当前位置： SCI文献检索 > EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS期刊下所有文献 > Pharmacokinetics, hepatic biotransformation and biliary and urinary excretion of bromosulfophthalein (BSP) in an experimental liver disease mimicking biliary cirrhosis.

Pharmacokinetics, hepatic biotransformation and biliary and urinary excretion of bromosulfophthalein (BSP) in an experimental liver disease mimicking biliary cirrhosis.

Abstract：

:We studied the hepatic handling of bromosulfophthalein in healthy rabbits with hepatic coccidiosis 28 days after an experimental infection with sporulated oocysts of Eimeria stiedai, an experimental model of liver disease histopathologically resembling primary biliary cirrhosis in man. A pharmacokinetic study of the results was performed following a multicompartmental model with 7 transfer constants to describe the physiological disposition of the dye. The study showed that the plasma disappearance, distribution volume (Vi), hepatic biotransformation and the biliary and urinary elimination of conjugated (BSPc) and unconjugated (BSPu) bromosulfophthalein were markedly altered. Whereas Vi and urinary excretion of the dye were significantly increased, the hepatic clearance, biotransformation and biliary excretion of BSPc and BSPu were drastically reduced in infected rabbits. Satisfactory agreement was obtained between the experimental and estimated data, particularly those relating to biotransformation clearance and biliary and urinary excretion of the dye. These results demonstrate that severe liver disease in rabbits with histopathological liver alterations resembling several hepatic dysfunctions in man markedly reduce hepatic uptake, metabolism and biliary excretion of a xenobiotic such as BSP.

journal_name

Eur J Drug Metab Pharmacokinet

journal_title

European journal of drug metabolism and pharmacokinetics

authors

Esteller A,Torres MD,Gomez-Bautista M,Mariño EL,Fernandez-Lastra C,Jimenez R

doi

10.1007/BF03190121

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

7-14

issue

1

eissn

0378-7966

issn

2107-0180

journal_volume

15

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS文献大全
  • Effect of stevioside and sodium salt of monoketocholic acid on glycemia in normoglycemic and diabetic rats.

    abstract：:This study investigated the effect of a commercial preparation of stevioside and a synthetic compound, sodium salt of monketocholic acid (MKC), administered per os (p.o.) and also adminstered via an osmotic pump, on glycemia in normoglycemic and diabetic Wistar rats. Diabetes was induced with alloxan, 100 mg/kg, i.p. ...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/BF03191014

    authors： Rasković A,Mikov M,Skrbić R,Jakovljević V,Vasović V,Posa M,Kuhajda K,Kevresan S,Tomic Z,Siladji D

    更新日期：2008-01-01 00:00:00

  • Potential Influence of Endothelial Adsorption on the Delayed Time to Maximum Concentration of Biopharmaceuticals.

    abstract：BACKGROUND AND OBJECTIVES:Maximum plasma concentration of biopharmaceuticals sometimes occurs long after completion of intravenous infusion. The objective of this research was to study the hypothetical adsorption of biopharmaceuticals to endothelium and infusion material, which may theoretically explain this phenomenon...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/s13318-017-0430-1

    authors： Reijers JAA,Dane MJC,van Zonneveld AJ,Burggraaf J,Moerland M

    更新日期：2018-02-01 00:00:00

  • Age related differences in plasma theophylline levels.

    abstract：:Because of its special pharmacokinetic properties, plasma levels of theophylline show significant differences between individuals and also its therapeutic index is very low. So, plasma theophylline concentration measurements are essential for an effective and safe treatment. In the present study, age related differenc...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF03188821

    authors： Elidemir O,Kośay S,Hepözden O,Aysan T,Tufan M

    更新日期：1994-01-01 00:00:00

  • A population approach to the forecasting of amikacin plasma and urinary levels using a prescribed dosage regimen.

