当前位置： SCI文献检索 > JOURNAL OF LIPID RESEARCH期刊下所有文献 > Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin.

Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin.

Abstract：

:Sterol-regulatory element binding protein-1c (SREBP-1c) is a transcription factor that controls lipogenesis in the liver. Hepatic SREBP-1c is nutritionally regulated, and its sustained activation causes hepatic steatosis and insulin resistance. Although regulation of SREBP-1c is known to occur at the transcriptional level, the precise mechanism by which insulin signaling activates SREBP-1c promoter remains to be elucidated. Here we show that protein kinase C beta (PKCbeta) is a key mediator of insulin-mediated activation of hepatic SREBP-1c and its target lipogenic genes. Activation of SREBP-1c in the liver of refed mice was suppressed by either adenoviral RNAi-mediated knockdown or dietary administration of a specific inhibitor of protein kinase C beta. The effect of PKCbeta inhibition was cancelled in insulin depletion by streptozotocin (STZ) treatment of mice. Promoter analysis indicated that PKCbeta activates SREBP-1c promoter through replacement of Sp3 by Sp1 for binding to the GC box in the sterol regulatory element (SRE) complex, a key cis-element of SREBP-1c promoter. Knockdown of Sp proteins demonstrated that Sp3 and Sp1 play reciprocally negative and positive roles in nutritional regulation of SREBP-1c, respectively. This new understanding of PKCbeta involvement in nutritional regulation of SREBP-1c activation provides a new aspect of PKCbeta inhibition as a potential therapeutic target for diabetic complications.

journal_name

J Lipid Res

journal_title

Journal of lipid research

authors

Yamamoto T,Watanabe K,Inoue N,Nakagawa Y,Ishigaki N,Matsuzaka T,Takeuchi Y,Kobayashi K,Yatoh S,Takahashi A,Suzuki H,Yahagi N,Gotoda T,Yamada N,Shimano H

doi

10.1194/jlr.M004234

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

1859-70

issue

7

eissn

0022-2275

issn

1539-7262

pii

jlr.M004234

journal_volume

51

pub_type

杂志文章

相关文献

JOURNAL OF LIPID RESEARCH文献大全
  • Cholesterol biosynthesis by the cornea. Comparison of rates of sterol synthesis with accumulation during early development.

    abstract：:The origin of the cholesterol needed by the cornea for growth and cell turnover was addressed by comparing absolute rates of sterol synthesis with rates of sterol accumulation during early development of the rabbit. Linearity of incorporation of 3H2O and [14C]mevalonate into digitonin-precipitable sterols with time of...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： Cenedella RJ,Fleschner CR

    更新日期：1989-07-01 00:00:00

  • Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells.

    abstract：:Ceramide-1-phosphate (C1P) is a novel bioactive sphingolipid formed by the phosphorylation of ceramide catalyzed by ceramide kinase (CERK). In this study, we evaluated the mechanism by which increased C1P during phagocytosis enhances phagocytosis and phagolysosome formation in COS-1 cells expressing hCERK. Stable tran...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：10.1194/jlr.M700442-JLR200

    authors： Hinkovska-Galcheva V,Clark A,VanWay S,Huang JB,Hiraoka M,Abe A,Borofsky M,Kunkel RG,Shanley T,Shayman JA,Lanni F,Petty HR,Boxer LA

    更新日期：2008-03-01 00:00:00

  • Utilization of different fatty acids for hepatic and biliary phosphatidylcholine formation and the effect of changes in phosphatidylcholine molecular species on biliary lipid secretion.

    abstract：:Biliary cholesterol secretion is ordinarily tightly coupled to phosphatidylcholine (PC) secretion. Bile PCs are distinct in composition and predominantly composed of molecular species with 16:0 in the sn-1 position and 18:2 and 18:1 in the sn-2 position. In an attempt to acutely change the composition of biliary PCs a...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： Robins SJ,Fasulo JM,Robins VF,Patton GM

