Disposition of epirubicin in an oily contrast medium after intravenous and intrahepato-arterial administration in liver cancer: a preliminary report.

abstract：:Parenteral phenytoin solution (Dilantin) was given rectally three times a day for three days to two beagle dogs. This was well tolerated, with no evidence of mucosal irritation noted either on endoscopic nor on rectal mucosal biopsy. When given in this manner, phenytoin is absorbed to a limited degree in canines. Pare...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Fuerst RH,Graves NM,Kriel RL,Olson R

更新日期：1988-10-01 00:00:00

abstract：:The disposition kinetics of the N-oxide of picobenzide were studied after administration to rabbits at a bolus dose of 30 mg/kg of picobenzide intravenously. The biotransformation process fits a first-order kinetic process, and the metabolite shows good access capacity to the peripheral compartment. The N-oxide of pic...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Santos Buelga D,Mariño EL,Domínguez-Gil A

更新日期：1989-01-01 00:00:00

abstract：:Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral (intragastric) cyclosporine A (CyA). Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. The factors responsib...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Schück O,Bohdanecká M,Sedivý J,Krajícková M,Chadimová M,Matousovic K

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:By using a population pharmacokinetic analysis method, we predicted the efficacy of Ceftriaxone (CTRX) based on the pharmacokinetics of CTRX in Japanese adults and the sensitivity of infective organisms to CTRX in 2004. In addition, we clarified the difference in efficacy between once-a-day administration and...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Iida S,Kinoshita H,Kawanishi T,Hayashi M

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Maximum plasma concentration of biopharmaceuticals sometimes occurs long after completion of intravenous infusion. The objective of this research was to study the hypothetical adsorption of biopharmaceuticals to endothelium and infusion material, which may theoretically explain this phenomenon...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Reijers JAA,Dane MJC,van Zonneveld AJ,Burggraaf J,Moerland M

更新日期：2018-02-01 00:00:00

abstract：:Carboxylesterases (CESs) play major roles in catalyzing the hydrolysis of a wide range of ester- and amide-containing compounds. CESs dominate both the biotransformation of numerous therapeutic drugs and the detoxification of environmental toxicants, and the activity alteration of CESs may be a determinant reason for ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Xu Y,Zhang C,He W,Liu D

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:MTBH, a novel hesperetin derivative, possesses in vivo hepatoprotective effects against carbon tetrachloride (CCl4)-induced acute liver injury in Institute of Cancer Research (ICR) mice. OBJECTIVES:This study investigated the pharmacokinetics and tissue distribution of MTBH and its conjugated metabolites in...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Shen C,Qian Z,Chen R,Meng X,Hu T,Chen Z,Li Y,Huang C,Hu C,Li J

更新日期：2016-12-01 00:00:00

abstract：:A simple and sensitive HPLC method has been developed and validated for the determination of tyrosol galactoside (TG) in rat plasma. After one-step protein precipitation with methanol, plasma samples were separated on an Ultimate AQ-C18 column (150 mm×4.6 mm, 5 μm) using acetonitrile-water (7:93, v/v) as mobile phase ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Wang Q,Wang Y,Deng Y,Shi T,Liu X,Sun X,Li X,Zhou D

更新日期：2011-01-01 00:00:00

abstract：:The aim of the present study was to investigate the relative bioavailability and bioequivalence of a new tablet formulation of metformin hydrochloride with reference to a standard product in healthy Chinese adult male volunteers. Two randomized, comparative, two-way crossover studies were therefore conducted. In study...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Li J,Jin Y,Wang TY,Lü XW,Li YH

更新日期：2007-01-01 00:00:00

abstract：:The effect of silymarin (SMN) on the pharmacokinetics of atorvastatin in diabetic rats was evaluated. Male Wistar rats were assigned into two major groups and then sub-grouped according to the purposes of the study. The first major group was subdivided into three groups (n = 6) including control, non-treated diabetic ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Malekinejad H,Rokhsartalab-Azar S,Hassani-Dizaj S,Alizadeh-Fanalou S,Rezabakhsh A,Amniattalab A

