Stable isotope methodology for studying the performance of metoprolol Oros tablets in comparison to conventional and slow release formulations.

abstract：BACKGROUND AND OBJECTIVES:Protein-calorie malnutrition (PCM) is one of the most suffered complications in cancer patients. Polyphyllin I (PPI), a saponin isolated from rhizome of Paris polyphylla, is a potential candidate in cancer therapy. In this study, the influence of nutritional status on the absorption of PPI in ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Yu FL,Gong WL,Xu FJ,Wu JW,Shakya S,Zhu H

更新日期：2018-10-01 00:00:00

abstract：:Blood loss during cesarean section was calculated based on post-operative decrement of hemoglobin (Hb) and hematocrit (Hct) level. The model used for pregnant women was previously validated for non-pregnant women who underwent gynecological surgery. 1,068 pregnant women who underwent cesarean section and 517 women who...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Milosevic N,Popovic J,Grujic Z,Rapaic M

更新日期：2011-09-01 00:00:00

abstract：:The purpose of this study was to determine the distribution of cyclosporin A (CsA) in various ocular fluids and tissues in the rabbit by two routes of administration. CsA was administered to two groups of two rabbits either by intramuscular route at a dose of 25 mg/kg/day or by local route using eyedrops, at a dose of...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Vernillet L,Lundh RL,Acezat-Mispelter F,Goizel C,Humbert H,Pouliquen Y

更新日期：1991-01-01 00:00:00

abstract：:Monoclonal antibodies are capable of modulating drug metabolising enzymes resulting in unexpected plasma concentrations of a drug when given concomitantly. Therefore plasma concentration of paclitaxel (PTX) and its metabolites has been monitored in 10 patients with advanced breast cancer during treatment with PTX alon...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Furtlehner A,Schueller J,Jarisch I,Ostermann E,Czejka M

更新日期：2005-07-01 00:00:00

abstract：:The effect of exogenous coenzyme Q10 (CoQ10) on the pharmacokinetic profiles and biliary excretion of doxorubicin and its main metabolites, doxorubicinol and doxorubicinolone, was investigated in rats. No statistically significant changes in the pharmacokinetic parameters of doxorubicin was observed following the intr...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zhou Q,Chowbay B

更新日期：2002-07-01 00:00:00

abstract：:The aim of this study was to investigate by HPLC the in vivo metabolism of 2-[1'-phenyl-3'-(3-chlorophenyl)-2'-propenylyden]hydrazino-3-methyl-4(3H)-quinazolinone as a substrate, and as a model compound in rats. The substrate was dissolved in DMSO/water (1:4) and administered intraperitoneally at a dose of 100 mg/kg i...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Kaymakçioğlu BK,Aktan Y,Süzen S,Gökhan N,Koyunoğlu S,Erol K,Yeşilada A,Rollas S

更新日期：2005-10-01 00:00:00

abstract：:Influence of two newly synthesized bile acids derivates, namely sodium salt of monoketocholic acid MKH-Na and methyl ester of monoketocholic acid MKH-Me on tramadol (12.5 mg/kg oral and intramuscular) analgesic effect was examined in this research. Analgesic effect was measured by antinociceptive hot plate method. Int...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Vasovic V,Vukmirovic S,Pjevic M,Mikov I,Mikov M,Jakovljevic V

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Omadacycline is a semisynthetic aminomethylcycline antibacterial derived from the tetracycline class. It is approved in the USA to treat adults with acute bacterial skin and skin-structure infections and community-acquired bacterial pneumonia. OBJECTIVES:This phase I, open-label study evaluated the effect o...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hunt TL,Tzanis E,Bai S,Manley A,Chitra S,McGovern PC

更新日期：2021-01-01 00:00:00

abstract：:The metabolic fate of the anti-Parkinsonian drug budipine was studied in rats after oral administration. The presence of an aromatic hydroxylation product, metabolite M1, and its O-sulphate conjugate was confirmed. Three new minor metabolites, budipine N-oxide, metabolite M1 N-oxide and a secondary metabolite derived ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Caputo O,Grosa G,Ceruti M,Rocco F,Biglino G

更新日期：1991-04-01 00:00:00

abstract：:The disposition of dihydroergotamine methanesulfonate following single subcutaneous doses was studied in man and the rabbit using radiotracer techniques. 3H-Dihydroergotamine was almost immediately and completely absorbed from the injection site; peak blood radioactivity levels were attained within 1 h of drug adminis...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Tse FL,Jaffe JM

