Dephosphorylation and benzoylation reactions occurring in the benzoolysis of diacyl-, alkylacyl-, alk-1-enylacyl-, and acyl-lyso-glycerophosphocholines.

abstract：:An enzyme (phosphatidyl glycerophosphate phosphatase) that catalyzes the formation of phosphatidyl glycerol from phosphatidyl glycerophosphate has been rendered soluble by treatment of the particulate fraction of E. coli with Triton X-100 in the presence of EDTA, and has been partially purified. The enzyme is specific...

journal_title：Journal of lipid research

authors： Chang YY,Kennedy EP

更新日期：1967-09-01 00:00:00

abstract：:The role of nuclear membrane phospholipids as targets of phospholipases resulting in the generation of nuclear signaling messengers has received attention. In the present study, we have exploited the utility of electrospray ionization mass spectrometry to determine the phospholipid content of nuclei isolated from perf...

journal_title：Journal of lipid research

authors： Williams SD,Hsu FF,Ford DA

更新日期：2000-10-01 00:00:00

abstract：:Autosomal recessive polycystic kidney disease (ARPKD) is a severe, monogenetically inherited kidney and liver disease. PCK rats carrying the orthologous mutant gene serve as a model of human disease, and alterations in lipid profiles in PCK rats suggest that defined subsets of lipids may be useful as molecular disease...

journal_title：Journal of lipid research

authors： Ruh H,Salonikios T,Fuchser J,Schwartz M,Sticht C,Hochheim C,Wirnitzer B,Gretz N,Hopf C

更新日期：2013-10-01 00:00:00

abstract：:Plasma levels of HDL cholesterol (HDL-C) have a strong inherited basis with heritability estimates of 40-60%. The well-established inverse relationship between plasma HDL-C levels and the risk of coronary artery disease (CAD) has led to an extensive search for genetic factors influencing HDL-C concentrations. Over the...

journal_title：Journal of lipid research

authors： Weissglas-Volkov D,Pajukanta P

更新日期：2010-08-01 00:00:00

abstract：:Cholesterol monohydrate crystal formation was studied in supersaturated model bile solutions, containing unlabeled cholesterol, sodium cholate and soybean phosphatidylcholine, and tracer amounts of [3H]cholesterol. Solutions were either seeded with cholesterol crystals to initiate growth, or not seeded to allow self-n...

journal_title：Journal of lipid research

authors： Whiting MJ,Watts JM

更新日期：1983-07-01 00:00:00

abstract：:The effects of intravenous injection of lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF) were investigated in cynomolgus monkeys (Macaca fascicularis). Injection of 20 micrograms/kg of LPS from E. coli (serotype 055:B5) into cynomolgus monkeys fed a monkey chow diet caused a twofold increase in plasma tr...

journal_title：Journal of lipid research

authors： Ettinger WH,Miller LD,Albers JJ,Smith TK,Parks JS

更新日期：1990-06-01 00:00:00

abstract：:Changes in the cellularity of various adipose tissues in growing cattle were analyzed. Fifty male cattle were slaughtered between 15 and 65% of mature weight. The whole adipose mass, separated by dissection, was divided into three parts: subcutaneous, intermuscular, and internal adipose tissues. Lipid content, cell si...

journal_title：Journal of lipid research

authors： Robelin J

更新日期：1981-03-01 00:00:00

abstract：:The addition of a trans isomer of arachidonic acid (20:4 delta 14trans) to rat platelet suspensions inhibited the aggregation induced by 7.5 microM of arachidonic acid. This inhibitory effect of 20:4 delta 14trans was significant at concentrations of 7.5-22.5 microM and the range of inhibition was 20% at an inhibitor/...

journal_title：Journal of lipid research

authors： Berdeaux O,Chardigny JM,Sébédio JL,Mairot T,Poullain D,Vatèle JM,Noël JP

更新日期：1996-10-01 00:00:00

abstract：:Several studies indicate that cholesterol esterification is deregulated in cancers. The present study aimed to characterize the role of cholesterol esterification in proliferation and invasion of two tumor cells expressing an activated cholecystokinin 2 receptor (CCK2R). A significant increase in cholesterol esterific...

journal_title：Journal of lipid research

authors： Paillasse MR,de Medina P,Amouroux G,Mhamdi L,Poirot M,Silvente-Poirot S

更新日期：2009-11-01 00:00:00

abstract：:Chronic inflammation contributes to cardiovascular disease. Increased levels of the inflammatory cytokine, TNF-α, are often present in conditions associated with cardiovascular disease risk, and TNF-α induces a number of pro-atherogenic effects in macrovascular endothelial cells, including expression of adhesion molec...

journal_title：Journal of lipid research

authors： Jung HS,Shimizu-Albergine M,Shen X,Kramer F,Shao D,Vivekanandan-Giri A,Pennathur S,Tian R,Kanter JE,Bornfeldt KE

