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Pharmacokinetics of chlordesmethyldiazepam after single-dose oral administration in humans.

Abstract：

:The pharmacokinetics of chlordemethyldiazepam--a pharmacologically very active new 1,4-benzodiazepine derivative--in healthy subjects after administration of a single oral dose of 2 mg, was studied. Peak concentrations were reached in 1.2 +/- 0.2 hours. Plasma levels declined with a biphasic pattern, and the elimination phase had a half-life of 82.9 +/- 14.1 hours. The concentrations of the main metabolite of chlordemethyldiazepam, lorazepam, were about 7% of those of the parent compound. In urine only conjugated lorazepam could be found its 96 hour excretion reaching about 15% of the administered dose of parent drug.

journal_name

Eur J Drug Metab Pharmacokinet

journal_title

European journal of drug metabolism and pharmacokinetics

authors

Bareggi SR,Pirola R,Leva S,Zecca L

doi

10.1007/BF03189844

subject

Has Abstract

pub_date

1986-07-01 00:00:00

pages

171-4

issue

3

eissn

0378-7966

issn

2107-0180

journal_volume

11

pub_type

杂志文章

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