Differences in Intestinal Metabolism of Ginseng Between Normal and Immunosuppressed Rats.

abstract：BACKGROUND:Aldehyde oxidase (AOX) is an important molybdenum-containing enzyme with high similarity with xanthine oxidase (XO). AOX involved in the metabolism of a large array of aldehydes and N-heterocyclic compounds and its activity is highly substrate-dependent. OBJECTIVES:The aim of this work was to study the effe...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Deris-Abdolahpour F,Abdolalipouran-Sadegh L,Dastmalchi S,Hamzeh-Mivehroud M,Zarei O,Dehgan G,Rashidi MR

更新日期：2019-04-01 00:00:00

abstract：:A comparative bioavailability study was undertaken between a new formulation of rifampicin 'Famcin' and a standard formulation of rifampicin 'R-cin' in eight healthy male volunteers at two dose levels: 300 mg and 450 mg given orally under both single dose and steady state conditions. Plasma rifampicin was assayed spec...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Garg SK,Chakrabarti A,Panigrahi D,Sharma M,Talwar P,Kumar N,Sharma PL

更新日期：1991-07-01 00:00:00

abstract：:Currently, macromolecular drugs such as proteins are mainly administered by means of injections due to their low intestinal epithelial permeability and poor stability in the gastrointestinal tract. This study investigated binary combinations of chemical drug absorption enhancers to determine if synergistic drug absorp...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： du Toit T,Malan MM,Lemmer HJ,Gouws C,Aucamp ME,Breytenbach WJ,Hamman JH

更新日期：2016-10-01 00:00:00

abstract：:The detection and the isolation in phenobarbital-induced rat liver microsomal incubation systems of a new metabolite of benzo(a)pyrene are described. The structure of this metabolite and the way in which it is formed are described. ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Lhoëst G

更新日期：1980-01-01 00:00:00

abstract：:The disposition kinetics of the N-oxide of picobenzide were studied after administration to rabbits at a bolus dose of 30 mg/kg of picobenzide intravenously. The biotransformation process fits a first-order kinetic process, and the metabolite shows good access capacity to the peripheral compartment. The N-oxide of pic...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Santos Buelga D,Mariño EL,Domínguez-Gil A

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Omadacycline is a semisynthetic aminomethylcycline antibacterial derived from the tetracycline class. It is approved in the USA to treat adults with acute bacterial skin and skin-structure infections and community-acquired bacterial pneumonia. OBJECTIVES:This phase I, open-label study evaluated the effect o...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hunt TL,Tzanis E,Bai S,Manley A,Chitra S,McGovern PC

更新日期：2021-01-01 00:00:00

abstract：:Danirixin (GSK1325756) is a small, high-affinity, selective and reversible CXCR2 antagonist in development for treatment of chronic obstructive pulmonary disease. The objective of the study was to evaluate the relative bioavailability, including the inter-subject variability, of a conventional immediate-release (IR) f...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Miller BE,Smart K,Mistry S,Ambery CL,Bloomer JC,Connolly P,Sanderson D,Shreeves T,Smith R,Lazaar AL

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Lidocaine 5% medicated plaster is the first lidocaine containing product for chronic use. As no previous investigations have been conducted to evaluate the population pharmacokinetics of long-term exposure to lidocaine 5% medicated plasters, further insights into the evaluation of the pharmaco...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Bursi R,Piana C,Grevel J,Huntjens D,Boesl I

更新日期：2017-10-01 00:00:00

abstract：:Pharmacokinetics of recombinant human basic fibroblast growth factor (rhbFGF) in mice were studied by using a radioiodination method combined with sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and a sandwich enzyme-Linked immunosorbent assay (ELISA). RhbFGF concentration in serum were dertermine...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zhang Q,Wang GJ,Sun JG

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Polyethylene glycol-modified canine uricase (PEG-UHC) prepared with a lower-molecular-weight (5 kDa) PEG is used to treat gout. This study investigated the comparative pharmacokinetics of single and multiple doses of PEG-UHC administered intravenously and a single dose of uricase (UHC) administ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Li H,Huo J,Sun D,Jiang L,Hu C,Bai Y,Ma X,Zhang H,Shi X,Zhao Z,Zhou J,Lu Y,Zhang C