更新日期：2020-01-01 00:00:00

abstract：:Bile salts of the coelacanth, Latimeria chalumnae, Smith, have been analyzed and shown to have three bile alcohols, latimerol, 5 alpha-cyprinol, and 5 alpha-cholestane-3 beta, 7 alpha,-12 alpha,25,26-pentol, two C24 bile acids, chenodeoxycholic acid and cholic acid, one C26 bile acid, probably 3 beta, 7 alpha, 12 alph...

journal_title：Journal of lipid research

authors： Kihira K,Akashi Y,Kuroki S,Yanagisawa J,Nakayama F,Hoshita T

更新日期：1984-12-01 00:00:00

abstract：:Cardiac triacylglycerol (TG) catabolism critically depends on the TG hydrolytic activity of adipose triglyceride lipase (ATGL). Perilipin 5 (Plin5) is expressed in cardiac muscle (CM) and has been shown to interact with ATGL and its coactivator comparative gene identification-58 (CGI-58). Furthermore, ectopic Plin5 ex...

journal_title：Journal of lipid research

authors： Pollak NM,Schweiger M,Jaeger D,Kolb D,Kumari M,Schreiber R,Kolleritsch S,Markolin P,Grabner GF,Heier C,Zierler KA,Rülicke T,Zimmermann R,Lass A,Zechner R,Haemmerle G

更新日期：2013-04-01 00:00:00

abstract：:In this article we report the effects of low and high fat diets on the arterial thrombosis tendency in rats. The animal system used was the aorta loop model, in which we compared the effect of saturated (hardened coconut oil, HCO) and unsaturated (sunflower seed oil, SSO; corn oil, CO) fatty acids on the arterial thro...

journal_title：Journal of lipid research

authors： Schurgers LJ,Vermeer C

更新日期：2001-07-01 00:00:00

abstract：:Sterol-regulatory element binding protein-1c (SREBP-1c) is a transcription factor that controls lipogenesis in the liver. Hepatic SREBP-1c is nutritionally regulated, and its sustained activation causes hepatic steatosis and insulin resistance. Although regulation of SREBP-1c is known to occur at the transcriptional l...

journal_title：Journal of lipid research

authors： Yamamoto T,Watanabe K,Inoue N,Nakagawa Y,Ishigaki N,Matsuzaka T,Takeuchi Y,Kobayashi K,Yatoh S,Takahashi A,Suzuki H,Yahagi N,Gotoda T,Yamada N,Shimano H

更新日期：2010-07-01 00:00:00

abstract：:Serum paraoxonase (PON1) is a HDL-associated enzyme exhibiting potentially antiatherogenic properties. Here, we examined the common PON1-192R/Q human polymorphism. Despite numerous studies, the effect of this polymorphism on the antiatherogenic potential of PON1 is yet unresolved. Our structural model suggests that am...

journal_title：Journal of lipid research

authors： Gaidukov L,Rosenblat M,Aviram M,Tawfik DS

更新日期：2006-11-01 00:00:00

abstract：:Bile acids are a group of molecular species of acidic steroids with peculiar physical-chemical and biological characteristics. At high concentrations they become toxic to mammalian cells, and their presence is pertinent in the pathogenesis of several liver diseases and colon cancer. Bile acid cytoxicity has been relat...

journal_title：Journal of lipid research

authors： Amaral JD,Viana RJ,Ramalho RM,Steer CJ,Rodrigues CM

更新日期：2009-09-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) is a receptor-active lipid mediator with a broad range of biological effects. Ovarian cancer cells synthesize LPA, which promotes their motility, growth, and survival. We show that a murine homolog of a human protein previously reported to hydrolyze LPA is a highly selective detergent-stimu...

journal_title：Journal of lipid research

authors： Luquain C,Singh A,Wang L,Natarajan V,Morris AJ

更新日期：2003-10-01 00:00:00

abstract：:ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Because SM depletion increases cellular PC content and stimulates PC and cholesterol efflux by ABCA1, a key transporter involved in generation of HDL, we predicted that SM depletion also stimu...

journal_title：Journal of lipid research

authors： Zhao Y,Ishigami M,Nagao K,Hanada K,Kono N,Arai H,Matsuo M,Kioka N,Ueda K

更新日期：2015-03-01 00:00:00

abstract：:Hepatic free cholesterol levels are influenced by cholesterol synthesis and ester formation, which, in turn, might regulate cholesterol secretion into bile and plasma. We manipulated the rates of hepatic cholesterol synthesis and esterification and measured biliary and very low density lipoprotein (VLDL) cholesterol s...

journal_title：Journal of lipid research

authors： Stone BG,Evans CD

更新日期：1992-11-01 00:00:00

abstract：:We have developed the technique of rapid (< 2 h) centrifugal ultrafiltration to measure the inter-mixed micellar/vesicular (non-lecithin-associated) bile salt (BS) concentrations (IMC) of individual BS in model biles. This methodology uses a centrifugal concentrator with a reinforced membrane, through which a small fr...

