Improvement of the diuretic effect of triamterene via solid dispersion technique with PEG 4000.

abstract：:The disposition of RS-tocainide in three healthy volunteers has been studied after oral administration of a pseudoracemic mixture containing S(+) [3H] tocainide as a radioactive tracer together with a therapeutic dose of the racemate. Analytical methods based on HPLC have been developed to measure S(+) and R(-) tocain...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hoffmann KJ,Renberg L,Bäärnhielm C

更新日期：1984-07-01 00:00:00

abstract：:The disposition of dihydroergotamine methanesulfonate following single subcutaneous doses was studied in man and the rabbit using radiotracer techniques. 3H-Dihydroergotamine was almost immediately and completely absorbed from the injection site; peak blood radioactivity levels were attained within 1 h of drug adminis...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Tse FL,Jaffe JM

更新日期：1984-01-01 00:00:00

abstract：:The pharmacokinetics of midazolam and of its main metabolite, 1-hydroxymidazolam, were investigated in intensive care patients after intravenous bolus of 0.2 mg/kg followed by a 0.1 mg/kg/h intravenous infusion of midazolam over 2 hours. A wide interpatient variability of the main pharmacokinetic parameters of midazol...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Boulieu R,Lehmann B,Salord F,Fisher C,Morlet D

更新日期：1998-04-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) play an important role in the biotransformation of endogenous compounds and xenobiotics as well as in the metabolic inactivation of pharmacologically active substances, including anticancer drugs. Using cisplatin as the prototype drug, we investigated if any correlation exists between...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Nagar R,Khan AR,Poonia A,Mishra PK,Singh S

更新日期：2015-03-01 00:00:00

abstract：:The pharmacokinetics of amiodarone was studied after single and multiple dosing in two groups of male Wistar and Albino rats. The first group (40 rats) received a single intraperitoneal (i.p.) dose of amiodarone (100 mg/kg) and 4 rats sacrificed 1, 2, 4, 6, 12, 18, 24, 36, 48 and 72 hours post dosing. The second group...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Najjar TA

更新日期：2000-07-01 00:00:00

abstract：:Bioavailability of lansoprazole, a new gastric proton pump inhibitor, was investigated in 12 healthy subjects. Each subject received in random order, lansoprazole (30 mg) alone or associated with standard meal or with antacids (aluminium and magnesium hydroxides) or one hour later than antacids. Lansoprazole and metab...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Delhotal-Landes B,Cournot A,Vermerie N,Dellatolas F,Benoit M,Flouvat B

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:LCZ696 (sacubitril/valsartan), a novel angiotensin receptor neprilysin inhibitor has been recently approved for the treatment of patients with heart failure (HF) and reduced ejection fraction. As several HF patients are likely to use statins as co-medications, the potential for a pharmacokineti...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ayalasomayajula S,Pan W,Han Y,Yang F,Langenickel T,Pal P,Zhou W,Yuan Y,Rajman I,Sunkara G

更新日期：2017-04-01 00:00:00

abstract：:This study investigated the effect of a commercial preparation of stevioside and a synthetic compound, sodium salt of monketocholic acid (MKC), administered per os (p.o.) and also adminstered via an osmotic pump, on glycemia in normoglycemic and diabetic Wistar rats. Diabetes was induced with alloxan, 100 mg/kg, i.p. ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Rasković A,Mikov M,Skrbić R,Jakovljević V,Vasović V,Posa M,Kuhajda K,Kevresan S,Tomic Z,Siladji D

更新日期：2008-01-01 00:00:00

abstract：:The evaluation of new intranasal medications requires the development of in vitro cell model suitable for high-throughput screening studies. The aim of a pharmacological model is to closely mimic the barrier properties of human nasal mucosa that will influence drug pharmacokinetics. In this context, the human nasal ce...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Mercier C,Perek N,Delavenne X

