Binding of cefalotin to human serum albumin.

abstract：:Sertraline potently inhibits cytochrome P450 2B6 (CYP2B6) in vitro. Bupropion is commonly co-prescribed with sertraline and is exclusively metabolized by CYP2B6 to its major active metabolite hydroxybupropion. Putatively the co-administration of bupropion and sertraline could lead to a significant pharmacokinetic drug...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Molnari JC,Hassan HE,Myers AL

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Drug-drug interactions (DDIs) can occur when one drug alters the metabolism of another drug. Drug metabolism mediated by cytochrome P450 enzymes (CYPs) is responsible for the majority of metabolism of known drugs and inhibition of CYP enzymes is a well-known cause of DDIs. In the current study...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Reinen J,Smit M,Wenker M

更新日期：2018-12-01 00:00:00

abstract：:The present study reports findings on the disposition of epirubicin after an intrahepato-arterial administration of the Lipiodol-drug complex, prepared by mixing the drug-aqueous phase with the iodized oil by ultra-sonification, in 14 patients with histologically proven hepatoma or hepatomegaly with serum alpha-fetopr...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Lee K,Chan K,Leung WT,Leung NW,Ho S,Chan M,Lau CC,Tao M,Lau WY,Shiu W

更新日期：1992-07-01 00:00:00

abstract：:The biotransformation of 1-(3-butoxy-2-carbamoyloxypropyl)-5-ethyl-5-phenyl-(1H,3H,5H)-pyrimidine-2,4,6-trione (febarbamate) has been investigated in man. Human volunteers received a single oral dose of 15 mg/kg febarbamate. Twenty two metabolites found in urine were separated and purified by means of an extraction wi...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Vachta J,Valter K,Gold-Aubert P

更新日期：1983-07-01 00:00:00

abstract：:YM466, a novel factor Xa inhibitor, is a hydrophilic compound with a carboxylic acid moiety. Previous studies in rats have shown that YM466 does nor undergo metabolism but is excreted into the bile and urine in unchanged form. Thus, in this study, we investigated in vivo hepatobiliary transport, focusing in particular...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Mano Y,Usui T,Kamimura H

更新日期：2006-04-01 00:00:00

abstract：:The disposition of cloflumide (VUFB 15496), 2-chloro-7-fluoro-10 [4-(carbamoylethyl)piperazino]-10,11-dihydrodibenzo [b,f] thiepin methansulfonate, a new neuroleptic agent, following single oral and intravenous dose was studied in the rat using radiotracer techniques. [3H]Cloflumide was almost completely absorbed from...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Lapka R,Franc Z,Smolík S

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The antitumor activity and toxicity of doxorubicin are potentiated and attenuated by calcitriol, respectively. Potentially, calcitriol can be combined with doxorubicin for clinical benefit in chemotherapy. To gain insight into the interaction between doxorubicin and calcitriol, proposed for com...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Durna Corum D,Uney K

更新日期：2020-10-01 00:00:00

abstract：:The absorption, disposition, biotransformation and excretion of the nonsteroidal anti-inflammatory drug pirazolac were investigated in 6 volunteers (3 males, 3 females, age 50 greater than years) after intravenous and oral administration of 50 mg 14C-pirazolac as an aqueous solution of the sodium salt. Pirazolac was v...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Täuber U,Weiss C,Krause W,Acksteiner B,Matthes H

更新日期：1985-01-01 00:00:00

abstract：:The activity of the molybdenum hydroxylase, aldehyde oxidase, was determined in crude homogenates and (NH4)2SO4 fractions prepared from guinea pig liver, lung, kidney, intestine, spleen and heart. Xanthine oxidase was also measured in (NH4)2SO4 fractions. In each case, xanthine oxidase levels were lower than those of ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Beedham C,Bruce SE,Rance DJ

更新日期：1987-10-01 00:00:00

abstract：:A generic drug product (test product) is bioequivalent to an innovator product (reference product) when their bioavailabilities in the same molar dose are similar. Bioavailability is expressed by pharmacokinetic parameters such as the area under plasma concentration-time curve (AUC), the maximum plasma concentration (...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zintzaras E

