Differential alternative splicing of PACAP receptor in pituitary cell subpopulations.

abstract：:Hypospadias is one of the most common congenital malformations. It is considered to be a mild form of the 46,XY disorders of sex development (DSD), but its precise etiology remains to be elucidated. Compromised androgen synthesis or effects can cause this frequent malformation, although the mutational analyses of the ...

journal_title：Molecular and cellular endocrinology

authors： Kalfa N,Philibert P,Baskin LS,Sultan C

更新日期：2011-03-30 00:00:00

abstract：:This paper reports the identification of five preprogalanin complementary deoxyribonucleic acids encoding preprogalanin peptides in the goldfish. Preprogalanin 1A, 1B and 1C are encoded in galanin gene 1 and 2A and 2B are encoded in gene 2. Preprogalanin 1B and 2B have a 24 amino acids insert in the mature peptide reg...

journal_title：Molecular and cellular endocrinology

authors： Unniappan S,Lin X,Peter RE

更新日期：2003-02-28 00:00:00

abstract：:Megalin mediates transcytosis of thyroglobulin (Tg), the thyroid hormone precursor, resulting in its passage into the bloodstream. The process involves especially hormone-poor Tg, which may favour hormone secretion by preventing competition with hormone-rich Tg for proteolytic degradation. To gain more insight into th...

journal_title：Molecular and cellular endocrinology

authors： Lisi S,Segnani C,Mattii L,Botta R,Marcocci C,Dolfi A,McCluskey RT,Pinchera A,Bernardini N,Marinò M

更新日期：2005-05-31 00:00:00

abstract：:The aim of our study was to investigate the direct effects of atypical antipsychotics on muscle cell functions in order to ascertain the diabetic liability of these drugs. We investigated the effects of olanzapine, clozapine and alpha-methyl-5-hydroxytryptamine on basal glucose uptake and glucose uptake in response to...

journal_title：Molecular and cellular endocrinology

authors： Tulipano G,Spano P,Cocchi D

更新日期：2008-09-24 00:00:00

abstract：:The LHRH receptor in alpha T3-1 gonadotrope cells was shown to bring about a marked and sustained activation of MAP kinase. This response was prevented by protein kinase C inhibition or down-regulation and could be partially mimicked by phorbol ester. Additional evidence for inhibition of this response by pertussis to...

journal_title：Molecular and cellular endocrinology

authors： Sim PJ,Wolbers WB,Mitchell R

更新日期：1995-08-11 00:00:00

abstract：:Urine based gonadotropin assays provide a practical means of analyzing hormone secretion patterns. While research protocols have revealed pulsatile patterns of gonadotropins such as LH in the blood, these assays are of limited clinical use since daily venipuncture sampling is not feasible outside of a research environ...

journal_title：Molecular and cellular endocrinology

authors： Birken S,McChesney R,Yershova O,Gaughan J,Pettersson K,Rechenberg G,Wu CH,Taliadouros G

更新日期：2007-01-02 00:00:00

abstract：:The present work describes the identification of (anti)progestin endocrine disrupting chemicals (EDC) using a two step screening system. In the first step a competitive binding assay was developed using recombinant human progesterone receptor (hPR). The tested chemicals were of various classes like insecticides, their...

journal_title：Molecular and cellular endocrinology

authors： Viswanath G,Halder S,Divya G,Majumder CB,Roy P

更新日期：2008-11-25 00:00:00

abstract：:The expression of the three genes encoding the components C1, C2 and C3 of prostatic binding protein (PBP) is under androgen control and restricted to the rat ventral prostate. The SstI-PvuII fragment of the first intron of the C3(1) gene displays two binding sites for ubiquitous transcription factors and one for a ti...

journal_title：Molecular and cellular endocrinology

authors： Celis L,Claessens F,Peeters B,Heyns W,Verhoeven G,Rombauts W

更新日期：1993-08-01 00:00:00

abstract：:The modulation of cardiac growth by estrogen in healthy mice is not completely understood. The aim was to investigate the effects of estrogen on cardiac growth in healthy mice lacking either estrogen receptor (ER) α or β. Wild-type (WT), ERα knockout (ERKO) and ERβ knockout (BERKO) 2-month-old mice were ovariectomized...

journal_title：Molecular and cellular endocrinology

authors： Kararigas G,Nguyen BT,Jarry H

更新日期：2014-02-15 00:00:00

abstract：:The red-spotted grouper, Epinephelus akaara, is a protogynous hermaphroditic fish that shows the characteristic of natural sex change. In this study, 2-year-old female groupers were successfully reversed to functional males by oral administration of 17alpha-methyltestosterone (MT) for 42 days. The protein inhibitor of...

journal_title：Molecular and cellular endocrinology

authors： Li SW,Long ZF,Du J,Liu SG,Wen JJ

更新日期：2009-10-15 00:00:00

abstract：:The binding of triiodothyronine (T3) to tadpole liver, intestine, and tail fin nuclei was consistent with a single class of binding sites. The KD for the binding of T3 to isolated nuclei from the liver (1.02 nM), intestine (1.40 nM), and tail fin (0.831 nM) nuclei were not significantly different. The number of bindin...

