The pharmacokinetics of lisuride hydrogen maleate in rat, rabbit and rhesus monkey.

abstract：:Permeability coefficients of seven compounds belonging to a true homologous series (4-alkylanilines) through several different synthetic and biological membranes were assayed in a two-chamber diffusion cell. Permeability-lipophilicity relationships for the experimental data were established and compared in order to as...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Díez-Sales O,Guzmán D,Cano D,Martín A,Sánchez E,Herráez M

更新日期：1991-01-01 00:00:00

abstract：:The influence of phenobarbital pretreatment on liver concentration of digitoxin and its metabolites was studied in guinea-pigs after i.p. administration of the cardiac glycoside. During the first hour an increase in liver uptake was observed in pretreated animals. The differences detected in the hepatic subcellular di...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Carvalhas ML,Figueira MA,Maya MR

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Drug-drug interactions (DDIs) can occur when one drug alters the metabolism of another drug. Drug metabolism mediated by cytochrome P450 enzymes (CYPs) is responsible for the majority of metabolism of known drugs and inhibition of CYP enzymes is a well-known cause of DDIs. In the current study...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Reinen J,Smit M,Wenker M

更新日期：2018-12-01 00:00:00

abstract：:The metabolic fate of anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043) was studied in rats after oral administration. An average of 12.2 +/- 1.5% of the dose was excreted in the urine in the course of 0-48 h; 56.7 +/- 2.6% with feces. Two metabolites were also detected in the urine and isolated b...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Caputo O,Grosa G,Ceruti M,Viola F,Rocco F

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:LCZ696 (sacubitril/valsartan), a novel angiotensin receptor neprilysin inhibitor has been recently approved for the treatment of patients with heart failure (HF) and reduced ejection fraction. As several HF patients are likely to use statins as co-medications, the potential for a pharmacokineti...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ayalasomayajula S,Pan W,Han Y,Yang F,Langenickel T,Pal P,Zhou W,Yuan Y,Rajman I,Sunkara G

更新日期：2017-04-01 00:00:00

abstract：:Pharmacokinetic gender-dependent differences in cytochrome P450-mediated drug metabolism, especially CYP3A4, and their clinical implications are increasingly apparent. CYP3A4 seems to be the most important CYP isoform in both bioactivation and N-dechloroethylation of the alkylating prodrug ifosfamide, but informations...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Schmidt R,Baumann F,Hanschmann H,Geissler F,Preiss R

更新日期：2001-07-01 00:00:00

abstract：:Blood loss during cesarean section was calculated based on post-operative decrement of hemoglobin (Hb) and hematocrit (Hct) level. The model used for pregnant women was previously validated for non-pregnant women who underwent gynecological surgery. 1,068 pregnant women who underwent cesarean section and 517 women who...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Milosevic N,Popovic J,Grujic Z,Rapaic M

更新日期：2011-09-01 00:00:00

abstract：:This study developed a physiologically based pharmacokinetic (PBPK) model in intraabdominally infected rats and extrapolated it to humans to predict the levofloxacin pharmacokinetics and penetration into tissues. Twelve male rats with intraabdominal infections induced by Escherichia coli received a single dose of 50 m...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zhu L,Zhang Y,Yang J,Wang Y,Zhang J,Zhao Y,Dong W

更新日期：2016-08-01 00:00:00

abstract：:The transdermally applied dopamine receptor agonist rotigotine is extensively metabolized in the liver. An open-label, parallel-group study was conducted to evaluate the effects of moderate hepatic impairment on the pharmacokinetics, safety and tolerability of rotigotine. Eight subjects with normal hepatic function an...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Cawello W,Fichtner A,Boekens H,Braun M

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Ginseng is usually consumed as a dietary supplement for health care in the normal state or prescribed as a herbal medicine in pathologic conditions. Although metabolic studies of ginseng are commonly performed on healthy organisms, the metabolic characteristics in pathologic organisms remain un...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zhu JH,Xu JD,Zhou SS,Zhang XY,Zhou J,Kong M,Mao Q,Zhu H,Li SL

