Abstract：
:Imatinib mesylate (STI 571, Gleevec) is a potent bcr-abl tyrosine kinase inhibitor. It also inhibits c-kit tyrosine kinase. Imatinib mesylate is active in the treatment of cronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). It is considered by some authorities to be the standard of care in newly diagnosed CML as well as patients in chronic phase who do not have a related match. C-kit and its ligand stem-cell factor regulate melanocyte development and survival. Hypopigmentation in patients receiving imatinib mesylate for CML has been reported recently. In this article, we report a black Nigerian male with GIST, who developed hypopigmentation of distal parts of digits, as well as generalized lightening of skin on the body three months after receiving imatinib mesylate. We believe that this is the first case of hypopigmentation reported in a black patient with GIST.
journal_name
J Natl Med Assocjournal_title
Journal of the National Medical Associationauthors
Hasan S,Dinh K,Lombardo F,Dawkins F,Kark Jkeywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
722-4issue
8eissn
0027-9684issn
1943-4693journal_volume
95pub_type
杂志文章abstract：:Multiple Myeloma (MM) is a neoplastic disorder derived from the malignant proliferation of monoclonal plasma cells. It is characterized by the overproduction of immunoglobulins (Ig). We report a rare case in which bulbar palsy was the initial manifestation of IgG-MM. A 66-year-old woman initially presented with progre...
journal_title：Journal of the National Medical Association
pub_type：
doi：10.1016/j.jnma.2020.12.007
更新日期：2021-01-18 00:00:00
abstract：:Numerous studies have documented the presence of racial disparities among Americans in health outcomes with respect to cardiovascular disease, infant mortality, cancer, and kidney disease. With regard to kidney diseases, these disparities are more dramatic. African, Hispanic, and Native Americans have the highest risk...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：2002-08-01 00:00:00
abstract：:Upper gastrointestinal bleeding occurs above the ligament of Treitz as a result of duodenal or gastric ulcers, gastric or esophageal varices caused by cirrhosis of the liver, or Mallory-Weiss syndrome. Bleeding that requires more than three units of blood in 24 hours usually demands operative measures. ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1985-11-01 00:00:00
abstract：:The harmful effects of tobacco use and nicotine are well known. There is strong epidemiological evidence for smoking as a risk factor for cancer of the lung and oral cavity. The evidence for second-hand smoke as a risk factor for breast cancer is rapidly accumulating. The anthracycline doxorubicin is used in the treat...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2007-04-01 00:00:00
abstract：:A comprehensive family practice clerkship program at Howard University College of Medicine has been conducted since 1970. This institution is one of three predominantly black institutions offering a family practice program. The senior clerkship is mandatory and at least 20 to 25 percent of each class elect to particip...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：OBJECTIVES:To assess the level and determinants of African-American physicians' employment in health maintenance organizations (HMOs), particularly early in their careers. METHODS:We analyzed data from the 1991 and 1996 Young Physicians Surveys to assess racial differences in the likelihood of HMO employment (n = 3,70...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:A pilot study to determine whether prenatal and neonatal sickle cell tests conform to the guidelines established by the American Congress of Obstetricians and Gynecologists and the American Academy of Pediatrics. METHODS:The project was initially structured as a pair of in-person interviews of postpartum wom...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,多中心研究
doi：10.1016/s0027-9684(15)30089-4
更新日期：2013-04-01 00:00:00
abstract：:In 1995, questionnaires were sent to the mailing list of the National Medical Association (NMA). The mail responses were supplemented by questionnaires distributed at the NMA annual meeting. Of the 709 respondents, approximately 63% were primary care providers, pediatricians, or obstetrician-gynecologists; 72% were tr...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
abstract：:This paper examines the previously studied topic of the prevalence of uncontrollable behavior in psychiatric emergencies, using the need for restraints as an indicator, and seeks to discover demographic characteristics that were associated with patients needing restraints. The variables considered are sex, referral so...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:Crohn's disease is less prevalent in blacks than in whites. However, when it does occur, it is associated with a high degree of morbidity and is frequently unrecognized at initial presentation. Forty-three patients with Crohn's disease presented to Howard University Hospital between 1965 and 1987. There were 156 hospi...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:Small-bowel obstruction due to foreign bodies is unusual in adults. Intestinal obstruction is occasionally caused by pits, bezoars, endoscopy capsules, and gastrostomy tube buttons. We report a rare case of distal small-bowel obstruction due to dental impression material. Avoidance of this potentially life-threatening...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)31143-3
更新日期：2009-12-01 00:00:00
abstract：:Pneumococcal and mycoplasma infection of the lung or pleura, infarction of lung or pleura, local abscess below the diaphragm, and heart, kidney, or pancreas involvement are among the many causes of pleural effusion. Several of these have an increased likelihood of occurrence in sickle cell disease as a direct conseque...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1977-08-01 00:00:00
abstract：:The author traces the history of theories of food digestion from the prescientific era to the chemical techniques of 19th century investigators. ...
