当前位置： SCI文献检索 > EUROPEAN UROLOGY期刊下所有文献 > Prognostic significance of bone metastases and bisphosphonate therapy in patients with renal cell carcinoma.

Prognostic significance of bone metastases and bisphosphonate therapy in patients with renal cell carcinoma.

Abstract：

BACKGROUND:Bone metastases (BMs) are frequently present in patients with metastatic renal cell carcinoma (mRCC) and cause significant morbidity. OBJECTIVE:The purpose of this analysis was to assess the impact of BMs and bisphosphonate therapy (BT) on outcomes in mRCC. DESIGN, SETTING, AND PARTICIPANTS:We conducted a pooled analysis of patients with mRCC treated from 2003 to 2011 in phase 2 and 3 trials. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:Statistical analyses were performed using Cox regression and the Kaplan-Meier method. RESULTS AND LIMITATIONS:We identified 2749 patients treated with sunitinib (n=1059), sorafenib (n=355), axitinib (n=359), temsirolimus (n=208), temsirolimus plus interferon-α (IFN-α) (n=208), or IFN-α (n=560), with 28% (n=781) having BMs. A total of 285 patients (10.4%) received BT. The presence of BMs in patients was associated with shorter overall survival (OS) when compared with patients without BMs (13.2 vs 20.2 mo, respectively; p<0.0001) and shorter progression-free survival (PFS) (5.1 vs 6.7 mo, respectively; p<0.0008). When stratified by risk groups, the presence of BMs was associated with shorter OS in all risk groups. The use of BT in patients with BMs was not associated with improved OS compared with patients who did not receive BT (13.3 vs 13.1 mo, respectively; p=0.3801) or improved PFS (5.1 vs 4.9 mo, respectively; p=0.1785). Bisphosphonate users with BMs did not have a decreased rate of skeletal-related events (SREs) compared with nonusers (8.6% vs 5.8%, respectively; p=0.191). In addition, BT was associated with increased rates of hypocalcemia, renal insufficiency, and osteonecrosis of the jaw (p<0.0001). Data were analyzed retrospectively. CONCLUSIONS:We confirm that the presence of BMs is associated with shorter survival in mRCC. BT did not affect survival or SRE prevention and was associated with increased toxicity. PATIENT SUMMARY:In this analysis, we demonstrate that bone metastases are associated with shorter survival in patients with metastatic renal cell carcinoma. In addition, we call into question the utility of bisphosphonate therapy in this population.

journal_name

Eur Urol

journal_title

European urology

authors

McKay RR,Lin X,Perkins JJ,Heng DY,Simantov R,Choueiri TK

doi

10.1016/j.eururo.2014.02.040

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

502-9

issue

3

eissn

0302-2838

issn

1873-7560

pii

S0302-2838(14)00169-9

journal_volume

66

pub_type

杂志文章

相关文献

EUROPEAN UROLOGY文献大全
  • Sexual functioning of adult patients born with meningomyelocele. A pilot study.

    abstract：OBJECTIVES:This pilot study was started to get an impression of the sexual activity and sexual difficulties of adult patients born with meningomyelocele in control at Utrecht University Hospital, and to find out whether these problems deserve more attention from the Spina Bifida Team. METHODS:Seventeen patients (9 men...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000019673

    authors： Vroege JA,Zeijlemaker BY,Scheers MM

    更新日期：1998-01-01 00:00:00

  • Etiological aspects and interest of early surgical management of priapism.

    abstract：:12 patients have been treated for priapism between March 1973 and September 1977. Etiologic conditions have been found 9 times, leaving only 3 idiopathic priapisms. Treatment of choice consisted of 8 saphenocavernous shunts, achieving detumescence in 7 cases and preserving sexual potency in 5. The precocity of operati...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000473100

    authors： Richard F,Fourcade R,Le Guillou M,Jardin A,Kuss R

    更新日期：1979-01-01 00:00:00

  • Acupuncture versus paroxetine for the treatment of premature ejaculation: a randomized, placebo-controlled clinical trial.

