Bioequivalency evaluation by comparison of in vitro dissolution and in vivo absorption using reference equations.

abstract：:A new high performance liquid chromatographic procedure has been developed for the simultaneous quantification of piribedil (PD) and its three main basic metabolites in rat plasma and urine, without and after hydrolysis. The procedure relies on isolation of the compounds from plasma and urine constituents using the Se...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Sarati S,Caccia S

更新日期：1992-07-01 00:00:00

abstract：:Chlormezanone plasma concentrations were determined in 5 volunteers (group 1) after a single oral dose of 200 mg of chlormezanone with high performance liquid chromatography. A plasma elimination half-life of 23 +/- 2.3 h was calculated. The mean peak chlormezanone plasma level was 1.86 +/- 0.2 micrograms/ml, 1 h afte...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Köppel C,Kristinsson J,Wagemann A,Tenczer J,Martens F

更新日期：1991-01-01 00:00:00

abstract：:Although the application of medical marijuana and cannabinoid drugs is controversial, it is a part of modern-day medicine. The list of diseases in which cannabinoids are promoted as a treatment is constantly expanding. Cases of significant improvement in patients with a very poor prognosis of glioma or epilepsy have a...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hryhorowicz S,Walczak M,Zakerska-Banaszak O,Słomski R,Skrzypczak-Zielińska M

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Protein-calorie malnutrition (PCM) is one of the most suffered complications in cancer patients. Polyphyllin I (PPI), a saponin isolated from rhizome of Paris polyphylla, is a potential candidate in cancer therapy. In this study, the influence of nutritional status on the absorption of PPI in ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Yu FL,Gong WL,Xu FJ,Wu JW,Shakya S,Zhu H

更新日期：2018-10-01 00:00:00

abstract：:A multicompartmental pharmacokinetic model is presented, which based upon data from a previous study, describes the effects of ethanol (60 mM) on the metabolism of codeine (10 microM) in isolated rat hepatocytes. According to this model, about one third of codeine metabolized was transformed to morphine (13%) and norc...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Bodd E,Green MH,Drevon CA,Mørland J

更新日期：1986-07-01 00:00:00

abstract：:The development of peptide therapeutics has increased enormously in recent decades. Many of the peptide drugs and antibody fragments that lack Fc backbone have a short half-life in circulation. In general, the half-life supports the design of the dosing regimen and frequency of administration, which are key aspects in...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hijazi Y

更新日期：2021-01-01 00:00:00

abstract：:The pharmacokinetics of amiodarone was studied after single and multiple dosing in two groups of male Wistar and Albino rats. The first group (40 rats) received a single intraperitoneal (i.p.) dose of amiodarone (100 mg/kg) and 4 rats sacrificed 1, 2, 4, 6, 12, 18, 24, 36, 48 and 72 hours post dosing. The second group...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Najjar TA

更新日期：2000-07-01 00:00:00

abstract：:A bioequivalence study compares the bioavailability between a test and a reference drug product in terms of the rate and extent of drug absorption. Area under the plasma concentration-time curve (AUC) and maximum plasma concentration (Cmax) are the pharmacokinetic parameters that serve as characteristics for the asses...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zintzaras E,Bouka P

更新日期：1999-07-01 00:00:00

abstract：:The effects of aluminium, manganese, ferrous and ferric iron, cobalt, nickel, copper, zinc, cadmium, barium, mercury and lead ions on the rat hepatic UDPglucuronosyltransferase activity with regard to 4-methylumbelliferone, 4-nitrophenol, bilirubin, and 2-aminophenol were investigated in vitro. Conjugation of bilirubi...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Aitio A,Ahotupa M,Parkki MG

更新日期：1980-01-01 00:00:00

abstract：:Danirixin (GSK1325756) is a small, high-affinity, selective and reversible CXCR2 antagonist in development for treatment of chronic obstructive pulmonary disease. The objective of the study was to evaluate the relative bioavailability, including the inter-subject variability, of a conventional immediate-release (IR) f...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Miller BE,Smart K,Mistry S,Ambery CL,Bloomer JC,Connolly P,Sanderson D,Shreeves T,Smith R,Lazaar AL

