当前位置： SCI文献检索 > JOURNAL OF DIABETES AND ITS COMPLICATIONS期刊下所有文献 > Skeletal muscle lipoprotein-lipase activity in insulin-dependent diabetic patients with and without albuminuria.

Skeletal muscle lipoprotein-lipase activity in insulin-dependent diabetic patients with and without albuminuria.

Abstract：

:In patients with insulin-dependent diabetes mellitus (IDDM), albuminuria reflects widespread vascular dysfunction. Albuminuria has been associated to defects of heparan sulfate proteoglycan (HSPG) within the extracellular matrix. Our hypothesis is that loss of HSPG in vascular walls reduces the HSPG-bound lipoprotein-lipase activity (LPLA), thereby causing elevated levels of plasma triglyceride (TG) seen in IDDM patients with albuminuria. The aim of the present study was to evaluate whether LPLA in muscle capillaries could be related to TG in IDDM patients with and without albuminuria. This is a cross-sectional study including ten healthy control subjects (group C), nine patients with IDDM and urinary albumin excretion rate (AER) of 30 mg/24 h or less (group D0) and 20 patients with IDDM and AER greater than 30 mg/24 h (group DA). Muscle LPLA, plasma TG, total cholesterol, high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), and very-low-density lipoprotein cholesterol (VLDL) were measured. Between groups no difference in total cholesterol, TG, VLDL, and LDL was found. In patients with albuminuria, LPLA was reduced compared to controls, however, the difference between the groups was not statistically significant [median (range)] 35.9 mU/g (20.4-103) versus 44.6 mU/g (28.2-57.2) and 40.9 mU/g (21.7-53.5) in group DA, C, and D0, respectively, p = 0.76. AER was not correlated to LPLA. An overall negative correlation between TG and LPLA was found; r = -0.33, p = 0.04, supported by an overall significant positive correlation between LPLA and HDL; r = 0.32, p = 0.045. We conclude that, in insulin-dependent diabetes mellitus, skeletal muscle lipoprotein-lipase activity is associated with plasma triglyceride, while an association between lipoprotein-lipase activity and urinary albumin excretion is questionable.

journal_name

J Diabetes Complications

journal_title

Journal of diabetes and its complications

authors

Hansen PM,Jensen T,Egeberg J,Lithell H,Kofoed-Enevoldsen A,Deckert T

doi

10.1016/s1056-8727(96)00048-7

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

230-5

issue

4

eissn

1056-8727

issn

1873-460X

pii

S1056872796000487

journal_volume

11

pub_type

杂志文章

相关文献

JOURNAL OF DIABETES AND ITS COMPLICATIONS文献大全
  • Beta thalassemia and energy consumption in hemoglobin A1C formation: a model.

    abstract：:Hemoglobin (Hb) A1C is the nonenzymatic glycated product of the Hb beta chain at the valine terminal residue. Recently, the nature of energy-consuming reaction in HbA1C formation was reported, and this was proposed as an underlying pathophysiology for poor nutritional status, muscle loss, and functional impairment in ...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2006.05.002

    authors： Wiwanitkit V

    更新日期：2007-09-01 00:00:00

  • Dietary instructions focusing on meal-sequence and nutritional balance for prediabetes subjects: An exploratory, cluster-randomized, prospective, open-label, clinical trial.

    abstract：BACKGROUND:Although lifestyle modifications are known to be effective in type 2 diabetes (T2D) as well as in prediabetes, adherence to a healthy diet is difficult for some, and interventions of lifestyle modifications need to be revised occasionally. Meal sequence has been gaining attention as a part of a healthy diet ...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2019.107450

    authors： Yabe D,Kuwata H,Fujiwara Y,Sakaguchi M,Moyama S,Makabe N,Murotani K,Asano H,Ito S,Mishima H,Takase H,Ota N,Seino Y,Hamamoto Y,Kurose T,Seino Y

    更新日期：2019-12-01 00:00:00

  • Comparison of β-cell dysfunction and insulin resistance correlating obesity with type 2 diabetes: A cross-sectional study.

