Rotavirus infection and prevention.

Abstract:

:The major advance in knowledge about rotavirus infection and prevention has been in vaccine development. Several large studies of tetravalent rhesis rotavirus vaccine have had encouraging results, and a first-generation vaccine is likely to be licensed by the 25th anniversary of the discovery of rotavirus (in 1973). Epidemiologic studies have highlighted a diversity of less common G types and non-group A strains, observations to be taken into account in further vaccine development. Disconcerting anecdotal reports of central nervous system involvement need to be cautiously interpreted. New information on pathophysiology raises the intriguing concept of viral toxin involvement. Oral immunoglobulin has been used for prophylaxis and also for treatment during active infection.

journal_name

Curr Opin Pediatr

authors

Barnes GL,Bishop RF

doi

10.1097/00008480-199702000-00006

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

19-23

issue

1

eissn

1040-8703

issn

1531-698X

journal_volume

9

pub_type

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