更新日期：2014-09-01 00:00:00

abstract：:Parenteral phenytoin solution (Dilantin) was given rectally three times a day for three days to two beagle dogs. This was well tolerated, with no evidence of mucosal irritation noted either on endoscopic nor on rectal mucosal biopsy. When given in this manner, phenytoin is absorbed to a limited degree in canines. Pare...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Fuerst RH,Graves NM,Kriel RL,Olson R

更新日期：1988-10-01 00:00:00

abstract：:10 healthy lactating women were treated orally with the anthelmintic praziquantel (Biltricide), and the resulting timedependent concentrations of the unchanged substance in plasma and milk were determined simultaneously. 5 of the women ("1st trial") received the single dose of 50 mg/kg; the other 5 women ("2nd trial")...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Pütter J,Held F

更新日期：1979-01-01 00:00:00

abstract：:The present investigation was designed and undertaken in order to substantiate further contention concerning the universality of the utilization of PEG polymers as matrix carriers. This study could then be considered an attempt to enhance the dissolution rate of triamterene, with the subsequent enhancement in its abso...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Arias MJ,Gines JM,Moyano JR,Perez-Barrales MJ,Vela MT,Rabasco AM

更新日期：1994-10-01 00:00:00

abstract：:The hypoxic cell radiosensitizing drug, misonidazole (Miso) (Ro 07-0582) and its demethylated metabolite were administered to Wistar rats at different dose levels to examine their renal elimination. The data were consistent with a model in which Miso is eliminated mainly after biotransformation into desmethylmisonidaz...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Akel G,Canal P,Soula G

更新日期：1985-07-01 00:00:00

abstract：:The disposition of RS-tocainide in three healthy volunteers has been studied after oral administration of a pseudoracemic mixture containing S(+) [3H] tocainide as a radioactive tracer together with a therapeutic dose of the racemate. Analytical methods based on HPLC have been developed to measure S(+) and R(-) tocain...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hoffmann KJ,Renberg L,Bäärnhielm C

更新日期：1984-07-01 00:00:00

abstract：:The pharmacokinetics, biotransformation, protein binding and tissue distribution of mitonafide and pinafide were studied after single i.v. and oral administration of each drug (20 mg/Kg) in female rats. In pregnant rats a study of cross placental-barrier after i.v. administration of the two drugs was also performed. T...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Rivera Cid P,Gonzalez Fernandez E,Martin FR,Braña MF

更新日期：1986-10-01 00:00:00

abstract：:YM466, a novel factor Xa inhibitor, is a hydrophilic compound with a carboxylic acid moiety. Previous studies in rats have shown that YM466 does nor undergo metabolism but is excreted into the bile and urine in unchanged form. Thus, in this study, we investigated in vivo hepatobiliary transport, focusing in particular...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Mano Y,Usui T,Kamimura H

更新日期：2006-04-01 00:00:00

abstract：:A short review on some pharmacokinetic parameters (mean residence time, sojourn time, transit time) is given in relation to compartmental models and some examples and application are discussed. In particular the use of the sojourn time is suggested because this parameter can give useful informations when comparing the...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Segre G,Urso R

更新日期：1991-01-01 00:00:00

abstract：:Permeability coefficients of seven compounds belonging to a true homologous series (4-alkylanilines) through several different synthetic and biological membranes were assayed in a two-chamber diffusion cell. Permeability-lipophilicity relationships for the experimental data were established and compared in order to as...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Díez-Sales O,Guzmán D,Cano D,Martín A,Sánchez E,Herráez M

更新日期：1991-01-01 00:00:00

abstract：:In the last years there appeared many articles about the adverse influence of non-steroidal anti-inflammatory drugs on the liver and heart. This study is concerned with the influence of the duration of treatment with diclofenac and ketoprofen on the macroscopic and microscopic changes in the liver, lungs, heart, and k...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Tomic Z,Milijasevic B,Sabo A,Dusan L,Jakovljevic V,Mikov M,Majda S,Vasovic V

更新日期：2008-10-01 00:00:00

abstract：:The antioxidant potential of a new flavonic derivative named conventionally theophylline-rutoside [TR-1722] was estimated by the measurement of G-6-Pase activity (marker enzyme for the endoplasmic reticulum), catalase activity (enzyme involved in the antioxidant defence process), and total -SH groups from the hepatic ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Paduraru I,Saramet A,Danila G,Nichifor M,Jerca L,Iacobovici A,Ungureanu D,Filip M

