当前位置： SCI文献检索 > EUROPEAN UROLOGY期刊下所有文献 > Analysis of the capillary architecture in the precursors of prostate cancer: recent findings and new concepts.

Analysis of the capillary architecture in the precursors of prostate cancer: recent findings and new concepts.

Abstract：

OBJECTIVE:To report on recent findings and new concepts in the remodeling of the capillary architecture in the precursors of prostate cancer. METHODS:Immunohistochemical methods have been adopted in prostate cancer and in its precursors (prostatic intra-epithelial neoplasia) to investigate capillary pattern changes-which were mainly analyzed as capillary frequency- and the degree of endothelial cell proliferation. Several features related to the capillary architecture have been considered. Manual, semiautomatic, and automatic (machine vision) types of evaluation have been used to quantify the features. RESULTS:The data available indicate that: (1) Going from normal prostate through prostatic intra-epithelial neoplasia up to invasive adenocarcinoma, an increasing proportion of capillaries becomes shorter, with open lumen and undulated external contour and with greater proliferation of the endothelial cells and greater expression of type IV collagenase. The highest proportion of touching capillaries is seen in normal prostate, while the lowest is found in invasive adenocarcinoma, being intermediate in prostatic intra-epithelial neoplasia. (2) When total androgen ablation is induced, there is no proliferation of the endothelium, whereas the capillaries are reduced in frequency and represented by small vessels lined by flat endothelial cells and with an open lumen. (3) Automation in the evaluation of the capillary architecture is feasible with a machine vision system. CONCLUSIONS:The progression in prostate carcinogenesis is associated with changes in the capillary architecture. There are some preliminary data indicating that total androgen ablation can inhibit the angiogenesis in precursors of prostate cancer.

journal_name

Eur Urol

journal_title

European urology

authors

Montironi R,Diamanti L,Thompson D,Bartels HG,Bartels PH

doi

10.1159/000474169

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

191-200

issue

2

eissn

0302-2838

issn

1873-7560

journal_volume

30

pub_type

杂志文章,评审

相关文献

EUROPEAN UROLOGY文献大全
  • Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan, China.

    abstract：BACKGROUND:Previous studies on coronavirus disease 2019 (COVID-19) have focused on populations with normal immunity, but lack data on immunocompromised populations. OBJECTIVE:To evaluate the clinical features and outcomes of COVID-19 pneumonia in kidney transplant recipients. DESIGN, SETTING, AND PARTICIPANTS:A total...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2020.03.039

    authors： Zhu L,Gong N,Liu B,Lu X,Chen D,Chen S,Shu H,Ma K,Xu X,Guo Z,Lu E,Chen D,Ge Q,Cai J,Jiang J,Wei L,Zhang W,Chen G,Chen Z

    更新日期：2020-06-01 00:00:00

  • Comparison of the clinical validity of free prostate-specific antigen, alpha-1 antichymotrypsin-bound prostate-specific antigen and complexed prostate-specific antigen in prostate cancer diagnosis.

    abstract：OBJECTIVE:To evaluate the diagnostic utility of free prostate specific antigen (fPSA), alpha-1- antichymotrypsin-bound PSA (PSA-ACT), complexed PSA (cPSA), and including their associated ratios to total PSA (tPSA) in serum for discrimination between prostate cancer (PCa) and benign prostatic hyperplasia (BPH). METHODS...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000052413

    authors： Lein M,Jung K,Elgeti U,Petras T,Stephan C,Brux B,Sinha P,Winkelmann B,Schnorr D,Loening S

    更新日期：2001-01-01 00:00:00

  • Relationship between prostatic cytoplasmic and nuclear androgen receptors in patients with carcinoma of the prostate.

    abstract：:Cytoplasmic and nuclear androgen receptors were measured in benign prostatic hypertrophy, untreated malignant prostates and diethylstilboestrol-treated malignant prostates. The levels of total androgen receptors in benign prostatic hypertrophy were not statistically different from those in the untreated or treated mal...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000473170

    authors： Ghanadian R,Auf G,Williams G

    更新日期：1981-01-01 00:00:00

  • Renal cysts. II. Chemical and dynamic study of cystic fluid.

