Biochemical and structural comparative study between bird and mammal pancreatic colipases.

abstract：:Apolipoprotein C-II (apoC-II) plays a critical role in the metabolism of plasma lipoproteins as an activator for lipoprotein lipase. Human apoC-II consists of 79 amino acid residues (pro-apoC-II). A minor fraction is converted to a mature form by cleavage at the site QQDE releasing the 6 amino-terminal residues. We ha...

journal_title：Journal of lipid research

authors： Andersson Y,Thelander L,Bengtsson-Olivecrona G

更新日期：1991-11-01 00:00:00

abstract：:We investigated, in the present study, the role of reactive oxygen intermediates (ROI) in the control of macrophage lipoprotein lipase (LPL) secretion. Exposure of murine macrophages to increasing concentrations of hydrogen peroxide (H2O2) resulted in enhanced basal LPL production and mRNA levels. The increase of LPL ...

journal_title：Journal of lipid research

authors： Renier G,Desfaits AC,Lambert A,Mikhail R

更新日期：1996-04-01 00:00:00

abstract：:The time course of the clearance from the blood and the tissue localization of [14C]L-glucosylceramide, a nonmetabolizable enantiomorph of D-glucosylceramide that accumulates in Gaucher's disease, has been determined. 14C-labeled L-glucosylceramide injected intravenously in the form of micelles or liposomes is rapidly...

journal_title：Journal of lipid research

authors： Tokoro T,Gal AE,Gallo LL,Brady RO

更新日期：1987-08-01 00:00:00

abstract：:Leukotriene B4 (LTB4) is a potent lipid mediator of inflammation that acts primarily via a seven-transmembrane-spanning, G-protein-coupled receptor denoted BLT1. Here, we describe the synthesis and characterization of fluorescent analogs of LTB4 that are easy to produce, inexpensive, and without the disadvantages of a...

journal_title：Journal of lipid research

authors： Sabirsh A,Wetterholm A,Bristulf J,Leffler H,Haeggström JZ,Owman C

更新日期：2005-06-01 00:00:00

abstract：:Cholesterol 7α-hydroxylase (CYP7A1) is the first and rate-limiting enzyme in the conversion of cholesterol to bile acids in the liver. In addition to absorption and digestion of nutrients, bile acids play a critical role in the regulation of lipid, glucose, and energy homeostasis. We have backcrossed Cyp7a1(-/-) mice ...

journal_title：Journal of lipid research

authors： Ferrell JM,Boehme S,Li F,Chiang JY

更新日期：2016-07-01 00:00:00

abstract：:A deficiency of lysosomal phospholipase A2 (LPLA2) causes macrophage-associated phospholipidosis, suggesting that the enzyme is important in the lipid catabolism. Because LPLA2 is secreted by macrophages, extracellular LPLA2 activity may potentially reflect a change in macrophage activation. In this report, the detect...

journal_title：Journal of lipid research

authors： Abe A,Kelly R,Shayman JA

更新日期：2010-08-01 00:00:00

abstract：:In Tangier disease, absence of ATP binding cassette transporter A1 (ABCA1) results in reduced plasma HDL and elevated triglyceride (TG) levels. We hypothesized that hepatocyte ABCA1 regulates VLDL TG secretion through nascent HDL production. Silencing of ABCA1 expression in oleate-stimulated rat hepatoma cells resulte...

journal_title：Journal of lipid research

authors： Chung S,Gebre AK,Seo J,Shelness GS,Parks JS

更新日期：2010-04-01 00:00:00

abstract：:Increased plasma concentrations of apolipoprotein A-IV (apoA-IV) in chronic renal disease suggest a metabolic role of the kidney for this antiatherogenic protein. Therefore, we investigated patients with various forms of proteinuria and found increased serum concentrations of apoA-IV in 124 nephrotic patients compared...

journal_title：Journal of lipid research

authors： Lingenhel A,Lhotta K,Neyer U,Heid IM,Rantner B,Kronenberg MF,König P,von Eckardstein A,Schober M,Dieplinger H,Kronenberg F

更新日期：2006-09-01 00:00:00

abstract：:The concentration dependence of the 500 MHz 1H-NMR spectra of taurocholate, taurochenodeoxycholate, taurodeoxycholate, and the monosulfate esters of taurochenodeoxycholate has been examined at 0.154 M NaCl in D2O. The resonances of the C18, C19, and C21 methyl groups and the C23 methylene group are differentially broa...

journal_title：Journal of lipid research

authors： Stevens RD,Ribeiro AA,Lack L,Killenberg PG

更新日期：1992-01-01 00:00:00

abstract：:Apolipoprotein (apo) B-100, the protein constituent of low density lipoproteins (LDL), is the determinant responsible for LDL binding to the apoB,E(LDL) receptor on cells. The current study was designed to identify the region(s) of apoB-100 that interact with the apoB,E(LDL) receptor. Apolipoprotein B-100 was fragment...