更新日期：2018-02-01 00:00:00

abstract：:The disposition of a single 80 mg/kg injection of quinine base was compared in control and Plasmodium berghei-infected mice. Pharmacokinetic parameters were determined on repeated whole blood samples from caudal vein (experiment 1) and quinine distribution was evaluated in tissues and blood fractions from mice sacrifi...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Pussard E,Bernier A,Fouquet E,Bouree P

更新日期：2003-01-01 00:00:00

abstract：:The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various experimental conditions. The influence of agitation intensity and pH value of the dissolution medi...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Radovanović J,Durić Z,Jovanović M,Ibrić S,Petrović M

更新日期：1998-01-01 00:00:00

abstract：:A bioequivalence study compares the bioavailability between a test and a reference drug product in terms of the rate and extent of drug absorption. Area under the plasma concentration-time curve (AUC) and maximum plasma concentration (Cmax) are the pharmacokinetic parameters that serve as characteristics for the asses...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zintzaras E,Bouka P

更新日期：1999-07-01 00:00:00

abstract：:The purpose of this study was to determine the distribution of cyclosporin A (CsA) in various ocular fluids and tissues in the rabbit by two routes of administration. CsA was administered to two groups of two rabbits either by intramuscular route at a dose of 25 mg/kg/day or by local route using eyedrops, at a dose of...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Vernillet L,Lundh RL,Acezat-Mispelter F,Goizel C,Humbert H,Pouliquen Y

更新日期：1991-01-01 00:00:00

abstract：:Diabetes mellitus is becoming an increasingly prevalent disease that concerns patients and healthcare professionals worldwide. Among many anti-diabetic agents in clinical uses, numerous reports are available on their altered pharmacokinetics because of changes in the expression of drug transporters and metabolic enzym...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ma L,He L,Wang L,Li L,Lin X,Pan G

更新日期：2016-06-01 00:00:00

abstract：:IdB 1016 is a complex of silybin (the main active component of silymarin) and phosphatidylcholine, which in animal models shows greater oral bioavailability and therefore greater pharmacological activity compared with pure silybin and silymarin. In order to assess its pharmacokinetic profile in man, plasma silybin lev...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Barzaghi N,Crema F,Gatti G,Pifferi G,Perucca E

更新日期：1990-10-01 00:00:00

abstract：:The effects of aluminium, manganese, ferrous and ferric iron, cobalt, nickel, copper, zinc, cadmium, barium, mercury and lead ions on the rat hepatic UDPglucuronosyltransferase activity with regard to 4-methylumbelliferone, 4-nitrophenol, bilirubin, and 2-aminophenol were investigated in vitro. Conjugation of bilirubi...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Aitio A,Ahotupa M,Parkki MG

更新日期：1980-01-01 00:00:00

abstract：:Benzo[alpha]pyrene (B[a]P) is a product derived from incomplete combustion of organic material and is considered responsible for chemically-induced cancer in humans. In the present study, the levels of noradrenaline (NA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 5-hydroxytryptamine (...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Stephanou P,Konstandi M,Pappas P,Marselos M

更新日期：1998-10-01 00:00:00

abstract：:Fucithalmic is a newly developed 1% microcrystalline suspension of the antistaphylococcal antibiotic fusidic acid. Penetration into the eye was investigated in twenty patients about to undergo cataract extraction. A single dose produced median antibiotic levels in the aqueous humour of 0.3 mcg/ml, maintained for at le...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hansen S

更新日期：1985-10-01 00:00:00

abstract：:The influence of Tamarindus indica L fruit extract incorporated in a traditional meal on the bioavailability of Ibuprofen tablets 400 mg dose when given concurrently was studied in 6 healthy human volunteers. There was a statistically significant increase in the plasma levels of Ibuprofen and its metabolites hydroxy-i...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Garba M,Yakasai IA,Bakare MT,Munir HY

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Even though lithium has been used for the treatment of bipolar disorder for several decades, its toxicities are still being reported. The major limitation in the use of lithium is its narrow therapeutic window. Several methods have been proposed to predict lithium doses essential to attain the...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Methaneethorn J