    abstract：:We retrospectively analyzed amikacin pharmacokinetics in 19 critically ill patients who received amikacin intravenously. Fourteen subjects (577 serum amikacin concentrations, 167 urine measurements) were studied to obtain data for population modeling, while 5 patients (267 serum amikacin concentrations, 68 urine measu...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/BF03190009

    authors： Joubert P,Bressolle F,Gouby A,Douçot PY,Saissi G,Gomeni R

    更新日期：1999-01-01 00:00:00

  • In vivo metabolism of 4-fluorobenzoic acid [(5-nitro-2-furanyl)methylene] hydrazide in rats.

    abstract：:It is known that substituted hydrazide hydrazone derivatives have several biological and pharmacological activities; there is limited literature on the metabolism of hydrazide hydrazones in rats. In our previous study, 4-fluorobenzoic acid [(5-nitro-2-furanyl)methylene]hydrazide (S) was found active against Staphyloco...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/BF03190075

    authors： Gülerman NN,Oruç EE,Kartal F,Rollas S

    更新日期：2000-04-01 00:00:00

  • Prediction of the pharmacokinetics and tissue distribution of levofloxacin in humans based on an extrapolated PBPK model.

    abstract：:This study developed a physiologically based pharmacokinetic (PBPK) model in intraabdominally infected rats and extrapolated it to humans to predict the levofloxacin pharmacokinetics and penetration into tissues. Twelve male rats with intraabdominal infections induced by Escherichia coli received a single dose of 50 m...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/s13318-015-0271-8

    authors： Zhu L,Zhang Y,Yang J,Wang Y,Zhang J,Zhao Y,Dong W

    更新日期：2016-08-01 00:00:00

  • Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis.

    abstract：:Pharmacokinetics of ketoprofen (KTP) enantiomers has been studied in patients with rheumatoid arthritis (RA) following administration of a single oral dose of 100 mg rac-KTP during multidrug therapy taking into consideration the genotype of RA patients Concentrations of (-)-R and (+)-S enantiomers of KTP in plasma, ur...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/s13318-011-0041-1

    authors： Główka F,Karaźniewicz-Łada M,Grześkowiak E,Rogozinska D,Romanowski W

    更新日期：2011-09-01 00:00:00

  • Supramolecular Complex of Ibuprofen with Larch Polysaccharide Arabinogalactan: Studies on Bioavailability and Pharmacokinetics.

    abstract：BACKGROUND AND OBJECTIVES:In the present work, pharmacological and pharmacokinetic properties of the supramolecular complex of non-steroid anti-inflammatory drug ibuprofen (IBU) with natural polysaccharide arabinogalactan (AG) were studied. The main goals of such complexation were the increase of ibuprofen's bioavailab...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/s13318-016-0357-y

    authors： Khvostov MV,Borisov SA,Tolstikova TG,Dushkin AV,Tsyrenova BD,Chistyachenko YS,Polyakov NE,Dultseva GG,Onischuk AA,An'kov SV

    更新日期：2017-06-01 00:00:00

  • Molecular profiling of non-genotoxic hepatocarcinogenesis using differential display reverse transcription-polymerase chain reaction (ddRT-PCR).

    abstract：:The technique of differential display reverse transcription-polymerase chain reaction (ddRT-PCR) has been used to produce unique profiles of up-regulated and down-regulated gene expression in the liver of male Wistar rats following short term exposure to the non-genotoxic hepatocarcinogens, phenobarbital and WY-14,643...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/BF03190966

    authors： Rockett JC,Esdaile DJ,Gibson GG

    更新日期：1997-10-01 00:00:00

  • Evaluation of hepatic dysfunction in endotoxin pretreated rats using tolbutamide as a marker.

    abstract：:The pharmacokinetics of tolbutamide (TB) have been studied in endotoxin pretreated rats with the aim of evaluating TB as a marker for endotoxin effects. Endotoxin dose of 10 mg/kg resulted in a 50% rate of mortality. TB was i.v. administered 24 h. after endotoxin dosing. Clearance (Cl) decreased by approximately 2/3 o...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/BF03190205

    authors： Kaka JS,al-Khamis K,Tanira MO

    更新日期：1990-07-01 00:00:00

  • The metabolic fate of the anti-parkinsonian drug budipine in rats.

