Repair phenotype in corneal fibroblasts is controlled by an interleukin-1 alpha autocrine feedback loop.

abstract：Purpose:Centripetal retinal degeneration in choroideremia (CHM) leads to early visual field restriction and late central vision loss. The latter marks an acute decline in quality of life but visual prognostication remains challenging. We investigated visual function in CHM by correlating best-corrected visual acuity (B...

journal_title：Investigative ophthalmology & visual science

authors： Jolly JK,Xue K,Edwards TL,Groppe M,MacLaren RE

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:This study explores variation in the axial location of Bruch's membrane opening (BMO) to determine if this reference plane varies with age and race. METHODS:There were 168 spectral-domain optical coherence tomography (SDOCT) optic nerve head volumes that were obtained from healthy subjects and manually delinea...

journal_title：Investigative ophthalmology & visual science

authors： Johnstone J,Fazio M,Rojananuangnit K,Smith B,Clark M,Downs C,Owsley C,Girard MJ,Mari JM,Girkin CA

更新日期：2014-03-28 00:00:00

abstract：PURPOSE:Recent evidence suggests that platelets play a major role in ischemia-reperfusion injury, not only through thrombus formation but also through participation in inflammatory reactions with leukocytes. This study was designed to investigate the contribution of platelets in leukocyte recruitment to inflamed region...

journal_title：Investigative ophthalmology & visual science

authors： Nishijima K,Kiryu J,Tsujikawa A,Miyamoto K,Honjo M,Tanihara H,Nonaka A,Yamashiro K,Katsuta H,Miyahara S,Honda Y,Ogura Y

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:Identification of novel proteins involved in retinal neovascularization may facilitate new and more effective molecular-based treatments for proliferative retinopathy. Tubedown-1 (Tbdn-1) is a novel protein that shows homology to the yeast acetyltransferase subunit NAT1 and copurifies with an acetyltransferase ...

journal_title：Investigative ophthalmology & visual science

authors： Wall DS,Gendron RL,Good WV,Miskiewicz E,Woodland M,Leblanc K,Paradis H

更新日期：2004-10-01 00:00:00

abstract：Purpose:Adult central nervous system (CNS) neurons are unable to regenerate their axons after injury. Krüppel-like transcription factor (KLF) family members regulate intrinsic axon growth ability in vitro and in vivo, but mechanisms downstream of these transcription factors are not known. Methods:Purified retinal gang...

journal_title：Investigative ophthalmology & visual science

authors： Galvao J,Iwao K,Apara A,Wang Y,Ashouri M,Shah TN,Blackmore M,Kunzevitzky NJ,Moore DL,Goldberg JL

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:The purpose of the present study was to investigate metabolic changes in different compartments of the rat lens (anterior, nuclear, posterior, and equatorial) after exposure to an acute double threshold dose of ultraviolet-B radiation (UVR-B) by using high-resolution magic angle spinning (HR-MAS) (1)H nuclear m...

journal_title：Investigative ophthalmology & visual science

authors： Tessem MB,Bathen TF,Löfgren S,Saether O,Mody V,Meyer L,Dong X,Söderberg PG,Midelfart A

更新日期：2006-12-01 00:00:00

abstract：Purpose:ISG15, a di-ubiquitin-like protein, is critical for controlling certain viral and bacterial infections. We sought to determine if ISG15 plays a role in corneal innate immunity against Candida albicans (C. albicans) using a C57BL/6 (B6) mouse model of human fungal keratitis. Methods:Scarified corneas of adult B...

journal_title：Investigative ophthalmology & visual science

authors： Dong C,Gao N,Ross BX,Yu FX

更新日期：2017-06-01 00:00:00

abstract：Purpose:To determine age-related alterations in the retinal tissue perfusion (RTP) and volumetric vessel density (VVD) in healthy subjects. Methods:Total 148 healthy subjects (age 18 to 83 years) were enrolled and divided into four groups (G1, <35 years; G2, 35 ∼ 49 years; G3, 50 ∼ 64 years; and G4, ≥65 years). The RT...

journal_title：Investigative ophthalmology & visual science

authors： Lin Y,Jiang H,Liu Y,Rosa Gameiro G,Gregori G,Dong C,Rundek T,Wang J

更新日期：2019-02-01 00:00:00

abstract：Purpose:There is evidence that choroidal blood flow (ChBF) is regulated in a complex way during changes in ocular perfusion pressure (OPP). We hypothesized that ChBF regulates better in response to changes in mean arterial pressure (MAP) than in intraocular pressure (IOP). Methods:Eighteen volunteers (mean age, 26 yea...

journal_title：Investigative ophthalmology & visual science

authors： Popa-Cherecheanu A,Schmidl D,Werkmeister RM,Chua J,Garhöfer G,Schmetterer L

更新日期：2019-01-02 00:00:00

abstract：:The study and therapy of age-related macular degeneration (AMD), a leading cause of blindness worldwide, have taken great strides over the past decade. During the same time, a central role for RNA in many human diseases has been discovered. We have identified anti-angiogenic functions for synthetic double stranded RNA...

