Bile salts of the coelacanth, Latimeria chalumnae.

abstract：:Type 1 diabetes mellitus is a devastating disorder affecting both glucose and lipid metabolism. Using the nonobese diabetic (NOD) mouse model, we found that diabetic mice had a liver-specific increase in steady state mRNA levels for enzymes involved in oxidation of fatty acids. Increased mRNA abundance was observed in...

journal_title：Journal of lipid research

authors： Kurtz DM,Tian L,Gower BA,Nagy TR,Pinkert CA,Wood PA

更新日期：2000-12-01 00:00:00

abstract：:ABCA1 plays a key role in the initial lipidation of apoA-I, which generates circulating HDL cholesterol. Whereas it is known that the transcriptional upregulation of ABCA1 promotes HDL formation and reverse cholesterol transport (RCT), it is not known how the inhibition of ABCA1 protein degradation impacts HDL functio...

journal_title：Journal of lipid research

authors： Huang L,Fan B,Ma A,Shaul PW,Zhu H

更新日期：2015-05-01 00:00:00

abstract：:In specialized cell types, lysosome-related organelles support regulated secretory pathways, whereas in nonspecialized cells, lysosomes can undergo fusion with the plasma membrane in response to a transient rise in cytosolic calcium. Recent evidence also indicates that lysosome secretion can be controlled transcriptio...

journal_title：Journal of lipid research

authors： Vacca F,Vossio S,Mercier V,Moreau D,Johnson S,Scott CC,Montoya JP,Moniatte M,Gruenberg J

更新日期：2019-04-01 00:00:00

abstract：:Naturally occurring derivatives of arachidonic acid are potent agonists for the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma) and block cancer cell proliferation through the induction of apoptosis. We have previously reported that induction of apoptosis using cyclopentenone pros...

journal_title：Journal of lipid research

authors： Clay CE,Monjazeb A,Thorburn J,Chilton FH,High KP

更新日期：2002-11-01 00:00:00

abstract：:The reversibility and regression of histological and biochemical findings in a mouse model of Gaucher disease (4L/PS-NA) was evaluated using a liver-enriched activator protein promoter control of a tetracycline-controlled transcriptional activation-responsive human acid beta-glucosidase (hGCase) transgenic system. 4L/...

journal_title：Journal of lipid research

authors： Sun Y,Quinn B,Xu YH,Leonova T,Witte DP,Grabowski GA

更新日期：2006-10-01 00:00:00

abstract：:This study sought to clarify the contributions of organic anion-transporting polypeptide (OATP) 1B1 and 1B3 to the liver uptake of chenodeoxycholic acid (CDCA). We synthesized a fluorescent version of CDCA, chenodeoxychilyl-(Nepsilon-NBD)-lysine (CDCA-NBD), to characterize transporter-mediated uptake. CDCA-NBD is effi...

journal_title：Journal of lipid research

authors： Yamaguchi H,Okada M,Akitaya S,Ohara H,Mikkaichi T,Ishikawa H,Sato M,Matsuura M,Saga T,Unno M,Abe T,Mano N,Hishinuma T,Goto J

更新日期：2006-06-01 00:00:00

abstract：:A method for quantitative analysis of serum bile acids by capillary gas--liquid chromatography--mass spectrometry is described. The main features of this method are a Grob-type barium carbonate/polyethyleneglycol 20,000 glass capillary column, an all-glass capillary interface, use of the lipophilic anion exchanger DEA...

journal_title：Journal of lipid research

authors： Karlaganis G,Schwarzenbach RP,Paumgartner G

更新日期：1980-03-01 00:00:00

abstract：:It is becoming increasingly accepted that removal of cellular cholesterol occurs by at least two pathways, one involving the well-described aqueous diffusion mechanism and another promoted by lipid-free apolipoproteins. We compared the contribution of apolipoprotein-dependent and -independent pathways, taking into con...

journal_title：Journal of lipid research

authors： Mendez AJ

更新日期：1997-09-01 00:00:00

abstract：:Acylglycerophosphate acyltransferase 4 (AGPAT4)/lysophosphatidic acid acyltransferase delta catalyzes the formation of phosphatidic acid (PA), a precursor of triacyl-glycerol (TAG). We investigated the effect of Agpat4 gene ablation on white adipose tissue (WAT) after finding consistent expression across depots. Epidi...

journal_title：Journal of lipid research

authors： Mardian EB,Bradley RM,Aristizabal Henao JJ,Marvyn PM,Moes KA,Bombardier E,Tupling AR,Stark KD,Duncan RE

更新日期：2017-10-01 00:00:00

abstract：:The objective of this study was to investigate the mobilization of individual fatty acids from human subcutaneous adipose tissue in vivo. Concentrations of individual non-esterified fatty acids were measured in arterialized plasma and in the venous drainage from subcutaneous abdominal adipose tissue in eight normal su...

