Abstract：
:It is believed that perioperative hemorrhage, in the hepatoportal area, results from a coagulopathy. This study determined if this could be quantitated by a modified recalcification time (MRT) test developed in our laboratory. Unlike prothrombin (PT) and activated partial thromboplastin times (APTT), the MRT is performed with whole blood to ensure the role of blood cells and chemicals (particularly tissue factor, a potent procoagulant) in the coagulation process. Candidates for liver transplantation (n = 11) were studied. Samples (5 mL) of citrated venous blood were obtained from the patients. Aliquots (1 mL) from these samples were divided into groups of vials labeled C, S, and E. Groups C and S received 20 microL saline and group E, 20 microL of saline containing 10 micrograms of Escherichia coli endotoxin (055: B5W). Vial C was incubated for 10 minutes and vials S and E for 120 minutes, all at 37 degrees C. Then, the MRT was determined on 300 microL of blood from each vial after adding 40 microL of 0.1M calcium chloride. Mean MRT values (minutes +/- standard deviation) for C (MRTC), for S (MRTS), and for E (MRTE) were compared with like values from healthy controls (n = 29). Despite prolonged PT and APTT values, MRT values were shortened in patients with cirrhosis. This hypercoagulability detected by the MRT exonerates a hemorrhagic coagulopathy and possibly implicates widened and thinned gaps in the walls of the portal venous tributaries as the cause of perioperative hemorrhage.
journal_name
J Natl Med Assocjournal_title
Journal of the National Medical Associationauthors
Sirikonda PR,Spillert CR,Koneru B,Ponnudurai R,Wilson DJ,Lazaro EJsubject
Has Abstractpub_date
1996-05-01 00:00:00pages
306-9issue
5eissn
0027-9684issn
1943-4693journal_volume
88pub_type
杂志文章abstract：:Imatinib mesylate (STI 571, Gleevec) is a potent bcr-abl tyrosine kinase inhibitor. It also inhibits c-kit tyrosine kinase. Imatinib mesylate is active in the treatment of cronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). It is considered by some authorities to be the standard of care in newly ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2003-08-01 00:00:00
abstract：:The achievements of 19th century medical education, practice, literature, and science and their affect on 20th century medicine are reviewed. The contributions made by 19th century physicians to change medical education are described, as well as the social processes that influenced medicine and science in both centuri...
journal_title：Journal of the National Medical Association
pub_type： 历史文章,杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：:Despite the widespread availability of firearms, stab wounds to the abdomen, back, and flank continue to account for a significant number of injuries. The proper sequencing of diagnostic modalities in this patient group is constantly undergoing change. We report our experience with these injuries and present a new alg...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:Educating a physician workforce that reflects the increasing racial and ethnic diversity of our nation is an ongoing challenge of urgent concern. Many medical school kindergarten through 1 2th grade (K-12) pipeline programs focus on "enriching" underrepresented minority (URM) students using strategies to change or "im...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2002-08-01 00:00:00
abstract：:The Masterson curette was used to sample the endometrial cavity of 25 women prior to scheduled hysterectomy for benign or malignant pathology. Adequate amount of tissue was obtained in 20 (87%) of 23 patients who did not have endometrial atrophy. The Masterson curettage detected all seven cases of endometrial hyperpla...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:The purpose of this cross-sectional study was to assess the 2009 prevalence of chlamydial and gonococcal infection in 2 populations in a midwestern city in the United States: patients at a public sexually transmitted disease (STD) clinic, and individuals seeking human immunodeficiency virus (HIV) counseling and testin...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)30312-6
更新日期：2011-04-01 00:00:00
abstract：INTRODUCTION:COVID-19 is an emerging, rapidly evolving global situation, infecting over 25 million people and causing more than 850,000 deaths. Several signs and symptoms have been described to be characteristic of the disease. However, there is a dearth of report on the description of the clinical characteristics of t...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/j.jnma.2020.11.011
更新日期：2020-12-22 00:00:00
abstract：:Little is known about the adverse consequences of anemia during infancy or maternal anemia during pregnancy on the behavioral development of the infant. The present research investigates one aspect of these relationships. ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1986-10-01 00:00:00
abstract：:The data of the Third National Cancer Survey show for many cancer types, large differences in cancer incidence between Euro-Americans and Afro-Americans.(1) As in other racial studies, it is difficult to separate environmental and genetic factors. For the cancers which are more frequent among Afro-Americans, environme...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：:The possibility that myocardial ischemia may be associated with chest pain during painful crises was evaluated prospectively in 20 patients (11 women and nine men) with sickle cell disease (19 SS, 1 S beta + thalassemia). Sixteen of 20 (80%) had abnormal ECGs, 7 (35%) had transient ST-T wave changes, and 3 (15%) had p...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
abstract：:Obesity is on the rise worldwide. An obesity subtype, metabolically healthy obese (MHO), is resilient to unfavorable metabolic and cardiovascular effects. Factors predicting MHO phenotype are not well characterized. We aimed to identify MHO and metabolically unhealthy obese (MUO) children and adolescents with respect ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/j.jnma.2017.02.008
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Dyslipidemia is among the most significant risk factors of cardiovascular disease. Many patients with dyslipidemia fail to meet certain therapeutic targets as a result of clinical inertia. AIMS:To explore the views and opinions of physicians who often see and provide healthcare to patients with dyslipidemia...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/j.jnma.2018.04.002
更新日期：2019-02-01 00:00:00
abstract：:During 2005, a risk assessment tool based on the Gail model was used to calculate the five-year risk of developing breast cancer for 445 women who live in socioeconomically disadvantaged urban communities in western Pennsylvania and who attended health fairs and other community-sponsored activities. This tool allowed ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