    abstract：AIM:To assess the contribution of β-cell dysfunction and insulin resistance to type 2 diabetes (T2D) in obese and non-obese Chinese people. METHODS:In this cross-sectional study, we recruited 1384 newly diagnosed T2D patients and 1712 healthy controls. Insulin resistance was estimated by homeostasis model assessment o...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2016.03.001

    authors： Liu J,Wang Y,Hu Y,Leng S,Wang G

    更新日期：2016-07-01 00:00:00

  • Associations between long chain polyunsaturated fatty acids and cardiovascular lipid risk factors in youth with type 1 diabetes: SEARCH Nutrition Ancillary Study.

    abstract：PURPOSE:In this longitudinal study we explored the relationships between plasma n-3 and n-6 polyunsaturated fatty acids (PUFAs) and Δ5 and Δ6 desaturase activities (D5D and D6D, respectively) and fasting lipids in youth with type 1 diabetes (T1D). METHODS:Incident cases of T1D in youth <20years of age who were seen fo...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2016.10.002

    authors： Couch SC,Crandell J,King I,Peairs A,Shah AS,Dolan LM,Tooze J,Crume T,Mayer-Davis E

    更新日期：2017-01-01 00:00:00

  • Exploratory lipidomics in patients with nascent Metabolic Syndrome.

    abstract：BACKGROUND:Metabolic Syndrome (MetS) is a cardio-metabolic cluster that confers an increased risk of developing both diabetes and atherosclerotic cardiovascular disease (ASCVD). The mechanisms governing the increased ASCVD risk remains to be elucidated. Moreover, lipidomics poses as an exciting new tool that has potent...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2018.05.014

    authors： Ramakrishanan N,Denna T,Devaraj S,Adams-Huet B,Jialal I

    更新日期：2018-08-01 00:00:00

  • High prevalence of the metabolic syndrome among Northern Jordanians.

    abstract：BACKGROUND:The prevalence of the metabolic syndrome is rapidly increasing with a considerable ethnic variation within and across populations. This study was conducted to estimate the prevalence of the metabolic syndrome and its individual components using Adult Treatment Panel III (ATP III) criteria among Northern Jord...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2005.11.003

    authors： Khader Y,Bateiha A,El-Khateeb M,Al-Shaikh A,Ajlouni K

    更新日期：2007-07-01 00:00:00

  • Relationship of medial arterial calcinosis to autonomic neuropathy and adverse outcomes in a diabetic veteran population.

    abstract：STATEMENT OF THE PROBLEM:Medial arterial calcinosis (MAC) is associated with neuropathy, amputation, and mortality through an unknown mechanism. We hypothesized that MAC was a marker of autonomic neuropathy rather than a risk factor and that the outcomes were due to autonomic neuropathy. METHODS:All subjects in an ong...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s1056-8727(01)00178-7

    authors： Mayfield JA,Caps MT,Boyko EJ,Ahroni JH,Smith DG

    更新日期：2002-03-01 00:00:00

  • Incretin-based therapy in type 2 diabetes: An evidence based systematic review and meta-analysis.

    abstract：:Incretin based therapies such as dipeptidyl peptidase-4 inhibitors (DPP-4i) and glucagon-like peptide-1 receptor agonists (GLP-1Ra) are increasingly used for the treatment of Type 2 diabetes mellitus. In clinical practice and in previously performed clinical trials, these agents are often used in combination with othe...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jdiacomp.2016.08.018

    authors： Waldrop G,Zhong J,Peters M,Goud A,Chen YH,Davis SN,Mukherjee B,Rajagopalan S

    更新日期：2018-01-01 00:00:00

  • Glycemic control is impaired in the evening in prediabetes through multiple diurnal rhythms.

    abstract：AIMS:Recent studies suggest that circadian rhythms regulate glucose metabolism, weight loss, and even drug efficacy. Moreover, molecules targeted at the circadian clock show promise in treating metabolic disease. Therefore, this study set out to better characterize interactions among diurnal rhythms in prediabetes. ME...

    journal_title：Journal of diabetes and its complications

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jdiacomp.2014.04.001

    authors： Sonnier T,Rood J,Gimble JM,Peterson CM

    更新日期：2014-11-01 00:00:00

  • Increased IL-6 levels are not related to NF-κB or HIF-1α transcription factors activity in the vitreous of proliferative diabetic retinopathy.