    abstract：BACKGROUND:Acupuncture therapy has been used by many researchers in both male and female sexual dysfunction studies. OBJECTIVE:To determine whether acupuncture is effective as a premature ejaculation (PE) treatment compared with paroxetine and placebo. DESIGN, SETTING, AND PARTICIPANTS:The study was conducted with me...

    journal_title：European urology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.eururo.2011.01.019

    authors： Sunay D,Sunay M,Aydoğmuş Y,Bağbancı S,Arslan H,Karabulut A,Emir L

    更新日期：2011-05-01 00:00:00

  • Laparoscopic partial nephrectomy for tumour excision in a horseshoe kidney.

    abstract：:A 62-yr-old woman with a 2-cm enhancing renal mass in the right moiety of a horseshoe kidney was treated via a four-port transperitoneal laparoscopic approach. The tumour was excised by cold scissors, and the parenchyma was sutured with Vicryl 1 sutures with Surgicel bolster and by using pledgets of Hem-o-lok((R)) cli...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2006.10.052

    authors： Tsivian A,Shtricker A,Benjamin S,Sidi AA

    更新日期：2007-04-01 00:00:00

  • New method of postprostatectomy bladder irrigation.

    abstract：:Bacterial filters have been used to sterilise the hospital water supply in order to provide irrigant for postprostatectomy irrigation. This method was compared retrospectively to bladder irrigation derived from a still on the ward. Postoperative bacteriuria was similar in both groups of 75 patients, occurring in 23.7%...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000471532

    authors： MacDermott JP,Ewing R,Gray BK

    更新日期：1989-01-01 00:00:00

  • Focal xanthogranulomatous pyelonephritis: partial nephrectomy as definitive treatment.

    abstract：OBJECTIVES:We report 11 cases of focal xanthogranulomatous pyelonephritis (FXGP), a disease that is very uncommon. The aim of the present work is to assess the effectivity of conservative treatment. MATERIAL AND METHODS:Eleven of the 82 cases of XGP (12.5%) diagnosed between 1970 and 1995 presented the focal form (FXG...

    journal_title：European urology

    pub_type： 杂志文章

    doi：

    authors： Osca JM,Peiro MJ,Rodrigo M,Martinez-Jabaloyas JM,Jimenez-Cruz JF

    更新日期：1997-01-01 00:00:00

  • Laparoscopic radical prostatectomy: technical and early oncological assessment of 40 operations.

    abstract：OBJECTIVE:To evaluate the technical feasibility, oncological efficacy and intraoperative and postoperative morbidity of laparoscopic radical prostatectomy. METHOD:We describe an original technique of laparoscopic radical prostatectomy performed in 40 patients between 26th January and 12th October, 1998. RESULTS:Radic...

    journal_title：European urology

    pub_type： 临床试验,杂志文章

    doi：10.1159/000019921

    authors： Guillonneau B,Cathelineau X,Barret E,Rozet F,Vallancien G

    更新日期：1999-01-01 00:00:00

  • Proposal for a "European Scoring System for Laparoscopic Operations in Urology".

    abstract：PURPOSE:To propose a scoring system of difficulties for the most currently performed laparoscopic procedures in urology. MATERIALS AND METHODS:Each current laparoscopic procedure has been evaluated according to three different criteria: technical difficulty, operative risk and the attention required. Each criterion is...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000049742

    authors： Guillonneau B,Abbou CC,Doublet JD,Gaston R,Janetschek G,Mandressi A,Rassweiler JJ,Vallancien G

    更新日期：2001-07-01 00:00:00

  • alpha1- and alpha2-adrenoceptors in BPH.

    abstract：:The dynamic obstruction of the bladder outlet secondary to benign prostatic hyperplasia (BPH), and the contractile properties of the human prostate are mediated primarily by alpha1-adrenoceptors. There are now at least three subtypes (A, B, and D) of alpha1-adrenoceptors, and recent work revealed that alpha1A-adrenoce...

    journal_title：European urology

    pub_type： 杂志文章,评审

    doi：10.1159/000052315

    authors： Takeda M,Hatano A,Arai K,Obara K,Tsutsui T,Takahashi K

    更新日期：1999-01-01 00:00:00

  • When should quality of life be measured after radical cystectomy?