    abstract：:The chemical analysis of the fluid obtained by puncturing 100 simple renal cysts in adults show that the composition of cystic fluid resembles that of interstitial fluid. The chemical balance between cystic fluid and the interstitial space seems to occur passively. Antibiotics which were given orally (amoxycilline, mi...

    journal_title：European urology

    pub_type： 杂志文章

    doi：

    authors： Steg A

    更新日期：1976-01-01 00:00:00

  • EAU Guidelines on benign prostatic hyperplasia (BPH).

    abstract：OBJECTIVE:To establish guidelines for the diagnosis, treatment, and follow-up of BPH. METHODS:A search of published work was conducted using Medline. In combination with expert opinions recommendations were made on the usefulness of tests for assessment and follow-up: mandatory, recommended, or optional. In addition, ...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000049784

    authors： de la Rosette JJ,Alivizatos G,Madersbacher S,Perachino M,Thomas D,Desgrandchamps F,de Wildt M,European Association of Urology.

    更新日期：2001-09-01 00:00:00

  • Describing the Grade of Prostate Cancer: Consistent Use of Contemporary Terminology Is Now Required.

    abstract：:Editors of the major urological literature advocate the use of the recent Gleason Grade groupings when reporting analyses of prostate cancer. ...

    journal_title：European urology

    pub_type： 社论

    doi：10.1016/j.eururo.2016.03.007

    authors： Zietman A,Smith J,Klein E,Droller M,Dasgupta P,Catto J

    更新日期：2016-07-01 00:00:00

  • Prognostic significance of bone metastases and bisphosphonate therapy in patients with renal cell carcinoma.

    abstract：BACKGROUND:Bone metastases (BMs) are frequently present in patients with metastatic renal cell carcinoma (mRCC) and cause significant morbidity. OBJECTIVE:The purpose of this analysis was to assess the impact of BMs and bisphosphonate therapy (BT) on outcomes in mRCC. DESIGN, SETTING, AND PARTICIPANTS:We conducted a ...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2014.02.040

    authors： McKay RR,Lin X,Perkins JJ,Heng DY,Simantov R,Choueiri TK

    更新日期：2014-09-01 00:00:00

  • Complications following vasectomy. A comparison between Mersilene and autosuture surgiclips.

    abstract：:Comparison of the use of autosuture surgiclips and Mersilene for occlusion of the vas deferens showed a significantly lower number of complications, such as local infections, granuloma and fistula, within a month following vasectomy, when autosuture surgiclips were used (0.005 less than p less than 0.01). After 6 mont...

    journal_title：European urology

    pub_type： 杂志文章

    doi：

    authors： Zeegers AG,van Helsdingen PJ

    更新日期：1988-01-01 00:00:00

  • Survival and Functional Stability in Chronic Kidney Disease Due to Surgical Removal of Nephrons: Importance of the New Baseline Glomerular Filtration Rate.

    abstract：BACKGROUND:Chronic kidney disease (CKD) can be associated with a higher risk of progression to end-stage renal disease and mortality, but the etiology of nephron loss may modify this. Previous studies suggested that CKD primarily due to surgical removal of nephrons (CKD-S) may be more stable and associated with better ...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2015.04.043

    authors： Lane BR,Demirjian S,Derweesh IH,Takagi T,Zhang Z,Velet L,Ercole CE,Fergany AF,Campbell SC

    更新日期：2015-12-01 00:00:00

  • Validation of the 2009 TNM version in a large multi-institutional cohort of patients treated for renal cell carcinoma: are further improvements needed?

    abstract：BACKGROUND:A new edition of the TNM was recently released that includes modifications for the staging system of kidney cancers. Specifically, T2 cancers were subclassified into T2a and T2b (< or =10 cm vs >10 cm), tumors with renal vein involvement or perinephric fat involvement were classified as T3a cancers, and thos...

    journal_title：European urology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.eururo.2010.07.006

    authors： Novara G,Ficarra V,Antonelli A,Artibani W,Bertini R,Carini M,Cosciani Cunico S,Imbimbo C,Longo N,Martignoni G,Martorana G,Minervini A,Mirone V,Montorsi F,Schiavina R,Simeone C,Serni S,Simonato A,Siracusano S,Volpe A

    更新日期：2010-10-01 00:00:00

  • Image analysis in the determination of ploidy and prognosis in renal cell carcinoma.

