Abstract：
:The onset of puberty may be late - in the latter part of the predicted normal range or truly delayed - beyond this range. The latest age to start is usually regarded as 13 years in girls and 14 years in boys. There may also be a delayed completion of puberty, 16 years in girls and 17 years in boys. The initial approach requires a detailed history and clinical examination to exclude other medical or psychological problems. The presence or absence or pubertal signs should be documented. Investigations should be targeted at ruling out any medical causes and determining whether the delay is due to central gonadotropin deficiency (hypogonadotropic hypogonadism) or a gonadal disorder (hypergonadotropic hypogonadism). Physiological or constitutional delay of growth and puberty (CDGP) is more common in boys but is a diagnosis of exclusion. Current research suggests that CDGP and congenital hypogonadotropic hypogonadism have distinct genetic profiles which may aid in the differential diagnosis. Treatment may be given using low doses of sex steroids, testosterone or estradiol initially in a short course of 3-6 months but continuing in escalating doses mimicking the normal course of puberty, watching regularly for the spontaneous resumption of progress and gonadotropin secretion. In gonadotropin deficiency, sex hormone treatment needs to be continued until completion of pubertal development and growth. Counselling, reassurance and support are key elements in the management of adolescents with delayed puberty.
journal_name
Minerva Pediatrjournal_title
Minerva pediatricaauthors
Butler G,Purushothaman Pdoi
10.23736/S0026-4946.20.05968-Xsubject
Has Abstractpub_date
2020-12-01 00:00:00pages
484-490issue
6eissn
0026-4946issn
1827-1715pii
S0026-4946.20.05968-Xjournal_volume
72pub_type
杂志文章abstract：INTRODUCTION:Chronic rhinosinusitis (CRS) is defined as an inflammatory disorder of the paranasal sinuses and of the nasal mucosa that lasts 12 weeks or longer. In CRS microbes contribute to the disease pathogenesis. Clinical microbiology is focused on finding single pathogens that causes the disease and the main goal ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.20.05850-8
更新日期：2020-07-29 00:00:00
abstract：:Cystic fibrosis (CF) is an inherited, prematurely lethal rare disease affecting more than 85,000 people worldwide. CF is caused by more than 2000 loss-of-function mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR). This review summarizes recent advances in the etiological t...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：10.23736/S0026-4946.19.05506-3
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:In epileptic patients with motor disability, it's difficult to disentangle the effects of antiepileptic drugs (AEDs) on bone health from those provoked by impaired mobility. The aim of this study was to evaluate the effects of AEDs on bone mineral status by phalangeal quantitative ultrasound (QUS), a no-radi...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.18.05235-0
更新日期：2019-05-23 00:00:00
abstract：:Noonan syndrome was first described over 20 years ago by Noonan and Ehmke. They defined a specific group of nine patients with valvular pulmonary stenosis who, in addition, had short stature, mild mental retardation, hypertelorism and unusual facies. The incidence of Noonan syndrome has been estimated to be between 1 ...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：1993-09-01 00:00:00
abstract：:Chronic viral hepatitis B and C infections are highly prevalent and create a substantial burden to healthcare systems globally. These two chronic infections are the cause of significant global morbidity and mortality with approximately 1 million annual deaths attributable to them and their sequelae. Children are vulne...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2014-10-01 00:00:00
abstract：AIM:Pectus excavatum is the commonest thoracic congenital malformation, but its treatment remains not well known. The authors present the results of the mini-invasive repair at G. Gaslini Institute of Genoa, Italy. METHODS:Nuss mini-invasive repair avoids anterior scars. The correction is achieved by the introduction ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2008-08-01 00:00:00
abstract：:Cystic fibrosis (CF) is a genetic disease associated with recurrent lung infections, that represent a major cause of mortality and morbidity. Cystic fibrosis requires frequent antibiotic treatments, sometimes by mouth or via aerosol but often via the intravenous route. Totally implanted venous access devices (ports) a...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2009-10-01 00:00:00
abstract：:More than one million neonatal deaths every year in the world are attributable to infection. In nurseries, infections occur with a reported incidence of 0.3-3%; in Neonatal Intensive Care Units (NICUs) the reported incidence is 7-24.5%, and up to 40% in newborns with birth weight less than 1000 g or gestational age at...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2013-02-01 00:00:00
abstract：:A case of phakomatosis pigmentovascularis type IIa in a, short stature, 6-year old girl with nevus flammeus of the face and palate, bilateral ocular melanosis, aberrant mongolian spots and minor dysmorphic traits is reported. The patient has been considered at risk for glaucoma and ocular melanoma and an ophthalmologi...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：AIM:To evaluate the possible effects of recombinant growth hormone (rhGH) therapy on mineral homeostasis and bone turnover, the authors studied calcium-phosphate metabolism parameters, including some bone markers, in 2 prepubertal subjects with Noonan's syndrome (NS). METHODS:Two prepubertal males suffering from NS, s...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:The objective of this study was to define the distribution of inhalant allergens in pediatric patients in whom sensitization was diagnosed with a skin prick test (SPT) who had presented with allergic complaints. In addition, the correlation between the inhalant allergens detected on the SPT and the patients'...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2016-08-01 00:00:00
abstract：:One of the principal duties of a staff nurse working in a NICU is the assistance of the ventilated infants. The management of the endotracheal tube is a key moment in the neonatal care and it is fundamental to prevent the ventilator induced lung injury and the change in the perfusion (especially in the brain) that may...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2010-06-01 00:00:00
abstract：:Neonatal analgesia is a recent issue: newborns were supposed to feel no pain until the late "80s; but from that date, many studies were performed to verify the extent of neonates" pain perception, ways to measure and overcome it. Pain can have harmful consequences in babies, due to several causes, and we investigated ...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2010-06-01 00:00:00
