Abstract：
:Obesity is on the rise worldwide. An obesity subtype, metabolically healthy obese (MHO), is resilient to unfavorable metabolic and cardiovascular effects. Factors predicting MHO phenotype are not well characterized. We aimed to identify MHO and metabolically unhealthy obese (MUO) children and adolescents with respect to metabolic factors, and to find predictors of MHO subtype. A retrospective chart review was done on children, ages 4-19 years, 99% African-American/Caribbean, with BMI ≥95th %tile. MUO was defined as meeting ≥1 of the following: fasting glucose ≥100 mg/dl, HbA1c >5.6%, BP ≥90th %tile, TG ≥150 mg/dl, or HDL <40 mg/dl. Study included 189 subjects, 37.6% were MHO and 62.4% MUO. MHO subjects were younger (mean ± SD, 11.6 ± 3.3 vs 12.9 ± 3.2 years; p < 0.009) and had lower BMI %tile (98.4 ± 1.4 vs 98.8 ± 2.1; p < 0.04), smaller waist (94.2 ± 15.2 vs 101.4 ± 17 cm; p < 0.003) and hip circumferences (105.3 ± 15.6 vs 113.5 ± 15.4 cm; p < 0.001), lower fasting insulin (18.5 ± 10.2 vs 24.2 ± 14.3 μU/ml; p < 0.022), and lower HOMA-IR (4.1 ± 2.4 vs 5.5 ± 3.6; p < 0.022). Acanthosis nigricans was noted less frequently in MHO than MUO (p < 0.005). In stepwise logistic regression, age and BMI %tile were significant predictors of MHO. We found that 38% of obese children are MHO. They are younger and have lower BMI %tiles. Lifestyle modification initiated at an early age may prevent metabolic abnormalities.
journal_name
J Natl Med Assocjournal_title
Journal of the National Medical Associationauthors
Khokhar A,Chin V,Perez-Colon S,Farook T,Bansal S,Kochummen E,Umpaichitra Vdoi
10.1016/j.jnma.2017.02.008subject
Has Abstractpub_date
2017-10-01 00:00:00pages
203-210issue
3eissn
0027-9684issn
1943-4693pii
S0027-9684(16)30151-1journal_volume
109pub_type
杂志文章abstract：:Prehospital delay is an important cause of out-of-hospital coronary mortality. To determine the effects of decision time delay in a patient population comprised mainly of blacks and the underprivileged, 74 consecutive patients with acute chest pain necessitating admission to the coronary care unit in a large urban hos...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
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journal_title：Journal of the National Medical Association
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更新日期：2000-08-01 00:00:00
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journal_title：Journal of the National Medical Association
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doi：
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journal_title：Journal of the National Medical Association
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
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doi：
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journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1980-06-01 00:00:00
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journal_title：Journal of the National Medical Association
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journal_title：Journal of the National Medical Association
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