更新日期：1984-01-01 00:00:00

abstract：:The pharmacokinetic-pharmacodynamic (PK-PD) relationship of the proton pump inhibitor rabeprazole in healthy Chinese volunteers was characterized via a population approach. Healthy Chinese male volunteers were enrolled in the clinical trial. Subjects were divided into three groups by their CYP2C19 genotype. Serum conc...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Chen ZY,Xie HT,Zheng QS,Sun RY,Hu G

更新日期：2006-01-01 00:00:00

abstract：:Chinese herbal medicines such as hawthorn, salvia, etc., are frequently combined with statins so as to treat cardiovascular diseases more effectively. Chinese herbal medicines contain many kinds of active components, which may have drug-drug interactions with statins. This study aims to explore the effect and mechanis...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hua WJ,Hua WX,Nan FY,Jiang WA,Yan C

更新日期：2014-09-01 00:00:00

abstract：:Weibull function C = Bts-1exp(-lambda ts) was used to describe plasma concentration-time data of ribavirin in 6 healthy subjects following an i.v. dose of 600 mg. A good fit was found in each of the subjects, where the coefficients of determination r2 were > 0.99. The parameters estimated were as follows: B, 5.90 +/- ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Liu XD,Xie L,Han KQ,Liu GQ

更新日期：1996-07-01 00:00:00

abstract：:Cytochrome P450 from rat brain mitochondrial and microsomal fractions was found to be inducible by 3-methylcholanthrene, both in quantity of enzyme and in activity towards 7-ethoxyresorufin, which is a model substrate for the cytochrome P450 isoform specifically induced by 3-methylcholanthrene. Conversely, a phenobarb...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ghersi-Egea JF,Walther B,Perrin R,Minn A,Siest G

更新日期：1987-10-01 00:00:00

abstract：:The dissolution kinetics of two solid and oral formulations of bezafibrate have been studied. These preparations are available in the Spanish market. Both of them are tablets, one conventional-release (A) and the other slow-release formulation (C). Dissolution studies have been performed using the system proposed by t...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Cadorniga R,Hernanez MT,Negro S,Burgos ML,Molina IT

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The antitumor activity and toxicity of doxorubicin are potentiated and attenuated by calcitriol, respectively. Potentially, calcitriol can be combined with doxorubicin for clinical benefit in chemotherapy. To gain insight into the interaction between doxorubicin and calcitriol, proposed for com...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Durna Corum D,Uney K

更新日期：2020-10-01 00:00:00

abstract：:The cardioselective beta-adrenergic blocking drug Visacor (ICI 141,292) was dosed to six beagle dogs in a randomized cross-over manner. Five formulations were examined i.e. a 15 mg/kg intravenous solution, a 50 mg/kg oral solution, and 50, 100 and 200 mg/kg oral powder formulations. Whole blood and urine samples were ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： McAinsh J,Smith RP,Ferguson RA

更新日期：1984-04-01 00:00:00

abstract：:A rapid and sensitive procedure is described for the quantitation of levamisole in plasma using high-performance liquid chromatography (HPLC). The procedure involves sample preparation using a reverse-phase C18 cartridge prior to chromatography and quantitation using peak area ratios (UV absorbance detection, 225 nm) ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Vandamme TF,Demoustier M,Rollmann B

更新日期：1995-04-01 00:00:00

abstract：:The transdermally applied dopamine receptor agonist rotigotine is extensively metabolized in the liver. An open-label, parallel-group study was conducted to evaluate the effects of moderate hepatic impairment on the pharmacokinetics, safety and tolerability of rotigotine. Eight subjects with normal hepatic function an...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Cawello W,Fichtner A,Boekens H,Braun M

更新日期：2014-09-01 00:00:00

abstract：:The metabolism of pentobarbitone has been investigated in two healthy volunteers, and the urinary excretion of unchanged drug, and the products of omega- and (omega-1)-oxidation, quantified for four days after each of three doses to each volunteer. The rates of excretion are discussed in terms which include enzyme ind...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Baldeo WC,Gilbert JN,Powell JW