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Acetaminophen (APAP, paracetamol) is currently the principal cause of acute liver failure in both the USA and the UK. However, relatively little is known about the influence of genes and race/ethnicity on the disposition of APAP and the extent to which genetic variation and ethnicity may predi...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zurlinden TJ,Reisfeld B

更新日期：2017-02-01 00:00:00

abstract：:10 healthy lactating women were treated orally with the anthelmintic praziquantel (Biltricide), and the resulting timedependent concentrations of the unchanged substance in plasma and milk were determined simultaneously. 5 of the women ("1st trial") received the single dose of 50 mg/kg; the other 5 women ("2nd trial")...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Pütter J,Held F

更新日期：1979-01-01 00:00:00

abstract：:Changes in liver perfusion may have a substantial influence on the pharmacokinetics of drugs with flow-controlled metabolism. This may have important implications for drug dosage in patients in an intensive care unit (ICU). The hepatic D-sorbitol plasma clearance has been suggested as a non-invasive test for evaluatin...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Köppel C,Pohle S,Müller C

更新日期：1993-10-01 00:00:00

abstract：:Angiogenesis is integral to tumour growth and invasion, and is a key target for cancer therapeutics. However, for many of the licensed indications, only a modest clinical benefit has been observed for both monoclonal antibody and small-molecule tyrosine kinase inhibitor anti-angiogenic therapy. Pre-clinical and clinic...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Morotti M,Dass PH,Harris AL,Lord S

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Experimental determination of a drug's oral bioavailability in humans is cost and time consuming; therefore, is usually performed on preclinical animals. It is believed that animal data are predictive of human data; however, there are some doubts regarding the reliability of this concept. The aim of this stu...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Beheshti S,Shayanfar A

更新日期：2020-12-01 00:00:00

abstract：:The aim of this study was to investigate by HPLC the in vivo metabolism of 2-[1'-phenyl-3'-(3-chlorophenyl)-2'-propenylyden]hydrazino-3-methyl-4(3H)-quinazolinone as a substrate, and as a model compound in rats. The substrate was dissolved in DMSO/water (1:4) and administered intraperitoneally at a dose of 100 mg/kg i...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Kaymakçioğlu BK,Aktan Y,Süzen S,Gökhan N,Koyunoğlu S,Erol K,Yeşilada A,Rollas S

更新日期：2005-10-01 00:00:00

abstract：:The detection and the isolation in phenobarbital-induced rat liver microsomal incubation systems of a new metabolite of benzo(a)pyrene are described. The structure of this metabolite and the way in which it is formed are described. ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Lhoëst G

更新日期：1980-01-01 00:00:00

abstract：:Permeability coefficients of seven compounds belonging to a true homologous series (4-alkylanilines) through several different synthetic and biological membranes were assayed in a two-chamber diffusion cell. Permeability-lipophilicity relationships for the experimental data were established and compared in order to as...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Díez-Sales O,Guzmán D,Cano D,Martín A,Sánchez E,Herráez M

更新日期：1991-01-01 00:00:00

abstract：:The kinetics of five cisplatin analogs binding to human plasma fractions possessing a molecular weight greater than 50,000 daltons were studied. Each drug solution in plasma ultrafiltrate or phosphate buffer (pH = 7.4, mu = 0.154) was mixed with human plasma and filterable platinum concentrations were measured versus ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Momburg R,Bourdeaux M,Sarrazin M,Roux F,Briand C

更新日期：1985-01-01 00:00:00

abstract：:Danirixin (GSK1325756) is a small, high-affinity, selective and reversible CXCR2 antagonist in development for treatment of chronic obstructive pulmonary disease. The objective of the study was to evaluate the relative bioavailability, including the inter-subject variability, of a conventional immediate-release (IR) f...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Miller BE,Smart K,Mistry S,Ambery CL,Bloomer JC,Connolly P,Sanderson D,Shreeves T,Smith R,Lazaar AL

更新日期：2014-09-01 00:00:00