    abstract：PURPOSE:The purpose was to assess the activity of nuclear factor (NF)-κB and hypoxia inducible factor (HIF)-1α transcription factors and the expression levels of inflammation markers [interleukin (IL)-6 and IL-8] in the vitreous of patients suffering from proliferative diabetic retinopathy (PDR) scheduled for elective ...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2011.06.002

    authors： Arjamaa O,Pöllönen M,Kinnunen K,Ryhänen T,Kaarniranta K

    更新日期：2011-11-01 00:00:00

  • Deteriorating tactile sensation in patients with hand syndromes associated with diabetes: a two-year observational study.

    abstract：AIMS:To observe the natural history of hand function during a two-year period in participants with hand syndromes associated with diabetes and to determine factors related to changing function. METHODS:Hand function was measured over three annual visits using Disability of the Arm, Shoulder and Hand (DASH) and SF-36v2...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2012.04.009

    authors： Redmond CL,Bain GI,Laslett LL,McNeil JD

    更新日期：2012-07-01 00:00:00

  • Comparison of traditional diabetes risk scores and HbA1c to predict type 2 diabetes mellitus in a population based cohort study.

    abstract：AIMS:Compare performances of diabetes risk scores and glycated hemoglobin (HbA1c) to estimate the risk of incident type 2 diabetes mellitus (T2DM) in Northeast Germany. METHODS:We studied 2916 subjects (20 to 81years) from the Study of Health in Pomerania (SHIP) in a 5-year follow-up period. Diabetes risk scores inclu...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2017.07.016

    authors： Krabbe CEM,Schipf S,Ittermann T,Dörr M,Nauck M,Chenot JF,Markus MRP,Völzke H

    更新日期：2017-11-01 00:00:00

  • Consequences of delayed pump infusion line change in patients with type 1 diabetes mellitus treated with continuous subcutaneous insulin infusion.

    abstract：OBJECTIVE:To systematically investigate the effect of lack of adherence to the recommended change in insulin pump infusion line use beyond 48 h and determine whether the type of insulin made a difference. RESEARCH DESIGN AND METHODS:This was a double-blind, randomized, crossover trial with 20 patients with diabetes me...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jdiacomp.2009.03.002

    authors： Thethi TK,Rao A,Kawji H,Mallik T,Yau CL,Christians U,Fonseca V

    更新日期：2010-03-01 00:00:00

  • Healthcare resource use and associated costs of hypoglycemia in patients with type 2 diabetes prescribed sulfonylureas.

    abstract：AIMS:The objective of this study was to evaluate diabetes-related healthcare resource use and associated costs in patients with type 2 diabetes (T2DM) treated with a sulfonylurea (SU), with and without hypoglycemia. METHODS:In this retrospective cohort study, patients 18years or older receiving SU monotherapy or as ad...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2017.07.012

    authors： Alemayehu B,Liu J,Rajpathak S,Engel SS

    更新日期：2017-11-01 00:00:00

  • Mortality risk in admitted patients with diabetes mellitus according to treatment.

    abstract：AIMS:Investigate the importance of treating diabetes by evaluating mortality risk of untreated and medically-treated diabetic patients. METHODS:Historical prospectively collected observational data of hospitalized patient ≥18years, admitted for any-cause to medical wards, between January 2011 and December 2013. Main o...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2016.04.011

    authors： Akirov A,Dicker D,Shochat T,Shimon I

    更新日期：2016-08-01 00:00:00

  • The impact of sensory and/or sensorimotor neuropathy on lower limb muscle endurance, explosive and maximal muscle strength in patients with type 2 diabetes mellitus.

    abstract：AIMS:The purpose of this study was to investigate the impact of diabetic neuropathy (dNP) on lower limb endurance, explosive and maximal muscle strength in patients with Type 2 Diabetes Mellitus (T2DM). METHODS:Fifty-four participants, aged between 55 and 85, were enrolled in this observational comparative study. The ...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2020.107562

    authors： Van Eetvelde BLM,Lapauw B,Proot P,Vanden Wyngaert K,Celie B,Cambier D,Calders P

    更新日期：2020-06-01 00:00:00

  • Polymorphisms in the RAGE gene influence susceptibility to diabetes-associated microvascular dermatoses in NIDDM.

    abstract：:To examine genetic polymorphism in the complete sequence of the Receptor of Advanced Glycation End products (RAGE) gene and its possible associations with diabetes-associated microvascular dermatoses (DAMD). Further, to analyze the distribution of individual genotype combinations on the particular polymorphic loci in ...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/s1056-8727(00)00135-5

    authors： Kanková K,Záhejský J,Márová I,Muzík J,Kuhrová V,Blazková M,Znojil V,Beránek M,Vácha J