更新日期：2021-01-01 00:00:00

abstract：:A new high performance liquid chromatographic procedure has been developed for the simultaneous quantification of piribedil (PD) and its three main basic metabolites in rat plasma and urine, without and after hydrolysis. The procedure relies on isolation of the compounds from plasma and urine constituents using the Se...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Sarati S,Caccia S

更新日期：1992-07-01 00:00:00

abstract：:Hepatic clearance of 3H-gitoxin was studied in the rabbit using an isolated perfused liver technique with an emulsion of a perfluorocarbon. The liposoluble material in the perfusion medium was extracted with dichloromethane, and gitoxin was assayed in the extract by high performance liquid chromatography. Pharmacokine...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Pellegrin PL,Lesne M

更新日期：1985-04-01 00:00:00

abstract：:We studied the hepatic handling of bromosulfophthalein in healthy rabbits with hepatic coccidiosis 28 days after an experimental infection with sporulated oocysts of Eimeria stiedai, an experimental model of liver disease histopathologically resembling primary biliary cirrhosis in man. A pharmacokinetic study of the r...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Esteller A,Torres MD,Gomez-Bautista M,Mariño EL,Fernandez-Lastra C,Jimenez R

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:By using a population pharmacokinetic analysis method, we predicted the efficacy of Ceftriaxone (CTRX) based on the pharmacokinetics of CTRX in Japanese adults and the sensitivity of infective organisms to CTRX in 2004. In addition, we clarified the difference in efficacy between once-a-day administration and...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Iida S,Kinoshita H,Kawanishi T,Hayashi M

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Previous studies reported that tapentadol-sulfate represented one of the major metabolites of tapentadol excreted in urine. The current study aimed to identify the human cytosolic sulfotransferases (SULTs) that is(are) capable of sulfating tapentadol and to examine whether human cells and huma...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Bairam AF,Rasool MI,Kurogi K,Liu MC

更新日期：2017-10-01 00:00:00

abstract：:The pharmacokinetics of tolbutamide (TB) have been studied in endotoxin pretreated rats with the aim of evaluating TB as a marker for endotoxin effects. Endotoxin dose of 10 mg/kg resulted in a 50% rate of mortality. TB was i.v. administered 24 h. after endotoxin dosing. Clearance (Cl) decreased by approximately 2/3 o...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Kaka JS,al-Khamis K,Tanira MO

更新日期：1990-07-01 00:00:00

abstract：:Using in vitro dissolution and in vivo absorption of different generics or batches for an appropriate drug and dosage form, a reference equation of form: ka = a+bkd+dkd2 can be proposed. In the case of availability of standardised in vitro-in vivo data for a specific drug, a Level A a correlation of this type containi...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Kayali A

更新日期：1994-07-01 00:00:00

abstract：:For many drugs administered per os, high variability in the concentration-time (C-T) values from first sampling to the phase of distribution may cause difficulty in pharmacokinetic analysis. Therefore, the aim of this study was to propose a method of transformation of C-T data, which would allow significantly reducing...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Grabowski T,Jaroszewski JJ,Piotrowski W,Sasinowska-Motyl M

更新日期：2014-06-01 00:00:00

abstract：:A total of 16 metabolites of bromocriptine could be isolated from rat bile and incubates of rat liver cell preparations using [6-methyl-14C]bromocriptine as substrate. Separation and purification was achieved by reversed-phase liquid chromatography and preparative thin-layer chromatography in conjunction with radioact...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Maurer G,Schreier E,Delaborde S,Loosli HR,Nufer R,Shukla AP

更新日期：1982-10-01 00:00:00

abstract：:The pharmacokinetics of amiodarone was studied after single and multiple dosing in two groups of male Wistar and Albino rats. The first group (40 rats) received a single intraperitoneal (i.p.) dose of amiodarone (100 mg/kg) and 4 rats sacrificed 1, 2, 4, 6, 12, 18, 24, 36, 48 and 72 hours post dosing. The second group...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Najjar TA