    abstract：AIM:In this prospective study our aim was to establish the time it takes cystectomized patients' to adapt to their new health status. MATERIALS AND METHOD:A total of 68 patients, having radical cystectomy for bladder cancer (64 males and 4 females) were enrolled in the study. The mean age of the group was 55.4 +/- 8.0...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/s0302-2838(02)00351-2

    authors： Kulaksizoglu H,Toktas G,Kulaksizoglu IB,Aglamis E,Unlüer E

    更新日期：2002-10-01 00:00:00

  • Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair.

    abstract：CONTEXT:Varicocele is a common condition, found in many men who present for infertility evaluation. OBJECTIVE:To assess the effect of varicocelectomy on male infertility. EVIDENCE ACQUISITION:A literature search was performed using Embase and Medline. Literature reviewed included meta-analyses and randomized and nonr...

    journal_title：European urology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.eururo.2011.06.018

    authors： Baazeem A,Belzile E,Ciampi A,Dohle G,Jarvi K,Salonia A,Weidner W,Zini A

    更新日期：2011-10-01 00:00:00

  • Muscle- and nerve-sparing bulbar urethroplasty: a new technique.

    abstract：BACKGROUND:To describe a new surgical technique for the repair of bulbar urethral strictures to preserve the bulbospongiosum muscle and its perineal innervation. OBJECTIVE:Surgical steps of muscle- and nerve-sparing bulbar urethroplasty are described. The outcome is provided regarding semen sequestration and postvoidi...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2008.03.018

    authors： Barbagli G,De Stefani S,Annino F,De Carne C,Bianchi G

    更新日期：2008-08-01 00:00:00

  • Localization of NADPH diaphorase and vasoactive intestinal polypeptide-containing neurons in the efferent pathway to the rat corpus cavernosum.

    abstract：OBJECTIVE:We examined the coexistence of nitric oxide synthase (NOS) and vasoactive intestinal peptide (VIP) in the efferent pathway to the rat corpus cavernosum. METHODS:We used NADPH diaphorase (ND) histochemical staining, a specific marker of neuronal NOS, in combination with retrograde axonal transport of True Blu...

    journal_title：European urology

    pub_type： 杂志文章

    doi：

    authors： Tamura M,Kagawa S,Tsuruo Y,Ishimura K,Kimura K,Kawanishi Y

    更新日期：1997-01-01 00:00:00

  • Anticholinergic Burden in the Elderly Population: An Emerging Concern.

    abstract：:Antimuscarinics are commonly used to treat overactive bladder, but increase anticholinergic burden, which has been associated with multiple adverse outcomes in older patients. We advocate for standardization of anticholinergic risk assessment and reevaluation of anticholinergic prescribing practices for the elderly. ...

    journal_title：European urology

    pub_type： 社论

    doi：10.1016/j.eururo.2019.03.021

    authors： Pierce H,Thomas D,Asfaw T,Chughtai B

    更新日期：2019-07-01 00:00:00

  • Neuroendocrine differentiation in hormone refractory prostate cancer following androgen deprivation therapy.

    abstract：OBJECTIVE:To evaluate the relationship between neuroendocrine differentiation (NED) status and hormone refractory prostate cancer (HRPC) following hormone therapy based on immunohistochemical study. METHODS:Seventy-two prostate cancer specimens obtained at radical prostatectomy and 21 prostate cancer autopsy specimens...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2003.11.032

    authors： Hirano D,Okada Y,Minei S,Takimoto Y,Nemoto N

    更新日期：2004-05-01 00:00:00

  • Nephroblastoma associated with mesangioproliferative glomerulonephritis.

    abstract：:The case of a girl showing left-sided Wilms tumor together with a nephrotic syndrome is presented. Recovery after tumor nephrectomy was uneventful. After cessation of cytostatic chemotherapy chronic renal failure developed. Open wedge biopsy of the right kidney revealed endstage glomerular disease. Renal histology in ...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000473495

    authors： Ringert RH,Pistor K

    更新日期：1982-01-01 00:00:00

  • Improved technique of tubeless cutaneous ureterostomy and results of permanent urinary diversion.

