Pharmacogenetics of Cannabinoids.

abstract：:A simple and sensitive HPLC method has been developed and validated for the determination of tyrosol galactoside (TG) in rat plasma. After one-step protein precipitation with methanol, plasma samples were separated on an Ultimate AQ-C18 column (150 mm×4.6 mm, 5 μm) using acetonitrile-water (7:93, v/v) as mobile phase ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Wang Q,Wang Y,Deng Y,Shi T,Liu X,Sun X,Li X,Zhou D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Mast cell-mediated allergic diseases are a significant global health problem. Nitric oxide (NO) produced by acute type 1 allergies greatly suppresses hepatic cytochrome P450 (CYP) metabolism. A recent in vitro study demonstrated that repeated FcεRI-mediated activation intrinsically modulates m...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Tanino T,Bando T,Okada Y,Nojiri Y,Hashimoto K,Ueda Y,Sakurai E

更新日期：2019-06-01 00:00:00

abstract：:Six healthy volunteers received the same oral dose of doxycycline, base (200 mg). Each received two of the three preparations at two-week intervals. Experimental results were interpreted on the basis of one or two-compartment models. The three preparations gave the elimination constants of the same order of magnitude ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Saux MC,Mosser J,Pontagnier H,Leng B

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hydronidone is a novel pyridine derivative with therapeutic potential for hepatic fibrosis. The aim of this study was to investigate the safety, tolerability, and pharmacokinetics of hydronidone in healthy subjects. Effects of sex and food on hydronidone pharmacokinetics were also evaluated. ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Liu Y,Wu J,Li Z,Luo Y,Zeng F,Shi S

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Ginseng is usually consumed as a dietary supplement for health care in the normal state or prescribed as a herbal medicine in pathologic conditions. Although metabolic studies of ginseng are commonly performed on healthy organisms, the metabolic characteristics in pathologic organisms remain un...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zhu JH,Xu JD,Zhou SS,Zhang XY,Zhou J,Kong M,Mao Q,Zhu H,Li SL

更新日期：2021-01-01 00:00:00

abstract：:Pharmacokinetics of recombinant human basic fibroblast growth factor (rhbFGF) in mice were studied by using a radioiodination method combined with sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and a sandwich enzyme-Linked immunosorbent assay (ELISA). RhbFGF concentration in serum were dertermine...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zhang Q,Wang GJ,Sun JG

更新日期：2004-07-01 00:00:00

abstract：:The MDR modulator, OC144-093, is a potential candidate for use in cancer therapy and exhibits potent biological activity in vitro and in vivo when combined with anticancer agents such as paclitaxel. Its inhibitory interaction with P-glycoprotein (Pgp), the mdr1 gene product and a mechanistic participant in multidrug r...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Guns ES,Denyssevych T,Dixon R,Bally MB,Mayer L

更新日期：2002-04-01 00:00:00

abstract：:The main objective of this study was to investigate the release and pharmacokinetic profiles of ketoprofen (KP) from developed thermosensitive and mucoadhesive liquid suppositories. Thermosensitive liquid suppositories were prepared using KP, poloxamer 407 (P 407), poloxamer 188 (P 188) and various amounts of differen...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ozgüney I,Kardhiqi A,Yıldız G,Ertan G

更新日期：2014-12-01 00:00:00

abstract：:The fate of Ticlopidine, a new inhibitor of platelet aggregation, has been studied in rats following single oral doses. The compound was quickly absorbed as evaluated by the time of the peak plasma concentration. The metabolism of Ticlopidine involved N-oxidation, cleavage of the N-C bond, oxidation of aliphatic carbo...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Tuong A,Bouyssou A,Paret J,Cuong TG

更新日期：1981-01-01 00:00:00

abstract：:Astragalus injection (AI) and Astragalus granules (AG) are the two representative clinical preparations from Astragali Radix. In order to investigate the regulation of metabolism, AI and AG were tested for their ability to affect the major enzyme cytochrome P450 3A isoforms in vivo and in vitro. In the study of CYP3A1...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zhang Y,Huang L,Bi H,Cui Y,Li J,Wang X,Qin X,Chen J,Huang M

