Abstract:
OBJECTIVE:To evaluate the efficacy and toxicity of gemcitabine plus vinorelbine chemotherapy in patients with advanced bladder carcinoma who are unsuitable for or who have failed cisplatin-containing chemotherapy. PATIENTS AND METHODS:Thirty-one patients with advanced transitional cell carcinoma (TCC) of the bladder were scheduled to receive gemcitabine and vinorelbine chemotherapy. Twenty-one patients had received no prior chemotherapy and their creatinine clearance was below 50 ml/min (group 1), and the remaining 10 patients did not respond to previous cisplatin-containing chemotherapy (group 2). RESULTS:In group 1, objective response rate was 47.6%, including 2 (9.5%) complete and 8 (38.9%) partial responses. In group 2, partial response was observed in 2 (20%) patients. The median survival time for patients in group 1 and 2 were 15 months (range 3-23) and 7 months (range 3-21), respectively. Grades 3 or 4 leukopenia developed in 16.1% of patients. Overall, 12.9% of the patients suffered from grade 3 nonhematologic toxicity. CONCLUSION:Our preliminary data indicate that the combination of gemcitabine and vinorelbine is active and well tolerated especially in patients with advanced TCC who are unsuitable for cisplatin-based chemotherapy.
journal_name
Eur Uroljournal_title
European urologyauthors
Türkölmez K,Bedük Y,Baltaci S,Göğüş C,Göğüş Odoi
10.1016/s0302-2838(03)00385-3keywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
682-6issue
6eissn
0302-2838issn
1873-7560pii
S0302283803003853journal_volume
44pub_type
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