journal_title：Molecular and cellular endocrinology

authors： Jaffe RC

更新日期：1987-07-01 00:00:00

abstract：:In amphibians, the main role of thyroid hormones (THs) is to regulate metamorphosis; however, there is evidence that THs also affect gonadal sexual differentiation. In this study, Silurana (Xenopus) tropicalis tadpoles were exposed to triiodothyronine (T3; 0, 0.5, 5 and 50 nM), the bioactive form of THs for 48h. Real-...

journal_title：Molecular and cellular endocrinology

authors： Duarte-Guterman P,Trudeau VL

更新日期：2011-01-01 00:00:00

abstract：:Members of the dual specificity tyrosine phosphorylated and regulated kinase family (Dyrk) were shown to have a highly testis-abundant or testis-restricted expression pattern. Furthermore, for some members of the family an involvement in gene expression regulation by phosphorylating transcription factors has been show...

journal_title：Molecular and cellular endocrinology

authors： Sacher F,Möller C,Bone W,Gottwald U,Fritsch M

更新日期：2007-03-15 00:00:00

abstract：:Cultured human luteinized granulosa cells (GC) are a unique model to study regulation of the human corpus luteum, e.g. by local factors, including acetylcholine (ACh). GC express functional ACh-receptors of the M1-type (M1R). Priming with the cholinergic agonist carbachol for 24 h, followed by a 24 h stimulation with ...

journal_title：Molecular and cellular endocrinology

authors： Fritz S,Grünert R,Stocco DM,Hales DB,Mayerhofer A

更新日期：2001-01-22 00:00:00

abstract：:During rapid development of the fetus, levels of high density lipoprotein (HDL) are elevated in pregnant women. The receptor for HDL, scavenger receptor class B type I (SR-BI), mediates selective cholesteryl ester uptake and is highly expressed in the human placenta. Because of the rapid growth of uterus during early ...

journal_title：Molecular and cellular endocrinology

authors： Kim JG,Vallet JL,Nonneman D,Christenson RK

更新日期：2004-07-30 00:00:00

abstract：:Presently, a growing interest is focused on the origins of the "Metabolic Syndrome", a cluster of several metabolic disorders linking obesity, dyslipidemia, hypertension and type 2 diabetes mellitus. Clearly, genetic predisposition and deleterious lifestyle, including low physical activity and hypercaloric alimentatio...

journal_title：Molecular and cellular endocrinology

authors： Somm E,Schwitzgebel VM,Vauthay DM,Aubert ML,Hüppi PS

更新日期：2009-05-25 00:00:00

abstract：:Mammalian α4 phosphoprotein binds to the protein phosphatase 2A catalytic subunit (PP2Ac) to regulate PP2A activity, and to poly(A)-binding protein (PABP) and progestin-inducible EDD E3 ubiquitin ligase. This study showed induction of the EDD protein by progesterone, 17β-estradiol and prolactin in breast cancer cells....

journal_title：Molecular and cellular endocrinology

authors： McDonald WJ,Thomas LN,Koirala S,Too CKL

更新日期：2014-01-25 00:00:00

abstract：:Wnt signaling is an evolutionarily conserved pathway that regulates cell proliferation, differentiation and apoptosis. To investigate the possible role of Wnt signaling in the regulation of ovarian follicular development, secondary follicles were isolated and cultured in vitro in the presence or absence of its activat...

journal_title：Molecular and cellular endocrinology

authors： Li L,Ji SY,Yang JL,Li XX,Zhang J,Zhang Y,Hu ZY,Liu YX

更新日期：2014-02-15 00:00:00

abstract：:Individual variation in sensitivity to glucocorticoids (GCs) poses a dilemma to the clinician. Currently available assays to determine individual sensitivity to GCs either seem imprecise, or they are based on mitogen-activated lymphocytes, although mitogens themselves may affect cellular GC sensitivity. To avoid these...

journal_title：Molecular and cellular endocrinology

authors： Vermeer H,Hendriks-Stegeman BI,van Suylekom D,Rijkers GT,van Buul-Offers SC,Jansen M

更新日期：2004-04-15 00:00:00

abstract：:Effects of insulin-like growth factor I on the expression of the immediate-early gene c-fos in adrenomedullary tissue were assessed in bovine chromaffin cells in primary culture. The expression of c-fos mRNA and FOS protein were studied by Northern blot and immunofluorescence microscopy. IGF-I induced c-fos mRNA expre...

journal_title：Molecular and cellular endocrinology

authors： Skar R,Larsen TH,Serck-Hanssen G

更新日期：1994-12-01 00:00:00

abstract：:The prostate gland is highly dependent on androgens for its development, growth and function. Consequently, the prostatic epithelium predominantly consists of androgen-dependent luminal cells, which express the androgen receptor at high levels. In contrast, androgens are not required for the survival of the androgen-r...