    abstract：:The usefulness of ploidy determination by flow cytometry in renal cell carcinoma is disputed. An alternative technique for DNA quantitation, computerised static image analysis, has several advantages over flow methods. Tissue from 90 cases of primary renal cell carcinoma was analysed by image analysis. Cases were assi...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000474761

    authors： Lanigan DJ,McLean PA,Murphy DM,Donovan MG,Leader M

    更新日期：1992-01-01 00:00:00

  • A placebo-controlled comparison of the efficiency of triple- and monotherapy in category III B chronic pelvic pain syndrome (CPPS).

    abstract：OBJECTIVES:To perform a prospective, placebo-controlled study to examine the efficacy of alpha-blocker compared with triple therapy (alpha-blocker, anti-inflammatory, and muscle relaxant) in the treatment of Category IIIB chronic pelvic pain syndrome (Category IIIB CPPS). MATERIALS AND METHODS:The study was conducted ...

    journal_title：European urology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.eururo.2006.09.036

    authors： Tuğcu V,Taşçi AI,Fazlioğlu A,Gürbüz G,Ozbek E,Sahin S,Kurtuluş F,Cek M

    更新日期：2007-04-01 00:00:00

  • The radius surgical system - a new device for complex minimally invasive procedures in urology?

    abstract：OBJECTIVE:Complex laparoscopic procedures in urology are technically demanding with an extended learning curve. Robotic systems add significant cost to laparoscopic procedures. We therefore evaluated the use of the Radius Surgical System (RSS), a mechanical manipulator, for complex laparoscopic cases in urology. MATER...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2006.11.046

    authors： Frede T,Hammady A,Klein J,Teber D,Inaki N,Waseda M,Buess G,Rassweiler J

    更新日期：2007-04-01 00:00:00

  • Posterior reconstruction of the rhabdosphincter allows a rapid recovery of continence after transperitoneal videolaparoscopic radical prostatectomy.

    abstract：OBJECTIVES:Urinary incontinence is one of the major drawbacks of radical retropubic prostatectomy (RRP). One of the possible reasons for this urinary incontinence is a postoperative deficiency of the rhabdosphincter (RS). It has been recently demonstrated that reconstruction of the posterior aspects of the RS allows a ...

    journal_title：European urology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.eururo.2006.10.014

    authors： Rocco B,Gregori A,Stener S,Santoro L,Bozzola A,Galli S,Knez R,Scieri F,Scaburri A,Gaboardi F

    更新日期：2007-04-01 00:00:00

  • Recoverability of erectile function in post-radical cystectomy patients: subjective and objective evaluations.

    abstract：BACKGROUND:Literature regarding both subjective and objective evaluations of erectile function following radical cystectomy is deficient. OBJECTIVE:To study the recoverability of erectile function in post-radical cystectomy patients on subjective and objective bases. DESIGN, SETTING, AND PARTICIPANTS:Between March 20...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2008.06.072

    authors： Hekal IA,El-Bahnasawy MS,Mosbah A,El-Assmy A,Shaaban A

    更新日期：2009-02-01 00:00:00

  • Value of duplex Doppler ultrasonography in renal colic.

    abstract：OBJECTIVES:The aim of our study was to determine the value of duplex Doppler ultrasonography (DDU) in the patients' evolution with renal colic. The study of the resistive index (RI), difference of the RI (ARI) associated with a DDU intravesical recording (ureteral jets) were compared with renographic findings in renal ...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/s0302-2838(01)00005-7

    authors： Geavlete P,Georgescu D,Cauni V,Niţa G

    更新日期：2002-01-01 00:00:00

  • BTA stat and BTA TRAK: A comparative evaluation of urine testing for the diagnosis of transitional cell carcinoma of the bladder.

    abstract：OBJECTIVE:We compared the BTA (bladder tumor antigen) stat test with the BTA TRAK assay in patients highly suspicious of bladder cancer. METHODS:The BTA stat and the BTA TRAK tests are two immunoassays that detect human complement factor H related protein in urine, employing the same antibody pair. The BTA stat is a q...