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:LCZ696 (sacubitril/valsartan), a novel angiotensin receptor neprilysin inhibitor has been recently approved for the treatment of patients with heart failure (HF) and reduced ejection fraction. As several HF patients are likely to use statins as co-medications, the potential for a pharmacokineti...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Ayalasomayajula S,Pan W,Han Y,Yang F,Langenickel T,Pal P,Zhou W,Yuan Y,Rajman I,Sunkara G

更新日期：2017-04-01 00:00:00

abstract：:The liver first pass effect of pinazepam in four anaesthetized rabbits was determined by measuring the concentrations of this compound and those of its metabolite N-desmethyldiazepam in the plasma from the portal and hepatic veins. Anaesthesia was induced with an i.p. injection of urethane (1.5 g/kg). Portal and hepat...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Pacifici GM,Placidi GF

更新日期：1982-01-01 00:00:00

abstract：:The in vitro and in vivo metabolism of RWJ-69442, an alpha-1A-adrenergic receptor antagonist, was investigated after incubation with rat, dog, and human hepatic S9 fractions in the presence of NADPH-generating system, and a single oral/iv dose administration to rats (oral: 100 mg/kg; iv: 10 mg/kg). Unchanged RWJ-69442...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Wu WN,McKown LA,Kuo GH

更新日期：2005-01-01 00:00:00

abstract：:A bioequivalence study compares the bioavailability between a test and a reference drug product in terms of the rate and extent of drug absorption. Area under the plasma concentration-time curve (AUC) and maximum plasma concentration (Cmax) are the pharmacokinetic parameters that serve as characteristics for the asses...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zintzaras E,Bouka P

更新日期：1999-07-01 00:00:00

abstract：:We retrospectively analyzed amikacin pharmacokinetics in 19 critically ill patients who received amikacin intravenously. Fourteen subjects (577 serum amikacin concentrations, 167 urine measurements) were studied to obtain data for population modeling, while 5 patients (267 serum amikacin concentrations, 68 urine measu...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Joubert P,Bressolle F,Gouby A,Douçot PY,Saissi G,Gomeni R

更新日期：1999-01-01 00:00:00

abstract：:Pharmacokinetics of recombinant human basic fibroblast growth factor (rhbFGF) in mice were studied by using a radioiodination method combined with sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and a sandwich enzyme-Linked immunosorbent assay (ELISA). RhbFGF concentration in serum were dertermine...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Zhang Q,Wang GJ,Sun JG

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Clopidogrel is an antiplatelet and antithrombotic prodrug. It has poor oral bioavailability due to poor dissolution and possible premature degradation in the intestine. Accordingly, the objective of this study was to enhance clopidogrel dissolution rate and to reduce its premature degradation ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Bali DE,Osman MA,El Maghraby GM

更新日期：2016-12-01 00:00:00

abstract：:Blood loss during cesarean section was calculated based on post-operative decrement of hemoglobin (Hb) and hematocrit (Hct) level. The model used for pregnant women was previously validated for non-pregnant women who underwent gynecological surgery. 1,068 pregnant women who underwent cesarean section and 517 women who...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Milosevic N,Popovic J,Grujic Z,Rapaic M

更新日期：2011-09-01 00:00:00

abstract：:Tectorigenin (Te) is a main active component in the flowers of Pueraria thomsonii Benth. and the rhizomes of Belamcanda chinensis (L.) DC. Previously, we have reported the pharmacokinetic properties of Te in rat plasma. The purpose of this study was to investigate the urinary excretion of Te after oral administration ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Shi Z,Zhang G,Zhao L,Wang S,Kano Y,Yuan D

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Mast cell-mediated allergic diseases are a significant global health problem. Nitric oxide (NO) produced by acute type 1 allergies greatly suppresses hepatic cytochrome P450 (CYP) metabolism. A recent in vitro study demonstrated that repeated FcεRI-mediated activation intrinsically modulates m...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Tanino T,Bando T,Okada Y,Nojiri Y,Hashimoto K,Ueda Y,Sakurai E