更新日期：1980-01-01 00:00:00

abstract：:The liver first pass effect of pinazepam in four anaesthetized rabbits was determined by measuring the concentrations of this compound and those of its metabolite N-desmethyldiazepam in the plasma from the portal and hepatic veins. Anaesthesia was induced with an i.p. injection of urethane (1.5 g/kg). Portal and hepat...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Pacifici GM,Placidi GF

更新日期：1982-01-01 00:00:00

abstract：:Two positional iodine derivatives of benzoic acid, i.e. ortho- (OIB) and para- (PIB), were used alone and in combination with salicylic acid (SA) to study the effects of plasma binding on their pharmacokinetics. Their lymphatic bioavailability (central lymph), their biotransformation and urinary excretion in rats were...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Lamka J,Láznícek M,Gallová S,Rudisar L,Kvĕtina J

更新日期：1993-07-01 00:00:00

abstract：:Microcomputers have been used in pharmacokinetics for several years, but their use in the area of formulation is a new application. By using appropriate data on the drug, the dosage form required and its mechanism of absorption and clearance, microcomputers can systematize and speed-up formulation, simplify manufactur...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Aiache JM,Turlier M,Tanguy A

更新日期：1984-04-01 00:00:00

abstract：:For many drugs administered per os, high variability in the concentration-time (C-T) values from first sampling to the phase of distribution may cause difficulty in pharmacokinetic analysis. Therefore, the aim of this study was to propose a method of transformation of C-T data, which would allow significantly reducing...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Grabowski T,Jaroszewski JJ,Piotrowski W,Sasinowska-Motyl M

更新日期：2014-06-01 00:00:00

abstract：:BACKGROUND AND OBJECTIVE: Efavirenz is commonly used in Africa and is frequently associated with neurocognitive toxicity, which may compromise clinical outcomes. Older individuals are at increased risk for drug toxicity and clinical outcomes may be worse in older age, particularly among those individuals with cytochro...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Torgersen J,Bellamy SL,Ratshaa B,Han X,Mosepele M,Zuppa AF,Vujkovic M,Steenhoff AP,Bisson GP,Gross R

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In the present work, pharmacological and pharmacokinetic properties of the supramolecular complex of non-steroid anti-inflammatory drug ibuprofen (IBU) with natural polysaccharide arabinogalactan (AG) were studied. The main goals of such complexation were the increase of ibuprofen's bioavailab...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Khvostov MV,Borisov SA,Tolstikova TG,Dushkin AV,Tsyrenova BD,Chistyachenko YS,Polyakov NE,Dultseva GG,Onischuk AA,An'kov SV

更新日期：2017-06-01 00:00:00

abstract：:A comparative bioavailability study was undertaken between a new formulation of rifampicin 'Famcin' and a standard formulation of rifampicin 'R-cin' in eight healthy male volunteers at two dose levels: 300 mg and 450 mg given orally under both single dose and steady state conditions. Plasma rifampicin was assayed spec...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Garg SK,Chakrabarti A,Panigrahi D,Sharma M,Talwar P,Kumar N,Sharma PL

更新日期：1991-07-01 00:00:00

abstract：:Penbutolol is a not cardioselective beta-adrenergic blocking drug; it is lipid soluble and differs in its protein binding from the other members of its group because shows linkage to alpha 1-glycoprotein, with no detectable binding to albumin. AAG levels change during pregnancy and so the binding of [3H]-penbutolol wa...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Aquirre C,Rodriguez-Sasiain JM,Navajas P,Calvo R

更新日期：1988-01-01 00:00:00

abstract：:The antioxidant potential of a new flavonic derivative named conventionally theophylline-rutoside [TR-1722] was estimated by the measurement of G-6-Pase activity (marker enzyme for the endoplasmic reticulum), catalase activity (enzyme involved in the antioxidant defence process), and total -SH groups from the hepatic ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Paduraru I,Saramet A,Danila G,Nichifor M,Jerca L,Iacobovici A,Ungureanu D,Filip M

更新日期：1996-01-01 00:00:00

abstract：:The kinetics of the nootropic drug oxiracetam was studied in 6 elderly female patients (age range 69-96 years) in good physical condition. After a single oral dose (800 mg), serum oxiracetam levels reached a peak (25 +/- 6 micrograms/ml) within 1-3 h and declined thereafter with a half-life of 3 to 6 h. Eighty-four pe...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Perucca E,Parini J,Albrici A,Visconti M,Ferrero E

更新日期：1987-04-01 00:00:00