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A novel trial design to study the effect of intravenous immunoglobulin in chronic inflammatory demyelinating polyradiculoneuropathy.

Abstract：

:Using a novel trial design, we prospectively examined the effect of intravenous immunoglobulin in seven patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in a double-blind, placebo-controlled cross-over study. We suggest that the commonly used manual muscle testing and Rankin scale are not sufficiently sensitive to measure changes in CIDP and should not be used as isolated outcome measures. We propose a timed 10-m walk, the Nine-Hole Peg Test, the Hammersmith Motor Ability Score, and myometry as alternative measures which are valid, reliable and sensitive. Our trial design permitted the measurement of a treatment response in three responders despite different patterns of disability typical of the broad clinical picture seen in CIDP.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Thompson N,Choudhary P,Hughes RA,Quinlivan RM

doi

10.1007/BF00868527

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

280-5

issue

3

eissn

0340-5354

issn

1432-1459

journal_volume

243

pub_type

临床试验,杂志文章,随机对照试验

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