    journal_title：European urology

    pub_type： 临床试验,杂志文章

    doi：10.1159/000019824

    authors： Irani J,Desgrandchamps F,Millet C,Toubert ME,Bon D,Aubert J,Le Duc A

    更新日期：1999-02-01 00:00:00

  • Hyaluronic acid: an effective alternative treatment of interstitial cystitis, recurrent urinary tract infections, and hemorrhagic cystitis?

    abstract：OBJECTIVES:Hyaluronic acid is a protective barrier of the urothelium. A damaged glycosaminoglycan layer may increase the possibility of bacterial adherence and infection. This damage is proposed to be a causative factor in the development of interstitial cystitis, common urinary tract infections, and hemorrhagic cystit...

    journal_title：European urology

    pub_type： 杂志文章,评审

    doi：10.1016/j.eururo.2007.03.020

    authors： Iavazzo C,Athanasiou S,Pitsouni E,Falagas ME

    更新日期：2007-06-01 00:00:00

  • Computerised assessment of maximum urinary flow: an efficient, consistent and valid approach.

    abstract：OBJECTIVES:To evaluate the relative accuracy of a computerised method to quantitatively assess maximum urinary flow. METHODS:A total of 1147 uroflows were evaluated by the computerised method and by three experts from different European countries. The sample consisted of uroflows from the respective visits by a 20% sa...

    journal_title：European urology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0302-2838(01)00037-9

    authors： Witjes WP,de la Rosette JJ,van den Berg-Segers A,Colongo D,Koch G,Zlotta AR,Colau A,de Wildt MJ,Wijkstra H

    更新日期：2002-02-01 00:00:00

  • Tamoxifen treatment in oligozoospermia.

    abstract：:This study of the effects of long-term tamoxifen administration on semen analysis of oligospermic males confirms the potential therapeutic efficacy in normogonadotrophic oligospermia. 38 out of the 56 patients responded well to long-term treatment with 30 mg tamoxifen daily. According to the nomenclature of Eliasson, ...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000473241

    authors： Bartsch G,Scheiber K

    更新日期：1981-01-01 00:00:00

  • Amsacrine and cisplatin in poor prognosis patients with metastatic transitional cell carcinoma of the urothelium: a phase-II study.

    abstract：OBJECTIVES:Amsacrine, as a single agent, was reported to be effective in patients with metastatic transitional cell carcinoma of the urinary bladder. Amsacrine is also associated with a lower toxicity than cyclophosphamide, doxorubicin and cisplatin therapy and has similar activity. But amsacrine has been forgotten in ...

    journal_title：European urology

    pub_type： 临床试验,杂志文章

    doi：10.1159/000049794

    authors： Popov I,Jelíc S,Radosavljevíc D,Nikolíc-Tomasevíc Z

    更新日期：2001-09-01 00:00:00

  • Gemcitabine plus vinorelbine chemotherapy in patients with advanced bladder carcinoma who are medically unsuitable for or who have failed cisplatin-based chemotherapy.

    abstract：OBJECTIVE:To evaluate the efficacy and toxicity of gemcitabine plus vinorelbine chemotherapy in patients with advanced bladder carcinoma who are unsuitable for or who have failed cisplatin-containing chemotherapy. PATIENTS AND METHODS:Thirty-one patients with advanced transitional cell carcinoma (TCC) of the bladder w...

    journal_title：European urology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0302-2838(03)00385-3

    authors： Türkölmez K,Bedük Y,Baltaci S,Göğüş C,Göğüş O

    更新日期：2003-12-01 00:00:00

  • Delay in the surgical treatment of bladder cancer and survival: systematic review of the literature.

    abstract：OBJECTIVES:Eighty per cent of the newly diagnosed invasive bladder tumours are invasive from the outset. Half of these patients already have occult distant metastases reflecting the rapid nature of progression. The aim of the current study was to review the literature to determine if delay in cystectomy leads to worse ...

    journal_title：European urology

    pub_type： 杂志文章,评审

    doi：10.1016/j.eururo.2006.05.046

    authors： Fahmy NM,Mahmud S,Aprikian AG

    更新日期：2006-12-01 00:00:00

  • Needle core length is a quality indicator of systematic transperineal prostate biopsy.

