Study of the disposition kinetics of the N-oxide-derivative: a metabolite of picobenzide.

abstract：:The pharmacokinetics of flumecinol (Zixoryn) a new hepatic enzyme inducer has been studied in four beagle dogs and six healthy volunteers. The beagle dogs and the volunteers received the drug orally in a dose of 40 mg/kg of body weight and of 100 mg single dose respectively. Flumecinol was extracted from plasma with d...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Klebovich I,Vereczkey L,Kerpel-Fronius S,Ringwald G,Bodrogligeti I

更新日期：1982-01-01 00:00:00

abstract：:The biotransformation of netobimin (NTB) pro-drug by ruminal, abomasal and intestinal fluids of sheep and cattle was investigated under anaerobic conditions in vitro. No metabolic conversion of NTB was observed upon incubation with abomasal fluid or boiled samples of different gastrointestinal fluids. NTB pro-drug was...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Lanusse CE,Nare B,Gascon LH,Prichard RK

更新日期：1992-04-01 00:00:00

abstract：:This paper deals with press-coated modified release tablets in which the drug dose is situated in the core or is divided between the core and the coat. The coat contains polymer (sodium alginate or hydroxypropylmethyl cellulose, HPMC) to control drug release. The main objective was to investigate how the pharmacokinet...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Halsas M,Ervasti P,Veski P,Jürjenson H,Marvola M

更新日期：1998-04-01 00:00:00

abstract：:The metabolism of galanthamine hydrobromide (Nivalin) was investigated in rat and rabbit liver homogenates. Experiments were carried out varying several parameters of incubation: substrate (galanthamine hydrobromide, galanthamine, galanthaminone and epigalanthamine), cofactor enrichment (NADPH, NADP/G-6-P, NAD), pH (7...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Mihailova D,Velkov M,Zhivkova Z

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Lidocaine 5% medicated plaster is the first lidocaine containing product for chronic use. As no previous investigations have been conducted to evaluate the population pharmacokinetics of long-term exposure to lidocaine 5% medicated plasters, further insights into the evaluation of the pharmaco...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Bursi R,Piana C,Grevel J,Huntjens D,Boesl I

更新日期：2017-10-01 00:00:00

abstract：:The hypoxic cell radiosensitizing drug, misonidazole (Miso) (Ro 07-0582) and its demethylated metabolite were administered to Wistar rats at different dose levels to examine their renal elimination. The data were consistent with a model in which Miso is eliminated mainly after biotransformation into desmethylmisonidaz...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Akel G,Canal P,Soula G

更新日期：1985-07-01 00:00:00

abstract：:The purpose of the study was to investigate the factors upon which the first order rate constant depends in order to assess the impact on the body-drug concentration when it changes throughout a treatment. A reasoning for linking the first order rate constants with several factors in a multiplicative way was proposed ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Fagiolino P

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Even though lithium has been used for the treatment of bipolar disorder for several decades, its toxicities are still being reported. The major limitation in the use of lithium is its narrow therapeutic window. Several methods have been proposed to predict lithium doses essential to attain the...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Methaneethorn J

更新日期：2018-02-01 00:00:00

abstract：:Herbal medicinal products have to meet comparable standards concerning the assessment of efficacy, safety and (bio)pharmaceutical quality as chemically defined synthetic drugs. However, these requirements are not fulfilled for many herbal products so far, particularly regarding in vitro dissolution and in vivo bioavai...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Blume HH,Schug BS

更新日期：2000-01-01 00:00:00

abstract：:The technique of differential display reverse transcription-polymerase chain reaction (ddRT-PCR) has been used to produce unique profiles of up-regulated and down-regulated gene expression in the liver of male Wistar rats following short term exposure to the non-genotoxic hepatocarcinogens, phenobarbital and WY-14,643...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Rockett JC,Esdaile DJ,Gibson GG

更新日期：1997-10-01 00:00:00

abstract：:The present investigation was designed and undertaken in order to substantiate further contention concerning the universality of the utilization of PEG polymers as matrix carriers. This study could then be considered an attempt to enhance the dissolution rate of triamterene, with the subsequent enhancement in its abso...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Arias MJ,Gines JM,Moyano JR,Perez-Barrales MJ,Vela MT,Rabasco AM