abstract：PURPOSE:The purpose of this review was to better understand possible social, economic, cultural, behavioral, and systems barriers to breast cancer screening among minority women. METHODS:Relevant manuscripts were identified through a MEDLINE/PubMed search for English-language literature from October 1971 through April...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：10.1016/s0027-9684(15)30527-7
更新日期：2010-03-01 00:00:00
abstract：:Strongyloides stercoralis affects 30 to 100 million people worldwide and is a common cause of abdominal pain and diarrhea. Strongyloidiasis is a chronic and limited disease; however, in immunocompromised patients, hyperinfection syndrome can occur. Diagnosing strongyloidiasis early is important, as almost all deaths d...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：10.1016/s0027-9684(15)30246-7
更新日期：2011-01-01 00:00:00
abstract：:This article describes a required primary care curriculum for all third and fourth year medical students at the Drew/UCLA Medical Education Program. The curriculum is a supplement to the traditional medical school clinical requirements. Key features of the primary care core curriculum in the third year include a weekl...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：:Vitamin D deficiency has been linked to fracture risk and chronic musculoskeletal pain. Adults with sickle cell disease have a high prevalence of low bone density and chronic pain with poorly defined etiologies. We recognized that vitamin D deficiency may represent a treatable etiology and sought to determine the prev...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,多中心研究
doi：10.1016/s0027-9684(15)30605-2
更新日期：2010-04-01 00:00:00
abstract：:The number of minority physician graduates depends upon both the recruitment and retention of physician manpower. Numbers cannot be increased until the problems of recruiting and retaining minority students are minimized. This paper describes the process by which one medical school initiated changes to overcome barrie...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1978-11-01 00:00:00
abstract：:The gastrointestinal tract is the largest lymphoid reservoir of the body and is subject to damage that compromises the cellular and humoral defense mechanism. With the increasing numbers of patients infected with the human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS), health-care practiti...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：1994-05-01 00:00:00
abstract：:Sixteen normal individuals and 100 hospital patients, all black, were tested for abnormal carcinoembryonic antigen (CEA) levels. Male and female subjects (smokers and non-smokers) were tested. The results of the tests are discussed. For normal subjects, the CEA values ranged from 0.0 ng/ml to 2.6 ng/ml. Among hospital...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1979-10-01 00:00:00
abstract：BACKGROUND:The endolymphatic sac has been proposed as a target organ responsible for inner-ear symptom in allergic subjects. This is a report of inner-ear symptoms in patients with nasal allergy. METHOD:Retrospective review of record charts of patients with known nasal allergy presenting to the otorhinolaryngology out...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)31403-6
更新日期：2008-08-01 00:00:00
abstract：:The authors established the specificity, reliability, and precision of human erythrocyte insulin radioreceptor assay. On the basis of insulin binding, cell viability, and degree of hemolysis, heparin sodium was found to be a more suitable anticoagulant than sodium fluoride, ethylenediaminetetraacetic acid, sodium oxal...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1983-05-01 00:00:00
abstract：OBJECTIVE AND AIM:Most studies have detected impairment of gallbladder motility among obese compared with nonobese people. However, the relationship between gallbladder motility and weight loss is not well defined. The aim of this study was to evaluate the relationship between percent of weight loss and gallbladder mot...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2006-10-01 00:00:00
abstract：:The harmful effects of tobacco use and nicotine are well known. There is strong epidemiological evidence for smoking as a risk factor for cancer of the lung and oral cavity. The evidence for second-hand smoke as a risk factor for breast cancer is rapidly accumulating. The anthracycline doxorubicin is used in the treat...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2007-04-01 00:00:00
abstract：UNLABELLED:The HIV/AIDS epidemic continues to have a devastating impact on the black community in the United States. Trusted community institutions within the black community--the Black Church among them--have often been reluctant to respond to the epidemic in a manner commensurate with the scope of the problem. The ai...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2005-12-01 00:00:00
abstract：:Growth data were analyzed on 406 infants (211 black, 195 white) during their first two years of life. Only term children weighing more than 2500 g were included in the study. Prenatal and postnatal care were provided at the same university affiliated health maintenance organization. Mean birth weight of black female n...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1986-12-01 00:00:00
abstract：BACKGROUND:This study was a randomized trial to test the impact of an informed decision-making intervention on prostate cancer screening use. METHODS:The study population included 242 African-American men from three primary care practices who were 40-69 years of age and had no history of prostate cancer. Participants ...
journal_title：Journal of the National Medical Association
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2005-08-01 00:00:00
abstract：:Stenosing tenosynovitis of the first dorsal compartment of the wrist (de Quervain's disease) is a common cause of radial wrist and hand pain and disability. Nonoperative management of the disease has been thought to provide only temporary relief of pain and swelling, while surgical intervention has been viewed as a mo...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：:Swainsonine, an indolizidine alkaloid with immunomodulatory activity, has been found to be effective in inhibiting metastatic dissemination and growth of primary tumors of both murine and human origins. The unique ability of swainsonine to exhibit antimetastatic, anti-proliferative, and immunomodulatory activity impar...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：1989-10-01 00:00:00
abstract：BACKGROUND:A number of techniques have been described for treatment of patients with sacrococcygeal pilonidal sinus disease. The author reports his experience in the surgical management of pilonidal sinus using radiofrequency sinus excision technique. The results are compared with those obtained after excision and mars...
journal_title：Journal of the National Medical Association
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2005-07-01 00:00:00