journal_title：Journal of lipid research

authors： Corsini A,Spilman CH,Innerarity TL,Arnold KS,Rall SC Jr,Boyles JK,Mahley RW

更新日期：1987-12-01 00:00:00

abstract：:The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro. Their role as physiological regulators under in vivo conditions is controversial, however. In the present work, we utilized a previousl...

journal_title：Journal of lipid research

authors： Ali Z,Heverin M,Olin M,Acimovic J,Lövgren-Sandblom A,Shafaati M,Båvner A,Meiner V,Leitersdorf E,Björkhem I

更新日期：2013-04-01 00:00:00

abstract：:ATP-citrate lyase (ACL) is a key lipogenic enzyme that converts citrate in the cytoplasm to acetyl-CoA, the initial precursor that yields malonyl-CoA for fatty acid biosynthesis. As cytosolic citrate is derived from the tricarboxylic acid cycle in the mitochondrion, ACL catalyzes a critical reaction linking cellular g...

journal_title：Journal of lipid research

authors： Wang Q,Li S,Jiang L,Zhou Y,Li Z,Shao M,Li W,Liu Y

更新日期：2010-09-01 00:00:00

abstract：:Sebaceous glands are intriguing glands that are found throughout the human body except on the palms of the hands and soles of the feet. The true function of these glands has yet to be determined, but there are several theories, including antioxidant effects, antibacterial effects, and transport of pheromones. Sebaceou...

journal_title：Journal of lipid research

authors： Smith KR,Thiboutot DM

更新日期：2008-02-01 00:00:00

abstract：:These studies examined the proposition that the small particle size of HDL3 in the plasma of hypertriglyceridemic subjects is the consequence of the sequential actions of lipid transfer protein and hepatic lipase on HDL. Incubation of unmodified total HDL or HDL3 in the presence of hepatic lipase resulted in a depleti...

journal_title：Journal of lipid research

authors： Hopkins GJ,Barter PJ

更新日期：1986-12-01 00:00:00

abstract：:Sequence homology indicates the existence of three human cytosolic acyl protein thioesterases, including APT1 that is known to depalmitoylate H- and N-Ras. One of them is the lysophospholipase-like 1 (LYPLAL1) protein that on the one hand is predicted to be closely related to APT1 but on the other hand might also func...

journal_title：Journal of lipid research

authors： Bürger M,Zimmermann TJ,Kondoh Y,Stege P,Watanabe N,Osada H,Waldmann H,Vetter IR

更新日期：2012-01-01 00:00:00

abstract：:Epoxyeicosatrienoic acids were isolated and purified from female rabbit kidneys. They were identified as a group, prior to resolution, by packed column gas-liquid chromatography-mass spectroscopic techniques as their methyl esters as well as their trimethylsilyl bromohydrin methyl esters. Initial capillary gas-liquid ...

journal_title：Journal of lipid research

authors： Falck JR,Schueler VJ,Jacobson HR,Siddhanta AK,Pramanik B,Capdevila J

更新日期：1987-07-01 00:00:00

abstract：:The immunoreactivities of LDL (low density lipoprotein) samples obtained from a variety of subjects were analyzed by comparing their capacities to compete with 125I-labeled LDL for binding to various monoclonal anti-LDL antibodies in competitive binding assays. A marked variation in epitope expression was observed. In...

journal_title：Journal of lipid research

authors： Tikkanen MJ,Cole TG,Schonfeld G

更新日期：1983-11-01 00:00:00

abstract：:This work describes the molecular mechanisms of fatty acid and hormonal modulations of the retinoid X receptor alpha (RXRalpha) in rat liver cells. We examined the effects of different fatty acids (myristic, stearic, oleic, linolenic, and arachidonic acids, EPA, and the peroxisomal proliferator TTA) and several hormon...

journal_title：Journal of lipid research

authors： Steineger HH,Arntsen BM,Spydevold O,Sørensen HN

更新日期：1998-04-01 00:00:00

abstract：:A synthetic analog of glucocerebroside, N-hexyl-O-glucosyl sphingosine, was found to inhibit the glucosidase in rat spleen that hydrolyzes glucocerebroside. At a concentration of 1 micro m, the analog inhibited the enzyme by 48%. The mode of action appeared to be competitive, probably aided by tight binding of the ami...

journal_title：Journal of lipid research

authors： Erickson JS,Radin NS

更新日期：1973-03-01 00:00:00

abstract：:The hepatic uptake of intravenously injected beta-very low density lipoprotein (beta-VLDL) in rabbits fed 2% (w/w) cholesterol for 3 weeks was investigated. In vitro studies were also conducted to examine the specificity and the capacity of the uptake in isolated liver parenchymal cells. The hepatic uptake of beta-VLD...

journal_title：Journal of lipid research

authors： Gudmundsen O,Berg T,Roos N,Nenseter MS

更新日期：1993-04-01 00:00:00

abstract：:HDL and its major component, apolipoprotein A-I (apoA-I), play a central role in reverse cholesterol transport. We recently reported the involvement of a glycosylphosphatidylinositol anchor (GPI anchor) in the binding of HDL and apoA-I on human macrophages, and purified an 80 kDa HDL/apoA-I binding protein. In the pre...