    abstract：OBJECTIVE:To analyse the length of needle cores sampled as a quality indicator in systematic transperineal prostate biopsy. We assessed the correlation of core length with the other clinical and topographic parameters. MATERIAL AND METHODS:We prospectively evaluated data from 509 consecutive patients who underwent a f...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2005.12.057

    authors： Ficarra V,Martignoni G,Novella G,Cerruto MA,Galfano A,Novara G,Pea M,Artibani W

    更新日期：2006-08-01 00:00:00

  • Holmium laser enucleation of the prostate versus open prostatectomy for prostates >70 g: 24-month follow-up.

    abstract：OBJECTIVE:Prospectively evaluate perioperative outcomes and 2-yr follow-up after holmium laser enucleation (HoLEP) and standard open prostatectomy (OP) for treating benign prostatic hyperplasia-related obstructed voiding symptoms, with prostates >70 g. METHODS:From March 2003 to December 2004, 80 consecutive patients ...

    journal_title：European urology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.eururo.2006.04.003

    authors： Naspro R,Suardi N,Salonia A,Scattoni V,Guazzoni G,Colombo R,Cestari A,Briganti A,Mazzoccoli B,Rigatti P,Montorsi F

    更新日期：2006-09-01 00:00:00

  • Correlation of embryonic development and adult neoplastic changes of human prostate.

    abstract：:We have studied embryonic and fetal differentiation of the human prostate in relation to androgen-producing Leydig cell differentiation. We have studied the differentiation of human prostatic glands and the synthesis of acid phosphatase in vivo and in vitro. These studies have shown that the mesenchyme at the level of...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000471623

    authors： Kellokumpu-Lehtinen P

    更新日期：1989-01-01 00:00:00

  • Lymphadenectomy in the surgical management of penile cancer.

    abstract：CONTEXT:Uncertainty remains about the extent and indications for inguinal lymphadenectomy in penile cancer, a procedure known for relatively high morbidity. Several attempts have been made to develop strategies which can improve the diagnostic quality and reduce the morbidity of the management of inguinal lymph nodes i...

    journal_title：European urology

    pub_type： 杂志文章,评审

    doi：10.1016/j.eururo.2009.02.021

    authors： Protzel C,Alcaraz A,Horenblas S,Pizzocaro G,Zlotta A,Hakenberg OW

    更新日期：2009-05-01 00:00:00

  • Augmented reality: a new tool to improve surgical accuracy during laparoscopic partial nephrectomy? Preliminary in vitro and in vivo results.

    abstract：BACKGROUND:Use of an augmented reality (AR)-based soft tissue navigation system in urologic laparoscopic surgery is an evolving technique. OBJECTIVE:To evaluate a novel soft tissue navigation system developed to enhance the surgeon's perception and to provide decision-making guidance directly before initiation of kidn...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2009.05.017

    authors： Teber D,Guven S,Simpfendörfer T,Baumhauer M,Güven EO,Yencilek F,Gözen AS,Rassweiler J

    更新日期：2009-08-01 00:00:00

  • Skeletal morbidity in men with prostate cancer: quality-of-life considerations throughout the continuum of care.

    abstract：OBJECTIVE:With current treatments, men usually survive many years after being diagnosed with prostate cancer. However, without supportive care, the systemic effects of prostate cancer and therapies such as androgen deprivation therapy (ADT) can undermine skeletal integrity, resulting in skeletal complications that may ...

    journal_title：European urology

    pub_type： 杂志文章,评审

    doi：10.1016/j.eururo.2004.08.016

    authors： Saad F,Olsson C,Schulman CC

    更新日期：2004-12-01 00:00:00

  • Duloxetine, a serotonin and noradrenaline reuptake inhibitor (SNRI) for the treatment of stress urinary incontinence: a systematic review.

    abstract：OBJECTIVE:Surgery and pelvic floor muscle training are established methods for treating stress urinary incontinence (SUI). A new serotonin and noradrenaline reuptake inhibitor, duloxetine, has been studied in multiple phase 3 trials as a form of medical management of this condition. This systematic review determined th...

    journal_title：European urology

    pub_type： 杂志文章,评审

    doi：10.1016/j.eururo.2006.08.041

    authors： Mariappan P,Alhasso A,Ballantyne Z,Grant A,N'Dow J

    更新日期：2007-01-01 00:00:00