    更新日期：1991-06-01 00:00:00

  • Bilayer characteristics of a diether phosphonolipid analog of the major lung surfactant glycerophospholipid dipalmitoyl phosphatidylcholine.

    abstract：:Thermal and lyotropic phase behavior was studied by X-ray diffraction and differential scanning calorimetry for a diether phosphonolipid analog (DEPN-8) of the major lung surfactant glycerophospholipid dipalmitoyl phosphatidylcholine (DPPC). DEPN-8 differs in an ether, rather than an ester, bond at the acyl chain-back...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： Skita V,Chester DW,Oliver CJ,Turcotte JG,Notter RH

    更新日期：1995-05-01 00:00:00

  • Apolipoprotein specificity of the chicken oocyte receptor for low and very low density lipoproteins: lack of recognition of apolipoprotein VLDL-II.

    abstract：:At onset of egg-laying in the chicken, plasma levels of apolipoprotein VLDL-II (apoII) increase dramatically, suggesting a function of apoII in yolk deposition of triglyceride-rich lipoproteins. Thus, the possibility that this female-specific homodimeric protein (Mr of subunit, 9500) is recognized by the oocyte recept...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： Nimpf J,George R,Schneider WJ

    更新日期：1988-05-01 00:00:00

  • Efficacy of two vitamin E formulations in patients with abetalipoproteinemia and chylomicron retention disease.

    abstract：:Abetalipoproteinemia (ABL) and chylomicron retention disease (CMRD) are extremely rare recessive forms of hypobetalipoproteinemia characterized by intestinal lipid malabsorption and severe vitamin E deficiency. Vitamin E is often supplemented in the form of fat-soluble vitamin E acetate, but fat malabsorption consider...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：10.1194/jlr.M085043

    authors： Cuerq C,Henin E,Restier L,Blond E,Drai J,Marçais C,Di Filippo M,Laveille C,Michalski MC,Poinsot P,Caussy C,Sassolas A,Moulin P,Reboul E,Charriere S,Levy E,Lachaux A,Peretti N

    更新日期：2018-09-01 00:00:00

  • Normolipemic dysbetalipoproteinemia and hyperlipoproteinemia type III in subjects homozygous for a rare genetic apolipoprotein E variant (apoE1).

    abstract：:A family with three heterozygote and two homozygote carriers of the rare apolipoprotein E1 isoform was detected by isoelectric focusing. One of the homozygous patients had type III hyperlipidemia, while the other showed normolipemic dysbetalipoproteinemia. Restriction fragment length analysis as well as allele specifi...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： Steinmetz A,Assefbarkhi N,Eltze C,Ehlenz K,Funke H,Pies A,Assmann G,Kaffarnik H

    更新日期：1990-06-01 00:00:00

  • Determination of mevalonate in blood plasma in man and rat. Mevalonate "tolerance" tests in man.

    abstract：:A method is described for the determination of mevalonate in ultrafiltrates of blood plasma. The method depends on the phosphorylation of mevalonate with [gamma-32P]ATP and mevalonate kinase to 5-[32P]phosphomevalonate, and the subsequent isolation of the 5-[32P]phosphomevalonate together with known amounts of added 5...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： Popják G,Boehm G,Parker TS,Edmond J,Edwards PA,Fogelman AM

    更新日期：1979-08-01 00:00:00

  • Key intestinal genes involved in lipoprotein metabolism are downregulated in dyslipidemic men with insulin resistance.

    abstract：:Insulin resistance (IR) is associated with elevated plasma levels of triglyceride-rich lipoproteins (TRLs) of intestinal origin. However, the mechanisms underlying the overaccumulation of apolipoprotein (apo)B-48-containing TRLs in individuals with IR are not yet fully understood. This study examined the relationships...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：10.1194/jlr.M040071

    authors： Couture P,Tremblay AJ,Kelly I,Lemelin V,Droit A,Lamarche B

    更新日期：2014-01-01 00:00:00

  • Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase.