journal_title：Molecular and cellular endocrinology

authors： Oldridge EE,Pellacani D,Collins AT,Maitland NJ

更新日期：2012-09-05 00:00:00

abstract：:Valproic acid (VPA) has been shown to increase the reprogramming efficiency of induced pluripotent stem cells (iPSC) from somatic cells, but the mechanism by which VPA enhances iPSC induction has not been defined. Here we demonstrated that VPA directly activated Oct4 promoter activity through activation of the PI3K/Ak...

journal_title：Molecular and cellular endocrinology

authors： Teng HF,Li PN,Hou DR,Liu SW,Lin CT,Loo MR,Kao CH,Lin KH,Chen SL

更新日期：2014-03-05 00:00:00

abstract：:Type 4 phosphodiesterases (PDE4s) of the large PDE enzyme superfamily have unique specificity for cAMP and may, therefore, be relevant for somatotroph tumorigenesis. Somatotroph adenomas typically overexpress PDEs probably as part of a compensatory mechanism to reduce cAMP levels. The rat PDE4A5 isoform (human homolog...

journal_title：Molecular and cellular endocrinology

authors： Bizzi MF,Pinheiro SVB,Bolger GB,Schweizer JROL,Giannetti AV,Dang MN,Ribeiro-Oliveira A Jr,Korbonits M

更新日期：2018-11-15 00:00:00

abstract：:The inhibins are secreted alpha:beta heterodimers of the TGF-beta superfamily that are mainly synthesized in Sertoli cells and granulosa cells, and are critical regulators of testicular and ovarian development and function. Mice homozygous for a targeted deletion of the inhibin alpha subunit gene (Inha(-/-)) develop s...

journal_title：Molecular and cellular endocrinology

authors： Nagaraja AK,Agno JE,Kumar TR,Matzuk MM

更新日期：2008-11-06 00:00:00

abstract：:Very few silver grains were seen on the luteal cell surface and none intracellularly after incubation for 2 h at 4 degrees C with 10 nM [3H]prostaglandin (PG) E1 or [3H]PGF2 alpha. However, incubation at 22 degrees C or 38 degrees C for 2 h resulted in association of numerous grains on the luteal cell surface as well ...

journal_title：Molecular and cellular endocrinology

authors： Chegini N,Rao CV,Cobbs G

更新日期：1984-12-01 00:00:00

abstract：:The endocrine function of the ovary is dependent upon the ovarian follicle, which on a cellular basis consists of an oocyte surrounded by adjacent somatic cells responsible for generating sex steroid hormones and maintenance of hormonal stasis with the hypothalamic-pituitary axis. As females age, both fertility and th...

journal_title：Molecular and cellular endocrinology

authors： Truman AM,Tilly JL,Woods DC

更新日期：2017-04-15 00:00:00

abstract：:alpha-Fetoprotein (AFP) is a serum protein expressed during fetal life, the expression of which is shut off after birth. The activity of the mouse Afp gene promoter region comprised between -80 and -38 bp is regulated by the thyroid hormone receptor (T3R): negatively in the presence of T3 and positively in the absence...

journal_title：Molecular and cellular endocrinology

authors： Van Reeth T,Gabant P,Szpirer C,Szpirer J

更新日期：2002-02-25 00:00:00

abstract：:G-protein-coupled estrogen receptor-30 (GPR30), also known as G-protein estrogen receptor-1 (GPER1), is a putative extranuclear estrogen receptor whose precise functions in the brain are poorly understood. Studies using exogenous administration of the GPR30 agonist, G1 suggests that GPR30 may have a neuroprotective ro...

journal_title：Molecular and cellular endocrinology

authors： Tang H,Zhang Q,Yang L,Dong Y,Khan M,Yang F,Brann DW,Wang R

更新日期：2014-04-25 00:00:00

abstract：:Successful natural reproduction normally requires vigorously motile spermatozoa. Using a signal peptide trapping strategy, we identified two new genes, a putative sperm Na+/H+ exchanger (sNHE) and the putative cation channel CatSper2, with unique and essential roles in sperm motility. Disruption of the sNHE or CatSper...

journal_title：Molecular and cellular endocrinology

authors： Quill TA,Wang D,Garbers DL

更新日期：2006-05-16 00:00:00

abstract：:1,25-Dihydroxyvitamin D(3) (1,25D(3)), the active metabolite of vitamin D(3), inhibits breast cancer cell growth in vivo and in vitro. To examine mechanisms of 1,25D(3) induced growth arrest and apoptosis, cell lines were established from DMBA induced mammary tumors derived from vitamin D(3) receptor knockout (VDRKO) ...

journal_title：Molecular and cellular endocrinology

authors： Zinser GM,McEleney K,Welsh J

更新日期：2003-02-28 00:00:00