Biologic functions of blood group antigens.

abstract：PURPOSE OF REVIEW:Adoptive T-cell therapy has become one of the most exciting fields of cancer therapy in the past few years. In this article, we describe a method which combines adoptive T-cell therapy with antibody therapy by arming T cells from cord blood, normal patients, and cancer patients with bispecific antibod...

journal_title：Current opinion in hematology

authors： Bhutani D,Lum LG

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent thrombosis and/or obstetrical morbidity in the presence of persistently positive antiphospholipid antibodies. Recent insights into the pathogenesis of APS have begun to elucidate pathophysiology and led to...

journal_title：Current opinion in hematology

authors： Chaturvedi S,McCrae KR

更新日期：2014-09-01 00:00:00

abstract：:Over the past year, substantial progress was made toward understanding transcriptional control of red cell differentiation. Complementary DNAs encoding two novel erythroid-restricted transcription factors--globin locus control region regulatory factor NF-E2 and CACC-binding protein EKLF--were cloned and characterized....

journal_title：Current opinion in hematology

authors： Andrews NC,Orkin SH

更新日期：1994-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite parenteral artesunate therapy, the fatality rate of cerebral malaria remains high. Adjunctive therapy targeting the underlying pathophysiology of cerebral malaria may further improve the clinical outcome. Endothelial activation and dysfunction is a central process in the pathogenesis of cerebr...

journal_title：Current opinion in hematology

authors： Kim H,Higgins S,Liles WC,Kain KC

更新日期：2011-05-01 00:00:00

abstract：:Coagulation preserves the homeostasis of internal body fluids against life-threatening blood losses. Although generally viewed as a regulated enzymatic cascade, this mechanism depends on the participation of vascular cells. Leukocytes, in particular, have evolved a formidable machinery to initiate and amplify blood cl...

journal_title：Current opinion in hematology

authors： Altieri DC

更新日期：1995-01-01 00:00:00

abstract：:Allogeneic barriers to transfusion are caused by differences between those portions of the donor and recipient genomes that define the antigenicity and immune response to the transfused cells. Historically, a blood group antigen was identified when an immune response (alloantibody) was detected by hemagglutination in ...

journal_title：Current opinion in hematology

authors： Reid ME,Lomas-Francis C

更新日期：2002-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT), despite improvements in our understanding of its pathophysiology as well as the generation of new monoclonal antibodies, immunomodulatory chemotherapy, cellular ...

journal_title：Current opinion in hematology

authors： Paczesny S,Choi SW,Ferrara JL

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss how mechanical cues and Rho signaling contribute to control of vascular development and hematopoiesis. RECENT FINDINGS:Rho guanine trinucleotide phosphatases are ubiquitious regulators of cytoskeletal structure and tension generation. Recent work shows that Rho-dependent mechanical interac...

journal_title：Current opinion in hematology

authors： Mammoto A,Mammoto T,Ingber DE

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Bone marrow transplantation is the only curative treatment for severe thalassemia. Since its successful first report in 1981, more than 4000 patients with this disease worldwide underwent bone marrow transplantation. The purpose of this review is to update the most recent reports of matched sibling do...

journal_title：Current opinion in hematology

authors： Issaragrisil S,Kunacheewa C

更新日期：2016-11-01 00:00:00

abstract：:Multiple myeloma is the second most common hematologic malignancy, with approximately 15,000 new cases each year in the United States. Our understanding of the pathophysiology underlying myeloma continues to expand, but the cause of this plasma cell dyscrasia remains unclear. Though controversy remains regarding a pos...

journal_title：Current opinion in hematology

authors： Sjak-Shie NN,Vescio RA,Berenson JR

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Core binding factor acute myeloid leukemia (CBF-AML) corresponds to two distinct subtypes of AML characterized by recurrent favorable chromosome translocations, namely t(8;21) and inv(16)/t(16;16). Given the relatively good outcome of patients with CBF-AML, when treated with intensive chemotherapy inc...

journal_title：Current opinion in hematology

authors： Dombret H,Preudhomme C,Boissel N

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Type 1 von Willebrand disease (VWD) is the most common form of VWD, but has remained [corrected] the least well understood. Recent work is changing this situation. This review summarizes recent analysis of the genetic basis of the disease. RECENT FINDINGS:Linkage analysis demonstrates that dominantly...

journal_title：Current opinion in hematology

authors： Goodeve A

更新日期：2007-09-01 00:00:00

abstract：:Whereas there are general guidelines for acceptable transfusion therapy, optimal transfusion therapy has not been determined for most clinical settings. Recent research has focused on controlled studies of red cell transfusion in specific clinical settings. Better determinations of oxygen delivery and consumption are ...

journal_title：Current opinion in hematology

authors： Clark P,Mintz PD

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review is designed to help readers understand seasonal blood shortages and provide solutions through the use of technology that can increase the number of red blood cell units collected and the use of recruitment and marketing initiatives that appeal to the increasingly diverse donor base. RECEN...

journal_title：Current opinion in hematology

authors： Gilcher RO,McCombs S

更新日期：2005-11-01 00:00:00

abstract：:Recent advances in our understanding of hypereosinophilia have related particularly to the definition of criteria for distinguishing between eosinophilic leukemia and the 'idiopathic' hypereosinophilic syndromes. In this article, leukemogenic mechanisms have been identified in a number of subtypes of eosinophilic leuk...

journal_title：Current opinion in hematology

authors： Bain BJ

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Hemolytic anemias caused by premature destruction of red blood cells occur in many disorders including hemoglobinopathies, autoimmune conditions, during infection or following reaction to drugs or transfusions. Recent studies which will be reviewed here have uncovered several novel mechanisms by which...

