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Replication focus-forming activity 1 and the Werner syndrome gene product.

Abstract：

:The initiation of DNA replication involves a minimum of four factors: a specific DNA sequence (origin), an initiator protein which binds to the origin, a helicase that unwinds the origin and a protein that binds single-stranded DNA that stabilizes the unwound origin. In eukaryotic cells, the origin recognition complex (ORC) is the initiator protein and replication protein A (RPA; ref. 3) is the single-stranded DNA-binding protein. However, the helicase has not been identified and the nature of origins remains elusive, except in the case of Saccharomyces cerevisiae. A unique feature of eukaryotic DNA replication is that it occurs at a few-hundred discrete foci. It has thus been proposed that a real origin must contain a specific DNA sequence and must be attached to replication foci. Using Xenopus laevis egg extracts, we have identified and purified a 170-kD protein, focus-forming activity 1 (FFA-1), which is required for the formation of replication foci. Here we report that FFA-1 has DNA-helicase activity. Moreover, it is a homologue of the human Werner syndrome gene product WRN, a protein associated with premature ageing in humans.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Yan H,Chen CY,Kobayashi R,Newport J

doi

10.1038/1263

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

375-8

issue

4

eissn

1061-4036

issn

1546-1718

journal_volume

19

pub_type

杂志文章

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