journal_title：Journal of lipid research

authors： Donovan JM,Jackson AA

更新日期：1993-07-01 00:00:00

abstract：:Expression of constitutively activated Akt in the mammary glands of transgenic mice results in a delay in post-lactational involution. We now report precocious lipid accumulation in the alveolar epithelium of mouse mammary tumor virus-myr-Akt transgenic mice accompanied by a lactation defect that results in a 50% decr...

journal_title：Journal of lipid research

authors： Schwertfeger KL,McManaman JL,Palmer CA,Neville MC,Anderson SM

更新日期：2003-06-01 00:00:00

abstract：:Apolipoprotein AV (apoAV) overexpression causes a decrease in plasma triglyceride (TG) levels, while deficiency of apoAV causes hypertriglyceridemia in both men and mice. However, contrary to what would be expected, plasma apoAV and TG levels in humans are positively correlated. To address this apparent paradox, we de...

journal_title：Journal of lipid research

authors： Vaessen SF,Dallinga-Thie GM,Ross CJ,Splint LJ,Castellani LW,Rensen PC,Hayden MR,Schaap FG,Kuivenhoven JA

更新日期：2009-05-01 00:00:00

abstract：:A method for the preparation of 1-alkyl 2-acyl glycero-3-phosphorylcholine, labeled in the 2-position with oleic acid-1-(14)C is described. This method, based on the acylation of a 1-alkyl glycero-3-phosphorylcholine-CdCl(2) complex which is, in turn, formed from 1-alk-1-enyl glycero-3-phosphorylcholine by hydrogenati...

journal_title：Journal of lipid research

authors： Poulos A

更新日期：1970-09-01 00:00:00

abstract：:Apolipoprotein (apo) B-100, the protein constituent of low density lipoproteins (LDL), is the determinant responsible for LDL binding to the apoB,E(LDL) receptor on cells. The current study was designed to identify the region(s) of apoB-100 that interact with the apoB,E(LDL) receptor. Apolipoprotein B-100 was fragment...

journal_title：Journal of lipid research

authors： Corsini A,Spilman CH,Innerarity TL,Arnold KS,Rall SC Jr,Boyles JK,Mahley RW

更新日期：1987-12-01 00:00:00

abstract：:Polymorphic transformations in two saturated-unsaturated mixed acid triacylglycerols, SOS (sn -1,3-distearoyl-2-oleoylglycerol) and OSO (sn -1,3-dioleoyl-2-stearoylglycerol), have been studied by FT-IR spectroscopy using deuterated specimens in which stearoyl chains are fully deuterated. A reversible phase transition ...

journal_title：Journal of lipid research

authors： Yano J,Sato K,Kaneko F,Small DM,Kodali DR

更新日期：1999-01-01 00:00:00

abstract：:The regulation of hepatic and intestinal 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and acyl-CoA; cholesterol acyltransferase (ACAT) activities by dietary fish oil was examined in the rabbit. Rabbits were fed 10% menhaden oil or menhaden oil plus 1% cholesterol for 14 days. They were compared with animals fed ...

journal_title：Journal of lipid research

authors： Field FJ,Albright EJ,Mathur SN

更新日期：1987-01-01 00:00:00

abstract：:Recent studies demonstrate that HDL's ability to promote cholesterol efflux from macrophages associates strongly with cardioprotection in humans independently of HDL-cholesterol (HDL-C) and apoA-I, HDL's major protein. However, the mechanisms that impair cholesterol efflux capacity during vascular disease are unclear....

journal_title：Journal of lipid research

authors： Vaisar T,Tang C,Babenko I,Hutchins P,Wimberger J,Suffredini AF,Heinecke JW

更新日期：2015-08-01 00:00:00

abstract：:Binding of the medium-chain fatty acids (MCFA), octanoic (OCT) and decanoic (DEC) acid, to human serum albumin (HSA) has been studied by 13C NMR spectroscopy. NMR spectra at 35 degrees C showed an apparently homogeneous binding environment (a single, narrow resonance for the 13C-enriched carboxyl carbon) at different ...

journal_title：Journal of lipid research

authors： Kenyon MA,Hamilton JA

更新日期：1994-03-01 00:00:00

abstract：:Acyl-coenzyme A:diacylglycerol transferase (DGAT), fatty acid synthetase (FAS), and LPL are three enzymes important in adipose tissue triglyceride accumulation. To study the relationship of DGAT1, FAS, and LPL with insulin, we examined adipose mRNA expression of these genes in subjects with a wide range of insulin sen...

journal_title：Journal of lipid research

authors： Ranganathan G,Unal R,Pokrovskaya I,Yao-Borengasser A,Phanavanh B,Lecka-Czernik B,Rasouli N,Kern PA

更新日期：2006-11-01 00:00:00

abstract：:The inverse relationship between plasma levels of high density lipoprotein (HDL) and coronary heart disease rates has suggested that HDL might influence body stores of cholesterol. Therefore, we have investigated potential relationships between the parameters of body cholesterol metabolism and the plasma levels of HDL...

journal_title：Journal of lipid research

authors： Blum CB,Dell RB,Palmer RH,Ramakrishnan R,Seplowitz AH,Goodman DS

更新日期：1985-09-01 00:00:00