journal_title：Journal of lipid research

authors： Matsuyama A,Sakai N,Hiraoka H,Hirano K,Yamashita S

更新日期：2006-01-01 00:00:00

abstract：:Each abdominal fat depot, such as mesenteric or epididymal, differently contributes to the development of insulin resistance. The aim of this study was to identify the genetic regions that contribute to fat accumulation in epididymal/mesenteric fat and to examine whether or not the genetic regions that affect glucose ...

journal_title：Journal of lipid research

authors： Kobayashi M,Ohno T,Hada N,Fujiyoshi M,Kuga M,Nishimura M,Murai A,Horio F

更新日期：2010-12-01 00:00:00

abstract：:Selenocysteine (Sec) insertion sequence-binding protein 2 (SBP2) is essential for the biosynthesis of Sec-containing proteins, termed selenoproteins. Subjects with mutations in the SBP2 gene have decreased levels of several selenoproteins, resulting in a complex phenotype. Selenoproteins play a significant role in ant...

journal_title：Journal of lipid research

authors： Saito Y,Shichiri M,Hamajima T,Ishida N,Mita Y,Nakao S,Hagihara Y,Yoshida Y,Takahashi K,Niki E,Noguchi N

更新日期：2015-11-01 00:00:00

abstract：:Autophagy is a catabolic process involved in maintaining energy and organelle homeostasis. The relationship between obesity and the regulation of autophagy is cell type specific. Despite adverse consequences of obesity on cardiac structure and function, the contribution of altered cardiac autophagy in response to fatt...

journal_title：Journal of lipid research

authors： Jaishy B,Zhang Q,Chung HS,Riehle C,Soto J,Jenkins S,Abel P,Cowart LA,Van Eyk JE,Abel ED

更新日期：2015-03-01 00:00:00

abstract：:CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) catalyzes the rate-controlling reaction of the CDP-ethanolamine (Kennedy) pathway. We have previously established that Pcyt2 is encoded by a single gene that can be alternatively spliced from an internal exon into two transcripts, designated Pcyt2alpha and Pcyt2beta...

journal_title：Journal of lipid research

authors： Tie A,Bakovic M

更新日期：2007-10-01 00:00:00

abstract：:We describe a method for estimating the total activity of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase (EC 1.1.1.34) in the small intestine of rats. An homogenate of the whole small intestine is prepared rapidly and assayed directly to maximize the yield of enzyme and to minimize opportunity for uncontrolled cha...

journal_title：Journal of lipid research

authors： Young NL,Saudek CD,Crawford SA,Zuckerbrod SL

更新日期：1982-02-01 00:00:00

abstract：:Cyclophosphamide injection into the fasted rabbit induces a hypertriglyceridemia (4.6 mM vs. 0.8 mM in controls) and a defect of lipoprotein lipase (LPL), as measured in post-heparin plasma (PHP). In contrast, administration of the drug into fed animals tends to increase PHP-LPL. The effects of cyclophosphamide on LPL...

journal_title：Journal of lipid research

authors： Lespine A,Azema C,Gafvels M,Manent J,Dousset N,Chap H,Perret B

更新日期：1993-01-01 00:00:00

abstract：:Adipose tissue contains one of the largest reservoirs of cholesterol in the body. Adipocyte dysfunction in obesity is associated with intracellular cholesterol accumulation, and alterations in cholesterol homeostasis have been shown to alter glucose metabolism in cultured adipocytes. ABCA1 plays a major role in choles...

journal_title：Journal of lipid research

authors： de Haan W,Bhattacharjee A,Ruddle P,Kang MH,Hayden MR

更新日期：2014-03-01 00:00:00

abstract：:Ricinoleic acid (12-hydroxyoctadec-cis-9-enoic acid) has many specialized uses in bioproduct industries, while castor bean is currently the only commercial source for the fatty acid. This report describes metabolic engineering of a microbial system (Pichia pastoris) to produce ricinoleic acid using a "push" (synthesis...

journal_title：Journal of lipid research

authors： Meesapyodsuk D,Chen Y,Ng SH,Chen J,Qiu X

更新日期：2015-11-01 00:00:00

abstract：:Exosomes are bioactive vesicles released from multivesicular bodies (MVB) by intact cells and participate in intercellular signaling. We investigated the presence of lipid-related proteins and bioactive lipids in RBL-2H3 exosomes. Besides a phospholipid scramblase and a fatty acid binding protein, the exosomes contain...

journal_title：Journal of lipid research

authors： Subra C,Grand D,Laulagnier K,Stella A,Lambeau G,Paillasse M,De Medina P,Monsarrat B,Perret B,Silvente-Poirot S,Poirot M,Record M

更新日期：2010-08-01 00:00:00