    abstract：:The metabolic fate of the anti-Parkinsonian drug budipine was studied in rats after oral administration. The presence of an aromatic hydroxylation product, metabolite M1, and its O-sulphate conjugate was confirmed. Three new minor metabolites, budipine N-oxide, metabolite M1 N-oxide and a secondary metabolite derived ...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/BF03189947

    authors： Caputo O,Grosa G,Ceruti M,Rocco F,Biglino G

    更新日期：1991-04-01 00:00:00

  • Influence of hepatic impairment on the pharmacokinetics of the dopamine agonist rotigotine.

    abstract：:The transdermally applied dopamine receptor agonist rotigotine is extensively metabolized in the liver. An open-label, parallel-group study was conducted to evaluate the effects of moderate hepatic impairment on the pharmacokinetics, safety and tolerability of rotigotine. Eight subjects with normal hepatic function an...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s13318-013-0153-x

    authors： Cawello W,Fichtner A,Boekens H,Braun M

    更新日期：2014-09-01 00:00:00

  • The Influence of Paracetamol on the Penetration of Sorafenib and Sorafenib N-Oxide Through the Blood-Brain Barrier in Rats.

    abstract：BACKGROUND AND OBJECTIVE:Sorafenib is an oral, multikinase inhibitor with established single-agent activity in several tumor types. Sorafenib was moderately transported by P-glycoprotein (P-gp) and more efficiently by breast cancer resistance protein. The constitutive androstane receptor (CAR) is a ligand-activated tra...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/s13318-020-00639-z

    authors： Karbownik A,Stanisławiak-Rudowicz J,Stachowiak A,Romański M,Grześkowiak E,Szałek E

    更新日期：2020-12-01 00:00:00

  • Pharmacokinetics of natural borneol after oral administration in mice brain and its effect on excitation ratio.

    abstract：:Previous studies have indicated that borneol has double side effects on the central nervous system (CNS), but the mechanism is unknown. The aim of this study was to clarify the relationship between excitation ratio [contents of excitatory amino acids (AAs) versus that of inhibitory] and the content of natural borneol ...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/s13318-011-0058-5

    authors： Li WR,Chen RY,Yang L,Huang TL,Xu QW,Mi SQ,Wang NS

    更新日期：2012-03-01 00:00:00

  • Effect of coenzyme Q10 on the disposition of doxorubicin in rats.

    abstract：:The effect of exogenous coenzyme Q10 (CoQ10) on the pharmacokinetic profiles and biliary excretion of doxorubicin and its main metabolites, doxorubicinol and doxorubicinolone, was investigated in rats. No statistically significant changes in the pharmacokinetic parameters of doxorubicin was observed following the intr...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/BF03190456

    authors： Zhou Q,Chowbay B

    更新日期：2002-07-01 00:00:00

  • The effect of aging on the pharmacokinetics of nizatidine.

    abstract：:A single oral dose of 300 mg of nizatidine was administered to two groups of volunteers: a first group of 12 young healthy subjects and a second group of 12 elderly patients, in order to compare the pharmacokinetic parameters and to verify a possible influence of the age on nizatidine's kinetics. Blood samples were co...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：

    authors： Villani P,Regazzi MB,Pecorini M,Tizzoni M,Savio D

    更新日期：1991-01-01 00:00:00

  • Pharmacokinetics of Polyethylene Glycol-Modified Canine Uricase Following Single and Multiple Intravenous Injections in Cynomolgus Monkeys.

