Abstract：
OBJECTIVE:Myelodysplastic syndrome (MDS) is recognized as a preleukemic disorder with a variable risk of transformation to acute myeloid leukemia. Usually the blast cells in leukemia are transformed after MDS displays a myeloid phenotype. Lymphoid progression had been reported as myeloid-lymphoid hybrid or early B phenotype, but our patient transformed acute T-lymphoblastic leukemia, which is a rare lymphoid transformation. CLINICAL PRESENTATION AND INTERVENTION:We present a case of refractory anemia with excess of blast that transformed into acute T-cell lymphoblastic leukemia. MDS was diagnosed in a 69-year-old man in April 2007. Twelve month later, he developed T-acute lymphoblastic leukemia. The blasts were positive for expression of CD2, CD3, CD5, CD7, CD45, and HLA-DR, leading to a diagnosis of T-lymphoblastic leukemia. The patient was treated with chemotherapy, but he died of multiple organ failure. CONCLUSION:The mechanism of lymphoid transformation is not yet fully understood. This case clinically supports the nature of MDS as a pluripotent hematopoietic stem cell disorder. MDS often transforms into acute leukemia, usually of a myeloid phenotype. The transformation of MDS into acute lymphoblastic leukemia is extremely rare.
journal_name
J Natl Med Assocjournal_title
Journal of the National Medical Associationauthors
Serefhanoglu S,Goker H,Buyukasik Y,Sayinalp N,Ozcebe OIdoi
10.1016/s0027-9684(15)30887-7subject
Has Abstractpub_date
2009-04-01 00:00:00pages
370-2issue
4eissn
0027-9684issn
1943-4693pii
S0027-9684(15)30887-7journal_volume
101pub_type
杂志文章abstract：PURPOSE:Prostate cancer provides the most dramatic evidence of cancer disparities based on race and ethnicity among U.S. men. African-American men still hold a commanding lead in both prostate cancer incidence and mortality, particularly among those of low socioeconomic status (SES) and the medically underserved. There...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
abstract：:The purpose of this cross-sectional study was to assess the 2009 prevalence of chlamydial and gonococcal infection in 2 populations in a midwestern city in the United States: patients at a public sexually transmitted disease (STD) clinic, and individuals seeking human immunodeficiency virus (HIV) counseling and testin...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)30312-6
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abstract：:Bouveret's Syndrome is obstruction of the duodenum secondary to an impacted gallstone, usually without the presence of pneumobilia. With the steadily increasing life expectancy, greater numbers of these cases are being seen. Gallstones enter the gastrointestinal tract following fistula formation between the gallbladde...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
abstract：:A comprehensive family practice clerkship program at Howard University College of Medicine has been conducted since 1970. This institution is one of three predominantly black institutions offering a family practice program. The senior clerkship is mandatory and at least 20 to 25 percent of each class elect to particip...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:A retrospective review of 20 cases of testicular neoplasia in cryptorchid patients is presented. These cases serve to emphasize the need for more effective diagnosis and management of the undescended testis. The various clinical presentations, diagnostic modalities, prognostic indicators, and types of management are r...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1978-09-01 00:00:00
abstract：:Labetalol and hydrochlorothiazide (HCTZ) were compared for their efficacy in controlling hypertension of blacks in a prospective, double-blind study. Sixty-one adult patients with mild to moderate hypertension (standing diastolic blood pressure greater than or equal to 95 mm Hg and less than or equal to 114 mm Hg) wer...
journal_title：Journal of the National Medical Association
pub_type： 临床试验,杂志文章,随机对照试验
doi：
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abstract：:This study identifies those variables, cognitive and noncognitive, that relate significantly to the successful completion of the combined BA/MD degree program. The study sample included 69 black students who entered at year one, directly from high school, between 1972 and 1981. The Student's t-test identified statisti...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1981-09-01 00:00:00
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
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journal_title：Journal of the National Medical Association
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doi：
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:While the author recognizes the positive impact community psychiatry has had on postpsychotic patients by the uses of medical management and environmental manipulation, he demonstrates that there is a deficiency in the treatment of lower socioeconomic patients with neurotic illnesses. Specifically, neurotic patients t...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1979-04-01 00:00:00
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1982-08-01 00:00:00
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journal_title：Journal of the National Medical Association
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1978-03-01 00:00:00
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1979-10-01 00:00:00
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：2001-07-01 00:00:00