更新日期：2020-08-01 00:00:00

abstract：:Tritiated tetrahydro-tetramethyl-naphthalenyl-propenyl benzoic acid (TTNPB; Ro 13-7410) was administered as a single oral bolus to pregnant hamsters (day 8) to determine the maternal plasma pharmacokinetic profile and peripheral tissue distribution patterns. Blood and tissue, including embryo or fetus, were collected ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Howard WB,Willhite CC,Sharma RP,Omaye ST,Hatori A

更新日期：1989-04-01 00:00:00

abstract：:Chlormezanone plasma concentrations were determined in 5 volunteers (group 1) after a single oral dose of 200 mg of chlormezanone with high performance liquid chromatography. A plasma elimination half-life of 23 +/- 2.3 h was calculated. The mean peak chlormezanone plasma level was 1.86 +/- 0.2 micrograms/ml, 1 h afte...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Köppel C,Kristinsson J,Wagemann A,Tenczer J,Martens F

更新日期：1991-01-01 00:00:00

abstract：:The technique of differential display reverse transcription-polymerase chain reaction (ddRT-PCR) has been used to produce unique profiles of up-regulated and down-regulated gene expression in the liver of male Wistar rats following short term exposure to the non-genotoxic hepatocarcinogens, phenobarbital and WY-14,643...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Rockett JC,Esdaile DJ,Gibson GG

更新日期：1997-10-01 00:00:00

abstract：:The kinetics of five cisplatin analogs binding to human plasma fractions possessing a molecular weight greater than 50,000 daltons were studied. Each drug solution in plasma ultrafiltrate or phosphate buffer (pH = 7.4, mu = 0.154) was mixed with human plasma and filterable platinum concentrations were measured versus ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Momburg R,Bourdeaux M,Sarrazin M,Roux F,Briand C

更新日期：1985-01-01 00:00:00

abstract：:Cytochrome P450-dependent enzymes from wheat catalyze the oxidation of endogenous compounds (lauric and oleic acids) and of several herbicides (diclofop, chlortoluron, bentazon). Treatment of wheat seedlings with the safener, naphthalic anhydride and with phenobarbital increases dramatically several P450-dependent enz...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Forthoffer N,Helvig C,Dillon N,Benveniste I,Zimmerlin A,Tardif F,Salaün JP

更新日期：2001-01-01 00:00:00

abstract：:The development of peptide therapeutics has increased enormously in recent decades. Many of the peptide drugs and antibody fragments that lack Fc backbone have a short half-life in circulation. In general, the half-life supports the design of the dosing regimen and frequency of administration, which are key aspects in...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hijazi Y

更新日期：2021-01-01 00:00:00

abstract：:The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various experimental conditions. The influence of agitation intensity and pH value of the dissolution medi...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Radovanović J,Durić Z,Jovanović M,Ibrić S,Petrović M

更新日期：1998-01-01 00:00:00

abstract：:The effect of silymarin (SMN) on the pharmacokinetics of atorvastatin in diabetic rats was evaluated. Male Wistar rats were assigned into two major groups and then sub-grouped according to the purposes of the study. The first major group was subdivided into three groups (n = 6) including control, non-treated diabetic ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Malekinejad H,Rokhsartalab-Azar S,Hassani-Dizaj S,Alizadeh-Fanalou S,Rezabakhsh A,Amniattalab A

更新日期：2014-12-01 00:00:00

abstract：:The liver first pass effect of pinazepam in four anaesthetized rabbits was determined by measuring the concentrations of this compound and those of its metabolite N-desmethyldiazepam in the plasma from the portal and hepatic veins. Anaesthesia was induced with an i.p. injection of urethane (1.5 g/kg). Portal and hepat...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Pacifici GM,Placidi GF

更新日期：1982-01-01 00:00:00

abstract：:Binding of cefalotin to human serum albumin was studied in vitro by equilibrium dialysis and the quantitative measurement of cefalotin was made by fluorimetric assay. The binding rate of cefalotin to human serum albumin found to be 61,1%. The determination of drug binding parameters showed a large number of binding si...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Decroix MO,Chaumeil JC,Flouvat B

