, S12, S14, S15, S18 and S20. ...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/0022-2836(84)90338-3

    authors： Ramakrishnan V,Capel M,Kjeldgaard M,Engelman DM,Moore PB

    更新日期：1984-04-05 00:00:00

  • In-vivo degradation pathway of an excised intervening sequence.

    abstract：:A study of the distribution in heterogeneous nuclear RNP (hnRNP) of the different forms of the first intervening sequence (IVSI) from the E3 transcription unit of adenovirus serotype 2 suggests a three-step pathway for IVS excision and degradation. First, the lariat IVS is formed in a large RNP of the size of premesse...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/0022-2836(87)90480-3

    authors： Sittler A,Gallinaro H,Kister L,Jacob M

    更新日期：1987-10-20 00:00:00

  • Refined crystallographic structure of Pseudomonas aeruginosa exotoxin A and its implications for the molecular mechanism of toxicity.

    abstract：:Exotoxin A of Pseudomonas aeruginosa asserts its cellular toxicity through ADP-ribosylation of translation elongation factor 2, predicated on binding to specific cell surface receptors and intracellular trafficking via a complex pathway that ultimately results in translocation of an enzymatic activity into the cytopla...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.2001.5195

    authors： Wedekind JE,Trame CB,Dorywalska M,Koehl P,Raschke TM,McKee M,FitzGerald D,Collier RJ,McKay DB

    更新日期：2001-12-07 00:00:00

  • The recognition of distorted DNA structures by HMG-D: a footprinting and molecular modelling study.

    abstract：:The high mobility group (HMG) domain is a DNA binding motif found in some eukaryotic chromosomal proteins and transcription factors. This domain binds in the minor groove of DNA inducing a sharp bend and also preferentially binds to certain distorted DNA structures. Although structures of sequence-specific HMG domains...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.1999.3246

    authors： Payet D,Hillisch A,Lowe N,Diekmann S,Travers A

    更新日期：1999-11-19 00:00:00

  • Structural and functional characterisation of a conserved archaeal RadA paralog with antirecombinase activity.

    abstract：:DNA recombinases (RecA in bacteria, Rad51 in eukarya and RadA in archaea) catalyse strand exchange between homologous DNA molecules, the central reaction of homologous recombination, and are among the most conserved DNA repair proteins known. RecA is the sole protein responsible for this reaction in bacteria, whereas ...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2009.04.060

    authors： McRobbie AM,Carter LG,Kerou M,Liu H,McMahon SA,Johnson KA,Oke M,Naismith JH,White MF

    更新日期：2009-06-19 00:00:00

  • The periplasmic binding protein of a tripartite tricarboxylate transporter is involved in signal transduction.

    abstract：:A new type of solute importer has been identified recently in various bacterial genera and called the tripartite tricarboxylate transporter (TTT). TTTs consist of two cytoplasmic membrane proteins and a periplasmic solute-binding protein. In the whooping cough agent Bordetella pertussis, a TTT system that has been cal...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2005.05.071

    authors： Antoine R,Huvent I,Chemlal K,Deray I,Raze D,Locht C,Jacob-Dubuisson F

    更新日期：2005-08-26 00:00:00

  • Crystallization and preliminary diffraction studies of recombinant human granulocyte-stimulating factor (KW2228).

    abstract：:Human granulocyte colony-stimulating factor (hG-CSF) specifically stimulates proliferation of neutrophils. Two crystal forms of a mutant of hG-CSF expressed in Escherichia coli have been obtained using the hanging drop vapour diffusion method. One form is triclinic, space group P1, with cell dimensions a = 37.3 A, b =...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/0022-2836(90)90143-A

    authors： Nagahara Y,Konishi N,Yokoo Y,Hirayama N

    更新日期：1990-07-05 00:00:00

  • The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.

    abstract：:Precise regulation of dNTPs within the cellular nucleotide pool is essential for high accuracy of DNA replication and is critical for retaining the genomic integrity. Recently, human dCTPase (deoxycytidine triphosphatase), also known as DCTPP1 (human all-alpha dCTP pyrophosphatase 1), has been revealed to be a key pla...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2020.01.005

    authors： Scaletti E,Claesson M,Helleday T,Jemth AS,Stenmark P

    更新日期：2020-02-14 00:00:00

  • Error rate and specificity of human and murine DNA polymerase eta.

