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Ranitidine treatment and cortisol metabolism in man.

Abstract：

:Experimental evidence suggested that H2-receptor antagonists may inhibit not only hepatic but also adrenal cytochrome P-450 dependent monooxygenases. Therefore, the effects of ranitidine (150 mg b.i.d. over 14 days) on cortisol metabolism and antipyrine clearance have been investigated in nine healthy volunteers. Urinary excretion of 6 beta-hydroxycortisol (6 beta-OHC) and 17-hydroxycorticosteroids (17-OHCS) remained unaffected by ranitidine pretreatment, as did the calculated 6 beta-OHC/17-OHCS ratio. Only marginal effects were observed on antipyrine kinetics and metabolite formation. We conclude that neither adrenal production of corticosteroids nor their hepatic metabolism is affected by ranitidine administration.

journal_name

Eur J Drug Metab Pharmacokinet

journal_title

European journal of drug metabolism and pharmacokinetics

authors

Mönig H,Hoffmann K,Ohnhaus EE,Schulte HM

doi

10.1007/BF03189981

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

9-12

issue

1

eissn

0378-7966

issn

2107-0180

journal_volume

17

pub_type

杂志文章

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