journal_title：Current opinion in hematology

authors： Zhong H,Yazdanbakhsh K

更新日期：2018-05-01 00:00:00

abstract：:The idea that blood in naturally occurring transmissible spongiform encephalopathies is not infectious has imploded in the face of recent transmissions from the blood of naturally occurring scrapie in sheep and of variant Creutzfeldt-Jakob disease in humans. Although donor exclusion criteria ensure that the number of ...

journal_title：Current opinion in hematology

authors： Brown P,Cervenakova L

更新日期：2004-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic inflammation and disordered lipid metabolism represent hallmarks of atherosclerosis. Considerable evidence has accumulated to suggest that innate immune defense mechanisms might interact with proinflammatory pathways and exacerbate or perhaps even initiate development of arterial plaques. Unti...

journal_title：Current opinion in hematology

authors： Michelsen KS,Arditi M

更新日期：2006-05-01 00:00:00

abstract：:This article presents the most recent insights into the biology, prognostic significance, and therapeutic approaches to TEL/AML1-positive leukemia. The TEL/AML1 fusion gene, also known as ETV6 /CBFA2, is the most commonly occurring gene rearrangement in pediatric acute lymphoblastic leukemia (ALL). Considerable contro...

journal_title：Current opinion in hematology

authors： Loh ML,Rubnitz JE

更新日期：2002-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The peptide hormone hepcidin regulates iron metabolism in response to erythropoietic demand, iron stores and inflammation. Major advances have been made in understanding the regulation of hepcidin production, and consequently the availability of iron for erythropoiesis. RECENT FINDINGS:It is becoming...

journal_title：Current opinion in hematology

authors： Nemeth E

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Although the zebrafish has been established as a research tool over the past two to three decades, in hematology it has primarily been used to investigate areas distinct from coagulation. The advantages of this vertebrate model include high fecundity, rapid and external development, and conservation o...

journal_title：Current opinion in hematology

authors： Weyand AC,Shavit JA

更新日期：2014-09-01 00:00:00

abstract：:Thrombopoietin, also termed the c-Mpl ligand, is a lineage-dominant hematopoietic factor that primarily regulates megakaryopoiesis and thrombopoiesis. Treatment of normal animals with recombinant human megakaryocyte growth and development factor, a truncated molecule of the c-Mpl ligand, which is modified with polyeth...

journal_title：Current opinion in hematology

authors： Miyazaki H

更新日期：1998-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight mechanisms that regulate the balance between latent and active von Willebrand factor (VWF), and describe pathological conditions leading to increased levels of active VWF. RECENT FINDINGS:Levels of circulating active VWF are increased in von Willebrand disease type 2B, HELLP syndrome, ma...

journal_title：Current opinion in hematology

authors： Groot E,de Groot PG,Fijnheer R,Lenting PJ

更新日期：2007-05-01 00:00:00

abstract：:Genetic defects of the blood platelet membrane glycoproteins, GPIIb-IIIa (alpha IIb/beta 3; CD41/CD61) and GPIb-V-IX (CD42) are the origin of several rare bleeding disorders, the best known of which are Glanzmann's thrombasthenia, Bernard-Soulier syndrome, and platelet-type von Willebrand's disease. In Glanzmann's thr...

journal_title：Current opinion in hematology

authors： Clemetson KJ,Clemetson JM

更新日期：1994-09-01 00:00:00

abstract：:Considerable data now support the hypothesis that platelets actively regulate the propagation of coagulation by (1) expressing specific, high-affinity receptors for coagulation proteases, zymogens, and cofactors; (2) protecting the bound coagulation enzymes from inactivation/inhibition; (3) restricting coagulant activ...

journal_title：Current opinion in hematology

authors： Bouchard BA,Tracy PB

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity has become a worldwide epidemic that is driving increased morbidity and mortality from thrombotic disorders such as myocardial infarction, stroke, and venous thromboembolism. Effective prevention and treatment of thrombosis in obese patients is limited by an incomplete understanding of the und...

journal_title：Current opinion in hematology

authors： Blokhin IO,Lentz SR

更新日期：2013-09-01 00:00:00

abstract：:Disorders of the erythrocyte membrane, such as hereditary spherocytosis, hereditary elliptocytosis, and hereditary pyropoikilocytosis, are characterized by heterogeneity in their clinical and laboratory manifestations. Recent work has shown that these disorders also exhibit marked genetic heterogeneity. Multiple genet...

journal_title：Current opinion in hematology

authors： Gallagher PG,Ferriera JD

更新日期：1997-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The leukocyte adhesion deficiency (LAD) syndromes are rare genetically determined conditions with challenging clinical features. These immunodeficiencies also provide insights that are broadly relevant to the biology of leukocytes, platelets, intercellular interactions, and intracellular signaling. Re...

journal_title：Current opinion in hematology

authors： Harris ES,Weyrich AS,Zimmerman GA

更新日期：2013-01-01 00:00:00

abstract：:Platelet aggregation, a process mediated by GP IIb-IIIa, is responsible for the occlusive events in thrombosis: indeed, GP IIb-IIIa antagonists are effective in blocking arterial thrombosis. Recent studies have suggested that activated platelets and platelet thrombi can contribute significantly to the initiation and p...

journal_title：Current opinion in hematology

authors： Prasad KS,Andre P,Yan Y,Phillips DR

更新日期：2003-09-01 00:00:00

abstract：:Hematopoietic stem cells, defined as cells with extensive self-renewal and pluripotent differentiation potential, represent a minor population of adult bone marrow (< 1 in 10(4) to 10(5) nucleated marrow cells). Recent advances in cell surface phenotype analysis and separation technology have permitted enrichment of h...

journal_title：Current opinion in hematology

authors： Moore MA,Shapiro F

更新日期：1994-05-01 00:00:00