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Design, synthesis, and correlation analysis of 7-substituted 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cellular respiration.

Abstract：

:Fifteen 7-substituted 4-hydroxyquinoline-3-carboxylic acids have been designed to minimize covariance between the physicochemical substituent parameters: pi, MR, and sigmap. The molecules have been synthesized and evaluated for their ability to inhibit the respiration of Ehrlich ascites cells as a whole cell model and for their ability to inhibit malate dehydrogenase as an intracellular target enzyme model. Correlation analysis indicates that ascites cell inhibition is linearly related to pi and that malate dehydrogenase inhibition is linearly related to MR.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Shah KJ,Coats EA

doi

10.1021/jm00218a003

subject

Has Abstract

pub_date

1977-08-01 00:00:00

pages

1001-6

issue

8

eissn

0022-2623

issn

1520-4804

journal_volume

20

pub_type

杂志文章

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