The metabolism and excretion of 7-mono-0-(beta-hydroxyethyl) rutoside in the dog.

abstract：:Benzo[alpha]pyrene (B[a]P) is a product derived from incomplete combustion of organic material and is considered responsible for chemically-induced cancer in humans. In the present study, the levels of noradrenaline (NA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 5-hydroxytryptamine (...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Stephanou P,Konstandi M,Pappas P,Marselos M

更新日期：1998-10-01 00:00:00

abstract：:Pharmacokinetic gender-dependent differences in cytochrome P450-mediated drug metabolism, especially CYP3A4, and their clinical implications are increasingly apparent. CYP3A4 seems to be the most important CYP isoform in both bioactivation and N-dechloroethylation of the alkylating prodrug ifosfamide, but informations...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Schmidt R,Baumann F,Hanschmann H,Geissler F,Preiss R

更新日期：2001-07-01 00:00:00

abstract：:The pharmacokinetics, biotransformation, protein binding and tissue distribution of mitonafide and pinafide were studied after single i.v. and oral administration of each drug (20 mg/Kg) in female rats. In pregnant rats a study of cross placental-barrier after i.v. administration of the two drugs was also performed. T...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Rivera Cid P,Gonzalez Fernandez E,Martin FR,Braña MF

更新日期：1986-10-01 00:00:00

abstract：:The MDR modulator, OC144-093, is a potential candidate for use in cancer therapy and exhibits potent biological activity in vitro and in vivo when combined with anticancer agents such as paclitaxel. Its inhibitory interaction with P-glycoprotein (Pgp), the mdr1 gene product and a mechanistic participant in multidrug r...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Guns ES,Denyssevych T,Dixon R,Bally MB,Mayer L

更新日期：2002-04-01 00:00:00

abstract：:Herbal medicinal products have to meet comparable standards concerning the assessment of efficacy, safety and (bio)pharmaceutical quality as chemically defined synthetic drugs. However, these requirements are not fulfilled for many herbal products so far, particularly regarding in vitro dissolution and in vivo bioavai...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Blume HH,Schug BS

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Even though lithium has been used for the treatment of bipolar disorder for several decades, its toxicities are still being reported. The major limitation in the use of lithium is its narrow therapeutic window. Several methods have been proposed to predict lithium doses essential to attain the...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Methaneethorn J

更新日期：2018-02-01 00:00:00

abstract：:The bioavailability of the recently developed 1 g dispersible tablet form of amoxicillin (B) and the 1 g dispersible tablet in suspension form (C) were compared to that of the 1 g standard reference formulation (A). Twelve healthy volunteers were involved in this single-dose, open, randomized, three-way cross-over stu...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Prevot MH,Jehl F,Rouveix B

更新日期：1997-01-01 00:00:00

abstract：:The metabolism of galanthamine hydrobromide (Nivalin) was investigated in rat and rabbit liver homogenates. Experiments were carried out varying several parameters of incubation: substrate (galanthamine hydrobromide, galanthamine, galanthaminone and epigalanthamine), cofactor enrichment (NADPH, NADP/G-6-P, NAD), pH (7...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Mihailova D,Velkov M,Zhivkova Z

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:UPARANT has emerged as a novel therapeutic agent with the potential to treat ocular diseases as assessed by studies in animal models. Since limited information is available on the pharmacokinetics of UPARANT, the aim of this study is to evaluate its pharmacokinetics after single and multiple a...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ciccone M,D'Alonzo D,Cangiano AM,De Fenza M,Pavone V,Mancinelli A

更新日期：2021-01-01 00:00:00

abstract：:The binding of three digitalis glycosides, digitoxin, digoxin and gitoxin, to human serum albumin was studied in vitro by equilibrium dialysis. The results obtained showed that binding is a non saturable process and that probably the same binding mechanism is involved for each of the three drugs. Their binding sites s...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Tillement JP,Zini R,Lecomte M,d'Athis P