更新日期：2005-01-01 00:00:00

abstract：:The pharmacokinetics of chlordemethyldiazepam--a pharmacologically very active new 1,4-benzodiazepine derivative--in healthy subjects after administration of a single oral dose of 2 mg, was studied. Peak concentrations were reached in 1.2 +/- 0.2 hours. Plasma levels declined with a biphasic pattern, and the eliminati...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Bareggi SR,Pirola R,Leva S,Zecca L

更新日期：1986-07-01 00:00:00

abstract：:UDP-glucuronosyltransferase 1A9 (UGT1A9) contributes to the glucuronidation of numerous drugs. Cynomolgus monkeys are regarded as experimental animals similar to humans in studies on safety evaluation and biotransformation for drug development. In this study, the similarities and differences in the enzymatic propertie...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Yamamoto K,Mukai M,Nagaoka K,Hayashi K,Hichiya H,Okada K,Murata M,Shigeyama M,Narimatsu S,Hanioka N

更新日期：2014-09-01 00:00:00

abstract：:10 healthy lactating women were treated orally with the anthelmintic praziquantel (Biltricide), and the resulting timedependent concentrations of the unchanged substance in plasma and milk were determined simultaneously. 5 of the women ("1st trial") received the single dose of 50 mg/kg; the other 5 women ("2nd trial")...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Pütter J,Held F

更新日期：1979-01-01 00:00:00

abstract：:The in vitro and in vivo metabolism of RWJ-69442, an alpha-1A-adrenergic receptor antagonist, was investigated after incubation with rat, dog, and human hepatic S9 fractions in the presence of NADPH-generating system, and a single oral/iv dose administration to rats (oral: 100 mg/kg; iv: 10 mg/kg). Unchanged RWJ-69442...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Wu WN,McKown LA,Kuo GH

更新日期：2005-01-01 00:00:00

abstract：:The aim of the study was to accelerate the dissolution of the sustained release dosage forms using both elevated temperature and high rpm rates. Teokap(®) SR 200 mg pellets were tested by in vitro sustained and accelerated dissolution studies using USP XXIII rotating paddle method. Sustained dissolution studies were c...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ertan G,Karasulu E,Ozgüney I,Karasulu Y,Apaydın S,Kantarcı G,Yurdasiper A,Ege MA

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Beraprost sodium (BPS) is a chemically stable and orally active prostacyclin analog that is used in the treatment of chronic arterial occlusive disease since 1992 and primary pulmonary hypertension since 1999 in Japan. Multiple-drug therapy is common in clinical practice, and BPS is co-administ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Oshida K,Shimamura M,Seya K,Ando A,Miyamoto Y

更新日期：2017-02-01 00:00:00

abstract：:A new high performance liquid chromatographic procedure has been developed for the simultaneous quantification of piribedil (PD) and its three main basic metabolites in rat plasma and urine, without and after hydrolysis. The procedure relies on isolation of the compounds from plasma and urine constituents using the Se...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Sarati S,Caccia S

更新日期：1992-07-01 00:00:00

abstract：:The novel substituted imidazole compound, OC144-093 exhibits potent biological activity in vitro and in vivo for reversal of P-glycoprotein (PgP) based resistance to cancer chemotherapy. Its mechanism of action relies upon its inhibitory interaction with the mdr1 gene product, a known mediator of multidrug resistance ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Guns ES,Bullock PL,Reimer ML,Dixon R,Bally M,Mayer LD

更新日期：2001-10-01 00:00:00

abstract：:The aim of this work was to use radiopharmaceuticals such as technetium (99mTc) and indium (DTPA-Ca111In) to visualize, with a gamma-camera, the disintegration area and time of 3 types of enteric coated hard gelatin capsules (obtained by 3 different preparation processes) and thus, to verify that they are really resis...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Catteau D,Barthélémy C,Deveaux M,Robert H,Trublin F,Marchandise X,Van Drunen H

更新日期：1994-04-01 00:00:00

abstract：:Hepatic clearance of gitoxin has been studied in the rabbit and compared with that of digoxin using an isolated perfused liver technique. During 1.5 hour perfusions with a modified Krebs-Henseleit solution, gitoxin perfusate levels decreased biexponentially; the distribution and elimination half-lives were estimated t...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Pellegrin P,Lesne M