    更新日期：2001-07-01 00:00:00

  • Concept paper: antihyperglycemic therapy and the diabetic heart--do we really know enough?

    abstract：:The purpose of this article is to provide reasons to start looking more critically at the existing glucose-lowering therapies in diabetes, from the point of their effect on cardiac metabolism. The presented arguments begin with the description of major differences between metabolism in myocardium and the skeletal musc...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2009.07.002

    authors： Kolaczynski JW

    更新日期：2011-01-01 00:00:00

  • Evaluation of pulmonary alveolo-capillary permeability in Type 2 diabetes mellitus: using technetium 99mTc-DTPA aerosol scintigraphy and carbon monoxide diffusion capacity.

    abstract：:The thickening of alveolar basement membrane is found in autopsies, along with microvascular pathologies, in Type 1 and 2 diabetes mellitus (DM). To detect the function and permeability of alveolar basement membrane, carbon monoxide diffusion capacity (DLCO) and technetium 99m-diethyltriaminepentaaceticacid ((99m)Tc-D...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2005.07.003

    authors： Ozşahin K,Tuğrul A,Mert S,Yüksel M,Tuğrul G

    更新日期：2006-07-01 00:00:00

  • Ambulatory blood pressure monitoring in insulin-dependent diabetes mellitus adolescents with and without microalbuminuria.

    abstract：:The aim of our study was to compare ambulatory blood pressure monitoring (ABPM) measures (mean systolic/diastolic blood pressure, diurnal rhythm, and pressure burden) in matched normo- and microalbuminuric (IDDM) adolescents and healthy controls. Twenty-four hour monitoring was undertaken in 39 normotensive (normal cl...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/s1056-8727(97)00050-0

    authors： Sochett EB,Poon I,Balfe W,Daneman D

    更新日期：1998-01-01 00:00:00

  • Vulvovaginitis and balanitis in patients with diabetes treated with dapagliflozin.

    abstract：BACKGROUND:Vulvovaginitis, balanitis, and related genital infections are common in patients with type 2 diabetes. Glucosuria, which is an outcome of treatment with sodium glucose cotransporter 2 (SGLT2) inhibitors, is among the possible causes. Dapagliflozin, an SGLT2 inhibitor with demonstrated glycemic benefits in pa...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jdiacomp.2013.04.012

    authors： Johnsson KM,Ptaszynska A,Schmitz B,Sugg J,Parikh SJ,List JF

    更新日期：2013-09-01 00:00:00

  • Hydrogen sulfide improves diabetic wound healing in ob/ob mice via attenuating inflammation.

    abstract：BACKGROUND:The proposed mechanisms of impaired wound healing in diabetes involve sustained inflammation, excess oxidative stress and compromised agiogenesis. Hydrogen sulfide (H2S) has been reported to have multiple biological activities. We aim to investigate the role of H2S in impaired wound healing in ob/ob mice and...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2017.06.011

    authors： Zhao H,Lu S,Chai J,Zhang Y,Ma X,Chen J,Guan Q,Wan M,Liu Y

    更新日期：2017-09-01 00:00:00

  • The 1h post glucose value best predicts future dysglycemia among normal glucose tolerance subjects.

    abstract：AIM:To analyse the OGTT glycemic parameters - fasting, 1h and 2h plasma glucose values singly and in various combinations; with respect to their prediction of future dysglycemia in subjects with normal glucose tolerance (NGT). METHODS:Electronic medical records of individuals who underwent an OGTT between 1991 and 201...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2017.07.017

    authors： Sai Prasanna N,Amutha A,Pramodkumar TA,Anjana RM,Venkatesan U,Priya M,Pradeepa R,Mohan V

    更新日期：2017-11-01 00:00:00

  • Effect of hyperglycemia and the aldose reductase inhibitor tolrestat on sural nerve biochemistry and morphometry in advanced diabetic peripheral polyneuropathy. The Tolrestat Study Group.

    abstract：:Tolrestat is a well tolerated nonhydantoin aldose reductase inhibitor that has been reported to improve nerve conduction in diabetic animals and humans. Its effects on nerve biochemistry and structure have not been studied in patients with diabetic neuropathy. Patients with advanced diabetic neuropathy treated with lo...