    abstract：:We describe here the error specificity of mammalian DNA polymerase eta (pol eta), an enzyme that performs translesion DNA synthesis and may participate in somatic hypermutation of immunoglobulin genes. Both mouse and human pol eta lack intrinsic proofreading exonuclease activity and both copy undamaged DNA inaccuratel...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.2001.4937

    authors： Matsuda T,Bebenek K,Masutani C,Rogozin IB,Hanaoka F,Kunkel TA

    更新日期：2001-09-14 00:00:00

  • One is Nothing without the Other: Theoretical and Empirical Analysis of Cell Growth and Cell Cycle Progression.

    abstract：:Small, fast-growing bacteria make ideal subjects for genetic and quantitative analysis alike. Long the darling of theoreticians, efforts to understand the relationship between cell growth and cell cycle progression in bacterial systems have been propelled by modelers and empiricist in equal measure. Taking a historica...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jmb.2019.04.004

    authors： Levin PA,Taheri-Araghi S

    更新日期：2019-05-17 00:00:00

  • Crystal Structure of a Complex of the Intracellular Domain of Interferon λ Receptor 1 (IFNLR1) and the FERM/SH2 Domains of Human JAK1.

    abstract：:The crystal structure of a construct consisting of the FERM and SH2-like domains of the human Janus kinase 1 (JAK1) bound to a fragment of the intracellular domain of the interferon-λ receptor 1 (IFNLR1) has been determined at the nominal resolution of 2.1Å. In this structure, the receptor peptide forms an 85-Å-long e...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2016.10.005

    authors： Zhang D,Wlodawer A,Lubkowski J

    更新日期：2016-11-20 00:00:00

  • Bacteriophage p22 portal vertex formation in vivo.

    abstract：:Bacteriophage with double-stranded, linear DNA genomes package DNA into pre-assembled icosahedral procapsids through a unique vertex. The packaging vertex contains an oligomeric ring of a portal protein that serves as a recognition site for the packaging enzymes, a conduit for DNA translocation, and the site of tail a...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.2001.5275

    authors： Moore SD,Prevelige PE Jr

    更新日期：2002-02-01 00:00:00

  • A divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for Reptin.

    abstract：:Anterior gradient-2 (AGR2) functions in a range of biological systems, including goblet cell formation, limb regeneration, inhibition of p53, and metastasis. There are no well-validated binding proteins for AGR2 protein despite the wealth of data implicating an important cellular function in vertebrates. The yeast two...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2010.09.035

    authors： Maslon MM,Hrstka R,Vojtesek B,Hupp TR

    更新日期：2010-12-03 00:00:00

  • Refined structure of the nicotinic acetylcholine receptor at 4A resolution.

    abstract：:We present a refined model of the membrane-associated Torpedo acetylcholine (ACh) receptor at 4A resolution. An improved experimental density map was obtained from 342 electron images of helical tubes, and the refined structure was derived to an R-factor of 36.7% (R(free) 37.9%) by standard crystallographic methods, a...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2004.12.031

    authors： Unwin N

    更新日期：2005-03-04 00:00:00

  • Regulation and targeted mutation of opsA, coding for the NOP-1 opsin orthologue in Fusarium fujikuroi.

    abstract：:Opsins are widespread photoreceptor proteins involved in a diversity of light-driven processes in all major taxa that use the apocarotenoid retinal as a light-absorbing prosthetic group. Proteins from the opsin family are also found in filamentous fungi, but no function has been attributed to them. The fungus Fusarium...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2009.01.057

    authors： Estrada AF,Avalos J

    更新日期：2009-03-20 00:00:00

  • On the nature of conformational openings: native and unfolded-state hydrogen and thiol-disulfide exchange studies of ferric aquomyoglobin.

    abstract：:Native-state amide hydrogen exchange (HX) of proteins in the presence of denaturant has provided valuable details on the structures of equilibrium folding intermediates. Here, we extend HX theory to model thiol group exchange (SX) in single cysteine-containing variants of sperm whale ferric aquomyoglobin. SX is comple...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.2001.5117

    authors： Feng Z,Butler MC,Alam SL,Loh SN

    更新日期：2001-11-16 00:00:00