    abstract：:Hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) is the rate-controlling enzyme of cholesterol synthesis, and owing to its biological and pharmacological relevance, researchers have investigated several compounds capable of modulating its activity with the hope of developing new hypocholesterolemic drugs. In particular,...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：10.1194/jlr.M011817

    authors： Cuccioloni M,Mozzicafreddo M,Spina M,Tran CN,Falconi M,Eleuteri AM,Angeletti M

    更新日期：2011-05-01 00:00:00

  • Cholesteryl ester transfer protein expression attenuates atherosclerosis in ovariectomized mice.

    abstract：:Reduced estrogen levels result in loss of protection from coronary heart disease in postmenopausal women. Enhanced and diminished atherosclerosis have been associated with plasma levels of cholesteryl ester transfer protein (CETP); however, little is known about the role of CETP-ovarian hormone interactions in atherog...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：10.1194/jlr.m100440-jlr200

    authors： Cazita PM,Berti JA,Aoki C,Gidlund M,Harada LM,Nunes VS,Quintão EC,Oliveira HC

    更新日期：2003-01-01 00:00:00

  • Genotyping of apolipoprotein A-IV by digestion of amplified DNA with restriction endonuclease Fnu4HI: use of a tailored primer to abolish additional recognition sites during the gene amplification.

    abstract：:Apolipoprotein A-IV (apoA-IV) is involved in the metabolism of chylomicrons and high density lipoproteins. It displays genetic polymorphism due to two co-dominant alleles apoA-IV1 and apoA-IV2. The mutation that causes the polymorphism is a G to T substitution in the third base of codon 360 in the apoA-IV2 allele whic...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： Tenkanen H

    更新日期：1991-03-01 00:00:00

  • Specific methylation of plasma nonesterified fatty acids in a one-step reaction.

    abstract：:Analysis of plasma nonesterified fatty acids (NEFA) by gas-liquid chromatography requires procedures that are both lengthy and cumbersome. A 45-min direct methylation procedure was carried out at 24-29 degrees C on 150 microliter of plasma added with an internal standard in 5.0 ml of methanol-acetyl chloride 50:1 (v/v...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： Lepage G,Roy CC

    更新日期：1988-02-01 00:00:00

  • Spectrophotometric determination of lipases, lysophospholipases, and phospholipases.

    abstract：:Spectrophotometric techniques for determining the activities of lipases, lysophospholipases, and phospholipases are reviewed. These methods involve the use of thioester substrate analogs as well as omega-nitrophenyl derivatives of the corresponding lipids. The most promising results are obtained with the thioester sub...

    journal_title：Journal of lipid research

    pub_type： 杂志文章,评审

    doi：

    authors： Farooqui AA,Taylor WA,Pendley CE 2nd,Cox JW,Horrocks LA

    更新日期：1984-12-15 00:00:00

  • Cyanidin-3-O-β-glucoside inhibits lipopolysaccharide-induced inflammatory response in mouse mastitis model.

    abstract：:Cyanidin-3-O-β-glucoside (C3G) (CAS number 7084-24-4), a typical anthocyanin pigment that exists in the human diet, has been reported to have anti-inflammatory properties. However, the effect of C3G on lipopolysaccharide (LPS)-induced mastitis and the molecular mechanisms have not been investigated. In this study, we ...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：10.1194/jlr.M047340

    authors： Fu Y,Wei Z,Zhou E,Zhang N,Yang Z

    更新日期：2014-06-01 00:00:00

  • Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio.

    abstract：:In mammals, because they share a single synthetic pathway, n-6/n-3 ratios of dietary PUFAs impact tissue arachidonic acid (ARA) and DHA content. Likewise, SNPs in the human fatty acid desaturase (FADS) gene cluster impact tissue ARA and DHA. Here we tested the feasibility of using heterozygous Fads2-null-mice (HET) as...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：10.1194/jlr.M064956

    authors： Su H,Zhou D,Pan YX,Wang X,Nakamura MT

    更新日期：2016-11-01 00:00:00

  • Role of triglyceride-rich lipoproteins and hepatic lipase in determining the particle size and composition of high density lipoproteins.