    abstract：:An improved technique of tubeless cutaneous ureterostomy through a single stoma was devised by modifing the traditional cutaneous ureterostomy. Using this method, urinary diversions were performed on 12 cases with malignancies: 6 had radical cystectomy and the other 6 had pelvic exenteration. Normal bilateral ureters ...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000471550

    authors： Hirokawa M,Iwasaki A,Yamazaki A,Asakura S,Nozaki A,Yamagishi T

    更新日期：1989-01-01 00:00:00

  • Systematic Review Links the Prevalence of Intraductal Carcinoma of the Prostate to Prostate Cancer Risk Categories.

    abstract：:Intraductal carcinoma of the prostate (IDC-P) is associated with poor prognosis. While it is often regarded as a rare pathology, the prevalence of IDC-P remains unclear, with variable reports from small and disparate patient populations. To determine how common IDC-P is across the spectrum of prostate cancer, we condu...

    journal_title：European urology

    pub_type： 杂志文章,评审

    doi：10.1016/j.eururo.2017.03.013

    authors： Porter LH,Lawrence MG,Ilic D,Clouston D,Bolton DM,Frydenberg M,Murphy DG,Pezaro C,Risbridger GP,Taylor RA

    更新日期：2017-10-01 00:00:00

  • Conservative management of renal stab wound by double-J ureteral stent and specific percutaneous arterial embolization.

    abstract：:We report on the conservative management of a renal stab wound by double-J stenting and specific percutaneous arterial embolization in a 34-year-old man. Surgical exploration was avoided because there was a little doubt about the associated intra-abdominal injuries. Recovery was excellent and the patient left the hosp...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000471710

    authors： de Jong Z,Rousseau H,Pontonnier F,Bouthirit S,Joffre F,Raillat C,Plante P

    更新日期：1991-01-01 00:00:00

  • Prognostic value of Ki-67 expression in renal cell carcinomas.

    abstract：OBJECTIVE:The aim of the study was to determine the prognostic power of Ki-67 immunostaining in renal cell carcinomas (RCC). METHODS:Clinical follow-up data were reviewed in 111 RCC and the results of Ki-67 immunolabelling were correlated to standard prognostic factors and survival data of the patients. RESULTS:Ki-67...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000474482

    authors： Aaltomaa S,Lipponen P,Ala-Opas M,Eskelinen M,Syrjänen K

    更新日期：1997-01-01 00:00:00

  • Cytogenetic and flow cytometric DNA analysis in renal cell carcinoma.

    abstract：:Cytogenetic and flow cytometric DNA analyses were performed on 37 tumor samples from 16 patients with renal cell carcinoma. 36 cultures were chromosomally abnormal and 1 was normal. The most frequent abnormality was trisomy or tetrasomy of chromosome 7 (13 of 16 tumors), suggesting that this abnormality might be a pri...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000473581

    authors： Ljungberg B,Nordenson I,Roos G

    更新日期：1991-01-01 00:00:00

  • Epithelioid leiomyoma of the prostate.

    abstract：:We report a case of an unusual mesenchymal tumor of the prostate. Rectal-digital palpation and transrectal ultrasound showed a circumscribed and inhomogeneous tumor within the right prostatic lobe. Surgical treatment consisted of transurethral resection of the right prostatic lobe. On the basis of morphology and immun...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000474157

    authors： Schumacher S,Moll R,Müller SC,Voges GE,Hohenfellner R

    更新日期：1996-01-01 00:00:00

  • PSA bouncing after short term androgen deprivation and 3D-conformal radiotherapy for localized prostate adenocarcinoma and the relationship with the kinetics of testosterone.

    abstract：OBJECTIVES:To assess the factors effecting PSA bounce and to identify any possible relationship with biochemical control after 3-D conformal radiotherapy (3D-CRT) and total androgen deprivation (TAD) for prostate cancer by evaluating four previously described PSA bounce definitions. METHODS:Between January 1998 and Ja...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2005.04.007

    authors： Akyol F,Ozyigit G,Selek U,Karabulut E

    更新日期：2005-07-01 00:00:00

  • Comparison of partial nephrectomy and percutaneous ablation for cT1 renal masses.