    abstract：BACKGROUND AND OBJECTIVE:Polyethylene glycol-modified canine uricase (PEG-UHC) prepared with a lower-molecular-weight (5 kDa) PEG is used to treat gout. This study investigated the comparative pharmacokinetics of single and multiple doses of PEG-UHC administered intravenously and a single dose of uricase (UHC) administ...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/s13318-020-00612-w

    authors： Li H,Huo J,Sun D,Jiang L,Hu C,Bai Y,Ma X,Zhang H,Shi X,Zhao Z,Zhou J,Lu Y,Zhang C

    更新日期：2020-08-01 00:00:00

  • Hepatic metabolism of doxorubicin in mice and rats.

    abstract：:We have studied the metabolism of doxorubicin in rat and mouse liver, heart and hepatocytes. Doxorubicinol was present in all cases at very low levels and 7-deoxyaglycones were present only in extraphysiological conditions: no aglycones were found either in fresh livers or in hearts of animals treated with the drug, b...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/BF03189834

    authors： Vrignaud P,Londos-Gagliardi D,Robert J

    更新日期：1986-04-01 00:00:00

  • Effect of metal salts on UDPglucuronosyltransferase activity of various aglycones in rat liver microsomes in vitro.

    abstract：:The effects of aluminium, manganese, ferrous and ferric iron, cobalt, nickel, copper, zinc, cadmium, barium, mercury and lead ions on the rat hepatic UDPglucuronosyltransferase activity with regard to 4-methylumbelliferone, 4-nitrophenol, bilirubin, and 2-aminophenol were investigated in vitro. Conjugation of bilirubi...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/BF03189441

    authors： Aitio A,Ahotupa M,Parkki MG

    更新日期：1980-01-01 00:00:00

  • Population Pharmacokinetic Modeling of Azithromycin Eyedrops in Tears Following Single-Dose Topical Administration in Healthy Volunteers.

    abstract：BACKGROUND AND OBJECTIVES:The disposition of azithromycin in the human eye following topical administration has not been fully explored. Population pharmacokinetic (PopPK) modeling can allow useful conclusions to be drawn based on limited tear sampling data. The aim of this study was therefore to develop and evaluate a...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s13318-018-0522-6

    authors： Wu F,Zhao X,Li X,Cui Y

    更新日期：2019-06-01 00:00:00

  • Hepatobiliary transport of YM466, a novel factor Xa inhibitor, in rats.

    abstract：:YM466, a novel factor Xa inhibitor, is a hydrophilic compound with a carboxylic acid moiety. Previous studies in rats have shown that YM466 does nor undergo metabolism but is excreted into the bile and urine in unchanged form. Thus, in this study, we investigated in vivo hepatobiliary transport, focusing in particular...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/BF03191128

    authors： Mano Y,Usui T,Kamimura H

    更新日期：2006-04-01 00:00:00

  • Pharmacokinetic plasma behaviors of intravenous and oral bioavailability of thymoquinone in a rabbit model.

    abstract：:Thymoquinone (THQ), the active constituent of Nigella sativa seeds, has demonstrated some potential pharmacological activities. The present study was designed to investigate the pharmacokinetic behavior of THQ following intravenous (IV) and oral (PO) administration using an animal model. THQ was given vascularly (5 mg...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/s13318-014-0207-8

    authors： Alkharfy KM,Ahmad A,Khan RM,Al-Shagha WM

    更新日期：2015-09-01 00:00:00

  • Disposition of 3H-labelled buserelin continuously infused into rats.

    abstract：:The disposition of the gonadotropin-releasing hormone (GnRH) agonist buserelin was studied in male rats under conditions of long-term administration. Rats were continuously infused with about 30 pmole [3H]-buserelin/24 h subcutaneously by osmotic minipumps for 4-7 days. After killing the rats, the 3H-activity of the t...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/BF03189737

    authors： Heinrich N,Albrecht E,Sandow J,Kertscher U,Lorenz D,Oehlke J,Berger H

    更新日期：1996-10-01 00:00:00

  • Pharmacokinetic Studies of Oxathio-Heterocycle Fused Chalcones.