    abstract：:These studies examined the proposition that the small particle size of HDL3 in the plasma of hypertriglyceridemic subjects is the consequence of the sequential actions of lipid transfer protein and hepatic lipase on HDL. Incubation of unmodified total HDL or HDL3 in the presence of hepatic lipase resulted in a depleti...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： Hopkins GJ,Barter PJ

    更新日期：1986-12-01 00:00:00

  • A facile synthesis of [14C] epicholesterol.

    abstract：:A facile procedure is described for the preparation of [14C]epicholesterol from [14C]cholesterol. Cholesterol is first converted to cholesteryl mesylate, which is treated with cesium acetate and 18-crown-6 in refluxing toluene to give epicholesteryl acetate. The latter is hydrolyzed, without isolation, with potassium ...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： Yan JS,Bittman R

    更新日期：1990-01-01 00:00:00

  • Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells.

    abstract：:Recombinant human pancreatic lipase-related protein 2 (rHPLRP2) was produced in the protease A-deficient yeast Pichia pastoris. A major protein with a molecular mass of 50 kDa was purified from the culture medium using SP-Sepharose and Mono Q chromatography. The protein was found to be highly sensitive to the proteoly...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：10.1194/jlr.M600486-JLR200

    authors： Eydoux C,De Caro J,Ferrato F,Boullanger P,Lafont D,Laugier R,Carrière F,De Caro A

    更新日期：2007-07-01 00:00:00

  • Identification of Rev-erbalpha as a physiological repressor of apoC-III gene transcription.

    abstract：:Elevated serum levels of triglyceride-rich remnant lipoproteins (TRL) are a major risk factor predisposing a subject to atherosclerosis. Apolipoprotein C-III (apoC-III) is a major constituent of TRL that impedes triglyceride hydrolysis and remnant clearance and, as such, may exert pro-atherogenic activities. In the pr...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：10.1194/jlr.m200386-jlr200

    authors： Raspé E,Duez H,Mansén A,Fontaine C,Fiévet C,Fruchart JC,Vennström B,Staels B

    更新日期：2002-12-01 00:00:00

  • Alternative splicing of CTP:phosphoethanolamine cytidylyltransferase produces two isoforms that differ in catalytic properties.

    abstract：:CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) catalyzes the rate-controlling reaction of the CDP-ethanolamine (Kennedy) pathway. We have previously established that Pcyt2 is encoded by a single gene that can be alternatively spliced from an internal exon into two transcripts, designated Pcyt2alpha and Pcyt2beta...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：10.1194/jlr.M600536-JLR200

    authors： Tie A,Bakovic M

    更新日期：2007-10-01 00:00:00

  • Resistin expression in 3T3-L1 adipocytes is reduced by arachidonic acid.

    abstract：:The resistin gene is expressed in adipocytes and encodes a protein proposed to link obesity and type 2 diabetes. Increased plasma FFA is associated with insulin resistance. We examined the effect of separate FFAs on the expression of resistin mRNA in cultured murine 3T3-L1 adipocytes. The FFAs tested did not increase ...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：10.1194/jlr.M400348-JLR200

    authors： Haugen F,Zahid N,Dalen KT,Hollung K,Nebb HI,Drevon CA

    更新日期：2005-01-01 00:00:00

  • Turnover of endogenous ceramide in cultured normal and Farber fibroblasts.

    abstract：:De novo synthesis and turnover of endogenous ceramide in cultured skin fibroblasts from patients affected with Farber lipogranulomatosis were studied by biosynthetical labeling of cellular sphingolipids with [14C]serine. The cellular uptake of [14C]serine and incorporation into de novo synthesized ceramide was similar...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： van Echten-Deckert G,Klein A,Linke T,Heinemann T,Weisgerber J,Sandhoff K

    更新日期：1997-12-01 00:00:00

  • Dynamics of apolipoprotein E metabolism in humans.