更新日期：1983-01-01 00:00:00

abstract：:Vitexin-4″-O-glucoside (VOG), being a main component in the leaves of Crataegus pinnatifida Bge. var. major, was isolated and then three different doses (20, 40, and 60 mg/kg) of VOG were administered intravenously to rats. To study its pharmacokinetics, a simple and rapid HPLC method was developed using hesperidin as...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ying XX,Wang F,Cheng ZZ,Zhang WJ,Li HB,Du Y,Liu X,Wang SY,Kang TG

更新日期：2012-06-01 00:00:00

abstract：:Pomegranate juice (PJ) is known to be a potent inhibitor of human cytochrome enzymes. The purpose of this study was to investigate the effect of acute and chronic PJ on the pharmacokinetics of oral nitrendipine (10 mg/kg) in rabbits. Male New Zealand rabbits were pretreated with PJ for 1 week and on the last day, a si...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Voruganti S,Rapolu K,Tota S,Yamsani SK,Yamsani MR

更新日期：2012-06-01 00:00:00

abstract：:Tectorigenin (Te) is a main active component in the flowers of Pueraria thomsonii Benth. and the rhizomes of Belamcanda chinensis (L.) DC. Previously, we have reported the pharmacokinetic properties of Te in rat plasma. The purpose of this study was to investigate the urinary excretion of Te after oral administration ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Shi Z,Zhang G,Zhao L,Wang S,Kano Y,Yuan D

更新日期：2015-09-01 00:00:00

abstract：:A single oral dose of 300 mg of nizatidine was administered to two groups of volunteers: a first group of 12 young healthy subjects and a second group of 12 elderly patients, in order to compare the pharmacokinetic parameters and to verify a possible influence of the age on nizatidine's kinetics. Blood samples were co...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Villani P,Regazzi MB,Pecorini M,Tizzoni M,Savio D

更新日期：1991-01-01 00:00:00

abstract：:The present study was carried out to find the in vivo performance of guar gum-based colon-targeted tablets of metronidazole as compared to an immediate release tablets in human volunteers. Six healthy volunteers participated in the study and a crossover design was used. Blood samples were obtained at different time in...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Krishnaiah YS,Veer Raju P,Dinesh Kumar B,Jayaram B,Rama B,Raju V,Bhaskar P

更新日期：2003-10-01 00:00:00

abstract：:In a single dose, randomized, cross-over study, with one week of wash-out period, the relative bioavailability of Dopegyt tablets containing 250 mg alpha-methyldopa (AMD) and Presinol film tablets with identical active ingredient content was examined in 24 healthy volunteers. Since technologically two completely diffe...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Róna K,Ary K,Renczes G,Gachályi B,Grézal GY,Drabant S,Klebovich I

更新日期：2001-01-01 00:00:00

abstract：:Herbal medicinal products have to meet comparable standards concerning the assessment of efficacy, safety and (bio)pharmaceutical quality as chemically defined synthetic drugs. However, these requirements are not fulfilled for many herbal products so far, particularly regarding in vitro dissolution and in vivo bioavai...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Blume HH,Schug BS

更新日期：2000-01-01 00:00:00

abstract：:This paper deals with press-coated modified release tablets in which the drug dose is situated in the core or is divided between the core and the coat. The coat contains polymer (sodium alginate or hydroxypropylmethyl cellulose, HPMC) to control drug release. The main objective was to investigate how the pharmacokinet...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Halsas M,Ervasti P,Veski P,Jürjenson H,Marvola M

更新日期：1998-04-01 00:00:00

abstract：:The inhibitory effects of 17 flavones and flavonols on ethoxy- and pentoxy-resorufin dealkylases of rat liver were investigated. Several findings concerning the relationship between structure and activity can be pointed out. The presence or lack of hydroxyl groups on the flavane nucleus has no influence on the efficie...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Siess MH,Pennec A,Gaydou E

更新日期：1989-07-01 00:00:00

abstract：:The technique of differential display reverse transcription-polymerase chain reaction (ddRT-PCR) has been used to produce unique profiles of up-regulated and down-regulated gene expression in the liver of male Wistar rats following short term exposure to the non-genotoxic hepatocarcinogens, phenobarbital and WY-14,643...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Rockett JC,Esdaile DJ,Gibson GG

更新日期：1997-10-01 00:00:00