Abstract：
BACKGROUND:The aim of this study was to investigate the potential of dexfenfluramine (dF) for reducing cardiovascular risk factors and improving compliance towards diet in a group of young patients hospitalized for essential obesity of high degree (BMI > or = 35). METHODS:103 adolescents (mean age 15.4 +/- 0.2) participated in a nine-week randomized double-blind study of dF (15 mg bid) versus placebo. All patients received a VLCD (2,512 kJ/day = 600 kcal/day) for two months. In basal conditions, and after 30 and 60 days of treatment, anthropometric variables (height, weight, BMI, and W/H) and cardiovascular risk factors (blood glucose concentration, total cholesterol, HDL-cholesterol, triglycerides, systolic and diastolic blood pressure) were monitored. Modifications in hunger and satiety were also assessed. RESULTS:During the treatment period, both the dF group and the placebo group presented a similar pattern of weight loss (BMI = dF: 36.7 +/- 0.5 vs 32.5 +/- 0.4 vs 30.1 +/- 0.4; placebo: 37.0 +/- 0.6 vs 33.1 +/- 0.5 vs 30.8 +/- 0.5). No important side-effects were recorded in either group. Blood pressure and metabolic markers decreased significantly in both groups. Earlier reductions in total cholesterol and diastolic blood pressure in dF-treated subjects were the only significant differences observed as compared to the patients receiving placebo (day 30 = total cholesterol: 120 +/- 2 (dF) vs 132 +/- 3 (placebo) mg/dI; p < 0.005; diastolic blood pressure: 73 +/- 1 (dF) vs 77 +/- 1 (placebo) mmHg; p < 0.01). However, after 60 days, these values were similar in the two groups. As far as non-parametric data are concerned, dF determined a reduction in hunger and an increase in satiety in a significantly higher number of subjects than did the placebo, not only after 30 days of treatment (92.8% vs 55.3% and 92.8% vs 45.5%, respectively; p < 0.0001), but also after two months of treatment (97.8% vs 67.4% and 97.8% vs 45.8%, respectively; p < 0.0001). CONCLUSIONS:These findings demonstrate that dF represents a useful support in the treatment of juvenile obesity and might ensure a better individual compliance towards restrictive diets, particularly in the initial "critical" stages, in the absence of important side-effects.
journal_name
Minerva Pediatrjournal_title
Minerva pediatricaauthors
Grugni G,Guzzaloni G,Ardizzi A,Moro D,Morabito Fsubject
Has Abstractpub_date
1997-03-01 00:00:00pages
109-17issue
3eissn
0026-4946issn
1827-1715journal_volume
49pub_type
临床试验,杂志文章,随机对照试验abstract：:The paper reports five cases of Kawasaki's syndrome diagnosed during the period 1985-89. The mean age of patients was 20 months (4/12; 4 years and 5/12). Symptomatology gradually regressed in four of these patients with a return to good health and normal cardiological controls. The fifth patient died suddenly followin...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：:Testosterone, LH, FSH, blood levels at birth were determined in 40 Italian true cryptorchid , 12 pseudo-cryptorchid and 71 healthy newborns. Testosterone concentrations were interpreted according to the localisation of the retained testicles. A greater incidence of spontaneous remission of the cryptorchidism was found...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) is a complex disorder, involving primarily ovarian hyperandrogenism in females and linked with insulin resistance in the majority of cases. Clinical features are widely variable and include a combination of menstrual irregularities, acne, hirsutism, and alopecia. Although it typically ...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND:The aim of this paper was to examine the present situation of adolescents admission for respiratory emergency, management of these patients, identify strategies for the best therapeutic options and better collaboration. METHODS:We have gathered data of adolescent patients who were referred to the Emergency ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：:Providing optimal mechanical ventilation to critically-ill children remains a challenge. Patient-ventilator dyssynchrony results frequently with numerous deleterious consequences on patient outcome including increased requirement for sedation, prolonged duration of ventilation, and greater imposed work of breathing. M...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:To investigate if high dose inhaled beclomethasone dipropionate started early after upper respiratory tract infection (URTI) could reduce recurrent wheezing in infants. METHODS:Twenty-six ambulatory infants, 7-12 months of age, with recurrent wheezing during upper respiratory tract infection participated. A...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：:The majority of childhood cancer patients can expect nowadays to be cured and the percentage is now between 70% and 80%. The number of long-term survivors, off- threatment for at least 5 years, is rising rapidly and is becoming a new population, which needs a special care. It is becoming increasingly important to know...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2005-12-01 00:00:00
abstract：:Splenic infarction has been associated with haematologic and tromboembolic disorders and, more rarely, with infectious diseases. A case of splenic infartion during an attack of brucellosis is reported. Symptoms included persistent left upper quadrant pain and fever. An abdomen scan confirmed the presence of a triangul...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:Intracranial tuberculoma is a possible complication of meningeal, miliary or pulmonary tuberculosis. In developing countries it represents 30% of space-occupying intracranial lesions, in industrialised countries only 0.1-0.2%. One recently recognised phenomenon is the development ex novo or the enlargement of the tube...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2005-10-01 00:00:00
abstract：AIM:To test the impact of a public health model to implement HIV pediatric care in Limited Resource Settings. METHODS:A retrospective study on the clinical files of 679 Mozambican children (mean age 4.4 years; SD 3.2), has been carried out. The pediatric patients received HAART (Highly Active Anti-Retroviral Therapy) ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2006-10-01 00:00:00
abstract：:A case of phakomatosis pigmentovascularis type IIa in a, short stature, 6-year old girl with nevus flammeus of the face and palate, bilateral ocular melanosis, aberrant mongolian spots and minor dysmorphic traits is reported. The patient has been considered at risk for glaucoma and ocular melanoma and an ophthalmologi...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:Post-traumatic stress disorder (PTSD) is a common psychiatric disorder which is frequently comorbid with major depressive disorder (MDD). It has been suggested that some or all individuals diagnosed with comorbid PTSD and MDD have a separate psychobiological condition that can be termed ''post-traumatic mood disorder'...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:The nutritional status of foster children, the quality of daily menus in group homes and the food security inside these organizations have been poorly studied. For this reason, the aim of this study was to investigate them. METHODS:A sample of 125 children, ranging in age from 0-17 years, among seven group ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.16.04802-7