journal_title：Journal of lipid research

authors： Halliwell KJ,Fielding BA,Samra JS,Humphreys SM,Frayn KN

更新日期：1996-09-01 00:00:00

abstract：:It was the aim of this study to i) compare the effects of glucose and other hexoses with that of oleate on secretion of apolipoproteins (apos) A-I and B by HepG2 cells, and ii) document the effect of various metabolic inhibitors on the secretion of these apos in the absence or presence of extra glucose/oleate. i) The ...

journal_title：Journal of lipid research

authors： Kempen HJ,Imbach AP,Giller T,Neumann WJ,Hennes U,Nakada N

更新日期：1995-08-01 00:00:00

abstract：:The Singer-Nicholson model of membranes postulated a uniform lipid bilayer randomly studded with floating proteins. However, it became clear almost immediately that membranes were not uniform and that clusters of lipids in a more ordered state existed within the generally disorder lipid milieu of the membrane. These c...

journal_title：Journal of lipid research

authors： Pike LJ

更新日期：2009-04-01 00:00:00

abstract：:Dietary n-3 long-chain PUFAs (LC-PUFAs) are associated with improvement in the parameters of the metabolic syndrome (MetS). Glucokinase regulatory protein (GCKR) is a key protein regulating intracellular glucose disposal. Our aim was to investigate: i) the relationship between the GCKR rs1260326 (Pro446Leu) polymorphi...

journal_title：Journal of lipid research

authors： Rousseaux J,Duhamel A,Dumont J,Dallongeville J,Molnar D,Widhalm K,Manios Y,Sjöström M,Kafatos A,Breidenassel C,Gonzales-Gross M,Cuenca-Garcia M,Censi L,Ascensión M,De Henauw S,Moreno LA,Meirhaeghe A,Gottrand F

更新日期：2015-09-01 00:00:00

abstract：:The composition of the emulsified oil and of the micellar phases obtained when a glyceride-fatty acid mixture is dispersed in bile salt solution has been defined. The micellar phase in equilibrium with the emulsified oil phase was obtained by filtration through Millipore filters. The behavior of different lipids in su...

journal_title：Journal of lipid research

authors： Borgström B

更新日期：1967-11-01 00:00:00

abstract：:ZR-78 and ZR-82 cells are two peroxisomal-deficient Chinese hamster ovary (CHO) cell mutants. These cells lack normal peroxisomes and show reduced levels of plasmalogen synthesis and other peroxisomal functions attributed to the deficiency of peroxisomal matrix enzymes. As we have recently identified two HMG-CoA reduc...

journal_title：Journal of lipid research

authors： Aboushadi N,Krisans SK

更新日期：1998-09-01 00:00:00

abstract：:Eubacterium sp. 144 dehydroxylated 16 alpha-hydroxy-progesterone; however, the expected intermediate, delta 16-progesterone, did not accumulate to significant concentrations in the culture medium. Moreover, the final end product of this biotransformation, 17 alpha-progesterone, was produced at a very slow rate. It was...

journal_title：Journal of lipid research

authors： Glass TL,Winter J,Bokkenheuser VD,Hylemon PB

更新日期：1982-02-01 00:00:00

abstract：:This study describes a variant of familial apoA-I deficiency associated with a moderate risk for premature coronary artery disease. The proband, a 25-year-old man of Philippine origin, and his 62-year-old maternal aunt had peripheral corneal opacification, xanthelasma, and planar xanthoma; the aunt had coronary artery...

journal_title：Journal of lipid research

authors： Bekaert ED,Alaupovic P,Knight-Gibson CS,Laux MJ,Pelachyk JM,Norum RA

更新日期：1991-10-01 00:00:00

abstract：:Synthesis of apolipoprotein (apo)E in hepatocytes leads to both secretion and retention in cell surface pools. Inclusion of Brefeldin A to HepG2 cells prompted a rapid decrease of cell surface apoE to about 37% of control values after a 3-h incubation. The t(1/2) for this dynamic pool was estimated to be 15 min. In co...

journal_title：Journal of lipid research

authors： Burgess JW,Marcel YL

更新日期：2001-09-01 00:00:00

abstract：:Although numerous studies have investigated the relationship between cholesteryl ester transfer protein (CETP) and high density lipoprotein (HDL) remodeling, the relationship between CETP and low density lipoproteins (LDL) is still not fully understood. In the present study, we examined the effect of the inhibition of...

journal_title：Journal of lipid research

authors： Sugano M,Sawada S,Tsuchida K,Makino N,Kamada M

更新日期：2000-01-01 00:00:00

abstract：:The sequences necessary for liver-specific expression of the apolipoprotein (apo) E gene have been shown to reside 3' to the gene, within the apoE/C-I/C-II gene cluster, but have not been precisely characterized. Utilizing a transient transfection reporter gene assay based on the apoC-II promoter, we have localized a ...