更新日期：2019-06-01 00:00:00

abstract：:Following i.v. administration of mono-HR to the beagle, plasma levels of both mono-HR and its glucuronide conjugates fell rapidly, neither being detectable 8 h after injection. Following oral administration of 14C-mono-HR, mono-HR-glucuronide was detected in plasma, confirming the absorption of mono-HR, and low levels...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hackett AM,Griffiths LA

更新日期：1979-01-01 00:00:00

abstract：:We have investigated the in vitro metabolism of three small antimicrobial β(2,2)-amino acid derivatives (M (w) < 500) that are highly potent against methicillin resistant Staphylococcus aureus, and are among the first compounds designed from small cationic antimicrobial peptides with potential ...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Hansen T,Moe MK,Anderssen T,Strøm MB

更新日期：2012-09-01 00:00:00

abstract：:The metabolism of (-)-(S)-nicotine has been investigated following intratracheal administration to the recirculating perfused rabbit lung model. The metabolic products present in the perfusate were identified by co-chromatography (HPLC and GC) with authentic standards and quantified by HPLC. After the 180 min perfusio...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Aislaitner G,Bello A,Tan SC,Hutt AJ,Marriott C,Gorrod JW

更新日期：1997-10-01 00:00:00

abstract：:Bioavailability of lansoprazole, a new gastric proton pump inhibitor, was investigated in 12 healthy subjects. Each subject received in random order, lansoprazole (30 mg) alone or associated with standard meal or with antacids (aluminium and magnesium hydroxides) or one hour later than antacids. Lansoprazole and metab...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Delhotal-Landes B,Cournot A,Vermerie N,Dellatolas F,Benoit M,Flouvat B

更新日期：1991-01-01 00:00:00

abstract：:Hydroxylated metabolites of diazepam can be conjugated and are therefore generally thought not to affect the metabolism of diazepam. Liver microsomes, obtained from phenobarbital-pretreated rats, showed an inhibition of diazepam (10(-5) M) metabolism by desmethyldiazepam as well as by N-methyloxazepam or oxazepam (5 X...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Savenije-Chapel EM,Bast A,Noordhoek J

更新日期：1985-01-01 00:00:00

abstract：:Mathematical models that can predict the kinetics of compounds have been increasingly adopted for drug development and risk assessment. Data for these models may be generated from in vitro experimental systems containing enzymes contributing to metabolic clearance, such as subcellular tissue fractions including micros...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Doerksen MJ,Jones RS,Coughtrie MWH,Collier AC

更新日期：2020-12-19 00:00:00

abstract：:Penbutolol is a not cardioselective beta-adrenergic blocking drug; it is lipid soluble and differs in its protein binding from the other members of its group because shows linkage to alpha 1-glycoprotein, with no detectable binding to albumin. AAG levels change during pregnancy and so the binding of [3H]-penbutolol wa...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Aquirre C,Rodriguez-Sasiain JM,Navajas P,Calvo R

更新日期：1988-01-01 00:00:00

abstract：:The fate of Ticlopidine, a new inhibitor of platelet aggregation, has been studied in rats following single oral doses. The compound was quickly absorbed as evaluated by the time of the peak plasma concentration. The metabolism of Ticlopidine involved N-oxidation, cleavage of the N-C bond, oxidation of aliphatic carbo...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Tuong A,Bouyssou A,Paret J,Cuong TG

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Chalcone constitutes one of the most used molecular frameworks in medicinal chemistry and its derivatives exhibit a broad spectrum of biological activities. Low absolute bioavailability, poor distribution, intensive metabolism and elimination of chalcones are the main problems in designing new...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Okoniewska K,Konieczny MT,Lemke K,Grabowski T

更新日期：2017-02-01 00:00:00

abstract：:The bioavailability of the recently developed 1 g dispersible tablet form of amoxicillin (B) and the 1 g dispersible tablet in suspension form (C) were compared to that of the 1 g standard reference formulation (A). Twelve healthy volunteers were involved in this single-dose, open, randomized, three-way cross-over stu...

journal_title：European journal of drug metabolism and pharmacokinetics

authors： Prevot MH,Jehl F,Rouveix B

更新日期：1997-01-01 00:00:00