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:UPARANT has emerged as a novel therapeutic agent with the potential to treat ocular diseases as assessed by studies in animal models. Since limited information is available on the pharmacokinetics of UPARANT, the aim of this study is to evaluate its pharmacokinetics after single and multiple a...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ciccone M,D'Alonzo D,Cangiano AM,De Fenza M,Pavone V,Mancinelli A

更新日期：2021-01-01 00:00:00

abstract：:BACKGROUND AND OBJECTIVE: Efavirenz is commonly used in Africa and is frequently associated with neurocognitive toxicity, which may compromise clinical outcomes. Older individuals are at increased risk for drug toxicity and clinical outcomes may be worse in older age, particularly among those individuals with cytochro...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Torgersen J,Bellamy SL,Ratshaa B,Han X,Mosepele M,Zuppa AF,Vujkovic M,Steenhoff AP,Bisson GP,Gross R

更新日期：2019-04-01 00:00:00

abstract：:Hepatic clearance of 3H-gitoxin was studied in the rabbit using an isolated perfused liver technique with an emulsion of a perfluorocarbon. The liposoluble material in the perfusion medium was extracted with dichloromethane, and gitoxin was assayed in the extract by high performance liquid chromatography. Pharmacokine...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Pellegrin PL,Lesne M

更新日期：1985-04-01 00:00:00

abstract：:The pharmacokinetics of chlordemethyldiazepam--a pharmacologically very active new 1,4-benzodiazepine derivative--in healthy subjects after administration of a single oral dose of 2 mg, was studied. Peak concentrations were reached in 1.2 +/- 0.2 hours. Plasma levels declined with a biphasic pattern, and the eliminati...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Bareggi SR,Pirola R,Leva S,Zecca L

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:LCZ696 (sacubitril/valsartan), a novel angiotensin receptor neprilysin inhibitor has been recently approved for the treatment of patients with heart failure (HF) and reduced ejection fraction. As several HF patients are likely to use statins as co-medications, the potential for a pharmacokineti...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ayalasomayajula S,Pan W,Han Y,Yang F,Langenickel T,Pal P,Zhou W,Yuan Y,Rajman I,Sunkara G

更新日期：2017-04-01 00:00:00

abstract：:A major biotransformation pathway for many NSAIDs from the group of optically active 2-arylpropionic acids is the conjugation with D-glucuronic acid, forming diastereomers. These conjugates of the S-(+)-and the R-(-)-enantiomers can be separated directly, e.g., by ion-pair chromatography on a C18-column using a mixtur...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Spahn H,Iwakawa S,Bevet LZ,Lin ET

更新日期：1987-10-01 00:00:00

abstract：:Hepatic transporters and metabolic enzymes affect drug pharmacokinetics. Limited information exists on the alteration in mRNA levels of hepatic transporters and metabolic enzymes with aging. We examined the effects of aging on the mRNA levels of representative hepatic drug transporters and metabolic enzymes by analyzi...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Kawase A,Ito A,Yamada A,Iwaki M

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:MTBH, a novel hesperetin derivative, possesses in vivo hepatoprotective effects against carbon tetrachloride (CCl4)-induced acute liver injury in Institute of Cancer Research (ICR) mice. OBJECTIVES:This study investigated the pharmacokinetics and tissue distribution of MTBH and its conjugated metabolites in...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Shen C,Qian Z,Chen R,Meng X,Hu T,Chen Z,Li Y,Huang C,Hu C,Li J

更新日期：2016-12-01 00:00:00

abstract：:Hyaluronic acid (HA), is a high molecular weight (HMW) glucosaminoglycan with significant acitivity, and which influences a number of physiological and pathological processes such as tumorogenesis, arthritis, etc. The aim of this study was to determine the difference in the biodistributional pathways of 111In-labeled ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Svanovsky E,Velebny V,Laznickova A,Laznicek M

更新日期：2008-07-01 00:00:00

abstract：:We retrospectively analyzed amikacin pharmacokinetics in 19 critically ill patients who received amikacin intravenously. Fourteen subjects (577 serum amikacin concentrations, 167 urine measurements) were studied to obtain data for population modeling, while 5 patients (267 serum amikacin concentrations, 68 urine measu...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Joubert P,Bressolle F,Gouby A,Douçot PY,Saissi G,Gomeni R