更新日期：1980-01-01 00:00:00

abstract：:The aim of the present study was to investigate the relative bioavailability and bioequivalence of a new tablet formulation of metformin hydrochloride with reference to a standard product in healthy Chinese adult male volunteers. Two randomized, comparative, two-way crossover studies were therefore conducted. In study...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Li J,Jin Y,Wang TY,Lü XW,Li YH

更新日期：2007-01-01 00:00:00

abstract：:A bioequivalence study compares the bioavailability between a test and a reference drug product in terms of the rate and extent of drug absorption. Area under the plasma concentration-time curve (AUC) and maximum plasma concentration (Cmax) are the pharmacokinetic parameters that serve as characteristics for the asses...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zintzaras E,Bouka P

更新日期：1999-07-01 00:00:00

abstract：:Angiogenesis is integral to tumour growth and invasion, and is a key target for cancer therapeutics. However, for many of the licensed indications, only a modest clinical benefit has been observed for both monoclonal antibody and small-molecule tyrosine kinase inhibitor anti-angiogenic therapy. Pre-clinical and clinic...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Morotti M,Dass PH,Harris AL,Lord S

更新日期：2018-04-01 00:00:00

abstract：:A short review on some pharmacokinetic parameters (mean residence time, sojourn time, transit time) is given in relation to compartmental models and some examples and application are discussed. In particular the use of the sojourn time is suggested because this parameter can give useful informations when comparing the...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Segre G,Urso R

更新日期：1991-01-01 00:00:00

abstract：:UDP-glucuronosyltransferase 1A9 (UGT1A9) contributes to the glucuronidation of numerous drugs. Cynomolgus monkeys are regarded as experimental animals similar to humans in studies on safety evaluation and biotransformation for drug development. In this study, the similarities and differences in the enzymatic propertie...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Yamamoto K,Mukai M,Nagaoka K,Hayashi K,Hichiya H,Okada K,Murata M,Shigeyama M,Narimatsu S,Hanioka N

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The disposition of azithromycin in the human eye following topical administration has not been fully explored. Population pharmacokinetic (PopPK) modeling can allow useful conclusions to be drawn based on limited tear sampling data. The aim of this study was therefore to develop and evaluate a...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Wu F,Zhao X,Li X,Cui Y

更新日期：2019-06-01 00:00:00

abstract：:The pharmacokinetics of chlordemethyldiazepam--a pharmacologically very active new 1,4-benzodiazepine derivative--in healthy subjects after administration of a single oral dose of 2 mg, was studied. Peak concentrations were reached in 1.2 +/- 0.2 hours. Plasma levels declined with a biphasic pattern, and the eliminati...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Bareggi SR,Pirola R,Leva S,Zecca L

更新日期：1986-07-01 00:00:00

abstract：:Penbutolol is a not cardioselective beta-adrenergic blocking drug; it is lipid soluble and differs in its protein binding from the other members of its group because shows linkage to alpha 1-glycoprotein, with no detectable binding to albumin. AAG levels change during pregnancy and so the binding of [3H]-penbutolol wa...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Aquirre C,Rodriguez-Sasiain JM,Navajas P,Calvo R

更新日期：1988-01-01 00:00:00

abstract：:A simple and sensitive HPLC method has been developed and validated for the determination of tyrosol galactoside (TG) in rat plasma. After one-step protein precipitation with methanol, plasma samples were separated on an Ultimate AQ-C18 column (150 mm×4.6 mm, 5 μm) using acetonitrile-water (7:93, v/v) as mobile phase ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Wang Q,Wang Y,Deng Y,Shi T,Liu X,Sun X,Li X,Zhou D

更新日期：2011-01-01 00:00:00

abstract：:The influence of Tamarindus indica L fruit extract incorporated in a traditional meal on the bioavailability of Ibuprofen tablets 400 mg dose when given concurrently was studied in 6 healthy human volunteers. There was a statistically significant increase in the plasma levels of Ibuprofen and its metabolites hydroxy-i...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Garba M,Yakasai IA,Bakare MT,Munir HY