更新日期：1994-10-01 00:00:00

abstract：:Fucithalmic is a newly developed 1% microcrystalline suspension of the antistaphylococcal antibiotic fusidic acid. Penetration into the eye was investigated in twenty patients about to undergo cataract extraction. A single dose produced median antibiotic levels in the aqueous humour of 0.3 mcg/ml, maintained for at le...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hansen S

更新日期：1985-10-01 00:00:00

abstract：:Benzo[alpha]pyrene (B[a]P) is a product derived from incomplete combustion of organic material and is considered responsible for chemically-induced cancer in humans. In the present study, the levels of noradrenaline (NA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 5-hydroxytryptamine (...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Stephanou P,Konstandi M,Pappas P,Marselos M

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Sorafenib is an oral, multikinase inhibitor with established single-agent activity in several tumor types. Sorafenib was moderately transported by P-glycoprotein (P-gp) and more efficiently by breast cancer resistance protein. The constitutive androstane receptor (CAR) is a ligand-activated tra...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Karbownik A,Stanisławiak-Rudowicz J,Stachowiak A,Romański M,Grześkowiak E,Szałek E

更新日期：2020-12-01 00:00:00

abstract：:The kinetics of the nootropic drug oxiracetam was studied in 6 elderly female patients (age range 69-96 years) in good physical condition. After a single oral dose (800 mg), serum oxiracetam levels reached a peak (25 +/- 6 micrograms/ml) within 1-3 h and declined thereafter with a half-life of 3 to 6 h. Eighty-four pe...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Perucca E,Parini J,Albrici A,Visconti M,Ferrero E

更新日期：1987-04-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) play an important role in the biotransformation of endogenous compounds and xenobiotics as well as in the metabolic inactivation of pharmacologically active substances, including anticancer drugs. Using cisplatin as the prototype drug, we investigated if any correlation exists between...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Nagar R,Khan AR,Poonia A,Mishra PK,Singh S

更新日期：2015-03-01 00:00:00

abstract：:The present study was carried out to find the in vivo performance of guar gum-based colon-targeted tablets of metronidazole as compared to an immediate release tablets in human volunteers. Six healthy volunteers participated in the study and a crossover design was used. Blood samples were obtained at different time in...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Krishnaiah YS,Veer Raju P,Dinesh Kumar B,Jayaram B,Rama B,Raju V,Bhaskar P

更新日期：2003-10-01 00:00:00

abstract：:The novel substituted imidazole compound, OC144-093 exhibits potent biological activity in vitro and in vivo for reversal of P-glycoprotein (PgP) based resistance to cancer chemotherapy. Its mechanism of action relies upon its inhibitory interaction with the mdr1 gene product, a known mediator of multidrug resistance ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Guns ES,Bullock PL,Reimer ML,Dixon R,Bally M,Mayer LD

更新日期：2001-10-01 00:00:00

abstract：:Thymoquinone (THQ), the active constituent of Nigella sativa seeds, has demonstrated some potential pharmacological activities. The present study was designed to investigate the pharmacokinetic behavior of THQ following intravenous (IV) and oral (PO) administration using an animal model. THQ was given vascularly (5 mg...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Alkharfy KM,Ahmad A,Khan RM,Al-Shagha WM

更新日期：2015-09-01 00:00:00

abstract：:Intermittent inhalation exposure of adult male rats to dichloromethane, trichloroethylene, 1,1,1-trichloroethane, perchloroethylene or to a combination of trichloroethylene and 1,1,1-trichloroethane for 5 days, for 6 h daily, induced significantly different accumulations of solvent molecules in the body. Adipose tissu...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Savolainen H

更新日期：1981-01-01 00:00:00

abstract：:A short review on some pharmacokinetic parameters (mean residence time, sojourn time, transit time) is given in relation to compartmental models and some examples and application are discussed. In particular the use of the sojourn time is suggested because this parameter can give useful informations when comparing the...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Segre G,Urso R

