Antioxidant action of a new flavonic derivative in acute carbon tetrachloride intoxication.

abstract：:Fluvastatin (FV), a new cholesterol-lowering agent, has been studied for its effects on hepatic microsomal drug-metabolizing enzymes in male rats. FV was orally administered in dosages of 1, 5, and 30 mg/kg/day for 7 consecutive days. 3-Hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase activities were markedly decrease...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ohtawa M,Masuda N,Karasawa Y,Tojo H

更新日期：1995-07-01 00:00:00

abstract：:Hydroxylated metabolites of diazepam can be conjugated and are therefore generally thought not to affect the metabolism of diazepam. Liver microsomes, obtained from phenobarbital-pretreated rats, showed an inhibition of diazepam (10(-5) M) metabolism by desmethyldiazepam as well as by N-methyloxazepam or oxazepam (5 X...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Savenije-Chapel EM,Bast A,Noordhoek J

更新日期：1985-01-01 00:00:00

abstract：:This study investigated the effect of a commercial preparation of stevioside and a synthetic compound, sodium salt of monketocholic acid (MKC), administered per os (p.o.) and also adminstered via an osmotic pump, on glycemia in normoglycemic and diabetic Wistar rats. Diabetes was induced with alloxan, 100 mg/kg, i.p. ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Rasković A,Mikov M,Skrbić R,Jakovljević V,Vasović V,Posa M,Kuhajda K,Kevresan S,Tomic Z,Siladji D

更新日期：2008-01-01 00:00:00

abstract：:Hepatic distributional volumes were investigated in the in situ perfused rat liver. Perfusion experiments were conducted using Krebs bicarbonate buffer delivered via the portal vein in single-pass mode at a total flow rate of 15 mL/min. A bolus dose of normal erythrocytes (RBC, vascular marker) and Evans blue (EB, ext...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Karabey Y,Sahin S

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Previous studies reported that tapentadol-sulfate represented one of the major metabolites of tapentadol excreted in urine. The current study aimed to identify the human cytosolic sulfotransferases (SULTs) that is(are) capable of sulfating tapentadol and to examine whether human cells and huma...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Bairam AF,Rasool MI,Kurogi K,Liu MC

更新日期：2017-10-01 00:00:00

abstract：:In the last years there appeared many articles about the adverse influence of non-steroidal anti-inflammatory drugs on the liver and heart. This study is concerned with the influence of the duration of treatment with diclofenac and ketoprofen on the macroscopic and microscopic changes in the liver, lungs, heart, and k...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Tomic Z,Milijasevic B,Sabo A,Dusan L,Jakovljevic V,Mikov M,Majda S,Vasovic V

更新日期：2008-10-01 00:00:00

abstract：:A single oral dose of 300 mg of nizatidine was administered to two groups of volunteers: a first group of 12 young healthy subjects and a second group of 12 elderly patients, in order to compare the pharmacokinetic parameters and to verify a possible influence of the age on nizatidine's kinetics. Blood samples were co...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Villani P,Regazzi MB,Pecorini M,Tizzoni M,Savio D

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Aldehyde oxidase (AOX) is an important molybdenum-containing enzyme with high similarity with xanthine oxidase (XO). AOX involved in the metabolism of a large array of aldehydes and N-heterocyclic compounds and its activity is highly substrate-dependent. OBJECTIVES:The aim of this work was to study the effe...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Deris-Abdolahpour F,Abdolalipouran-Sadegh L,Dastmalchi S,Hamzeh-Mivehroud M,Zarei O,Dehgan G,Rashidi MR

更新日期：2019-04-01 00:00:00

abstract：:The aim of this work was to use radiopharmaceuticals such as technetium (99mTc) and indium (DTPA-Ca111In) to visualize, with a gamma-camera, the disintegration area and time of 3 types of enteric coated hard gelatin capsules (obtained by 3 different preparation processes) and thus, to verify that they are really resis...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Catteau D,Barthélémy C,Deveaux M,Robert H,Trublin F,Marchandise X,Van Drunen H

更新日期：1994-04-01 00:00:00

abstract：:A short review on some pharmacokinetic parameters (mean residence time, sojourn time, transit time) is given in relation to compartmental models and some examples and application are discussed. In particular the use of the sojourn time is suggested because this parameter can give useful informations when comparing the...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Segre G,Urso R

