Abstract：
:Vitamin D deficiency has been linked to fracture risk and chronic musculoskeletal pain. Adults with sickle cell disease have a high prevalence of low bone density and chronic pain with poorly defined etiologies. We recognized that vitamin D deficiency may represent a treatable etiology and sought to determine the prevalence of vitamin D deficiency in adults with sickle cell. We measured 25-hydroxy vitamin D levels in adults at 2 university-based sickle cell disease-management programs. Regression was performed in 142 patients to identify predictors of low vitamin D. Mean vitamin D levels were 9.0 ng/mL at Eastern Virginia Medical School and 12.8 ng/mL at University of Chicago; 139 of 142 (98%) had suboptimal levels (<30 ng/mL) and 85/142 (60%) were severely deficient (<10 ng/mL). Vitamin D level was not related to age, sex, hydroxyurea use, sickle cell type, or date of lab draw. Vitamin D deficiency was, therefore, nearly ubiquitous in our patient population, with a majority being severely deficient. Further studies are warranted to evaluate the effects of vitamin D repletion on clinical outcomes such as bone density, chronic musculoskeletal pain, and functional status. Clinicians caring for patients with sickle cell disease should be aware of and screen for this important clinical state.
journal_name
J Natl Med Assocjournal_title
Journal of the National Medical Associationauthors
Goodman BM 3rd,Artz N,Radford B,Chen IAdoi
10.1016/s0027-9684(15)30605-2subject
Has Abstractpub_date
2010-04-01 00:00:00pages
332-5issue
4eissn
0027-9684issn
1943-4693pii
S0027-9684(15)30605-2journal_volume
102pub_type
杂志文章,多中心研究abstract：:Circumcision is one of the most common surgical procedures performed on males in the United States. Ethical considerations of the procedure have been considered for many years and, recently, research on the topic has shed more light on the debate. The purpose of this study was to review the history and emergence, curr...
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journal_title：Journal of the National Medical Association
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journal_title：Journal of the National Medical Association
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journal_title：Journal of the National Medical Association
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
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journal_title：Journal of the National Medical Association
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doi：
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更新日期：2007-06-01 00:00:00