更新日期：1999-01-01 00:00:00

abstract：:The metabolism of (-)-(S)-nicotine has been investigated following intratracheal administration to the recirculating perfused rabbit lung model. The metabolic products present in the perfusate were identified by co-chromatography (HPLC and GC) with authentic standards and quantified by HPLC. After the 180 min perfusio...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Aislaitner G,Bello A,Tan SC,Hutt AJ,Marriott C,Gorrod JW

更新日期：1997-10-01 00:00:00

abstract：:Influence of two newly synthesized bile acids derivates, namely sodium salt of monoketocholic acid MKH-Na and methyl ester of monoketocholic acid MKH-Me on tramadol (12.5 mg/kg oral and intramuscular) analgesic effect was examined in this research. Analgesic effect was measured by antinociceptive hot plate method. Int...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Vasovic V,Vukmirovic S,Pjevic M,Mikov I,Mikov M,Jakovljevic V

更新日期：2010-09-01 00:00:00

abstract：:The dissolution kinetics of two solid and oral formulations of bezafibrate have been studied. These preparations are available in the Spanish market. Both of them are tablets, one conventional-release (A) and the other slow-release formulation (C). Dissolution studies have been performed using the system proposed by t...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Cadorniga R,Hernanez MT,Negro S,Burgos ML,Molina IT

更新日期：1991-01-01 00:00:00

abstract：:Binding of cefalotin to human serum albumin was studied in vitro by equilibrium dialysis and the quantitative measurement of cefalotin was made by fluorimetric assay. The binding rate of cefalotin to human serum albumin found to be 61,1%. The determination of drug binding parameters showed a large number of binding si...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Decroix MO,Chaumeil JC,Flouvat B

更新日期：1984-07-01 00:00:00

abstract：:The biotransformation of netobimin (NTB) pro-drug by ruminal, abomasal and intestinal fluids of sheep and cattle was investigated under anaerobic conditions in vitro. No metabolic conversion of NTB was observed upon incubation with abomasal fluid or boiled samples of different gastrointestinal fluids. NTB pro-drug was...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Lanusse CE,Nare B,Gascon LH,Prichard RK

更新日期：1992-04-01 00:00:00

abstract：:The liver first pass effect of pinazepam in four anaesthetized rabbits was determined by measuring the concentrations of this compound and those of its metabolite N-desmethyldiazepam in the plasma from the portal and hepatic veins. Anaesthesia was induced with an i.p. injection of urethane (1.5 g/kg). Portal and hepat...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Pacifici GM,Placidi GF

更新日期：1982-01-01 00:00:00

abstract：:The aim of this work was to study the influence of labelling on caffeine metabolism according to the incubation mode. It has been observed that labelling induces an isotopic effect on metabolisation speed: apparent half-lives are systematically increased. Moreover, isotopic effects are in agreement with those previous...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Benchekroun Y,Dautraix S,Desage M,Brazier JL

更新日期：1997-04-01 00:00:00

abstract：:Weibull function C = Bts-1exp(-lambda ts) was used to describe plasma concentration-time data of ribavirin in 6 healthy subjects following an i.v. dose of 600 mg. A good fit was found in each of the subjects, where the coefficients of determination r2 were > 0.99. The parameters estimated were as follows: B, 5.90 +/- ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Liu XD,Xie L,Han KQ,Liu GQ

更新日期：1996-07-01 00:00:00

abstract：:The effect of exogenous coenzyme Q10 (CoQ10) on the pharmacokinetic profiles and biliary excretion of doxorubicin and its main metabolites, doxorubicinol and doxorubicinolone, was investigated in rats. No statistically significant changes in the pharmacokinetic parameters of doxorubicin was observed following the intr...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zhou Q,Chowbay B

更新日期：2002-07-01 00:00:00

abstract：:The present investigation was designed and undertaken in order to substantiate further contention concerning the universality of the utilization of PEG polymers as matrix carriers. This study could then be considered an attempt to enhance the dissolution rate of triamterene, with the subsequent enhancement in its abso...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Arias MJ,Gines JM,Moyano JR,Perez-Barrales MJ,Vela MT,Rabasco AM

更新日期：1994-10-01 00:00:00