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Ginseng is usually consumed as a dietary supplement for health care in the normal state or prescribed as a herbal medicine in pathologic conditions. Although metabolic studies of ginseng are commonly performed on healthy organisms, the metabolic characteristics in pathologic organisms remain un...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zhu JH,Xu JD,Zhou SS,Zhang XY,Zhou J,Kong M,Mao Q,Zhu H,Li SL

更新日期：2021-01-01 00:00:00

abstract：:Chlormezanone plasma concentrations were determined in 5 volunteers (group 1) after a single oral dose of 200 mg of chlormezanone with high performance liquid chromatography. A plasma elimination half-life of 23 +/- 2.3 h was calculated. The mean peak chlormezanone plasma level was 1.86 +/- 0.2 micrograms/ml, 1 h afte...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Köppel C,Kristinsson J,Wagemann A,Tenczer J,Martens F

更新日期：1991-01-01 00:00:00

abstract：:The present study reports findings on the disposition of epirubicin after an intrahepato-arterial administration of the Lipiodol-drug complex, prepared by mixing the drug-aqueous phase with the iodized oil by ultra-sonification, in 14 patients with histologically proven hepatoma or hepatomegaly with serum alpha-fetopr...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Lee K,Chan K,Leung WT,Leung NW,Ho S,Chan M,Lau CC,Tao M,Lau WY,Shiu W

更新日期：1992-07-01 00:00:00

abstract：:This paper deals with press-coated modified release tablets in which the drug dose is situated in the core or is divided between the core and the coat. The coat contains polymer (sodium alginate or hydroxypropylmethyl cellulose, HPMC) to control drug release. The main objective was to investigate how the pharmacokinet...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Halsas M,Ervasti P,Veski P,Jürjenson H,Marvola M

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Sorafenib is an oral, multikinase inhibitor with established single-agent activity in several tumor types. Sorafenib was moderately transported by P-glycoprotein (P-gp) and more efficiently by breast cancer resistance protein. The constitutive androstane receptor (CAR) is a ligand-activated tra...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Karbownik A,Stanisławiak-Rudowicz J,Stachowiak A,Romański M,Grześkowiak E,Szałek E

更新日期：2020-12-01 00:00:00

abstract：:The aim of the current investigation was to assess the ability GFJ to modulate the pharmacokinetic profile of paracetamol following single or repeated administrations of GFJ in Sprague-Dawley rats. Diclofenac and carbamazepine were both used as positive controls. Rats received single GFJ or single distilled water dose...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Qinna NA,Ismail OA,Alhussainy TM,Idkaidek NM,Arafat TA

更新日期：2016-04-01 00:00:00

abstract：:Chinese herbal medicines such as hawthorn, salvia, etc., are frequently combined with statins so as to treat cardiovascular diseases more effectively. Chinese herbal medicines contain many kinds of active components, which may have drug-drug interactions with statins. This study aims to explore the effect and mechanis...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hua WJ,Hua WX,Nan FY,Jiang WA,Yan C

更新日期：2014-09-01 00:00:00

abstract：:Torcetrapib was the lead candidate belonging to the class of cholesteryl ester transfer protein (CETP) inhibitor which was being developed for the management of cardiovascular risk factors by raising HDL. The availability of pharmacokinetic parameters (clearance: CL/F, volume of distribution: Vd/F, elimination rate co...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Mullangi R,Ahlawat P,Trivedi RK,Srinivas NR

更新日期：2009-01-01 00:00:00

abstract：:Apomorphine was administered subcutaneously and intranasally to 7 patients suffering from Parkinsonism with 'on-off' problems. This comparative pharmacokinetic study showed that the two routes of administration are comparable with respect to absorption kinetics. Apomorphine is rapidly absorbed when administered intran...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Sam E,Jeanjean AP,Maloteaux JM,Verbeke N

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hydronidone is a novel pyridine derivative with therapeutic potential for hepatic fibrosis. The aim of this study was to investigate the safety, tolerability, and pharmacokinetics of hydronidone in healthy subjects. Effects of sex and food on hydronidone pharmacokinetics were also evaluated. ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Liu Y,Wu J,Li Z,Luo Y,Zeng F,Shi S

更新日期：2017-02-01 00:00:00