    abstract：BACKGROUND:Partial nephrectomy (PN) is a preferred treatment for cT1 renal masses, whereas thermal ablation represents an alternative nephron-sparing option, albeit with higher reported rates of recurrence. OBJECTIVE:To review our experience with PN, percutaneous radiofrequency ablation (RFA), and percutaneous cryoabl...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2014.07.021

    authors： Thompson RH,Atwell T,Schmit G,Lohse CM,Kurup AN,Weisbrod A,Psutka SP,Stewart SB,Callstrom MR,Cheville JC,Boorjian SA,Leibovich BC

    更新日期：2015-02-01 00:00:00

  • Treatment of uretero-intestinal and ureterovesical strictures by Acucise balloon catheter.

    abstract：OBJECTIVE:Acucise balloon catheter has been proposed as an alternative to open surgery for the treatment of strictures of the ureteropelvic junction because of its low morbidity and the short hospital stay following the endoscopic procedure. The objective of this study was to evaluate the results of this technique appl...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/s0302-2838(02)00070-2

    authors： Touiti D,Gelet A,Deligne E,Fassi-Fehri H,Benrais H,Martin X,Dubernard JM

    更新日期：2002-07-01 00:00:00

  • The concept of uroselectivity.

    abstract：:Alpha1-adrenoceptor antagonists have been shown to decrease both the voiding and storage symptoms of benign prostatic hyperplasia (BPH). Based on the assumption that these symptoms can be attributed to the consequences of the increase in outflow resistance caused by noradrenaline stimulation of stromal alpha1-adrenoce...

    journal_title：European urology

    pub_type： 杂志文章,评审

    doi：10.1159/000052228

    authors： Andersson KE

    更新日期：1998-01-01 00:00:00

  • Safety study of umbilical single-port laparoscopic radical prostatectomy with a new DuoRotate system.

    abstract：BACKGROUND:Laparoendoscopic single-site (LESS) radical prostatectomy (RP) has been performed through different approaches. A new DuoRotate manual system developed by Richard Wolf (KeyPort; Richard Wolf GmbH, Knittlingen, Germany) can be applied to RP. OBJECTIVES:Our aim was to describe the surgical technique and repor...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2012.04.043

    authors： Cáceres F,Cabrera PM,García-Tello A,García-Mediero JM,Angulo JC

    更新日期：2012-12-01 00:00:00

  • The microbiological and pharmacokinetic profile of an antibacterial agent useful for the single-dose therapy of urinary tract infection.

    abstract：:Single-dose therapy of uncomplicated urinary tract infection (UTI) has been shown to be effective in many trials in adult women. The question which will be explored in this presentation is what properties constitute the ideal agent for the therapy of UTI. Important microbiological properties include spectrum of activi...

    journal_title：European urology

    pub_type： 临床试验,杂志文章

    doi：10.1159/000472856

    authors： Slack R,Greenwood D

    更新日期：1987-01-01 00:00:00

  • Further experiences with the specific red cell adherence test (SRCA) in bladder cancer. a histological and cytological study.

    abstract：:The red cell adherence test allows the disclosure of the blood group antigens incorporated on the surface of the urothelium. In the course of dedifferentiation the urothelium will lose its antigenicity. We applied this test on superfical bladder tumours (T1), carcinoma in situ and cytological specimens and observed a ...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1159/000473993

    authors： Jakse G,Hofstädter F

    更新日期：1978-01-01 00:00:00

  • Incidence and remission of female urinary incontinence over 6.5 years: analysis of a health screening project.

    abstract：OBJECTIVES:To analyse the incidence and remission of female urinary incontinence (UI) over 6.5 years and to identify risk factors for the development of UI. METHODS:Women who underwent a health investigation in 1998 or 1999 in the area of Vienna completed the Bristol Female Lower Urinary Tract Symptoms questionnaire. ...

    journal_title：European urology

    pub_type： 杂志文章

    doi：10.1016/j.eururo.2006.02.010

    authors： Wehrberger C,Temml C,Ponholzer A,Madersbacher S

    更新日期：2006-08-01 00:00:00