更新日期：2020-12-01 00:00:00
abstract：:One may have only minutes to change the trajectory of a child who is deteriorating from either congenital or acquired cardiac disease. However, these children may present with rather cryptic patterns of symptoms (e.g. failure to thrive, lethargy, colic, neonatal shock, respiratory distress, wheezing and syncope with e...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2009-04-01 00:00:00
abstract：:Contiguous gene deletion syndromes: the importance of an accurate genetic definition for a careful clinical monitoring. Contiguous gene deletion syndromes are so named because the deletion manifests as a distinctive cluster of otherwise unrelated single-gene disorders in the same subject. An accurate genetic definitio...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2010-06-01 00:00:00
abstract：:Personal experience of a series of mycoplasma-induced pneumoniae is reported. The importance of early diagnosis for the purpose of speedy target antibiotic therapy is reiterated. Stress is laid on the absence of complications in all patients studied. ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1989-06-01 00:00:00
abstract：:Certain humoral and cellular immunological parameters were assessed in patients with either pure atopic dermatitis or dermatitis combined with asthma in order to discover if there were any significant differences between the two clinical forms. The study was conducted on 15 children of both sexes who were investigated...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:Megapolycalicosis is defined as a congenital dilatation of calices without evidence of obstruction. In absence of complications such as infection and stones, megapolycalicosis would not have a particular clinical relevance if not for the possible misinterpretation as hydronephrosis. A case of megapolycalicosis is pres...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:A complex association has been observed between birth weight (BW) and depression/anxiety symptoms at various stages of life. The purpose of this study was to evaluate whether adolescents with low or insufficient BW were more likely to report depressive/anxiety symptoms. METHODS:A cross-sectional study was c...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.17.04452-8
更新日期：2018-10-01 00:00:00
abstract：:Hyperinsulinism is an important cause of hypoglycemia in early infancy. Many forms of hyperinsulinemic hypoglycemia are described: transient, prolonged, persistent. Transient forms are well recognized in infants of diabetic mother; prolonged forms are responsible for the hypoglycemia in small-for-date (SGA) infants an...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2003-02-01 00:00:00
abstract：:The onset of puberty may be late - in the latter part of the predicted normal range or truly delayed - beyond this range. The latest age to start is usually regarded as 13 years in girls and 14 years in boys. There may also be a delayed completion of puberty, 16 years in girls and 17 years in boys. The initial approac...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.20.05968-X
更新日期：2020-12-01 00:00:00
abstract：:The diagnosis and treatment of anorexia nervosa (AN) in children and adolescents has some commonality but also differs from that of this condition in adults. A new understanding of AN is emerging: research data from the fields of epidemiology, genetics, and brain biology, suggest that there may be an underlying brain ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2013-02-01 00:00:00
abstract：:Severe atopic dermatitis causes major impairment in the life of both children and their parents. Generally, symptoms can be controlled with emollients, topical steroids, antibiotics, antihistaminic but some patients remain intensely ill and may require treatment with systemic steroids and so on. Cyclosporin has been f...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2004-04-01 00:00:00
abstract：:The clinical importance of the measurement of bone mineral content (BMC) in fullterm infants by photon absorptiometry relies on a comparatively narrow normative range that is necessary requisite to interpret the data from a single child. In the attempt to reduce the artifactual scattering of data, it was undertaken a ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1989-08-01 00:00:00
abstract：:In a short girl with celiac disease and Hashimoto's thyroiditis (HT), suspicion of an associated pituitary lesion was suggested by the finding of a thyroid function pattern that was not compatible with HT-related hypothyroidism (low FT4 with normal TSH). This case report reinforces the view that the finding of a norma...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2016-04-01 00:00:00
abstract：AIM:Glioneuronal tumors (especially gangliogliomas and dysembryoplastic neuroepithelial tumors) are an increasingly recognised cause of drug-resistant epilepsy in children. The optimal surgical strategy (lesionectomy vs. extended resection of epileptogenic peritumoral areas) to obtain seizure control has not been fully...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2013-12-01 00:00:00
abstract：:This paper reports a case of pyloric duplication, an extremely rare abnormality usually discovered during infancy. Clinical findings involved mainly symptoms of obstruction and radiological evaluation included abdominal US, plain radiography and CT imaging. Pyloric duplication was diagnosed by US and confirmed by CT s...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2006-08-01 00:00:00
abstract：:The diagnosis of fetal tachyarrhythmia during a routine ultrasound scan imposes a continuous monitoring of fetal heart function through ECG and M-mode echocardiography. Since fetal dysrhythmia can lead to non-immune hydrops or to fetal death a correct diagnosis and an adequate intrauterine therapy are fundamentally im...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：: ...
journal_title：Minerva pediatrica
pub_type： 信件
doi：10.23736/S0026-4946.19.05297-6
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Obesity is a condition that increases the risk of developing several health problems, resulting in high health care costs worldwide. Therefore, it is important to investigate several avenues for the control of this condition. This study aimed to identify a dermatoglyphical condition that distinguishes obesit...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.20.05731-X
更新日期：2021-01-13 00:00:00