journal_title：Journal of lipid research

authors： Shachter NS,Zhu Y,Walsh A,Breslow JL,Smith JD

更新日期：1993-10-01 00:00:00

abstract：:The addition of a trans isomer of arachidonic acid (20:4 delta 14trans) to rat platelet suspensions inhibited the aggregation induced by 7.5 microM of arachidonic acid. This inhibitory effect of 20:4 delta 14trans was significant at concentrations of 7.5-22.5 microM and the range of inhibition was 20% at an inhibitor/...

journal_title：Journal of lipid research

authors： Berdeaux O,Chardigny JM,Sébédio JL,Mairot T,Poullain D,Vatèle JM,Noël JP

更新日期：1996-10-01 00:00:00

abstract：:Lysophospholipid (LP) research has experienced a period of renaissance with the discovery of the lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) receptors in the late 1990s. Vertebrate LP receptors regulate embryogenesis, vascular development, neurogenesis, uterine development, oocyte survival, immune ce...

journal_title：Journal of lipid research

authors： Skoura A,Hla T

更新日期：2009-04-01 00:00:00

abstract：:Oxidized forms of cholesterol (oxysterols) are present in atherosclerotic lesions and may play an active role in lesion development. For example, 7-ketocholesterol (7KC) inhibits cholesterol efflux from macrophage foam cells induced by apolipoprotein A-I (apoA-I). Such oxysterols may promote foam cell formation in ath...

journal_title：Journal of lipid research

authors： Gelissen IC,Rye KA,Brown AJ,Dean RT,Jessup W

更新日期：1999-09-01 00:00:00

abstract：:An enzyme (phosphatidyl glycerophosphate phosphatase) that catalyzes the formation of phosphatidyl glycerol from phosphatidyl glycerophosphate has been rendered soluble by treatment of the particulate fraction of E. coli with Triton X-100 in the presence of EDTA, and has been partially purified. The enzyme is specific...

journal_title：Journal of lipid research

authors： Chang YY,Kennedy EP

更新日期：1967-09-01 00:00:00

abstract：:The fatty acid composition of human skin fibroblasts grown in 10% dialyzed fetal calf serum can be modified considerably by adding supplemental fatty acids to the culture medium. The degree of modification was dependent on the concentration of added fatty acid over the range tested, 2.5 X 10(-5) to 1 X 10(-4) M. At th...

journal_title：Journal of lipid research

authors： Spector AA,Kiser RE,Denning GM,Koh SW,DeBault LE

更新日期：1979-05-01 00:00:00

abstract：:As microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apoB-containing lipoproteins by intestinal epithelial cells, the characterization and regulation of MTP in human intestinal cells, CaCo-2, was studied. CaCo-2 cells express MTP mRNA of 4.2 kb and a 97 kDa subunit of MTP pro...

journal_title：Journal of lipid research

authors： Mathur SN,Born E,Murthy S,Field FJ

更新日期：1997-01-01 00:00:00

abstract：:The density distribution of electronegative LDL [LDL(-)], a cytotoxic and inflammatory fraction of LDL present in plasma, was studied in 10 normolipemic (NL), 6 FH, and 11 hypertriglyceridemic (HTG) subjects. Six LDL subclasses of increased density (LDL1 to LDL6) were isolated by density-gradient ultracentrifugation (...

journal_title：Journal of lipid research

authors： Sánchez-Quesada JL,Benítez S,Otal C,Franco M,Blanco-Vaca F,Ordóñez-Llanos J

更新日期：2002-05-01 00:00:00

abstract：:Three colipases were purified from pancreas of two birds (ostrich and turkey) and one mammal (dromedary). After acidic and/or heat treatment and precipitation by sulfate ammonium and then ethanol, cofactors were purified by Sephadex G-50 gel filtration followed by ion-exchange chromatography first on Mono S and then o...

journal_title：Journal of lipid research

authors： Ben Bacha A,Frikha F,Djemal I,Fendri A,Miled N,Gargouri Y,Mejdoub H

更新日期：2006-12-01 00:00:00

abstract：:The mitochondrial lipids from avocado fruit, cauliflower buds, and potato tubers, and the lipids of chloroplasts isolated from avocado fruit and from cauliflower leaves were identified and the concentrations were determined. The lipid composition was compared with that of beef heart mitochondria. Phospholipids constit...

journal_title：Journal of lipid research

authors： Schwertner HA,Biale JB

更新日期：1973-03-01 00:00:00

abstract：:Niacin, the first antidyslipidemic drug, has been at the center stage of lipid research for many decades before the discovery of statins. However, to date, despite its remarkable effects on lipid profiles, the clinical outcomes of niacin treatment on cardiac events is still debated. In addition to its historically wel...

journal_title：Journal of lipid research

authors： Romani M,Hofer DC,Katsyuba E,Auwerx J

更新日期：2019-04-01 00:00:00