abstract：:Little is known about the overlapping symptoms and comorbidity of pediatric bipolar disorder (BD) and pervasive developmental disorders (PDD) in youth. The aim of this study was to clearly differentiate the symptoms, understand the prevalence and patterns of comorbid presentations, as well as to provide a summary of e...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to asses the validity of the TCB nomogram for the European population for predicting significant hyperbilirubinemia in healthy term and late-preterm newborns. METHODS:This observational study was conducted from February 2009 to December 2009 in the well-baby nurseries of Gemelli hos...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Developmental Dyslexia is a disorder, highly frequent in the school population, for which the recommended rehabilitation procedures are not well defined. This study aimed to automatize reading decoding skills by using an innovative system for rehabilitation, based on a telerehabilitation method. It requires ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.16.04426-1
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Hirschsprung's disease is an important cause of pediatric constipation with high risk of bacterial enterocolitis. Its diagnosis is histological and the suction biopsy is the gold standard. In resource-limited countries, the main diagnostic exam is the contrast enema and mini-invasive surgery lacks. We presen...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.19.05487-2
更新日期：2019-03-21 00:00:00
abstract：:Syringocele is a cystic dilation of the excretory bulbourethral Cowper gland duct, and is a rather uncommon finding in pediatric age. It is frequently asymptomatic but sometimes may cause voiding symptoms and urinary tract infection (UTI). This case report describes an unusual manifestation of syringocele presenting w...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2009-02-01 00:00:00
abstract：:Aspecific chronic diarrhea is one of the most common causes of protracted diarrhea in infancy. The pathology is characterised by an increased frequency of daily bowel movement with half-formed feces; it is not associated to malabsorption syndrome or enteric infections and appears to be correlated to an unbalanced diet...
journal_title：Minerva pediatrica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-04-01 00:00:00
abstract：:Thoracic tumours of childhood arise either in the mediastinum, or from the chest wall and rarely from the lung parenchyma. Mediastinal teratoma occur in the anterior mediastinum and are usually very large at presentation; initial treatment is under discussion, but it appears that surgical excision and histological exa...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：:Chronic kidney disease (CKD) is a continuum of progressive reduction in kidney function lasting for more than three months, due to either structural and/or functional renal abnormalities that may lead to irreversible kidney damage. The term "renal supportive therapy" (RST) generally characterizes the spectrum of dialy...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2012-04-01 00:00:00
abstract：:Between 1973 and 1993 7 perineal testis are observed and operated on in our surgical department. The perineal testis is a rare ectopic testis probably caused by some mechanical obstacles in the entrance of the testis in the scrotum. A diagnosis is easy if also the less frequent localizations of testicular ectopia are ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND:YouTube is overloaded with various medical videos and has become a common source for surgeons and the general public alike to update on surgical procedures. This study determined the quality and benefits of information with regards to laparoscopic pyloromyotomy on YouTube. METHODS:A search was performed on ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.18.05178-2
更新日期：2018-07-18 00:00:00
abstract：BACKROUND:In the present study we investigated the levels of proapoptotic Caspase-9 and antiapoptotic Bcl-2 proteins in the sera of children and adolescents with idiopathic epilepsy and tried to relate the findings to the patients clinical parameters. METHODS:This retrospective study consisted of 118 children and adol...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.17.04787-9
更新日期：2017-06-22 00:00:00
abstract：:Intra-abdominal lymphangiomas are rare benign tumours that can cause various symptoms, mainly during childhood. They are diagnosed by ultrasonography, CT scanning or at laparotomy; ultrasonographic examination often shows a voluminous tumoral cystic formation with septa. The location of the cyst may be determined eith...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2006-02-01 00:00:00
abstract：:Age of diagnosis and clinical pattern were studied in 97 celiac patients, diagnosed with jejunal biopsy, between 1976-1991. They were selected on the basis of clinical and laboratory patterns. The laboratory tests utilized were steatorrhea and xylose in the first years, while in recent years AGA, ARA and AEA were also...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:Low grade gliomas (LGG) are the most common brain tumors of childhood and adolescence, consisting of a mixed group of grade I and grade II neoplasms. In general, their location and resectability are the most important predictors of outcome. Surgery is curative, usually for superficial tumors of the cerebral or cerebel...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2013-04-01 00:00:00
abstract：:Distinguishing between constitutional delay of growth and puberty (CDGP) and congenital hypogonadotropic hypogonadism (CHH) may be challenging. CDGP and CHH appear to belong to the same clinical spectrum (with low sex hormones and low LH and FSH), although one is classically transient and known as a self-limited form ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.20.05860-0
更新日期：2020-08-01 00:00:00
abstract：:The authors describe Poland's anomaly in a boy aged three years and four months, characterised by a depression in the right hemithorax caused by the absence of the medial extremity of the large pectoral muscle with hypoplasia of the remaining venter musculi. Moreover, the scan showed the absence of the small homolater...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:We report a case of esophageal achalasia in a nine months old baby. Recurrent cough and cyanosis were the most important clinical findings. Esophagomyotomy remarkably improved the clinical symptoms. Disorders of esophageal motility may be an important cause of respiratory emergencies in the first year of life. ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