journal_title：Investigative ophthalmology & visual science

authors： Ambati J

更新日期：2011-04-06 00:00:00

abstract：:PURPOSE. To investigate the anti-inflammatory effect of aminoimidazole carboxamide ribonucleotide (AICAR), an analog of adenosine monophosphate (AMP), in endotoxin-induced uveitis (EIU). METHODS. EIU was induced by subcutaneous injection of lipopolysaccharide (LPS) (200 μg) in Lewis rats. AICAR (50 mg/kg, intraperiton...

journal_title：Investigative ophthalmology & visual science

authors： Suzuki J,Manola A,Murakami Y,Morizane Y,Takeuchi K,Kayama M,Miller JW,Sobrin L,Vavvas DG

更新日期：2011-08-22 00:00:00

abstract：PURPOSE:Neural ectopic rewiring in retinal degeneration such as retinitis pigmentosa (RP) may form functional synapses between cones and rod bipolar cells that cause atypical signal processing. In this study, the multifocal electroretinograms (mfERGs) of a large animal model of RP, the rhodopsin P347L transgenic (Tg) p...

journal_title：Investigative ophthalmology & visual science

authors： Ng YF,Chan HH,Chu PH,To CH,Gilger BC,Petters RM,Wong F

更新日期：2008-05-01 00:00:00

abstract：Purpose:To compare the changes in human tear proteome and clinical effects following topical cyclosporine A (CsA) 0.05% or diquafosol tetrasodium (DQS) 3% treatment of dry eye disease (DED), and to identify biomarkers for determining disease severity and treatment effectiveness in DED. Methods:A total of 18 patients w...

journal_title：Investigative ophthalmology & visual science

authors： Ji YW,Kim HM,Ryu SY,Oh JW,Yeo A,Choi CY,Kim MJ,Song JS,Kim HS,Seo KY,Kim KP,Lee HK

更新日期：2019-12-02 00:00:00

abstract：PURPOSE:To isolate and characterize bovine lens endopeptidase activity that cleaves the Phe-Ser bond in peptide substrates. METHODS:The protease activity in young bovine lens homogenate was measured using the Mca-(Ala(7),Lys(Dnp)(9))-bradykinin substrate. Degradation of bradykinin and other unlabeled peptide substrate...

journal_title：Investigative ophthalmology & visual science

authors： Chaerkady R,Sharma KK

更新日期：2004-04-01 00:00:00

abstract：Purpose:Although normal function of the lacrimal gland is essential for vision (and thus for human well-being), the lacrimal gland remains rather poorly understood at a molecular level. The purpose of this study was to identify new genes and signaling cascades involved in lacrimal gland development. Methods:To identif...

journal_title：Investigative ophthalmology & visual science

authors： Dvoriantchikova G,Tao W,Pappas S,Gaidosh G,Tse DT,Ivanov D,Pelaez D

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To examine the relationship between circulating inflammatory markers, hemostatic factors, and age-related maculopathy (ARM). METHODS:A population-based, cross-sectional case-control study drawn from the Blue Mountains Eye Study included 159 early and 38 late ARM cases, and 433 controls matched for age, gender,...

journal_title：Investigative ophthalmology & visual science

authors： Wu KH,Tan AG,Rochtchina E,Favaloro EJ,Williams A,Mitchell P,Wang JJ

更新日期：2007-05-01 00:00:00

abstract：:Monkeys eyes were fixed with glutaraldehyde in vivo at positive intraocular pressure of 35 or 25 mm Hg and compared with eyes fixed without a positive pressure gradient, with the use of light microscopy and transmission and scanning electron microscopy. The entire endothelial lining of the inner wall of Schlemm's cana...

journal_title：Investigative ophthalmology & visual science

authors： Johnstone MA

更新日期：1979-01-01 00:00:00

abstract：:The free epsilon-amino groups and 5-hydroxymethylfurfural (5-HMF) contents were determined in soluble and insoluble proteins of clear human lenses and diabetic and nondiabetic senile cataractous lenses. The free epsilon-amino group content of soluble proteins in diabetic cataracts was decreased by 37% (P less than 0.0...

journal_title：Investigative ophthalmology & visual science

authors： Rao GN,Cotlier E

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Optical coherence tomography (OCT) has been used to investigate papilledema in single-site, mostly retrospective studies. We investigated whether spectral-domain OCT (SD-OCT), which provides thickness and volume measurements of the optic nerve head and retina, could reliably demonstrate structural changes due t...

journal_title：Investigative ophthalmology & visual science

authors： OCT Sub-Study Committee for NORDIC Idiopathic Intracranial Hypertension Study Group.,Auinger P,Durbin M,Feldon S,Garvin M,Kardon R,Keltner J,Kupersmith M,Sibony P,Plumb K,Wang JK,Werner JS