journal_title：Journal of the National Medical Association
pub_type： 历史文章,杂志文章
doi：
更新日期：1987-11-01 00:00:00
abstract：:In the past 2 years, cities have reported skyrocketing rates of violence, crime, and abusive behavior including intrafamilial homicides. Of the 1838 homicide deaths last year among teenagers between the ages of 15 and 19, 71% involved the use of a firearm. Among black males in the same age group, 82% of the deaths wer...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：OBJECTIVE:To identify social, behavioral and epidemiologic factors associated with HIV infection among HIV-infected and HIV-uninfected black women residing in North Carolina. DESIGN:A case-control study conducted in August 2004 in North Carolina. METHODS:Cases were 18-40-year-old women with HIV infections diagnosed f...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2006-11-01 00:00:00
abstract：:Wilms' tumor is a malignancy that most often affects children. It usually is discovered incidentally by a parent or family member in an asymptomatic child. The development of surgical techniques and the addition of adjuvant therapies have made this once incurable disease curable. The National Wilms' Tumor Study group,...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Bellevue Hospital, the oldest public hospital in the United States and a lineal descendant of an infirmary for slaves, accepted its first African-American resident, Dr. Ubert Conrad Vincent, in 1918. This occurred at a time when many medical centers were not accepting African-American residents. At the end of WWII, on...
journal_title：Journal of the National Medical Association
pub_type： 历史文章,杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：:This report describes the treatment of a Viet Nam veteran with an α(2)-adrenergic agonist (clonidine) for hypertension which had an additional beneficial effect of allowing withdrawal in ten days from 20 mg of methadone a day with minimal withdrawal symptoms. ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：PURPOSES:To assess patterns of dementia/Alzheimer's disease (AD) management and to investigate predictive factors of cholinesterase inhibitor prescriptions. METHODOLOGY:A cross-sectional study was conducted using a national survey among the elderly aged >60 from 2000 to 2002. Visit characteristics and cholinesterase i...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:Enlarged spleen without a clear-cut etiology, and believed to be related to malarial infestations, has been referred to as "tropical splenomegaly" and "cryptogenetic splenomegaly." Splenectomy performed in such cases after a failure of antimalarial therapy shows histopathologically, while some of these meet the criter...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1980-04-01 00:00:00
abstract：:We present a case of multiple degloving injuries in an elderly man following a fall from a palm tree. Multiple midface injuries are very rare, although individual types have been reported. Our patient sustained injuries in the lower and middle thirds of the face, including multiple tongue lacerations and a deep jagged...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
abstract：:This analysis represents the first national look at family and individual use of home remedies by African Americans. The purpose is to examine home remedy usage by African-American individuals and their families and assess the relationship between sociodemographic characteristics and home remedy usage for African-Amer...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
abstract：:Hypertension is the leading cause of renal failure in this dialysis and transplant center. When malignant hypertension is encountered, the symptom complex of cachexia and failure to thrive highlights its clinical presentation. The courses of 32 black renal hypertensive patients studied retrospectively demonstrated thi...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
abstract：:A questionnaire was administered to 52 females with sickle disease of genotypes Hgb SS, SC, and S-thalassemia, and to 80 control subjects. They answered questions pertaining to their contraceptive habits, their reproductive habits, and their sexual activity. It was found that sexual activity differed significantly f...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：:Even with major advancements in medical knowledge and significant improvements in health sciences technology, evidence still exists that blacks do not enjoy as full a measure of health as do other racial and ethnic groups. To attempt a better understanding of this situation, literature was reviewed to consider relatio...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:To a cancer patient, pain is a very distressing symptom and to the physician it heralds advanced nature of the disease. While the mechanisms of initiation of pain are simple, its perception is very complex. In cancer, the tumor growth which results in producing pressure, destruction of tissue, and obstruction is the m...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
abstract：OBJECTIVE:Breast cancer mortality has declined, yet disease outcomes have not improved equally across populations. Disparities may initiate early in the continuum of care, in health behavior patterns, and screening practices. We examined variations in mammography, exercise, fruit and vegetable intake, alcohol consumpti...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)30937-8
更新日期：2009-06-01 00:00:00
abstract：CONTEXT:The reasons for African-American men to seek care for lower urinary care symptoms has not been determined due to sparse population-based data. OBJECTIVE:Our study examines the solicitation and receipt of medical care for urinary symptoms among racially oversampled elderly urban and rural cohort of African Amer...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2007-04-01 00:00:00
abstract：:The growing incidence of diabetes mellitus in the world is a widespread concern. While there has been improvement in the epidemiology and management of the disease in the developed world, the same cannot be said in sub-Saharan Africa. The disease is getting less attention as is the funding that it merits compared to c...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)30643-x
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:The purpose of this study is to characterize African-American women attending a community clinic who report frequent douching (douching > or = 2 times per week). METHODS:A consecutive sample of 115 black women attending a community clinic were interviewed face-to-face about their douching practices. Logistic...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2005-10-01 00:00:00