更新日期：1991-01-01 00:00:00

abstract：:The aim of this study was to investigate by HPLC the in vivo metabolism of 2-[1'-phenyl-3'-(3-chlorophenyl)-2'-propenylyden]hydrazino-3-methyl-4(3H)-quinazolinone as a substrate, and as a model compound in rats. The substrate was dissolved in DMSO/water (1:4) and administered intraperitoneally at a dose of 100 mg/kg i...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Kaymakçioğlu BK,Aktan Y,Süzen S,Gökhan N,Koyunoğlu S,Erol K,Yeşilada A,Rollas S

更新日期：2005-10-01 00:00:00

abstract：:Guizhi decoction (GZD) is a classic traditional Chinese medicine formula, clinically used for the treatment of influenza, common cold, and other pyretic conditions. A sensitive, specific, and validated liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed to investigate the pharmacokinetic pr...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Chen Y,Gao C,Ma Y,Qiu F

更新日期：2013-12-01 00:00:00

abstract：:The metabolism of galanthamine hydrobromide (Nivalin) was investigated in rat and rabbit liver homogenates. Experiments were carried out varying several parameters of incubation: substrate (galanthamine hydrobromide, galanthamine, galanthaminone and epigalanthamine), cofactor enrichment (NADPH, NADP/G-6-P, NAD), pH (7...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Mihailova D,Velkov M,Zhivkova Z

更新日期：1987-01-01 00:00:00

abstract：:The disposition of RS-tocainide in three healthy volunteers has been studied after oral administration of a pseudoracemic mixture containing S(+) [3H] tocainide as a radioactive tracer together with a therapeutic dose of the racemate. Analytical methods based on HPLC have been developed to measure S(+) and R(-) tocain...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hoffmann KJ,Renberg L,Bäärnhielm C

更新日期：1984-07-01 00:00:00

abstract：:The kinetics of five cisplatin analogs binding to human plasma fractions possessing a molecular weight greater than 50,000 daltons were studied. Each drug solution in plasma ultrafiltrate or phosphate buffer (pH = 7.4, mu = 0.154) was mixed with human plasma and filterable platinum concentrations were measured versus ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Momburg R,Bourdeaux M,Sarrazin M,Roux F,Briand C

更新日期：1985-01-01 00:00:00

abstract：:The biotransformation of 1-(3-butoxy-2-carbamoyloxypropyl)-5-ethyl-5-phenyl-(1H,3H,5H)-pyrimidine-2,4,6-trione (febarbamate) has been investigated in man. Human volunteers received a single oral dose of 15 mg/kg febarbamate. Twenty two metabolites found in urine were separated and purified by means of an extraction wi...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Vachta J,Valter K,Gold-Aubert P

更新日期：1983-07-01 00:00:00

abstract：:The disposition of the gonadotropin-releasing hormone (GnRH) agonist buserelin was studied in male rats under conditions of long-term administration. Rats were continuously infused with about 30 pmole [3H]-buserelin/24 h subcutaneously by osmotic minipumps for 4-7 days. After killing the rats, the 3H-activity of the t...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Heinrich N,Albrecht E,Sandow J,Kertscher U,Lorenz D,Oehlke J,Berger H

更新日期：1996-10-01 00:00:00

abstract：:[14C]Haloperidol decanoate was hydrolysed by partially purified carboxylesterase but not in plasma, blood, lymph and lymphatic liquid. These fluids inhibited the enzyme-mediated hydrolysis of the ester. Within the same incubation period as above, the ester was found hydrolysed to various extents in cell cultures of is...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Oh-e Y,Miyazaki H,Matsunaga Y,Nambu K,Kobayashi N,Hashimoto M

更新日期：1987-07-01 00:00:00

abstract：:The influence of Tamarindus indica L fruit extract incorporated in a traditional meal on the bioavailability of Ibuprofen tablets 400 mg dose when given concurrently was studied in 6 healthy human volunteers. There was a statistically significant increase in the plasma levels of Ibuprofen and its metabolites hydroxy-i...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Garba M,Yakasai IA,Bakare MT,Munir HY

更新日期：2003-07-01 00:00:00

abstract：:YM466, a novel factor Xa inhibitor, is a hydrophilic compound with a carboxylic acid moiety. Previous studies in rats have shown that YM466 does nor undergo metabolism but is excreted into the bile and urine in unchanged form. Thus, in this study, we investigated in vivo hepatobiliary transport, focusing in particular...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Mano Y,Usui T,Kamimura H