更新日期：1991-01-01 00:00:00

abstract：:A total of 16 metabolites of bromocriptine could be isolated from rat bile and incubates of rat liver cell preparations using [6-methyl-14C]bromocriptine as substrate. Separation and purification was achieved by reversed-phase liquid chromatography and preparative thin-layer chromatography in conjunction with radioact...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Maurer G,Schreier E,Delaborde S,Loosli HR,Nufer R,Shukla AP

更新日期：1982-10-01 00:00:00

abstract：:This study developed a physiologically based pharmacokinetic (PBPK) model in intraabdominally infected rats and extrapolated it to humans to predict the levofloxacin pharmacokinetics and penetration into tissues. Twelve male rats with intraabdominal infections induced by Escherichia coli received a single dose of 50 m...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zhu L,Zhang Y,Yang J,Wang Y,Zhang J,Zhao Y,Dong W

更新日期：2016-08-01 00:00:00

abstract：:Monoclonal antibodies are capable of modulating drug metabolising enzymes resulting in unexpected plasma concentrations of a drug when given concomitantly. Therefore plasma concentration of paclitaxel (PTX) and its metabolites has been monitored in 10 patients with advanced breast cancer during treatment with PTX alon...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Furtlehner A,Schueller J,Jarisch I,Ostermann E,Czejka M

更新日期：2005-07-01 00:00:00

abstract：:The aim of this work was to use radiopharmaceuticals such as technetium (99mTc) and indium (DTPA-Ca111In) to visualize, with a gamma-camera, the disintegration area and time of 3 types of enteric coated hard gelatin capsules (obtained by 3 different preparation processes) and thus, to verify that they are really resis...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Catteau D,Barthélémy C,Deveaux M,Robert H,Trublin F,Marchandise X,Van Drunen H

更新日期：1994-04-01 00:00:00

abstract：:Tritiated tetrahydro-tetramethyl-naphthalenyl-propenyl benzoic acid (TTNPB; Ro 13-7410) was administered as a single oral bolus to pregnant hamsters (day 8) to determine the maternal plasma pharmacokinetic profile and peripheral tissue distribution patterns. Blood and tissue, including embryo or fetus, were collected ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Howard WB,Willhite CC,Sharma RP,Omaye ST,Hatori A

更新日期：1989-04-01 00:00:00

abstract：:The co-administration of lidocaine and propranolol leads to significant drug-drug interactions. Beta-blockers decrease liver perfusion and inhibit the activity of hepatic microsomal lidocaine metabolizing enzymes of the P450_2D subfamily. Hence, there is a resulting reduction in the hepatic breakdown of lidocaine and ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Tesseromatis C,Kotsiou A,Tsagataki M,Tigka E,Vovou J,Alevizou A,Perisanidis C,Saranteas T,Karakitsos D,Karabinis A,Kostopanagiotou G

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Beraprost sodium (BPS) is a chemically stable and orally active prostacyclin analog that is used in the treatment of chronic arterial occlusive disease since 1992 and primary pulmonary hypertension since 1999 in Japan. Multiple-drug therapy is common in clinical practice, and BPS is co-administ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Oshida K,Shimamura M,Seya K,Ando A,Miyamoto Y

更新日期：2017-02-01 00:00:00

abstract：:The pharmacokinetics of lisuride hydrogen maleate (LHM) were investigated in rat, rabbit and rhesus monkey. Experiments were designed to meet not only the requirements of drug registration but also to serve other preclinical disciplines (toxicology, pharmacology). LHM is absorbed almost completely at a dose level of 1...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Humpel M,Toda T,Oshino N,Pommerenke G

更新日期：1981-01-01 00:00:00

abstract：:Pharmacokinetics of recombinant human basic fibroblast growth factor (rhbFGF) in mice were studied by using a radioiodination method combined with sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and a sandwich enzyme-Linked immunosorbent assay (ELISA). RhbFGF concentration in serum were dertermine...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zhang Q,Wang GJ,Sun JG

更新日期：2004-07-01 00:00:00