    journal_title：Journal of diabetes and its complications

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/1056-8727(93)90041-v

    authors： Sima AA,Greene DA,Brown MB,Hohman TC,Hicks D,Graepel GJ,Bochenek WJ,Beg M,Gonen B

    更新日期：1993-07-01 00:00:00

  • Cost-utility of empagliflozin in patients with type 2 diabetes at high cardiovascular risk.

    abstract：AIMS:In the Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes (EMPA-REG) trial, empagliflozin reduced cardiovascular and all-cause mortality in type 2 diabetes (T2D) patients at high cardiovascular risk. We sought to estimate the cost-effectiveness of empagliflozin versus standard treatment for t...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2017.10.006

    authors： Nguyen E,Coleman CI,Nair S,Weeda ER

    更新日期：2018-02-01 00:00:00

  • Maximum BMI and microvascular complications in a cohort of Japanese patients with type 2 diabetes: the Japan Diabetes Complications Study.

    abstract：AIMS:The aim of this study was to examine the associations between possible indices of obesity based on information on weight history and the incidence of microvascular complications. METHODS:A cohort of individuals with type 2 diabetes from 59 institutes in Japan was followed for 8years. Patients were classified into...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jdiacomp.2016.02.020

    authors： Tanaka S,Tanaka S,Iimuro S,Ishibashi S,Yamashita H,Moriya T,Katayama S,Akanuma Y,Ohashi Y,Yamada N,Araki A,Ito H,Sone H,Japan Diabetes Complications Study Group.

    更新日期：2016-07-01 00:00:00

  • Bicarbonate dialysis compared to hemodiafiltration on glycemic excursions in patients with end-stage renal disease with and without type 2 diabetes mellitus.

    abstract：AIM:To evaluate the effects on glycemic excursions during bicarbonate dialysis (BHD) compared to hemodiafiltration (HDF) in type 2 diabetic or not diabetic patients affected by end-stage renal disease (ESRD). MATERIAL AND METHODS:Thirty-six patients (20 affected by type 2 diabetes mellitus, and 16 not diabetic patient...

    journal_title：Journal of diabetes and its complications

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.jdiacomp.2015.08.009

    authors： Derosa G,Libetta C,Esposito P,Borettaz I,Tinelli C,D'Angelo A,Maffioli P

    更新日期：2015-11-01 00:00:00

  • Elevated serum KL-6 concentrations in patients with diabetes mellitus.

    abstract：:To clarify the influence of blood glucose level or diabetes mellitus on serum KL-6, a mucin-like glycoprotein, concentrations, they were measured against 176 diabetic subjects, including receiving insulin (INS) group (n=54), oral antidiabetics (OAD) group (n=78), and diet and exercise (D&E) group (n=44). Serum KL-6 co...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/s1056-8727(01)00220-3

    authors： Takahashi T,Takamura K,Sakaue S,Ishii J,Yokouchi H,Nasuhara Y

    更新日期：2002-09-01 00:00:00

  • Hepatitis C infection and diabetes.

    abstract：:Since the discovery of the hepatitis C virus (HCV) in 1989, attention has been paid to the association of chronic HCV infection and the development of diabetes. The risk factors for diabetes include older age, HCV genotype 3, severe liver fibrosis, family history of diabetes, and liver/kidney transplantation. Emerging...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章,评审

    doi：10.1016/j.jdiacomp.2006.01.001

    authors： Noto H,Raskin P

    更新日期：2006-03-01 00:00:00

  • Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes.

    abstract：:Early diabetic kidney disease (DKD) occurs in adolescents with type 1 diabetes (T1D). Lower serum uromodulin (SUMOD) predicts DKD progression in adults with T1D. In this study, we demonstrate that lower SUMOD is associated with urinary albumin excretion in adolescents with T1D, suggesting a potential relationship betw...

    journal_title：Journal of diabetes and its complications

    pub_type： 杂志文章

    doi：10.1016/j.jdiacomp.2019.05.023

    authors： Wiromrat P,Bjornstad P,Roncal C,Pyle L,Johnson RJ,Cherney DZ,Lipina T,Bishop F,Maahs DM,Wadwa RP

    更新日期：2019-09-01 00:00:00