Abstract:
:The technique of differential display reverse transcription-polymerase chain reaction (ddRT-PCR) has been used to produce unique profiles of up-regulated and down-regulated gene expression in the liver of male Wistar rats following short term exposure to the non-genotoxic hepatocarcinogens, phenobarbital and WY-14,643. Animals were treated for 3 days, whereupon their livers were extracted and snap frozen. mRNA was prepared from the livers and used for ddRT-PCR. Individual bands from the differential displays were extracted and cloned. False positives were eliminated by dotblot screening and true positives then sequenced and identified.
journal_name
Eur J Drug Metab Pharmacokinetjournal_title
European journal of drug metabolism and pharmacokineticsauthors
Rockett JC,Esdaile DJ,Gibson GGdoi
10.1007/BF03190966subject
Has Abstractpub_date
1997-10-01 00:00:00pages
329-33issue
4eissn
0378-7966issn
2107-0180journal_volume
22pub_type
杂志文章abstract::The absorption, disposition, biotransformation and excretion of the nonsteroidal anti-inflammatory drug pirazolac were investigated in 6 volunteers (3 males, 3 females, age 50 greater than years) after intravenous and oral administration of 50 mg 14C-pirazolac as an aqueous solution of the sodium salt. Pirazolac was v...
journal_title:European journal of drug metabolism and pharmacokinetics
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doi:10.1007/BF03189696
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journal_title:European journal of drug metabolism and pharmacokinetics
pub_type: 杂志文章
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journal_title:European journal of drug metabolism and pharmacokinetics
pub_type: 杂志文章
doi:10.1007/BF03189562
更新日期:1982-01-01 00:00:00
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journal_title:European journal of drug metabolism and pharmacokinetics
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doi:10.1007/BF03189441
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pub_type: 杂志文章
doi:10.1007/s13318-014-0208-7
更新日期:2015-06-01 00:00:00
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journal_title:European journal of drug metabolism and pharmacokinetics
pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
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journal_title:European journal of drug metabolism and pharmacokinetics
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-04-01 00:00:00
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journal_title:European journal of drug metabolism and pharmacokinetics
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:1993-01-01 00:00:00
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journal_title:European journal of drug metabolism and pharmacokinetics
pub_type: 杂志文章
doi:10.1007/BF03190121
更新日期:1990-01-01 00:00:00
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journal_title:European journal of drug metabolism and pharmacokinetics
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doi:10.1007/s13318-011-0053-x
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journal_title:European journal of drug metabolism and pharmacokinetics
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更新日期:1990-07-01 00:00:00
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journal_title:European journal of drug metabolism and pharmacokinetics
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journal_title:European journal of drug metabolism and pharmacokinetics
pub_type: 杂志文章
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journal_title:European journal of drug metabolism and pharmacokinetics
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更新日期:2021-01-01 00:00:00
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journal_title:European journal of drug metabolism and pharmacokinetics
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更新日期:1984-04-01 00:00:00
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journal_title:European journal of drug metabolism and pharmacokinetics
pub_type: 杂志文章
doi:10.1007/BF03189844
更新日期:1986-07-01 00:00:00
abstract::Danirixin (GSK1325756) is a small, high-affinity, selective and reversible CXCR2 antagonist in development for treatment of chronic obstructive pulmonary disease. The objective of the study was to evaluate the relative bioavailability, including the inter-subject variability, of a conventional immediate-release (IR) f...
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pub_type: 杂志文章,随机对照试验
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更新日期:2014-09-01 00:00:00
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journal_title:European journal of drug metabolism and pharmacokinetics
pub_type: 杂志文章
doi:10.1007/s13318-013-0145-x
更新日期:2014-06-01 00:00:00
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journal_title:European journal of drug metabolism and pharmacokinetics
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journal_title:European journal of drug metabolism and pharmacokinetics
pub_type: 杂志文章
doi:10.1007/BF03189644
更新日期:1984-07-01 00:00:00
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journal_title:European journal of drug metabolism and pharmacokinetics
pub_type: 杂志文章
doi:10.1007/BF03188865
更新日期:1994-10-01 00:00:00
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journal_title:European journal of drug metabolism and pharmacokinetics
pub_type: 杂志文章
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更新日期:1991-10-01 00:00:00