    abstract：:The dynamics of human apoE metabolism were explored by examining the effects of alimentary lipemia and postheparin lipolysis on the plasma level and lipoprotein distribution of apoE. In the studies of alimentary lipemia, fasting and postprandial plasma samples were obtained from five normal adult males, each of whom d...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： Blum CB

    更新日期：1982-12-01 00:00:00

  • Human plasma lipid exchange protein(s): a method for separation of donor and acceptor lipoproteins by heparin-Sepharose chromatography.

    abstract：:The transfer or exchange of cholesteryl esters, triglycerides, and phospholipids between plasma very low (VLDL), low (LDL), and high (HDL) density lipoproteins is facilitated by specific lipid transfer proteins. The present report describes a method to separate donor and acceptor lipoprotein pools used in assays for l...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： Ellsworth JL,McVittie L,Jackson RL

    更新日期：1982-05-01 00:00:00

  • Effects of cholesterol in chylomicron remnant models of lipid emulsions on apoE-mediated uptake and cytotoxicity of macrophages.

    abstract：:Chylomicron remnants have been suggested to be involved in the development of atherosclerosis. To investigate the mechanisms of chylomicron remnant-induced atherosclerosis, we prepared cholesterol (Chol)-containing emulsion particles as models for chylomicron remnants. Chol markedly increased the apolipoprotein E (apo...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：10.1194/jlr.M500167-JLR200

    authors： Sakurai A,Morita SY,Wakita K,Deharu Y,Nakano M,Handa T

    更新日期：2005-10-01 00:00:00

  • Recovery and activation of hydroxymethylglutaryl coenzyme A reductase from rat small intestine.

    abstract：:We describe a method for estimating the total activity of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase (EC 1.1.1.34) in the small intestine of rats. An homogenate of the whole small intestine is prepared rapidly and assayed directly to maximize the yield of enzyme and to minimize opportunity for uncontrolled cha...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： Young NL,Saudek CD,Crawford SA,Zuckerbrod SL

    更新日期：1982-02-01 00:00:00

  • Effects of high-glucose and high-fat diets on concanavalin A binding to rat liver plasma membranes and on the amount and pattern of their glycoprotein carbohydrates.

    abstract：:Purified liver plasma membranes were prepared from rats fed a high-fat, carbohydrate-free diet or a high-glucose, fat-free diet. Membranes from rats fed the high-fat diet bound significantly less 125I-labeled concanavalin A (Con A) than did those from rats fed the fat-free diets. The magnitude of the binding differenc...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：

    authors： Henriquez DS,Tepperman HM,Tepperman J

    更新日期：1979-07-01 00:00:00

  • Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.

    abstract：:Recent studies suggest that 7-dehydrocholesterol (7-DHC)-derived oxysterols play important roles in the pathophysiology of Smith-Lemli-Opitz syndrome (SLOS), a metabolic disorder that is caused by defective 3β-hydroxysterol-Δ(7)-reductase (DHCR7). Although 14 oxysterols have been identified as the primary products of ...

    journal_title：Journal of lipid research

    pub_type： 杂志文章

    doi：10.1194/jlr.M035733

    authors： Xu L,Korade Z,Rosado DA Jr,Mirnics K,Porter NA

    更新日期：2013-04-01 00:00:00

  • Postprandial lipemia enhances the capacity of large HDL2 particles to mediate free cholesterol efflux via SR-BI and ABCG1 pathways in type IIB hyperlipidemia.

    abstract：:Lipid and cholesterol metabolism in the postprandial phase is associated with both quantitative and qualitative remodeling of HDL particle subspecies that may influence their anti-atherogenic functions in the reverse cholesterol transport pathway. We evaluated the capacity of whole plasma or isolated HDL particles to ...

    journal_title：Journal of lipid research

    pub_type： 临床试验,杂志文章

    doi：10.1194/jlr.P009746

    authors： Julia Z,Duchene E,Fournier N,Bellanger N,Chapman MJ,Le Goff W,Guerin M

    更新日期：2010-11-01 00:00:00