更新日期：2000-07-01 00:00:00

abstract：:The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various experimental conditions. The influence of agitation intensity and pH value of the dissolution medi...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Radovanović J,Durić Z,Jovanović M,Ibrić S,Petrović M

更新日期：1998-01-01 00:00:00

abstract：:A simple and sensitive HPLC method has been developed and validated for the determination of tyrosol galactoside (TG) in rat plasma. After one-step protein precipitation with methanol, plasma samples were separated on an Ultimate AQ-C18 column (150 mm×4.6 mm, 5 μm) using acetonitrile-water (7:93, v/v) as mobile phase ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Wang Q,Wang Y,Deng Y,Shi T,Liu X,Sun X,Li X,Zhou D

更新日期：2011-01-01 00:00:00

abstract：:Following i.v. administration of mono-HR to the beagle, plasma levels of both mono-HR and its glucuronide conjugates fell rapidly, neither being detectable 8 h after injection. Following oral administration of 14C-mono-HR, mono-HR-glucuronide was detected in plasma, confirming the absorption of mono-HR, and low levels...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hackett AM,Griffiths LA

更新日期：1979-01-01 00:00:00

abstract：:Monoclonal antibodies are capable of modulating drug metabolising enzymes resulting in unexpected plasma concentrations of a drug when given concomitantly. Therefore plasma concentration of paclitaxel (PTX) and its metabolites has been monitored in 10 patients with advanced breast cancer during treatment with PTX alon...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Furtlehner A,Schueller J,Jarisch I,Ostermann E,Czejka M

更新日期：2005-07-01 00:00:00

abstract：:The metabolism of galanthamine hydrobromide (Nivalin) was investigated in rat and rabbit liver homogenates. Experiments were carried out varying several parameters of incubation: substrate (galanthamine hydrobromide, galanthamine, galanthaminone and epigalanthamine), cofactor enrichment (NADPH, NADP/G-6-P, NAD), pH (7...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Mihailova D,Velkov M,Zhivkova Z

更新日期：1987-01-01 00:00:00

abstract：:Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral (intragastric) cyclosporine A (CyA). Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. The factors responsib...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Schück O,Bohdanecká M,Sedivý J,Krajícková M,Chadimová M,Matousovic K

更新日期：1997-07-01 00:00:00

abstract：:The disposition of cloflumide (VUFB 15496), 2-chloro-7-fluoro-10 [4-(carbamoylethyl)piperazino]-10,11-dihydrodibenzo [b,f] thiepin methansulfonate, a new neuroleptic agent, following single oral and intravenous dose was studied in the rat using radiotracer techniques. [3H]Cloflumide was almost completely absorbed from...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Lapka R,Franc Z,Smolík S

更新日期：1987-04-01 00:00:00

abstract：:The disposition kinetics of the N-oxide of picobenzide were studied after administration to rabbits at a bolus dose of 30 mg/kg of picobenzide intravenously. The biotransformation process fits a first-order kinetic process, and the metabolite shows good access capacity to the peripheral compartment. The N-oxide of pic...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Santos Buelga D,Mariño EL,Domínguez-Gil A

更新日期：1989-01-01 00:00:00

abstract：:Although the application of medical marijuana and cannabinoid drugs is controversial, it is a part of modern-day medicine. The list of diseases in which cannabinoids are promoted as a treatment is constantly expanding. Cases of significant improvement in patients with a very poor prognosis of glioma or epilepsy have a...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hryhorowicz S,Walczak M,Zakerska-Banaszak O,Słomski R,Skrzypczak-Zielińska M

更新日期：2018-02-01 00:00:00

abstract：:The aim of the present study was to investigate the relative bioavailability and bioequivalence of a new tablet formulation of metformin hydrochloride with reference to a standard product in healthy Chinese adult male volunteers. Two randomized, comparative, two-way crossover studies were therefore conducted. In study...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Li J,Jin Y,Wang TY,Lü XW,Li YH

更新日期：2007-01-01 00:00:00