更新日期：1996-01-01 00:00:00

abstract：:The activity of the molybdenum hydroxylase, aldehyde oxidase, was determined in crude homogenates and (NH4)2SO4 fractions prepared from guinea pig liver, lung, kidney, intestine, spleen and heart. Xanthine oxidase was also measured in (NH4)2SO4 fractions. In each case, xanthine oxidase levels were lower than those of ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Beedham C,Bruce SE,Rance DJ

更新日期：1987-10-01 00:00:00

abstract：:SC-46264 is an antagonist of the alpha 2-adrenergic receptor. Distribution and excretion of [14C]-SC-46264 were studied after single and repeated daily oral administrations to the Cynomolgus monkey at a 1.5 mg/kg dose. After a single oral administration, more than 95% of the administered dose was recovered within 48 h...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Jacqmin P,Hérin M,Cavalier R,Lesne M

更新日期：1993-07-01 00:00:00

abstract：:The aim of this study was to investigate the response of cortisol, insulin and lipid parameters [serum Lipoprotein Lipase activity, choleseryl-ester transfer protein, triglycerides, total Cholesterol, High Density Lipoprotein, Free Fatty Acids] during the perioperative period in obese patients undergoing laparoscopic ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Saranteas T,Voukena V,Zotos N,Stranomiti J,Kondadaki A,Tachmintzi A,Pantos C,Tesseromatis C,Dimitriou V

更新日期：2004-07-01 00:00:00

abstract：:Weibull function C = Bts-1exp(-lambda ts) was used to describe plasma concentration-time data of ribavirin in 6 healthy subjects following an i.v. dose of 600 mg. A good fit was found in each of the subjects, where the coefficients of determination r2 were > 0.99. The parameters estimated were as follows: B, 5.90 +/- ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Liu XD,Xie L,Han KQ,Liu GQ

更新日期：1996-07-01 00:00:00

abstract：:This paper deals with press-coated modified release tablets in which the drug dose is situated in the core or is divided between the core and the coat. The coat contains polymer (sodium alginate or hydroxypropylmethyl cellulose, HPMC) to control drug release. The main objective was to investigate how the pharmacokinet...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Halsas M,Ervasti P,Veski P,Jürjenson H,Marvola M

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Effective management of immunosuppressants is extemely important to improve prognosis of heart transplant recipients. We aim to investigate the effects of cytochrome P450 (CYP) 3A5 (rs776746) single nucleotide polymorphisms (SNPs) on serum tacrolimus concentrations/doses (C/Ds, ng/mL per mg/kg...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Liu BY,Chen WQ,Chen ZG,Huang J,Liao ZK,Liu Q,Zheng Z,Song YH,Wang W,Hu SS

更新日期：2019-12-01 00:00:00

abstract：:We studied the hepatic handling of bromosulfophthalein in healthy rabbits with hepatic coccidiosis 28 days after an experimental infection with sporulated oocysts of Eimeria stiedai, an experimental model of liver disease histopathologically resembling primary biliary cirrhosis in man. A pharmacokinetic study of the r...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Esteller A,Torres MD,Gomez-Bautista M,Mariño EL,Fernandez-Lastra C,Jimenez R

更新日期：1990-01-01 00:00:00

abstract：:The aim of this study was to investigate by HPLC the in vivo metabolism of 2-[1'-phenyl-3'-(3-chlorophenyl)-2'-propenylyden]hydrazino-3-methyl-4(3H)-quinazolinone as a substrate, and as a model compound in rats. The substrate was dissolved in DMSO/water (1:4) and administered intraperitoneally at a dose of 100 mg/kg i...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Kaymakçioğlu BK,Aktan Y,Süzen S,Gökhan N,Koyunoğlu S,Erol K,Yeşilada A,Rollas S

更新日期：2005-10-01 00:00:00

abstract：:Experimental evidence suggested that H2-receptor antagonists may inhibit not only hepatic but also adrenal cytochrome P-450 dependent monooxygenases. Therefore, the effects of ranitidine (150 mg b.i.d. over 14 days) on cortisol metabolism and antipyrine clearance have been investigated in nine healthy volunteers. Urin...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Mönig H,Hoffmann K,Ohnhaus EE,Schulte HM

更新日期：1992-01-01 00:00:00