更新日期：2014-11-04 00:00:00

abstract：Purpose:Vision decline with healthy aging is a major public health concern with the unceasing growth of the aged population. In order to prevent or remedy the age-related visual loss, a better understanding of the underlying causes is needed. The current psychophysical study used a novel noise paradigm to investigate t...

journal_title：Investigative ophthalmology & visual science

authors： Silvestre D,Arleo A,Allard R

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:To investigate the effect of hyperbaric oxygen (HBO) chamber treatment in mouse models of retinal ischemia. METHODS:Unilateral central retinal artery occlusion (CRAO) or optic nerve crush (ONC) was induced in 50 mice each, of which 30 were treated with 100% oxygen at 2 atm for 90 minutes immediately after inju...

journal_title：Investigative ophthalmology & visual science

authors： Gaydar V,Ezrachi D,Dratviman-Storobinsky O,Hofstetter S,Avraham-Lubin BC,Goldenberg-Cohen N

更新日期：2011-09-29 00:00:00

abstract：PURPOSE:The aim of this study was to determine the function of the tight junction protein occludin in the control of permeability, under diffusive and hydrostatic pressures, and its contribution to the control of cell division in retinal pigment epithelium. METHODS:Occludin expression was inhibited in the human retina...

journal_title：Investigative ophthalmology & visual science

authors： Phillips BE,Cancel L,Tarbell JM,Antonetti DA

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:Identification of causative mutations for retinal blinding disorders is often limited by restricted understanding of gene expression and underlying molecular mechanisms that trigger degenerative processes. This study was conducted to develop a catalog of canine retina-expressed genes that would provide a unique...

journal_title：Investigative ophthalmology & visual science

authors： Zangerl B,Sun Q,Pillardy J,Johnson JL,Schweitzer PA,Hernandez AG,Liu L,Acland GM,Aguirre GD

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:To investigate concentrations of growth factors and inflammatory cytokines in eyes with central (CRVO) and branch (BRVO) retinal vein occlusion before and during therapy with bevacizumab and to identify associations with disease activity. METHODS:In a prospective clinical trial, 13 eyes of patients with CRVO (...

journal_title：Investigative ophthalmology & visual science

authors： Funk M,Kriechbaum K,Prager F,Benesch T,Georgopoulos M,Zlabinger GJ,Schmidt-Erfurth U

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:The authors recently showed that the retinal circulation can be accessed by transfemoral endovascular catheterization. The purpose of this study was to examine whether endovascular coiling can be used to induce different degrees of ischemic injury. The possibility of creating occlusions at different sites in th...

journal_title：Investigative ophthalmology & visual science

authors： Morén H,Gesslein B,Undrén P,Andreasson S,Malmsjö M

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To determine the effects of blocking substance P (SP) interactions with its major receptor (NK1-R) using the antagonist spantide I in susceptible mice infected with Pseudomonas aeruginosa. METHODS:Immunohistochemistry and enzyme immunosorbent assay (EIA) tested levels of SP in the cornea of B6 and BALB/c mice....

journal_title：Investigative ophthalmology & visual science

authors： Hazlett LD,McClellan SA,Barrett RP,Liu J,Zhang Y,Lighvani S

更新日期：2007-02-01 00:00:00

abstract：:Interocular differences in apparent size (aniseikonia) are typically associated with interocular differences in refractive error (anisometropia). Aniseikonia is generally thought to reflect disparities in retinal image size that often accompany anisometropia. This assumption was examined with seven highly anisometropi...

journal_title：Investigative ophthalmology & visual science

authors： Bradley A,Rabin J,Freeman RD

更新日期：1983-04-01 00:00:00

abstract：PURPOSE:One of the methods used in macular translocation (MT) surgery for subfoveal neovascularization is to create a temporary total retinal detachment followed by a 360 degrees retinotomy. The whole retina is then shifted from the original surface of the retinal pigment epithelium (RPE), resulting in an unusual retin...

journal_title：Investigative ophthalmology & visual science

authors： Terasaki H,Miyake Y,Suzuki T,Niwa T,Piao CH,Suzuki S,Nakamura M,Kondo M

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:National programs for trachoma control are implementing mass treatment programs in which azithromycin is used as part of the control strategy. Dose is determined by weight, which can be difficult to determine in field conditions. The purposes of this study were to determine whether an accurate dose could be det...

journal_title：Investigative ophthalmology & visual science

authors： Muñoz B,Solomon AW,Zingeser J,Barwick R,Burton M,Bailey R,Mabey D,Foster A,West SK

更新日期：2003-04-01 00:00:00

abstract：:Although aqueous outflow is most likely a passive, nonenergy-dependent process, alterations in cellular function in the trabecular meshwork presumably are involved in the development of some types of glaucoma. Accordingly, it seems important to define both the normal and abnormal biochemistry of this tissue. The autho...

journal_title：Investigative ophthalmology & visual science

authors： Anderson PJ,Karageuzian LN,Cheng HM,Epstein DL

更新日期：1984-11-01 00:00:00