Abstract:
:Selenocysteine (Sec) insertion sequence-binding protein 2 (SBP2) is essential for the biosynthesis of Sec-containing proteins, termed selenoproteins. Subjects with mutations in the SBP2 gene have decreased levels of several selenoproteins, resulting in a complex phenotype. Selenoproteins play a significant role in antioxidative defense, and deficiencies in these proteins can lead to increased oxidative stress. However, lipid peroxidation and the effects of antioxidants in subjects with SBP2 gene mutations have not been studied. In the present study, we evaluated the lipid peroxidation products in the blood of a subject (the proband) with mutations in the SBP2 gene. We found that the proband had higher levels of free radical-mediated lipid peroxidation products, such as 7β-hydroxycholesterol, than the control subjects. Treatment of the proband with vitamin E (α-tocopherol acetate, 100 mg/day), a lipid-soluble antioxidant, for 2 years reduced lipid peroxidation product levels to those of control subjects. Withdrawal of vitamin E treatment for 7 months resulted in an increase in lipid peroxidation products. Collectively, these results clearly indicate that free radical-mediated oxidative stress is increased in the subject with SBP2 gene mutations and that vitamin E treatment effectively inhibits the generation of lipid peroxidation products.
journal_name
J Lipid Resjournal_title
Journal of lipid researchauthors
Saito Y,Shichiri M,Hamajima T,Ishida N,Mita Y,Nakao S,Hagihara Y,Yoshida Y,Takahashi K,Niki E,Noguchi Ndoi
10.1194/jlr.M059105subject
Has Abstractpub_date
2015-11-01 00:00:00pages
2172-82issue
11eissn
0022-2275issn
1539-7262pii
jlr.M059105journal_volume
56pub_type
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journal_title:Journal of lipid research
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journal_title:Journal of lipid research
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journal_title:Journal of lipid research
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journal_title:Journal of lipid research
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更新日期:2000-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Journal of lipid research
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journal_title:Journal of lipid research
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doi:
更新日期:1996-06-01 00:00:00
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journal_title:Journal of lipid research
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journal_title:Journal of lipid research
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doi:
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journal_title:Journal of lipid research
pub_type: 杂志文章
doi:
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journal_title:Journal of lipid research
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doi:
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journal_title:Journal of lipid research
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doi:
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journal_title:Journal of lipid research
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