更新日期：2006-04-01 00:00:00

abstract：:The co-administration of lidocaine and propranolol leads to significant drug-drug interactions. Beta-blockers decrease liver perfusion and inhibit the activity of hepatic microsomal lidocaine metabolizing enzymes of the P450_2D subfamily. Hence, there is a resulting reduction in the hepatic breakdown of lidocaine and ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Tesseromatis C,Kotsiou A,Tsagataki M,Tigka E,Vovou J,Alevizou A,Perisanidis C,Saranteas T,Karakitsos D,Karabinis A,Kostopanagiotou G

更新日期：2007-10-01 00:00:00

abstract：:The pharmacokinetics of chlordemethyldiazepam--a pharmacologically very active new 1,4-benzodiazepine derivative--in healthy subjects after administration of a single oral dose of 2 mg, was studied. Peak concentrations were reached in 1.2 +/- 0.2 hours. Plasma levels declined with a biphasic pattern, and the eliminati...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Bareggi SR,Pirola R,Leva S,Zecca L

更新日期：1986-07-01 00:00:00

abstract：:We studied the hepatic handling of bromosulfophthalein in healthy rabbits with hepatic coccidiosis 28 days after an experimental infection with sporulated oocysts of Eimeria stiedai, an experimental model of liver disease histopathologically resembling primary biliary cirrhosis in man. A pharmacokinetic study of the r...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Esteller A,Torres MD,Gomez-Bautista M,Mariño EL,Fernandez-Lastra C,Jimenez R

更新日期：1990-01-01 00:00:00

abstract：:Vitexin-4″-O-glucoside (VOG), being a main component in the leaves of Crataegus pinnatifida Bge. var. major, was isolated and then three different doses (20, 40, and 60 mg/kg) of VOG were administered intravenously to rats. To study its pharmacokinetics, a simple and rapid HPLC method was developed using hesperidin as...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ying XX,Wang F,Cheng ZZ,Zhang WJ,Li HB,Du Y,Liu X,Wang SY,Kang TG

更新日期：2012-06-01 00:00:00

abstract：:The fate of Ticlopidine, a new inhibitor of platelet aggregation, has been studied in rats following single oral doses. The compound was quickly absorbed as evaluated by the time of the peak plasma concentration. The metabolism of Ticlopidine involved N-oxidation, cleavage of the N-C bond, oxidation of aliphatic carbo...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Tuong A,Bouyssou A,Paret J,Cuong TG

更新日期：1981-01-01 00:00:00

abstract：:Hepatic clearance of gitoxin has been studied in the rabbit and compared with that of digoxin using an isolated perfused liver technique. During 1.5 hour perfusions with a modified Krebs-Henseleit solution, gitoxin perfusate levels decreased biexponentially; the distribution and elimination half-lives were estimated t...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Pellegrin P,Lesne M

更新日期：1983-01-01 00:00:00

abstract：:The bioavailability of the recently developed 1 g dispersible tablet form of amoxicillin (B) and the 1 g dispersible tablet in suspension form (C) were compared to that of the 1 g standard reference formulation (A). Twelve healthy volunteers were involved in this single-dose, open, randomized, three-way cross-over stu...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Prevot MH,Jehl F,Rouveix B

更新日期：1997-01-01 00:00:00

abstract：:The transdermally applied dopamine receptor agonist rotigotine is extensively metabolized in the liver. An open-label, parallel-group study was conducted to evaluate the effects of moderate hepatic impairment on the pharmacokinetics, safety and tolerability of rotigotine. Eight subjects with normal hepatic function an...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Cawello W,Fichtner A,Boekens H,Braun M

更新日期：2014-09-01 00:00:00

abstract：:The pharmacokinetic profile of triflusal (2-acetoxy-4-trifluoromethyl benzoic acid) and its main metabolite HTB (2-hydroxy-4-trifluoromethyl benzoic acid) has been studied in 8 healthy subjects (4 males and 4 females), after a single oral dose of 900 mg of triflusal. Plasma concentrations were determined by a sensitiv...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ramis J,Mis R,Forn J,Torrent J,Gorina E,Jané F

更新日期：1991-10-01 00:00:00

abstract：:Herbal medicinal products have to meet comparable standards concerning the assessment of efficacy, safety and (bio)pharmaceutical quality as chemically defined synthetic drugs. However, these requirements are not fulfilled for many herbal products so far, particularly regarding in vitro dissolution and in vivo bioavai...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Blume HH,Schug BS

更新日期：2000-01-01 00:00:00