更新日期：1984-07-01 00:00:00

abstract：:Urodynamic model was developed which, in conjunction with a compartmental pharmacokinetic model, was used for study of factors influencing drug concentrations in urine: urine flow rate, residual bladder urine, maximal bladder urine, stage of renal failure, and elimination kinetics of drugs. Norfloxacin (NOR) was used ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Primozic S,Karba R,Mrhar A,Drinovec J,Kozjek F

更新日期：1991-01-01 00:00:00

abstract：:A multicompartmental pharmacokinetic model is presented, which based upon data from a previous study, describes the effects of ethanol (60 mM) on the metabolism of codeine (10 microM) in isolated rat hepatocytes. According to this model, about one third of codeine metabolized was transformed to morphine (13%) and norc...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Bodd E,Green MH,Drevon CA,Mørland J

更新日期：1986-07-01 00:00:00

abstract：:The in vivo assessment of percutaneous absorption of molecules is a very important step in the evaluation of any transdermal drug delivery system and a key goal in the design and optimization of transdermal dosage forms lies in understanding the factors that determine a good in vivo performance. The objective of the p...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Swain K,Pattnaik S,Yeasmin N,Mallick S

更新日期：2011-12-01 00:00:00

abstract：:Metoprolol Oros tablets were designed to deliver their drug content as a constant rate over a period of time longer than that currently recorded with slow-release dosage forms. The bioavailability of 7/95, 14/190 and 21/285 Oros tablets was compared to that of either 100 mg conventional or 200 mg slow-release Lopresor...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Richard J,Cardot JM,Godbillon J

更新日期：1994-10-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) play an important role in the biotransformation of endogenous compounds and xenobiotics as well as in the metabolic inactivation of pharmacologically active substances, including anticancer drugs. Using cisplatin as the prototype drug, we investigated if any correlation exists between...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Nagar R,Khan AR,Poonia A,Mishra PK,Singh S

更新日期：2015-03-01 00:00:00

abstract：:In a single dose, randomized, cross-over study, with one week of wash-out period, the relative bioavailability of Dopegyt tablets containing 250 mg alpha-methyldopa (AMD) and Presinol film tablets with identical active ingredient content was examined in 24 healthy volunteers. Since technologically two completely diffe...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Róna K,Ary K,Renczes G,Gachályi B,Grézal GY,Drabant S,Klebovich I

更新日期：2001-01-01 00:00:00

abstract：:The metabolic fate of anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043) was studied in rats after oral administration. An average of 12.2 +/- 1.5% of the dose was excreted in the urine in the course of 0-48 h; 56.7 +/- 2.6% with feces. Two metabolites were also detected in the urine and isolated b...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Caputo O,Grosa G,Ceruti M,Viola F,Rocco F

更新日期：1989-10-01 00:00:00

abstract：:Sertraline potently inhibits cytochrome P450 2B6 (CYP2B6) in vitro. Bupropion is commonly co-prescribed with sertraline and is exclusively metabolized by CYP2B6 to its major active metabolite hydroxybupropion. Putatively the co-administration of bupropion and sertraline could lead to a significant pharmacokinetic drug...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Molnari JC,Hassan HE,Myers AL

更新日期：2012-03-01 00:00:00

abstract：:We studied the pharmacokinetics of moguisteine, a racemic non-narcotic peripheral antitussive drug, in 12 healthy male subjects after a single oral administration of 200 mg. The unchanged drug was absent in plasma and urine of all subjects. Moguisteine was immediately and completely hydrolyzed to its main active metab...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Bernareggi A,Crema A,Carlesi RM,Castoldi D,Ratti E,Renoldi MI,Ratti D,Ceserani R,Tognella S

更新日期：1995-10-01 00:00:00

abstract：:Fluvastatin (FV), a new cholesterol-lowering agent, has been studied for its effects on hepatic microsomal drug-metabolizing enzymes in male rats. FV was orally administered in dosages of 1, 5, and 30 mg/kg/day for 7 consecutive days. 3-Hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase activities were markedly decrease...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ohtawa M,Masuda N,Karasawa Y,Tojo H

更新日期：1995-07-01 00:00:00