    abstract：BACKGROUND AND OBJECTIVES:Chalcone constitutes one of the most used molecular frameworks in medicinal chemistry and its derivatives exhibit a broad spectrum of biological activities. Low absolute bioavailability, poor distribution, intensive metabolism and elimination of chalcones are the main problems in designing new...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/s13318-016-0320-y

    authors： Okoniewska K,Konieczny MT,Lemke K,Grabowski T

    更新日期：2017-02-01 00:00:00

  • Pharmacokinetic and pharmacodynamic aspects of concomitant mibefradil-digoxin therapy at therapeutic doses.

    abstract：:This study investigated the effect of mibefradil on digoxin pharmacokinetics an pharmacodynamics. Following a loading dose of digoxin (0.375 mg, three times, day 1), 0.375 mg was administered once daily to 40 healthy subjects (days 2-15). Mibefradil was administered daily at 50 mg, 100 mg, or 150 mg (days 9-15). With ...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF03190358

    authors： Peters J,Welker HA,Bullingham R

    更新日期：1999-04-01 00:00:00

  • Evidence of reduced oral bioavailability of paracetamol in rats following multiple ingestion of grapefruit juice.

    abstract：:The aim of the current investigation was to assess the ability GFJ to modulate the pharmacokinetic profile of paracetamol following single or repeated administrations of GFJ in Sprague-Dawley rats. Diclofenac and carbamazepine were both used as positive controls. Rats received single GFJ or single distilled water dose...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/s13318-014-0251-4

    authors： Qinna NA,Ismail OA,Alhussainy TM,Idkaidek NM,Arafat TA

    更新日期：2016-04-01 00:00:00

  • Population Pharmacokinetic Analyses of Lithium: A Systematic Review.

    abstract：BACKGROUND AND OBJECTIVES:Even though lithium has been used for the treatment of bipolar disorder for several decades, its toxicities are still being reported. The major limitation in the use of lithium is its narrow therapeutic window. Several methods have been proposed to predict lithium doses essential to attain the...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章,评审

    doi：10.1007/s13318-017-0421-2

    authors： Methaneethorn J

    更新日期：2018-02-01 00:00:00

  • Method of variability optimization in pharmacokinetic data analysis.

    abstract：:For many drugs administered per os, high variability in the concentration-time (C-T) values from first sampling to the phase of distribution may cause difficulty in pharmacokinetic analysis. Therefore, the aim of this study was to propose a method of transformation of C-T data, which would allow significantly reducing...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/s13318-013-0145-x

    authors： Grabowski T,Jaroszewski JJ,Piotrowski W,Sasinowska-Motyl M

    更新日期：2014-06-01 00:00:00

  • Tissue distribution of the molybdenum hydroxylases, aldehyde oxidase and xanthine oxidase, in male and female guinea pigs.

    abstract：:The activity of the molybdenum hydroxylase, aldehyde oxidase, was determined in crude homogenates and (NH4)2SO4 fractions prepared from guinea pig liver, lung, kidney, intestine, spleen and heart. Xanthine oxidase was also measured in (NH4)2SO4 fractions. In each case, xanthine oxidase levels were lower than those of ...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/BF03189918

    authors： Beedham C,Bruce SE,Rance DJ

    更新日期：1987-10-01 00:00:00

  • Use of bile correction factors for allometric prediction of human pharmacokinetic parameters of torcetrapib, a facile cholesteryl ester transfer protein inhibitor.

    abstract：:Torcetrapib was the lead candidate belonging to the class of cholesteryl ester transfer protein (CETP) inhibitor which was being developed for the management of cardiovascular risk factors by raising HDL. The availability of pharmacokinetic parameters (clearance: CL/F, volume of distribution: Vd/F, elimination rate co...

    journal_title：European journal of drug metabolism and pharmacokinetics

    pub_type： 杂志文章

    doi：10.1007/BF03191385

    authors： Mullangi R,Ahlawat P,Trivedi RK,Srinivas NR

    更新日期：2009-01-01 00:00:00